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Simultaneously Estimation of Paracetamol, Aceclofenac

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Asian Journal <strong>of</strong> Pharmacy & Life Science, Vol. 1 (2), March-June, 2011 ISSN 2231 – 4423<br />

7 Robustness<br />

98.52+<br />

0.438<br />

99.38+<br />

0.794<br />

99.67 +<br />

0.454<br />

98.62+<br />

0.38<br />

99.36+<br />

0.24<br />

99.81+<br />

0.18<br />

FIG 1: FIRST ORDER DERIVATIVE OVERLAY<br />

SPECTRA OF PCM (a), ACF (b) & RAB(c).<br />

ACKNOWLEDGEMENTS<br />

The authors are thankful to Ipca laboratories, Mumbai<br />

for providing gift samples <strong>of</strong> acecl<strong>of</strong>enac and<br />

paracetamol and Cadila Pharmaceuticals Ltd.,<br />

Ahmedabad for providing a gift sample <strong>of</strong> rabepracole.<br />

The authors are grateful to College <strong>of</strong> pharmacy, IPS<br />

academy, Indore for providing facilities to carry out this<br />

work.<br />

REFERENCES -<br />

1) The British Pharmacopoeia Commission. British<br />

Pharmacopoeia, Vol. II, London: the Stationery<br />

Office Books; 1998. p. 33.<br />

2) Indian Pharmacopoeia, 4 th edition. New Delhi:<br />

The Controller <strong>of</strong> Publications, Government <strong>of</strong><br />

India; 1996. p. 347-348.<br />

3) The British Pharmacopoeia Commission. British<br />

Pharmacopoeia, Vol. I, London: the Stationery<br />

Office Books; 2003.p. 1123-1124.<br />

4) Hinz B, Auge D, Rau T, Rietbrock S, Brune K,<br />

Werner U. Simultaneous Determination <strong>of</strong><br />

117<br />

Acecl<strong>of</strong>enac and Three <strong>of</strong> its Metabolites in<br />

Human Plasma by High-Performance Liquid<br />

Chromatography. Biomed Chromatography<br />

2003; 17:268-269.<br />

5) Saharty YS, Refaat M, Khateeb SZ. Stability<br />

Indicating Spectrophotometric and<br />

Densitometric Methods for Determination <strong>of</strong><br />

Acecl<strong>of</strong>enac. Journal <strong>of</strong> Pharmaceutical and<br />

Biomedical Analysis 2002; 27:249-251.<br />

6) Kousy NM. Spectrophotometric and<br />

Spectr<strong>of</strong>luorimetric Determination <strong>of</strong> Etodolac<br />

and Acecl<strong>of</strong>enac. Journal <strong>of</strong> Pharmaceutical and<br />

Biomedical Analysis. 1999; 20:185-188.<br />

7) Zawilla NH, Mohammad MA, Kousy NM,<br />

Moghazy AS. Determination <strong>of</strong> Acecl<strong>of</strong>enac in<br />

Bulk and Pharmaceutical Formulations. Journal<br />

<strong>of</strong> Pharmaceutical and Biomedical Analysis,<br />

2003; 27:243-245.<br />

8) Mahaparale PR, Sangshetti JN, Kuchekar BS<br />

(2007) Simultaneous spectrophotometric<br />

estimation <strong>of</strong> acecl<strong>of</strong>enac and paracetamol in<br />

tablet dosage form. Indian J Pharm Sci., 2007;<br />

69:289-292.<br />

9) Gopinath R, Rajan S, Meyyanathan SN,<br />

Krishnaveni N, Suresh BA (2007) RP-HPLC<br />

method for simultaneous estimation <strong>of</strong><br />

paracetamol and acecl<strong>of</strong>enac in tablets. Indian J<br />

Pharm Sci., 2007; 69:137-140.<br />

10) ICH, Q2A Text on Validation <strong>of</strong> Analytical<br />

Procedures, International Conference on<br />

Harmonization, October 1994.<br />

11) ICH, Q3B Validation <strong>of</strong> Analytical Procedures:<br />

Methodology, International Conference on<br />

Harmonization, November 1996.<br />

Available online on www.ajpls.com Original Research Article

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