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HARN - Nanotech Regulatory Document Archive

HARN - Nanotech Regulatory Document Archive

6 RECOMMENDATIONS This

6 RECOMMENDATIONS This review has highlighted the potential hazard of HARN. The evidence so far has shown that there are similarities in the mode of action of HARN and asbestos. However, further work is needed to ascertain the relationship between the HARN physico-chemical properties and their toxicity. We make the following prioritised recommendations for future research: • For HARN measurement & characterisation requirements o Of high priority are the studies designed for • Characterisation and quantification of Length/Diameter; Durability; Chemistry; Surface Composition etc…of HARN • Investigation on how to measure HARN physico-chemical properties in suspension and biological tissue • For HARN Toxicology Studies o The following in vivo studies are of high priority • Bio-kinetic study to investigate the distribution of HARN in the pulmonary system. • Chronic and sub-chronic multi-dose inhalation experiments with HARN to investigate a range of endpoints (see in vitro below). Most importantly, there is a need for the creation of respirable aerosols of HARN for the study. o And the following in vitro studies • To Investigate the potential for oxidative stress, inflammation and genotoxicity of HARN • For Exposure and Risk Assessment o The following studies are of high priority • Exposure Assessment: Develop models of occupational, consumer and environmental exposure to HARN • Risk Assessment: Develop model of exposure-dose-response for HARN, calculate DNEL and compare with the exposure levels identified in Exposure Assessment Page 46

7 ACKNOWLEDGEMENT We gratefully acknowledge the valuable contribution made by all those attending the workshop. Without their enthusiasm and their contribution this project would not have been possible. This work was funded by Defra under project CB0406. Page 47

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