3 years ago

Clinical Research Experience

Clinical Research Experience

Potential for false

Potential for false negative findings if power assumptions are not assessed during trials Treatment effect on biomarker Anticipated relative risk reduction Active (n=4000) 1.0 20% 480 (12.0%) 0.7 14% 516 (12.9%) Control (n=4000) 600 (15.0%) 600 (15.0%) Power at p=0.01 91% 54% Not to check these assumptions may have adverse public health implications

SUMMARY: how can we innovate? • Innovation may be less important than doing what we already know better – Ensure that trials are LARGE enough to be informative by reducing costs per patient – Avoiding bad statistical practice (eg, country-specific subgroups, non-randomised analyses) • Quality can be built into trials by DESIGN, • Some procedures could be streamlined (eg, adjudication, on-site monitoring) • Statistical methods to improve sensitivity (but not solely as a way of reducing sample size) • Main problem in trials is type II errors: monitoring biomarkers can help avoid this

Clinical Research Experience
Clinical outcomes assessments to revive feasibility of trials in CV
Examples of ethnicity and geography issues in global clinical trials ...
Protection of persons in clinical research - FDIME
CLINICAL STUDIES - PharmXpert Academy
Using computerised clinical data for epidemiological research
PrEP Clinical Trials Results and Future Directions for a ... - amfAR
Community Participation In HIV Clinical Research In Thailand
Clinical Research In Central Oregon -
Outcomes Research and Clinical Research Networks
Innovative design of trials
3 Pharmaceutical Research and Clinical Trials - The Canadian ...
Clinical research participation and adoption of clinical innovations:
Integrating Wound Care Research into Clinical Practice
Clinical Practice Improvement - Primary Health Care Research and ...
Clinical Experience with the Xience V stent ... -
Lecture 12: Randomized Clinical Trials - jhsph ocw
Diploma in Clinical Research - Edutech
M S Ramaiah Clinical Research Centre coordinates all Clinical trials ...
Navigating into a Key Role in Clinical Research - VascularWeb
Advancing Clinical Research on - Friends of the National Library of ...
Clinical research underpins the pharmaceutical and ... - ICON plc
Clinical Research Today - Winter (RBCH Research Newsletter)
clinical experience has shown that patients suffering from
clinical research to Practice: translational - National Institute of ...
CoreValve Clinical Experience