2007 Annual Report - College of Pharmacy - The Ohio State University
2007 Annual Report - College of Pharmacy - The Ohio State University
2007 Annual Report - College of Pharmacy - The Ohio State University
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Academic Divisions, 2006-<strong>2007</strong><br />
Division <strong>of</strong> Medicinal Chemistry and Pharmacognosy<br />
Li, Pui-Kai<br />
Brueggemeier, Robert W.<br />
Carcache de-Blanco, Esperanza<br />
Chen, Ching-Shih<br />
Curley, Robert W.<br />
Kinghorn, A Douglas<br />
Li, Chenglong<br />
Tjarks, Werner<br />
Werbovetz, Karl A.<br />
Whetstone, Jennifer L.<br />
Cassady, John M.<br />
Doskotch, Raymond<br />
Jagadeesh, Jogikal<br />
Olson, Carter<br />
Robertson, Larry<br />
Soloway, Albert<br />
Associate Pr<strong>of</strong>essor and Chair<br />
Pr<strong>of</strong>essor and Dean<br />
Assistant Pr<strong>of</strong>essor (joint, <strong>Pharmacy</strong> Practice and Admin.)<br />
Pr<strong>of</strong>essor<br />
Pr<strong>of</strong>essor<br />
Pr<strong>of</strong>essor and Jack L. Beal Chair<br />
Assistant Pr<strong>of</strong>essor<br />
Assistant Pr<strong>of</strong>essor<br />
Assistant Pr<strong>of</strong>essor<br />
Visiting Assistant Pr<strong>of</strong>essor<br />
Emeritus Pr<strong>of</strong>essor and Dean<br />
Pr<strong>of</strong>essor Emeritus<br />
Pr<strong>of</strong>essor Emeritus<br />
Pr<strong>of</strong>essor Emeritus<br />
Pr<strong>of</strong>essor Emeritus<br />
Emeritus Pr<strong>of</strong>essor and Dean<br />
<strong>The</strong> Division <strong>of</strong> Medicinal Chemistry and Pharmacognosy is composed <strong>of</strong> faculty members<br />
with diversified research interests representing synthetic organic,<br />
natural products, and biological chemistry. Research in medicinal<br />
chemistry emphasizes drug design and includes:<br />
❖ the synthesis <strong>of</strong> organic medicinal products,<br />
❖ elucidation <strong>of</strong> the biochemistry <strong>of</strong> medicinal agents,<br />
❖ examination <strong>of</strong> the relationship <strong>of</strong> chemical structure to<br />
biological activity, qualitative and quantitative analysis <strong>of</strong><br />
drugs and related products, application <strong>of</strong> computational<br />
chemistry to drug design.<br />
Research in pharmacognosy emphasizes drug discovery and<br />
encompasses:<br />
❖ the isolation and structure determination <strong>of</strong><br />
pharmacologically active natural products from plants and<br />
microbes,<br />
❖ studies on the structure and biochemistry <strong>of</strong> biological products,<br />
❖ examination <strong>of</strong> the biosynthesis <strong>of</strong> natural products,<br />
❖ evaluation <strong>of</strong> the biochemical effects <strong>of</strong> these active constituents.<br />
Pui-Kai (Tom) Li<br />
Chair<br />
Werner Tjarks was born and<br />
raised in Bremen Germany, a<br />
northern seaport town. Werner’s<br />
studies in chemistry, drug design<br />
and environmental aspects in<br />
Germany led him to the US in the<br />
early nineties to work with<br />
Dr. Albert Soloway in a postdoctoral<br />
position. In 1997 he took<br />
a position as a Research Scientist<br />
and now as a faculty member,<br />
focuses in the area <strong>of</strong> cancer<br />
research, specifically nucleoside<br />
chemistry. Wener is attempting to<br />
apply this science to the<br />
development <strong>of</strong> anti-cancer drugs.<br />
His research team is using<br />
neutron-capture therapy to treat<br />
cancer. Werner recalls that Dr.<br />
Soloway was never too busy to<br />
talk with any <strong>of</strong> his colleagues.<br />
His <strong>of</strong>fice door was always open<br />
giving his research group the<br />
accessibility to him so critical to<br />
their success in the lab.<br />
Werner finds the academic<br />
climate at OSU conducive to<br />
collaboration and has forged<br />
important relationships with<br />
colleagues from the <strong>College</strong> <strong>of</strong><br />
Medicine and the Veterinary<br />
Biological Science Department.<br />
This year, Dr. Tjarks was<br />
promoted to Associate Pr<strong>of</strong>essor<br />
<strong>of</strong> <strong>Pharmacy</strong>.<br />
Karl Werbovetz’s experience at the<br />
Walter Reed Army Institute <strong>of</strong><br />
Research gave him the opportunity to<br />
see drug development in action and<br />
formed his ideas for current<br />
programs and collaborations here at<br />
OSU. His research now is in the area<br />
<strong>of</strong> anti-parasitic drug discovery and<br />
development. A major problem in<br />
developing countries, lethal<br />
parasites, carried by insects, are a<br />
major cause <strong>of</strong> death. As there is no<br />
financial incentive to develop drugs<br />
in this area, Karl works with NIH,<br />
WHO and the Bill and Melinda Gates<br />
Foundation to fund his research.<br />
Karl joined our <strong>College</strong> in 2000 and<br />
found a new commitment to<br />
infectious disease research here at<br />
OSU. His collaborations with<br />
colleagues across campus are<br />
building a bridge between <strong>Pharmacy</strong><br />
and other health units to continue<br />
this important work in the area <strong>of</strong><br />
infectious disease.<br />
From a small town in upstate<br />
New York (Holland Patent), Karl is<br />
happy to have found a home at <strong>Ohio</strong><br />
<strong>State</strong>, both pr<strong>of</strong>essionally and<br />
personally. He and his wife, Julie,<br />
are raising their family <strong>of</strong> 3 (Luke,<br />
Ben and Graham) in Worthington.<br />
This year, Dr. Werbovetz was<br />
promoted to Associate Pr<strong>of</strong>essor <strong>of</strong><br />
<strong>Pharmacy</strong>.<br />
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