3 years ago

Clinical Research Experience

Clinical Research Experience

Review underlying

Review underlying assumptions for statistical power during the trial • Assess overall rates of the main clinical outcomes (blinded to allocated treatment) • Assess impact of compliance to allocated treatment on risk factor levels (for example unblinded differences in lipids or BP) • Modify study duration, number of events and/or pre-specified outcomes (blinded to effects of allocation on clinical outcomes)

FDA draft guidance: Adaptive design clinical trials for drugs and biologics “Statistical bias can be introduced into adaptive design studies that make modifications based on interim analyses of a biomarker or an intermediate clinical endpoint thought to be related to the study final endpoint even though the final study analysis uses a clinical efficacy endpoint. This is because of the correlation between the biomarker and final study endpoint.” Not true: assessing the effect on a biomarker (such as blood lipids or pressure) does NOT introduce bias (ie, does not inflate type 1 error)

Clinical Research Experience
Clinical outcomes assessments to revive feasibility of trials in CV
Using computerised clinical data for epidemiological research
Examples of ethnicity and geography issues in global clinical trials ...
Protection of persons in clinical research - FDIME
Clinical research participation and adoption of clinical innovations:
Lecture 12: Randomized Clinical Trials - jhsph ocw
Research Design Considerations for Clinical Trials of ... - immpact
Understanding Clinical Trial Design - Research Advocacy Network
Implementation of Medical Research in Clinical Practice - European ...
QPS Late Stage Clinical Research Overview -
Adverse Events in Clinical Research
Big Research on Bacterial Vaginosis Global Clinical Market Growth,Trends, H2
Clinical Research Applied to Daily Clinical Practice
Grasgow Royal Infirmary Fractire Clinic Experience Presentation
Program - Cleveland Clinic Lerner Research Institute
Data management in clinical research - the Research Centre Page
update on clinical trials for ipf - Coalition for Pulmonary Fibrosis
Clinical Trials Market
Mentoring and Developing an Academic Clinical Research Career
UCSF Resident Clinical &Translational Research ... - Accelerate
Translational and Clinical Research Course for Clinician-Scientists
Applying the Participatory Action Research Model in Clinical Settings
The Center for Clinical Imaging Research - Mallinckrodt Institute of ...
Program - Institute for Clinical Research Education - University of ...
Clinical Research - American Association of Neurological Surgeons
Dr. Kibende Samson - Joint Clinical Research Centre