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HARN - Nanotech Regulatory Document Archive

HARN - Nanotech Regulatory Document Archive

The second study, Poland

The second study, Poland et al (2008) compared the behaviour and biological impact of a variety of CNT types. It found that long fibre-like CNT elicited a similar biological response in the Apo E -/- mouse to long fibre amosite. This review has identified many similarities between HARN and asbestos with regard to their physico-chemical properties and toxicological effects and has concluded that there is sufficient evidence to suggest that HARN which have the same characteristics (diameter, length and biopersitence) as pathogenic fibres are likely to have similar pathology. This review has also highlighted the lack of data in key areas of toxicology, exposure and assessment. Based on the growing bank of evidence for serious concern to be raised about HARN, a research strategy to further elucidate and address HARN toxicity was constructed. The main components of this strategy are: • Hazard Identification: The characterisation of the physico-chemical properties of HARN especially the length of the fibres and their biopersistence • Dose-Response Assessment: Acute and chronics adverse effects of HARN; Cellular and molecular mechanisms of HARN toxicity investigated with in vitro and in vivo models • Exposure Assessment: Identification and quantification of the routes (e.g. inhalation, dermal); the pattern and the intensity of exposure • The Risk Assessment of HARN: Combining exposure and Hazard to calculate the health risks from exposure to HARN. This review has identified the important issues concerning each of these components and has prioritised them. Finally, recommendations on future studies to cover the information gap are made. Page 44

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Document 4 - ICTF-JPA
Level 0 to ASC Archive Interface Control Document
Level 0 to ASC Archive Interface Control Document