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Clinical Research Experience

Clinical Research Experience

DANGERS OF SUBGROUP

DANGERS OF SUBGROUP ANALYSES: example from ISIS-2 randomised trial of effects on death of aspirin treatment for heart attacks Astrological birth sign No. of DEATHS ASPIRIN PLACEBO Statistical significance Gemini or Libra (taken together) All other signs (taken together) Any birth signs (i.e. appropriate overall analysis) 150 147 0.5 (NS adverse) 654 869

MERIT-HF: Effects on total mortality of betablocker in heart failure in various subgroups US patient subgroup FDA datasheet: “..mortality plus “Analyses of US patients heart failure hospitalization showed were carried consistent out effects because in the overall study population and subgroups, of the overall including population”. women and the US population. However, in the Why US is subgroup that justification (n=1071) and for women (n=898), overall mortality post hoc data-dependent and cardiovascular mortality appeared emphasis less on affected.” a subgroup? they represented about 25%

Clinical Research Experience
Clinical outcomes assessments to revive feasibility of trials in CV
Using computerised clinical data for epidemiological research
Clinical Research In Central Oregon - Stcharlesresearch.org
Innovative design of trials
Protection of persons in clinical research - FDIME
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Clinical research participation and adoption of clinical innovations:
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Ethical Principles in Clinical Research
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Introduction to Statistics in Pharmaceutical Clinical Trials
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The Clinical Trial - Signup4.net
Understanding Clinical Trial Design - Research Advocacy Network
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Research Design Considerations for Clinical Trials of ... - immpact
Minimizing Placebo Response in Clinical Trials - IIR
QPS Late Stage Clinical Research Overview - Qps.com
Postgraduate Research Experience Survey 2008 Final report
Adverse Events in Clinical Research