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Artesunate versus quinine for severe malaria in children - iDOC Africa

Artesunate versus quinine for severe malaria in children - iDOC Africa

Quality of evidence

Quality of evidence cont… Quality assessment Quality Importance Studies Design Limitations in study methods Outcome: Neurological sequelae at discharge 3 RCTs Some limitations ⊕⊕⊕Ο MODERATE CRITICAL • Slight increase in sequelae at discharge (RR 1.36, 1.01 to 1.83) but after 28 days, there is no significant difference.

Quality of evidence cont… Quality assessment Quality Importance Studies Design Limitations in study methods Outcome: Hypoglycaemia episodes 4 RCTs Some limitations ⊕⊕⊕Ο MODERATE CRITICAL • RRR 38% (13% to 55%) • Intervention beneficial – supported by evidence.

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