S. aureus - GLOBE Network

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S. aureus - GLOBE Network

Commensal

S. aureus- commensal and pathogen

The carrier paradox

25% of healthy adults: permanent symptom-free

carriers of S. aureus 1

Pathogen

S. aureus: second most

common causative agent of

HA infections in the

industrialized world: mild skin

infection to severe deepinvasive

diseases

S. aureus carriers :4-fold higher risk for an S.

aureus bacteremia, when hospitalized 3,4

1

Heiman et al., PLos Med 2008

2

Heiman et al., The Lancet Infectious

Diseases2005; Lebon et al., JCM 2008

3

Wertheim et al., Lancet 2004

4

Wertheim et al., Lancet Infect. Dis, 2005

In case of an S. aureus

bacteremia: much better

prognosis for carriers than

non-carriers 3, 4

Hypothesis: Colonization

with S. aureus tunes the

adaptive system, which

results in (partial) protection

| 6

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