3 years ago

Clinical Research Experience

Clinical Research Experience

PLATO trial: Effect on

PLATO trial: Effect on primary outcome of vascular mortality, MI or stroke in ACS Region Patients Ticr (%) Clop (%) HR (95%CI) Asia/Australia 1714 11.4 14.8 0.80 (0.61-1.04) Central/South America Europe/Middle East/Africa 1237 15.2 17.9 0.86 (0.65-1.13) 13859 8.8 11.0 0.80 (0.72-0.90) North America 1814 11.9 9.6 1.25 (0.93-1.67) ALL REGIONS 18624 9.8 11.7 0.84 (0.77-0.92) P-value for interaction = 0.05 (before any adjustment for this being 1 of 33 pre-specified subgroup analyses)

JUPITER: Non-randomized comparison of effects of different apparent response (Lancet 2009) • “Compared with placebo, participants allocated to rosuvastatin who did not achieve LDL cholesterol less If pre-specified randomized comparisons are than 1.8 mmol/L had no significant reduction in required vascular events to detect …whereas the overall we recorded effects a 55% on outcome, reduction in then those why who would did achieve analyses this target” based on non-randomized subgroup comparisons be considered appropriate (and, indeed, often • But, patients defined by the difference in postrandomization by regulatory cholesterol-lowering authorities)? response to required treatment may well not differ only randomly from each other (e.g. factors related to lipid-response might also be related to clinical outcome).

Clinical Research Experience
Clinical outcomes assessments to revive feasibility of trials in CV
Examples of ethnicity and geography issues in global clinical trials ...
Protection of persons in clinical research - FDIME
CoreValve Clinical Experience
Using computerised clinical data for epidemiological research
CLINICAL STUDIES - PharmXpert Academy
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Clinical Research In Central Oregon -
Innovative design of trials
Clinical resea arch -
PrEP Clinical Trials Results and Future Directions for a ... - amfAR
Outcomes Research and Clinical Research Networks
Community Participation In HIV Clinical Research In Thailand
Clinical research participation and adoption of clinical innovations:
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M S Ramaiah Clinical Research Centre coordinates all Clinical trials ...
Lecture 12: Randomized Clinical Trials - jhsph ocw
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Clinical research underpins the pharmaceutical and ... - ICON plc
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Linking research to clinical practice - SIRM
Clinical Research - Medical Graphics Corporation
Cleveland Clinic Lerner Research Institute