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3 years ago

Clinical Research Experience

Clinical Research Experience

PLATO trial: Effect on

PLATO trial: Effect on primary outcome of vascular mortality, MI or stroke in ACS Region Patients Ticr (%) Clop (%) HR (95%CI) Asia/Australia 1714 11.4 14.8 0.80 (0.61-1.04) Central/South America Europe/Middle East/Africa 1237 15.2 17.9 0.86 (0.65-1.13) 13859 8.8 11.0 0.80 (0.72-0.90) North America 1814 11.9 9.6 1.25 (0.93-1.67) ALL REGIONS 18624 9.8 11.7 0.84 (0.77-0.92) P-value for interaction = 0.05 (before any adjustment for this being 1 of 33 pre-specified subgroup analyses)

JUPITER: Non-randomized comparison of effects of different apparent response (Lancet 2009) • “Compared with placebo, participants allocated to rosuvastatin who did not achieve LDL cholesterol less If pre-specified randomized comparisons are than 1.8 mmol/L had no significant reduction in required vascular events to detect …whereas the overall we recorded effects a 55% on outcome, reduction in then those why who would did achieve analyses this target” based on non-randomized subgroup comparisons be considered appropriate (and, indeed, often • But, patients defined by the difference in postrandomization by regulatory cholesterol-lowering authorities)? response to required treatment may well not differ only randomly from each other (e.g. factors related to lipid-response might also be related to clinical outcome).

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