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BIOMEDICAL SCIENCES

RESEARCH INSTITUTE

ANNUAL REPORT

1 AUGUST 2005 - 31 JULY 2006


BIOMEDICAL SCIENCES

RESEARCH INSTITUTE

ANNUAL REPORT

1 August 2005 – 31 July 2006


BIOMEDICAL SCIENCES

RESEARCH INSTITUTE

ANNUAL REPORT

(1 AUGUST 2005 - 31 JULY 2006)

CONTENTS

Page No

1. Foreword by the Pro-Vice Chancellor (Research and Innovation) 3

2. Foreword by the Director of the Research Institute 4

3. Research Institute Members 7

4. Research Students 13

5. Research Publications 23

6. Research Funding 37

7. Indicators of Esteem 40


1. Foreword by the Pro-Vice Chancellor (Research and Innovation)

Foreword

‘Excellence, Innovation and Regional Engagement.’ This is the

phrase that summarizes the objectives of the University of Ulster

and was derived through institution-wide consultation in the past

academic year. All three parts are highly relevant to research

and, together with the specific core objective to ‘undertake

excellent research in selected areas of activity’, make it clear

that research is, and will continue to be, a highly prized activity

of the University.

When our 17 Research Institutes were established in the 2004-05 academic year

those staff colleagues with research outputs of the highest quality were designated

as members. Over time the number of members has increased, and the research

resources of the University are increasingly focussed on meeting their needs.

Additionally mechanisms have been put in place across all institutes to ensure the

targeted support of colleagues at earlier stages in research careers who have the

potential to emerge as significant researchers in their own right. Our Research

Institutes will be supported to achieve longevity and establish a reputation amongst

external peers, research funders and research users.

This first Annual Report documents a significant body of work much of which is

internationally significant. As a reader, you may be a member of another research

institution, perhaps seeking to collaborate with UU, or perhaps you are a graduate, or

soon-to-be graduate, considering postgraduate research as a starting-point in your

career, or perhaps you are involved in the private sector. You may even have been

responsible for funding some of the research, or you are seeking solutions or

expertise to solve a problem. Whatever your perspective, I hope that the material

contained in this Annual Report will be useful and informative. The precise work

underway in an institute may change with time, as will the Institute’s membership,

and annual reports will be one mechanism through which this evolution will be

tracked.

I commend each colleague whose achievements are documented in this report for

the excellence of her/his work and I assure every reader of the University’s

continuing commitment to supporting the achievement of excellence.

Professor Bernie Hannigan

Pro-Vice Chancellor (Research & Innovation)

3


2. Foreword by the Research Institute Director

2005-6 has seen the Biomedical Sciences Research Institute’s

further expansion into the new SPUR Centre for Molecular

Biosciences building – 6,700 m 2 , £10M, completed on time and

within budget. This has proceeded till the Centre, opened only in

2004, is now nearly full. During this expansion, the internal structure

of the Institute has been considerably modified, by the creation of

additional Research Groups that concentrate on the application of

specific research techniques, rather than on particular research

areas. The overall aim remains as previously, to concentrate on

research into human degenerative diseases, especially those with a

nutritional aspect. Of course, some irrepressible shoots of research

have followed other directions. The new arrangement of groups is

intended to favour inter-group collaboration, especially when

applying one or more specialist techniques to a particular area. As will be obvious from a

perusal of the research students, research publications, and new research income within the

Institute, such collaboration is flourishing. It is at its most striking in the Centre for Functional

Genomics (CFG), a £2M INI-funded project to develop advanced marketable products, which

has contributions from five of the ten groups.

The arrangement of research groups in 2005-6 has been:

Area-related groups:

NICHE, the Northern Ireland Centre for Food and Health, the largest and most productive

Group, covering all aspects of nutritional research, but with particular emphases on

gastrointestinal effects, the biology of satiety, effects and mechanisms of action of

micronutrients, the creation of nutritionally advanced foods, aspects of food safety and

prevention of infection, and nutritional effects on exercise and physiology. CFG member.

Cancer & Ageing Research Group, which regards cancer as (usually) an aspect of ageing.

Direct research into ageing involves studies of Alzheimer disease, through transgenic rodent

models and dietary studies, and of Werner syndrome, a premature ageing disease. Cancerrelated

work encompasses aspect of DNA damage, repair, replication and methylation, often

with nutrition-related angles: particular aspects include studies of DNA metabolism at the

single-cell and single-gene level, and through microarrays. One aspect of cancer therapy

which has shown considerable promise is the specific targeting of hypoxic tumour cells with

drugs, that are only activated in these treatment resistant cells, CFG member.

Diabetes Research Group, seeking to understand the pathological effects of diabetes

through an analysis of the mechanisms of pancreatic beta-cell dysfunction and insulin

glycation; to discover new antidiabetic drugs by isolation of new compounds from natural

sources, and especially by studying the antidiabetic actions of structurally modified peptides;

and by creating insulin-secreting surrogate cells suitable for unraveling the mechanisms of

pancreatic beta cell function and dysfunction. The Diabetes Research Group is intimately

related to its spin-off company, Diabetica, which this year has concluded a very promising

licencing agreement with Amylin Pharmaceuticals, Inc. CFG member.

Vision Science Research Group, working on visual electrophysiology (especially on

functional characteristics of the short wavelength visual system, and on cortical contribution

4


to spatial vision); and on visual impairment (especially on limits to foveal and peripheral

vision in diseased eyes, on optical and retinal changes with age, on ocular blood-flow

associated with nutritional deficiencies, and on visual development in Down Syndrome and

cerebral palsy.

Technique-related groups

Bioimaging Research Group, incorporating the FEI Phillips Centre for Advanced

Bioimaging. This Group has an outstanding array of imaging instruments and software, partly

for support of other Groups, and partly for research into their own areas of interest:

toxicology of nanoparticles, brain regeneration, angiogenesis in wound healing and in tumor

neovascularisation, imaging of living cell surfaces at atomic resolution, and viral growth.

Biomedical Genomics Research Group, applying molecular genomic techniques, including

yeast genetics, to tumor development and metastasis; to hormone/receptor interactions,

especially the role of vitamin D in cancer; and to identification of unusual DNA structures

involved in control mechanisms. CFG member.

Microbial Biotechnology Research Group, concentrating on the exploitation of

microorganisms for therapeutic purposes, and on their diagnosis. Research priorities include

the development of rapid molecular tools are for diagnosis of the water-borne pathogen

Cryptosporidium parvum; the genomic and proteomic studies of thermophilic bacteria, and

their use as sources of new enzymes and antibiotics; biofilm formation in cystic fibrosis; and

the biosynthesis of organophosphonate compounds with biocidal activity. CFG member.

Pharmaceutical Technology Research Group, focusing on the isolation of novel bioactive

peptides and small molecules from a variety of unusual biological sources, including frog,

snake and scorpion venoms and plants. The proteomics of rare human tumors and their cell

lines are also of interest; as is a recent development into the interrelationship of antimalarial

and antiretroviral drugs. One line of research, initially intended to develop an improved form

of gene therapy, has resulted in a successful spinoff company, Gendel, which despite its

name now concentrates on a direct physiological method of treating oesophageal cancer.

Stem Cells and Epigenetics Research Group, working on the identification and

manipulation of lymphopoietic stem cells, and on the role of DNA imprinting in embryo

development.

Systems Biology Research Group, using the modern techniques of massive data

processing and analysis, and image processing to cope with the equally massive amounts of

data being generated by molecular biology and microscopy, and to create in silico models of

biological processes.

Equipment available in the Research Institute includes

Imaging

Histology lab with cryo-ultramicrotome and automatic tissue processor

Quanta 200 environmental SEM

Nova 200 Nanolab twin beam FIB/SEM with cryostage

Tecnai G2 Biotwin TEM

Atomic force microscope

2-photon confocal microscope and four other confocals

4 fluorescence microscopes with a wide range of image analysis software

PALM laser microdissection and capture microscope

5


Molecular and cell biology

Extensive culture facilities including Cat II lab

An array of LC/MS systems including QTOF Ultima, ICP-MS, TSQ Quantum Ultra, Q-trap

LC/MS/MS; MALDI-TOF, Trace MS-EV70 mass spectrometers

Vision and Microflow Pathfinder workstations

Gamma and Xray sources

Electrofusion apparatus

16 thermocyclers plus 2 real-time PCR

2 microarray scanners

Peptide and DNA synthesisers

Protein and DNA sequencers

Nanodrop spectrometer

Nutrition

Residential suite with accommodation for up to 12 volunteers, kitchen for preparation of

duplicate meals

Exercise suite with BodPod, ergometer, treadmill, ergospirometer, bone densitometer

Food sensory lab

Gastrointestinal laboratory

Vision science

Refractometers

Keratometer

Tonometers

Ophthalmometers

Fundus imaging camera

Field analyser

Optical coherence tomographer.

Future prospects include the creation of the £3.9 M Centre for Metabolomics, to be sited

opposite the Centre for Molecular Bioscience. This will bring together researchers from the

NICHE, Diabetes and Biomedical Genomics Research Groups, for the study of complex

metabolic effects. It will allow the concentration of our mass spectrometry expertise,

combined with a NMR laboratory for further study of metabolite molecular structure. It will be

supported by £500,000 of Research Council UK fellowships.

Stephen Downes

Professor Stephen Downes

Director of Biomedical Sciences Research Institute

6


3. Research Institute Members

BIOIMAGING RESEARCH GROUP

Surname Forename Title Position

Howard Vyvyan Prof Group Leader: Professor of Bioimaging

Bridgen Anne Dr Lecturer in Bioimaging

Duffin Nicola Dr Research Associate

McKerr George Dr Senior Lecturer

Mitchell Christopher Dr Senior Lecturer in DNA Metabolism

O’Hagan Barry Dr Research Associate

Staats de Yanés Gesa Dr Research Fellow

BIOMEDICAL GENOMICS RESEARCH GROUP

Surname Forename Title Position

Bjourson Anthony Prof Group Leader: Professor of Genomics

Melcher Karsten Dr Lecturer in Yeast Genetics

Thompson Paul Dr Lecturer in Molecular Biology

Webba Da Silva Mateus Dr Lecturer in Pharmaceutical Chemistry

Bradley Glyn Dr Research Associate

Deligianni Elena Dr Research Associate

Falchi Adriana Dr Research Associate

Schmidt Joachim Dr Research Associate

7


CANCER & AGEING RESEARCH GROUP

Surname Forename Title Position

Downes Stephen Prof Group Leader: Director, BMSRI

Dare Rae Dr Research Associate

Doherty Sharon Dr Research Associate

Hannigan Bernadette Prof PVC (Research & Innovation)

Hölscher Christian Dr Lecturer in Neurobiology

Kurth Mary-Jo Dr Research Associate

McGlynn Angela Dr Research Fellow

McKelvey-Martin Valerie Prof Head of School of Biomedical Sciences

McKenna Declan Dr Research Fellow

McKeown Stephanie Prof Professor of Cancer Biology

Quinn Danny Dr Lecturer in Molecular Biology

Smyth Anca Dr Research Associate

Wasson Gillian Dr Research Associate

Worthington Jenny Dr Research Fellow

DIABETES RESEARCH GROUP

Surname Forename Title Position

Flatt Peter Prof

Group Leader: Professor of Biological &

Biomedical Sciences

Abdel-Wahab Yasser Hassan Atef Dr Senior Research Fellow

Cassidy Roslyn Dr Research Associate

Gault Victor Dr Lecturer in Molecular Biosciences

Green Brian Dr Research Associate

Irwin Nigel Dr Research Associate

Marenah Lamin Dr Research Associate

McClenaghan Neville Dr Senior Lecturer in Biomedical Sciences

McKillop Aine Dr

Lecturer in Clinical & Endocrine

Biochemistry

8


McCluskey Jane Teresa Dr Research Fellow

O'Harte Finbarr Prof Professor of Endocrinology & Metabolism

Patterson Steven Dr Research Associate

Thompson Heather Dr Research Associate

Turbitt Julie Dr Research Associate

MICROBIAL BIOTECHNOLOGY RESEARCH GROUP

Surname Forename Title Position

McMullan Geoff Prof Group Leader: Professor of Microbiology

Banat Ibrahim Mohammed Prof Professor of Microbiology

Dooley James Dr Senior Lecturer

Lowery Colm Dr Lecturer in Medical Microbiology

Marchant Roger Prof Head of Research Graduate School

Ternan Nigel Dr Lecturer in Microbiology

Graham Bobby Dr Research Associate

Snelling Bill Dr Research Associate

NORTHERN IRELAND CENTRE FOR FOOD AND HEALTH

Surname Forename Title Position

Rowland Ian Prof Director, NICHE

Blair Ian Prof Head of School of Health Sciences

Bonham Maxine Dr Research Fellow

Campbell David Dr Research Associate

Clewes Christine Dr Senior Research Fellow

Dowey Le Roy Dr Quality Assurance Officer

Duffy Emeir Dr Lecturer in Human Nutrition

Gallagher Alison Dr Lecturer in Biomedical Sciences

Gill Christopher Dr Lecturer

Graham Cíaren Dr Research Associate

9


Haldar Sumanto Dr Research Associate

Hannon-Fletcher Mary Dr Lecturer in Cellular Pathology

Hoey Leane Dr Research Associate

Livingstone Margaret Barbara Prof Professor of Nutrition

Magee Pamela Dr Lecturer in Human Nutrition

McAnena Liadhan Dr Research Associate

McDowell David Prof Professor of Food Studies

McNulty Helene Prof Professor of Nutritional Science

Naughton Patrick Dr Lecturer in Medical Microbiology

O'Connor Jacqueline Dr Associate Head of School

Owusu-Apenten Richard Dr Lecturer in Food & Nutrition

Pentieva Kristina Dr Senior Research Fellow

Rennie Kirsten Dr Research Fellow

Stewart-Knox Barbara Dr Senior Research Fellow

Strain Sean Prof Professor of Human Nutrition

Thurnham David Prof Emeritus Professor

Wallace Julie Dr Senior Research Fellow

Walsh Paula Dr Research Associate

Ward Mary Dr Senior Lecturer in Biomedical Sciences

Welch Robert Dr Senior Lecturer

PHARMACEUTICAL TECHNOLOGY RESEARCH GROUP

Surname Forename Title Position

Panchagnula Ramesh Prof Group Leader: Professor of Pharmacy

Doherty Bernie Dr Research Associate

Janneh Omar Dr Lecturer in Pharmacology

McClean Stephen Dr Lecturer in Proteomics

McHale Anthony Prof Professor of Medical Biotechnology

Orr David Dr Research Fellow

Ramachandran Ram Dr Research Fellow

Sarker Satyajit Dr Reader in Pharmacy

Smyth Franklin Prof Professor of Bio-Analytical Chemistry

10


STEM CELL & EPIGENETICS RESEARCH GROUP

Surname Forename Title Position

Walsh Colum Dr

Group Leader: Senior Lecturer in

Molecular Genetics

Freeburn Robin Dr

Lecturer in Haematology and

Immunology

Gilmore Billy Dr Reader in Haematology

Lees-Murdock Diane Dr Research Fellow

McDaid Jennifer Dr Research Associate

Lynch Catherine Dr Research Associate

Wheadon Helen Dr Lecturer in Immunology

SYSTEMS BIOLOGY RESEARCH GROUP

Surname Forename Title Position

Dubitzky Werner Prof

Group Leader: Professor of

Bioinformatics

Berrar Daniel Dr Research fellow

Bradbury Ian Dr Lecturer in Statistics

Brolly Thomas Mr Research Associate

Hack Catherine Dr Lecturer in Process Biotechnology

Ma Yingliang Dr Research Fellow

McCanny Paul Dr Research Associate

McConnell Aaron Mr Research Associate

Ostropytskyy Vitaliy Mr Research Associate

Robinson Stephen Dr Research Fellow

Rodriguez Patricia Dr Research Associate

Romberg Mathilde Dr Research Fellow

Saetzler Kurt Dr Lecturer in Computational Biology

Swain Martin Dr Research Associate

11


VISION SCIENCES RESEARCH GROUP

Surname Forename Title Position

Anderson Roger Prof

Group Leader: Professor of Vision

Science

Bierne Raymond Dr Lecturer in Optometry

Hunter David Mr Lecturer in Ethics

Lauritzen Jan Dr Lecturer in Optometry

McClelland Julie Ms Lecturer in Optometry

Moore Tara Dr Lecturer in Immunology

Pierscionek Barbara Prof Professor of Optometry & Vision Science

Saunders Kathryn Dr Senior Lecturer in Vision Science

Vidinova

(publishes

as Zlatkova) Margarita Dr Research Associate

12


4. Research Students

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Allsopp, Philip

Dr David Campbell

Professor Ian Rowland

Effect of novel fructan carbohydrates on gut microflora and its

activities.

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Barrett, Eimear

Professor Stephanie McKeown

Dr Jenny Worthington

Enhancement of nitric oxide production: strategies to target

tumour cell kill.

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Borkowski, Tomasz

Dr Satyajit Sarker

Dr Chris Gill

Evaluation of plant extracts for anticancer potential in in vitro

assay using colon cancer cell lines

Vice Chancellor's Research Studentship

Poland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Bradley, Brendan

Professor Valerie McKelvey-Martin

Mr David Hunter

Does access to focused scientific information affect

opinion on human embryonic stem cell policy

ESF

Northern Ireland

13


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Butterworth, Karl

Professor Stephanie McKeown

Dr Jenny Worthington

An Investigation into the influence of Hypoxia on the Malignant

Progression of Prostate Cancer

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Campbell, Naomi

Dr Mary Hannon-Fletcher

Prof Barbara Livingstone

Investigation of the contribution made by food portion sizes to

food and energy intakes.

DEL UU

UK

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Conant, Eleanor

Professor CS Downes

Professor AJ Bjourson

Investigation of the Y chromosome genetics of Northern Irish

populations.

Vice Chancellor's Research Studentship

USA

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Devlin, Andrea

Professor Stephanie McKeown

Dr Jenny Worthington

A study of CYP1B1 expression in tumourigenesis

No Fees Due, Member of Staff

Northern Ireland

14


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Dienava, Illze

Professor Tony McHale

Professor Tony Bjourson

Virus medicated gene therapy using an erythrocyte based

carrier system

ESF

Latvia

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Dimitriadis, Savvas

Professor Tony McHale

Dr Poonam Singh

Electric field-mediated biosorption – medical applications

Research Office Funding

Greece

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Doherty, Declan

Dr Paul Thompson

Professor Ian Rowland

The nuclear vitamin D receptor-new physiological roles

revealed through Novel interacting proteins

Vice Chancellor's Research Studentship

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Douglas, Donna

Dr Mary Hannon-Fletcher

Dr Alison Gallagher

The impact of modulating micronutrient status on clinical

outcomes in diabetes.

DEL UU

Northern Ireland

15


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Egan, David

Dr Patrick Naughton

Dr James Dooley

To investigate the incidence of salmonella in pigs and pork

meat on the island of Ireland.

FSPB Research Studentship

Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Feeny, Katherine

Professor CS Downes

Late cell cycle control checkpoints

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Fuss, Hendrik

Dr MJ Kurth

Prof W Dubitzky

Prof CS Downes

Analysis and modeling of interactions in kinase/phosphatase

systems.

Vice Chancellor's Research Studentship

Germany

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Gilleece, Teresa

Dr Ian Bradbury

Dr Kurt Saetzler

Assessing the cost-utility of PET/CT scanning in cancer

No Fees Due Member of Staff

Northern Ireland

16


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Guo, Chunteng

Professor Tony Bjourson

Reptile venom peptide proteomics and genomics

Vice Chancellor's Research Studentship

China

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Hamill, Lesley

Dr Rob Welch

Professor Sean Strain

Does dietary iron supplementation inhibit the potential

beneficial effects of phenolics in plant foods

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Hughes, Paul

Professor Tony McHale

Dr Poonam Singh

Electro-biosorbative recovery of economic metals from waste

streams

No Fees Due Member of Staff

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Jamison, Deirdre

Dr Mary Ward

Professor Helene McNulty

B-vitamin status, homocysteine and gastrointestinal disease:

implications for long-term disease risk,

DEL UU

Northern Ireland

17


Name

Supervisor

Johnson, Felicity

Dr Oliver Slevin

Dr Helen McGarvey

Title of Project Process & product in postgraduate nurse education.

Exploring the impact of specialist education programmes on

postgraduate nurses’ clinical practice.

Grant Source

Country of Origin

Self or Parent

Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Keaveney, Edel

Dr Rob Welch

Dr Julie Wallace

Bioavailability and bioactivity of wholegrain components

CEC Framework 6 Food Quality

Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Keenan, Jonathan

Professor Barbara Pierscionek

Dr David Orr

Crystallin protein distributions in the eye lens

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Kelly, Mary

Professor Barbara Livingstone

Dr Mary Hannon-Fletcher

Investigation of the contribution made by food portion size to

food and energy intake

Self or Parent

Ireland

18


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Lecky, Allison

Dr John Winder

Professor David McDowell

Advanced 3D Multislice CT Mapping of the Paranasal Sinuses

Self or Parent

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Li, Ying-suet

Professor Tony McHale

Professor Tony Bjourson

Ultrasound Mediated Gene Transfection – Studies on

Transfection of Mammalian Cells

Vice Chancellor's Research Studentship

China

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Loughery, Jayne

Dr Colum Walsh

Dr Helen Wheadon

Investigating a protein expressed in male stem cells.

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Machado, Maria

Dr Christopher Mitchell

Dr George McKerr

Angiogenesis in healing wounds: bio imaging in situ

Vice Chancellor's Research Studentship

Portugal

19


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Madavo, Crispin

Professor Tony Bjourson

Dr Stephen McClean

Isolation and characterisation of VIP from tape-worms

Self

Zimbabwe

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Maguire Orla

Dr Paul Thompson

Dr Colum Walsh

Professor Stephanie McKeown

Nuclear hormone receptors and prostate cancer: how do the

receptors for vitamin D, androgens and oestrogen functionally

interact to regulate prostate cell growth

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Maingot, Catherine

Professor Tony McHale

Professor Tony Bjourson

The use of sono-sensitive erythrocytes

Vice Chancellor's Research Studentship

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Mandel, Johannes

Professor Werner Dubitzky

Graph-based modeling of biochemical systems

Vice Chancellor's Research Studentship

Germany

20


Name

Supervisor

Title of Project

Grant Source

Country of Origin

McAfee, Alison

Dr Alison Gallagher

Dr Ciaren Graham

Dietary salicylates: a link to reduced breast cancer incidence

ESF

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McAllister, Katherine

Professor Valerie McKelvey-Martin

Professor Stephen Downes

Role of thymidine kinase in DNA metabolism

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McAllister, Roisin Mary

Prof Stephen Downes

Prof Tony Bjourson

Mitotic spindle assembly checkpoint

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McClean, Paula

Professor Finbarr O’Harte

Dr Victor Gault

Inhibition of GIP signalling for alleviation of insulin resistance

and type 2 diabetes

DEL

Northern Ireland

21


Name

Supervisor

Title of Project

Grant Source

Country of Origin

McClelland, Nicholas

Dr Liz Simpson

Dr Jacqueline O’Connor

The impact of fish oil supplementation on the psychological

functioning of ageing human volunteers.

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McConville, Damien

Professor Stephanie McKeown

Professor Werner Dubitsky

An investigation into malignant progression in prostate cancer

No Fees Due, Member of Staff

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McGeough, Cathy

Professor Tony Bjourson

KIR gene expression profiles in Rheumatoid Arthritis

DEL CAST

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

McGurk, Paula

Professor Peter Flatt

Dr Alyson Hill

Studies on the relationships between maternal diet, diabetes

control and pregnancy outcome.

DEL UU

Northern Ireland

22


Name

Supervisor

Title of Project

Grant Source

Country of Origin

McKee, Seona

Professor Tony Bjourson

Dr Paul Thompson

Genetic profiling of breast cancer

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Molha, Duarte

Dr Catherine Hack

Professor Roger Marchant

A data mining approach to thermophily in eubacteria

Vice Chancellor's Research Studentship

Portugal

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Moschonas, Galatios

Professor David McDowell

Professor Ian Blair

Control of blown pack spoilage in vacuum packaged beef

Self or Parent

Greece

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Mullee, Amy

Dr Julie Wallace

Professor Sean Strain

The effect of g-tocopherol (g-T) supplementation on g-T

status, antioxidant capacity and nitrosative stress in

apparently healthy smokers

Food Safety

Ireland

23


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Natarajan, Jeyakumar

Prof W Dubitzky

Dr C Hack

Automated analysis of biomedical literature and its application

to microarray data analysis and interpretation

Vice Chancellor's Research Studentship

India

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Nomikou, Nikolitsa

Professor Roger Marchant

Dr Poonam Singh

Electric field mediated biosorption

DEL UU

Greece

Name

Supervisor

Title of Project

Grant Source

Country of Origin

O’Doherty, Alan

Dr Colum Walsh

Dr Helen Wheadon

Investigating a protein expressed in male stem cells

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

O’Donoghue, Elizabeth

Dr Kathryn Saunders

Dr Julie McClelland

Epidemiology of Myopia.

College of Optometrists

Northern Ireland

24


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Okraszewska, Wioletta

Professor David McDowell

Professor Ian Blair

Development of a technique to determine the influence of

aerial contamination on beef, pork and lamb carcasses during

slaughter.

Self or Parent

Poland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Pearson, Jennifer

Professor Ian Rowland

Dr Chris Gill

Molecular investigation of faecal water

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Power, Gavin

Prof Peter Flatt

Dr Victor Gault

Receptor interaction and signal transduction pathways of

novel bioengineered GIP peptides in diabetes therapy

ESF

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Redmond, Tony

Professor Roger Anderson

Dr Margarita Vidnova

Spatial summation for chromatic and achromatic stimuli with

age and glaucoma

DEL UU

Ireland

25


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Scullion, Siobhan

Dr Neville McClenaghan

Prof Peter Flatt

Investigation of the detrimental pancreatic beta-cell actions of

key metabolic syndrome risk factor, homocysteine

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Smyth, Stephen

Dr Colum Lowery

Dr James Dooley

Dr William Snelling

Genotyping of cryptosporidium in Northern Ireland using laser

capture micro dissection and PCR

Self or Parent

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Srivastava, Malay

Dr Catherine Hack

Dr Poonam Singh

A data mining approach to understanding thermophily

Vice Chancellor's Research Studentship

India

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Thomas, Keith

Dr Robin Freeburn

Dr Helen Wheadon

Role of the Wnt proteins in haemopoietic development

ESF

Northern Ireland

26


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Thompson, Alan

Dr Stephen McClean

Professor Tony Bjourson

Amphibian venom peptide proteomics and genomics-1

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Tracey, Joel

Professor Tony Bjourson

Dr Stephen McClean

Analyses of NMU-splice variants

DEL

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Wang, Chong

Professor W Dubitzky

Quantitative multi-cellular modeling of cardiac electrical fields

Self or parent

Germany

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Ward, Claire

Professor Stephanie McKeown

Dr Jenny Worthington

AQ4N: evaluation and enhancement of its role as an antitumour

agent

DEL UU

Northern Ireland

27


Name

Supervisor

Title of Project

Grant Source

Country of Origin

Whiteford, Joy

Professor Sean Strain

Dr Ciaren Graham

Production of Se-enriched milk and its ability to raise Se levels

in a Northern Ireland population (in collaboration with Dale

Farm Ltd)

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Whittle, Claire

Professor Helene McNulty

Professor Sean Strain

Homocysteine related B vitamins and genetic factors, and

bone health

DEL UU

Northern Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Young, Sheila

Dr Colum Walsh

Professor Stephanie McKeown

Molecular and functional characterisation of a novel gene

DIR1

HPSS Northern Ireland (Research and Development office)

Ireland

Name

Supervisor

Title of Project

Grant Source

Country of Origin

Zhong, Peipei

Dr Karsten Melcher

Dr Paul Thompson

Identification of activator-co activator contacts in yeast

Vice Chancellor's Research Studentship

China

28


5. Research Publications

BIOIMAGING RESEARCH GROUP

Boyd A, Fazakerley JK, Bridgen A. Pathogenesis of Dugbe virus infection in

wild-type and interferon-deficient mice. J General Virology 87, pp 2005-2009,

2006

Ellis KA, Innocent G, Grove-White D, Cripps P, McLean WG, Howard CV, and

Mihm M, Comparing the fatty acid composition of organic and conventional milk.

Journal of Dairy Science. 89, pp 1938-1950, 2005.

Howard CV and Ikah DSK, Nanotechnology and nanoparticle toxicity: A case for

precaution. In: Nanotechnology: Risk, ethics and law. Eds Hunt G and Mehta M

(Earthscan, London 2006, ISBN 1-84407-358-0), pp154-166.

Howard C V and Reed M G. Unbiased Stereology. 2 nd Edition (Garland Bios

Scientific Publishers, Abingdon UK, 2005, ISBN 1-8599-6089-8) 277.

Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC,

Rowe T, Majerus PW and Mitchell CA, The type Ialpha inositol polyphosphate 4-

phosphatase generates and terminates phosphoinositide 3-kinase signals on

endosomes and the plasma membrane. Mol Biol Cell, 16, pp 2218-2233, 2005

Kannekens EM , Murray RD, Howard CV and Currie J, Stereological method for

estimating feto-maternal exchange surface area in the bovine placentome at

135 days gestation. Res. Vet. Sci.81, pp 120-127, 2006.

Lau K, McLean WG, Williams DP and Howard CV, Synergistic interactions

between commonly used food additives in a developmental neurotoxicity test.

Toxicological Sciences, 90, pp 178-187, 2006

McEnery O, Lucas L, Ma YL, Morrow P, Mitchell C, Saetzler K, A fast, robust

and scale-independent approach to estimate vessel diameters in intravital

fluorescence microscopy images. Proc. IEEE Int. Symp. Biomedical Imaging:

From Nano to Macro, 101-104, 2006

Newby J, Howard CV, Environmental influences in cancer aetiology. J. Nutr.

and Envir. Med. 15, pp 56-114, 2005.

29


Nicolopoulou-Stamati P, Hens L, Lammar P and Howard CV. The effects of

mobility on health – an overview. In: Environmental health impacts of transport and

mobility. Eds. Nicolopoulou-Stamati P, Hens L and Howard CV (Springer,

Dordrecht, 2005, ISBN 1-4020-4304-X), pp 277-307.

Rutland CS, Mukhopadhyay M, Underwood S, Clyde N, Mayhew TM and

Mitchell CA. Induction of intrauterine growth restriction by reducing placental

vascular growth with the angioinhibin TNP-470 Biol. Reproduction 73: 1164-

1173 2005

Sneddon JC, Boomker E and Howard CV, Mucosal surface area and

fermentation activity in the hind gut of hydrated and chronically dehydrated

working donkeys. J. Anim. Sci. 84, pp 119-124, 2006.

Stewart AG, Wilkinson E and Howard CV.

Health: A necessity for sustainable development. In: The World Summit on

Sustainable Development. The Johannesburg Conference. Eds Hens L and

Nath B (Springer, Dordrecht 2005, ISBN 1-4020-3652-3), pp151-181.

BIOMEDICAL GENOMICS RESEARCH GROUP

Adams DJ, Webba da Silva M, Flowers JL, Kohlwagen G, Pommier Y, Colvin

OM, Manikumar G, and Wani MC, Camptothecin analogs with enhanced

activity against human breast cancer cells, Cancer Chemotherapy

Pharmacology, 57, pp 135-144, 2006

Falchi A, Scott N, Hayes VEA, Barnett YA, Garstin I, Logan P, Morrison PJ and

Bjourson AJ, Analysis of BRCA2 Point mutations and exon

deletions/amplifications in breast and breast/ovarian cancer families, ISCO2005,

Belfast, 2005

Falchi A, Scott N, Hayes VEA, Barnett YA, Garstin I, Logan P, Morrison PJ and

Bjourson AJ, Analysis of BRCA2 point mutations and exon

deletions/amplifications in breast and breast/ovarian cancer families, Cellular

Oncology, 27, pp 100-101, 2005

Melcher K, Mutational hypersensitivity of a gene regulatory protein:

Saccharomyces. cerevisiae Gal80p, Genetics, 171, pp 469-476, 2005

Mergny J-L, De Cian A, Amrane S, Webba Da Silva M, Kinetics of double-chain

reversals bridging contiguous quartets in tetramolecular quadruplexes, Nucleic

Acids Research, 34, pp 2386-2397, 2006

Noll DM, Webba da Silva M, Noronha AM, Colvin OM, Gamcsik MP and Miller

PS, Structure flexibility and repair of two different orientations of interstrand

DNA cross-links, Biochemistry, 44, pp 6764-6775, 2005

30


Webba da Silva M, Wilds CJ, Noronha AM, Colvin OM, Miller PS, and Gamcsik

MP, Staggering In mispair aligned N3T-Butyl-N3T interstrand crosslink

modulates widening of the major groove in B-DNA, Biorganic and Medicinal

Chemistry, 13, pp 4580- 4587, 2005

Webba da Silva M, Experimental Demonstration of T:(G:G:G):T Hexad and

T:A:A:T tetrad alignments within a DNA quadruplex stem, Biochemistry, 44, pp

3754-3764, 2005

CANCER & AGEING RESEARCH GROUP

Berrar D, Sturgeon B, Bradbury I, Downes CS and Dubitzky W, Survival trees

for analyzing clinical outcome in lung adenocarcinomas based on gene

expression profile: identification of neogenin and diacyclglycerol kinase alpha

expression as critical factors, Journal of Computational Biology, 12, pp 534-544,

2005

Campbell DJ, Heaton PR, Prichard DI, Strain JJ, Rawlings JM, Hannigan BM,

Assessment of ex vivo responses to T-cell mitogens and oxidative stress in

lymphocytes from healthy adult and senior cats, Journal of Nutrition, 136, pp

2084S-2086S, 2006

Choi SW, Benzie IF, Lam CS, Chat SW, Lam J, Yiu CH, Kwan JJ, Tang YH,

Yeung GS, Yeung VT, Woo GC, Hannigan BM and Strain JJ, Inter-relationships

between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes

mellitus, Diabetic Medicine, 22, pp 1347-1353, 2005

Doherty SC, McKeown SR, Lopez JA, Walsh IK, McKelvey-Martin VJ,

Gene expression in normal urothelium depends on location within the bladder: A

possible link to bladder carcinogenesis. European Urology 50, pp 290-301 2006

Fuss H, Dubitzky W, Downes CS and Kurth MJ, Mathematical models of cell

cycle regulation, Briefings in Bioinformatics, 6, pp 163-177, 2005

Gengler S, Mallot HA and Holscher C, Inactivation of the rat dorsal striatum

inpairs performance in spatial tasks and alters hippocampal theta in the freely

moving rat, Behavioral Brain Research, 164(1), pp 73-82, 2005

Hodkinson CF, Kelly M, Coudray C, Gilmore WS, Hannigan BM, O’Connor JM,

Strain JJ and Wallace JMW, Zinc status and age-related changes in peripheral

blood leukocyte sub-populations in healthy men and women aged 55-70 years:

The ZENITH study, European Journal of Clinical Nutrition, 59(2), pp S63-S67,

Nov 2005

Holscher C, Schmid S, Pilz P, Van der Putten H and Plappert C, Lack of the

metabotropic glutamate receptor subtype 7 selectively modulates theta rhythm

and working memory, Learning Memory, 12, pp 450-455, 2005

31


Holscher C, Schnee A, Dahmen H, Setial L and Mallot HA, Rats are able to

navigate in virtual environments, Journal of Experimental Biology, 208, pp 561-

569, 2005

Holscher C (Ed), Neuronal mechanisms of memory formation: Concepts of long

term potentiation and beyond, Cambridge University Press, 0-521-01803-X,

2005

McErlane V, Yakkundi A, McCarthy HO, Hughes CM, Patterson LH, Hirst DG,

Robson T and McKeown SR; A cytochrome P450 2B6 meditated gene therapy

strategy to enhance the effects of radiation or cyclophosamide when combined

with the bioreductive drug AQ4N, J Gene Med, 7, pp 851-859, 2005

McIlroy M, O'Rourke M, McKeown SR, Hirst DG and Robson T, Pericytes

influence endothelial cell growth characteristics: Role of plasminogen activator

inhibitor type 1 (PAI-1) Cardiovasc. Res, 69, pp 207-217, 2006

Rajab NF, McKenna DJ, Diamond J, Williamson K, Hamilton PW, McKelvey-

Martin VJ. Prediction of radiosensitivity in human bladder cell lines using nuclear

chromatin phenotype. Cytometry Part A 69A: 1077-1085, 2006

Robson T, Worthington J, McKeown SR, Hirst DG. Radiogenic therapy: novel

approaches for enhancing tumor radiosensitivity. Technol Cancer Res Treat.

2005 4, pp 343-61, 2005.

Smyth WF, Leslie JC, McClean S, Hannigan BM, McKenna HP, Doherty B,

Joyce C and O’Kane E; The characterisation of selected antidepressant drugs

using electrospray ionisation with ion trap mass spectrometry and with

quadrupole time of flight mass spectrometry and their determination by HPLC-

ESI-MSn; Rapid Communications in Mass Spectrometry, 20, pp 1637-1642,

2006

Szabó E, Kalmár T, Csányi B, Tömöry G, Czibula A, Horváth F, Downes CS and

Raskó I, Mitochondrial DNA of ancient Cumanians: culturally Asian steppe

nomadic immigrants with substantially more Western Eurasian mitochondrial

DNA lineages, Human Genetics, 77, pp 639-662, 2005

Worthington J, Robson T, Scott S, Hirst DG Evaluation of a synthetic CArG

promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy 19,

pp 1417-23, 2005

Yakkundi A, McErlane V, Murray M, McCarthy HO, Ward C, Hughes CM,

Patterson LH, Hirst DG, McKeown SR, Robson T. Tumor-selective drug

activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N

Cancer Gene Therapy 13 (6): 598-605 2006

32


DIABETES RESEARCH GROUP

Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM.

NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide

in water. Journal Biological Chemistry 16:281(24):16370-6 (2006)

Cunningham GA, McClenaghan NH, Flatt PR, Newsholme P. L-Alanine induces

changes in metabolic and signal transduction gene expression in a clonal rat

pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced

apoptosis Clin Sci (Lond) 109(5):447-55 (2005)

Gault VA, Irwin N, Green BD, McCluskey JT, Greer B, Bailey CJ, Harriott P,

O'harte FP, Flatt PR. Chemical ablation of gastric inhibitory polypeptide

receptor action by daily (Pro3)GIP administration improves glucose tolerance

and ameliorates insulin resistance and abnormalities of islet structure in obesityrelated

diabetes Diabetes 54(8):2436-46 (2005)

Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C. Histaminereleasing

and antimicrobial peptides from the skin secretions of the dusky

gopher frog, Rana sevosa Peptides 27(6):1313-9 (2006)

Green BD, Irwin N, Flatt PR. Pituitary adenylate cyclase-activating peptide

(PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing

activity and antidiabetic potential Peptides 27(6):1349-58 (2006)

Green BD, Gault VA, O'Harte FP, Flatt PR. A comparison of the cellular and

biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like

peptide-1 and glucose-dependent insulinotropic polypeptide Diabetes Obes

Metab 7(5):595-604 (2005)

Green BD, Liu HK, McCluskey JT, Duffy NA, O'Harte FP, McClenaghan NH,

Flatt PR. Function of a long-term, GLP-1-treated, insulin-secreting cell line is

improved by preventing DPP IV-mediated degradation of GLP-1 Diabetes Obes

Metab 7(5):563-9 (2005)

Hannan JM, Ali L, Khaleque J, Akhter M, Flatt PR, Abdel-Wahab YH. Aqueous

extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2

diabetes by inhibition of intestinal glucose absorption British Journal Nutriton

96(1):131-7 (2006)

Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YH. Ocimum

sanctum leaf extracts stimulate insulin secretion from perfused pancreas,

isolated islets and clonal pancreatic beta-cells J Endocrinol. 189(1):127-36

(2006)

Irwin N, Green BD, Parker JC, Gault VA, O'Harte FP, Flatt PR. Biological

activity and antidiabetic potential of synthetic fragment peptides of glucose-

33


dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16)

Regulatory Peptides 5;135(1-2):45-53 (2006)

Irwin N, O'Harte FP, Gault VA, Green BD, Greer B, Harriott P, Bailey CJ, Flatt

PR. GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues

of glucose-dependent insulinotropic polypeptide with improved antidiabetic

potential Journal Medical Chemistry 9:49(3):1047-54 (2006)

Irwin N, Green BD, Gault VA, Harriot P, O'Harte FP, Flatt PR. Stable agonist of

glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell

glucose responsiveness but not glucose intolerance in aging mice Exp Gerontol.

41(2):151-6 (2006)

Irwin N, Green BD, Gault VA, Cassidy RS, O'Harte FP, Harriott P, Flatt PR.

Effects on glucose homeostasis and insulin secretion of long term activation of

the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-

AcGIP(LysPAL37) in normal mice Peptides.27(4):893-900 (2006)

Irwin N, Gault VA, Green BD, Greer B, Harriott P, Bailey CJ, Flatt PR, O'Harte

FP. Antidiabetic potential of two novel fatty acid derivatised, N-terminally

modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-

AcGIP(LysPAL16) and N-AcGIP(LysPAL37) Biological Chemistry 386(7):679-87

(2005)

Irwin N, Green BD, Mooney MH, Greer B, Harriott P, Bailey CJ, Gault VA,

O'Harte FP, Flatt PR. A novel, long-acting agonist of glucose-dependent

insulinotropic polypeptide suitable for once-daily administration in type 2

diabetes J Pharmacol Exp Ther.314(3):1187-94. Epub 2005 May 27 (2005)

Liu HK, Green BD, McClenaghan NH, McCluskey JT, Flatt PR. Deleterious

effects of supplementation with dehydroepiandrosterone sulphate or

dexamethasone on rat insulin-secreting cells under in vitro culture condition

Biosci Rep 26(1):31-8 (2006)

Marenah L, McCluskey JT, Abdel-Wahab YH, O'Harte FP, McClenaghan NH,

Flatt PR. A stable analogue of glucose-dependent insulinotropic polypeptide,

GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem

cells into cells expressing islet-specific genes and hormones Bioogicall

Chemistry 387(7) : 941-7 (2006)

Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH. Skin secretions of

Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and

brevinins-1E and -2EC with novel insulin releasing activity Journal Endocrinol

188(1):1-9 (2006)

Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH. Isolation and

structural characterization of novel Rugosin A-like insulinotropic peptide from

the skin secretions of Rana saharica frog Peptides 26(11):2117-23 (2005)

34


Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH. Characterization of

naturally occurring peptides in the skin secretion of Rana pipiens frog reveal

pipinin-1 as the novel insulin-releasing agent Journal Pept Res 66(4):204-10

(2005)

Mathews JN, Flatt PR, Abdel-Wahab YH. Asparagus adscendens (Shweta

musali) stimulates insulin secretion, insulin action and inhibits starch digestion

British Journal Nutrition 95(3):576-81 (2006)

McKillop AM, Lindsay JR, Au S, Mahood KI, O'Harte FP, Flatt PR, Bell PM.

Meal-dependent regulation of circulating glycated insulin in type 2 diabetic

subjects. Horm Metab Res 38(2):94-7 (2006)

Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH.

Detrimental actions of metabolic syndrome risk factor, homocysteine, on

pancreatic beta-cell glucose metabolism and insulin secretion J Endocrinol

189(2):301-10 (2006)

Patterson S, Flatt PR, McClenaghan NH. Related Articles, Links Homocysteine

and other structurally-diverse amino thiols can alter pancreatic beta cell function

without evoking cellular damage Biochim Biophys Acta 1760(7):1109-14 (2006)

MICROBIAL BIOTECHNOLOGY RESEARCH GROUP

Gan CS, Ternan NG, McMullan G, Reardon KF and Wright PC, Proteomicsbased

systems biology study of phosphorus starvation in Synechocystis,

American Institute of Chemical Engineers annual meeting, Cincinnati, USA,

2005

Graham RL, Ternan NG and McMullan G, Shotgun proteomic analysis of heat

stress responses in Geobacillus thermoleovorans T80, International symposium

on extremeophiles and their applications, Tokyo, Japan, 2005

Graham RL, Graham C, McClean S, Chen T, O'Rourke M, Hirst D, Theakston D

and Shaw C, Identification and functional analysis of a novel bradykinin

inhibitory peptide in the venoms of New World Crotalinae pit vipers, Biochemical

and Biophysical Research Communications, 338, pp 1587-1592, 2005

Graham RLJ, Pollock CE, Ternan NG and McMullan G, Top-down proteomic

analysis of the soluble sub-proteome of the obligate thermophile, Geobacillus

thermoleovorans T80: Insights into its cellular processes; Journal of Proteome

Research; 5, pp 822-826, 2006

Lowery C and Dooley J, `Molecular Diagnosis and Bioterrorism’ in ‘Molecular

Diagnostics: Current Technology and Applications’, Caister Academic Press &

Horizon Scientific Press, Norwich, 2006

35


Lowery CJ, Xiao L, Ryan UM, Dooley JSG, Millar BC and Moore JE, Laboratory

Protocols for Cryptosporidium species, in ‘Food-Borne Pathogens; Methods

and Protocols’, Humana Press, Totowa, NJ, 2005

McEvoy JM, Duffy G, Moriarty EM, Lowery CJ, Sherian JJ, Blair IS and

McDowell DA, The prevalence and characterisation of Cryptosporidium spp. in

beef abattoir water supplies, Water Research, 39, pp 3697-3703, 2005

Moriarty EM, McEvoy J, Lowery CJ, Thompson HP, Finn M, Sheridan JJ, Blair

IS, McDowell DA and Duffy G, Prevalence and characterisation of

Cryptosporidium species in cattle faeces and on beef carcases at slaughter,

Veterinary Record, 5: 156, pp 165-168, 2005

Rodrigues I, Banat IM, Teixeira J and Oliveira R. Biosurfactants: potential

applications in medicine, Journal of Antimicrobial Chemotherapy, 57, pp 609-

618, 2006

Panas P, Ternan NG, Dooley JS and McMullan G, Detection of

phosphonoacetate degradation and phnA genes in soil bacteria from distinct

geographical origins suggest its possible biogenic origin; Environmental

Microbiology, 8, pp 939-945, 2006

Snelling WJ, McKenna JP, Lecky DM, and Dooley JSG, Survival of

Campylobacter jejuni in waterborne protozoa, Applied And Environmental

Microbiology, 71, pp 5560-5571, 2005

Snelling WJ, Moore JE, McKenna JP, Lecky DM and Dooley JS, Bacterialprotozoa

interactions; an update on the role these phenomena play towards

human illness; Microbes and Infection, 8, pp 578-587, 2006

Ternan NG, Graham RL, Banat IM, Zhulin I, Marchant R, McMullan G,

Description of the genome of Geobacillus thermoleovorans T80 and comparison

with related organisms. International Symposium on Extremophiles and their

applications, Tokyo, Japan, 2005

NORTHERN IRELAND CENTRE FOR FOOD AND HEALTH

Adulyatham P and Owusu-Apenten R, Stabilization and partial purification of a

protease from ginger rhizome (Zingiber offinale Roscoe), Journal of Food

Science, 70, pp C231- C234, 2005

Barnes MS, Robson PJ, Bonham MP, Strain JJ, Wallace JMW, Effect of vitamin

D supplementation on vitamin D status and bone turnover markers in young

adults, European Journal of Clinical Nutrition, 60, pp 727-733, 2006

Bugel S, Strain JJ, O’Connor JM, Bonham MP and Sandstrom BM, Effect of

copper supplementation on indices of copper status and certain CVD risk

36


markers in young healthy women, British Journal of Nutrition, 94, pp 231-236,

2005

Campbell DJ, Heaton PR, Prichard DI, Strain JJ, Rawlings JM, Hannigan BM,

Assessment of ex vivo responses to T-cell mitogens and oxidative stress in

lymphocytes from healthy adult and senior cats, Journal of Nutrition, 136, pp

2084S-2086S, 2006

Choi SW, Benzie IF, Lam CS, Chat SW, Lam J, Yiu CH, Kwan JJ, Tang YH,

Yeung GS, Yeung VT, Woo GC, Hannigan BM and Strain JJ, Inter-relationships

between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes

mellitus, Diabetic Medicine, 22, pp 1347-1353, 2005

Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM and Rowland IR,

Effects of fermentation products of pro and prebiotics on trans-epithelial

electrical resistance in an in vitro model of the colon, Nutrition and Cancer, 5, pp

102-109, 2005

Gill CI, Boyd A, McDermott E, McCann M, Servili M, Selvaggini R, Taticchi A,

Esposto S, Montedoro G, McGlynn H and Rowland I, Potential anti-cancer

effects of virgin olive oil phenolson colorectal carcinogenesis models in vitro,

International Journal of Cancer, 117, pp 1-7, 2005

Graham RL, Graham C, McClean S, Chen T, O'Rourke M, Hirst D, Theakston D

and Shaw C, Identification and functional analysis of a novel bradykinin

inhibitory peptide in the venoms of New World Crotalinae pit vipers, Biochemical

and Biophysical Research Communications, 338, pp 1587-1592, 2005

Hedemann MS, Mikkelsen LL, Naughton PJ and Jensen BB, Effect of feed

particle size and feed processing on morphological characteristics in the small

and large intestine of pigs and on adhesion of Salmonella enterica serovar

Typhimurium DT12 in the ileum in vitro, Journal of Animal Science, 83, pp 1554-

1562, 2005

Hodkinson CF, Kelly M, Coudray C, Gilmore WS, Hannigan BM, O’Connor JM,

Strain JJ and Wallace JMW, Zinc status and age-related changes in peripheral

blood leukocyte sub-populations in healthy men and women aged 55-70 years:

The ZENITH study, European Journal of Clinical Nutrition, 59, pp S63-S67,

2005

Holmes VA, Wallace JM, Alexander HD, Gilmore WS, Bradbury I, Ward M,

Scott JM, McFaul P, McNulty H, Homocysteine is lower in the third trimester of

pregnancy in women with enhanced folate status from continued folic acid

supplementation, Clinical Chemistry, 51, pp 629-634, 2005

Holzapfel WH and Naughton PJ, Microbial Ecology in Growing Animals,

Elsevier, London, 2005

Kealey C, Brown S, Woodside JV, Young I, Murray L, Boreham CA, McNulty H,

Strain JJ, McPartlin J, Scott JM, Whitehead AS, A common insertion/deletion

37


polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red

blood cell folate and homocysteine concentrations, Human Genetics, 116, pp

347-353, 2005

Kennedy J, Jackson V, Blair IS, McDowell DA, Cowan C and Bolton DJ, Food

safety knowledge of consumers and the microbiological and temperature status

of their refrigerators, J Food Protect, 68, pp 1421-1430, 2005

Kennedy OB, Stewart-Knox BJ, Mitchell PC and Thurnham DI, Colour affects

consumer sensory perceptions of poultry, Appetite, 44, pp 181-186, 2005

Kennedy OB, Stewart-Knox BJ, Mitchell PC and Thurnham DI, Vitamin E

supplementation, cereal feed type and consumer sensory perceptions of poultry

meat quality, British Journal of Nutrition, 93, pp 333-338, 2005

Lesniewska V, Rowland I, Laerke HN, Grant G and Naughton PJ, Relationship

between dietary-induced changes in intestinal commensal microflora and

duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in

vivo, Journal of Experimental Physiology, 91, pp 229-237, 2006

Livingstone MBE and Rennie KL, Bio-behavioural determinants of energy intake

and childhood obesity, in Childhood Obesity: Contemporary issues. Published

symposia for Society for the Study of Human Biology, 8, pp 101-118, 2005

Marks LI, Gallagher AM, Strain JJ, Rodger G, Welch RW, Can differences in

filament length explain the effect of mycoprotein on glucose diffusion in vitro,

Proceedings of the Nutrition Society, 63, p 86A, 2005

McCabe AJ, Wallace JMW, Gilmore WS, McGlynn H and Strain JJ,

Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by

elevation of TIMP-1 levels, Journal of Nutritional Biochemistry, 16, pp 17-22,

2005

McCann MJ, Gill CIR, Rowland I, Role of mammalian lignans in the prevention

and treatment of prostate cancer, Nutrition and Cancer, 52, pp 1-14, 2005

McConville C, Simpson EEA, Rae G, Polito A, Andriollo-Sanchez M, Meunier M,

Stewart-Knox BJ, O'Connor JM, Roussel AM, Cuzzolaro M and Coudray C,

Positive and Negative mood in the elderly: The ZENITH Study, European

Journal of Clinical Nutrition, 59(2), pp S22-S25, 2005

McEvoy JM, Duffy G, Moriarty EM, Lowery CJ, Sherian JJ, Blair IS and

McDowell DA, The prevalence and characterisation of Cryptosporidium spp. in

beef abattoir water supplies, Water Research, 39, pp 3697-3703, Sep 2005

McKillop DJ, McNulty H, Scott JM, McPartlin JM, Strain JJ, Bradbury I, Girvan J,

Hoey L, McCreedy R, Alexander J, Patterson K, Hannon-Fletcher M, Pentieva

K; The rate of intestinal absorption of natural food folates is not related to the

extent of folate conjugation; American Journal of Clinical Nutrition 84, pp 167-

173, 2006

38


McKinley MC, Lowis C, Robson PJ, Wallace J, Morrissey M, Moran A,

Livingstone MBE, It's good to talk: children's views on food and nutrition as a

basis for intervention, European Journal of Clinical Nutrition, 59, pp 542-551,

2005

McNulty H, Dowey L, Strain JJ, Dunne A, Ward M, Moloy AM, McAnena LB,

Hughes JP, Hannon-Fletcher M and Scott JM., Riboflavin lowers homocysteine

in individuals homozygous for the MTHFR 677C->T polymorphism, Circulation,

113, pp 74-80, 2006

Moriarty EM, McEvoy J, Lowery CJ, Thompson HP, Finn M, Sheridan JJ, Blair

IS, McDowell DA and Duffy G, Prevalence and characterisation of

Cryptosporidium species in cattle faeces and on beef carcases at slaughter,

Veterinary Record, 156, pp 165-168, 2005

O’Brien SB, Duffy G, Carney E, Sheridan JJ, McDowell DA, Blair IS; Prevalence

and numbers of Escherichia coli O157 on bovine hides at a beef slaughter plant,

J Food Protect, 68: 660-665, 2005

Owusu-Apenten RK, Introduction to food chemistry, CRC Press, Boca Raton,

USA, 250 pp, 2005

Owusu-Apenten RK. Colorimetric analysis of protein sulfhydryl groups in milk:

Applications and processing effects, Critical Reviews in Food Science &

Nutrition, 45, p 123, 2005

Rennie KL and Jebb SA, Prevalence of obesity in Great Britain, Obesity

Reviews, 6, pp 11-12, 2005

Rennie KL, Jebb SA, Wright A and Coward WA, Under-reporting of energy

intake in the National Diet and Nutrition Survey of young people, British Journal

of Nutrition, 93, pp 241- 247, 2005

Rennie KL, Livingstone MB, Wells JC, McGloin A, Coward WA, Prentice AM

and Jebb SA, Association of physical activity with body-composition indexes in

children aged 6-8y at varied risk of obesity, Am J Clin Nutr, 82, pp 13-20, 2005

Simpson EEA, O'Connor JM, Livingstone MBE, Rae G, Stewart-Knox BJ,

Andriollo-Sanchez M, Toti E, Meunier N, Ferry M, Polito A and Coudray C,

Health and lifestyle characteristics of older European adults. The ZENITH

Study, European Journal of Clinical Nutrition, 59, pp S13-S21, 2005

Simpson EEA, Maylor EA, Rae G, Meunier N, Andriollo-Sanchez M, Caststa G,

McConville C, Ferry M, Polito A, Stewart-Knox BJ, Secker D and Coudray C,

Cognitive Function in Healthy Older European Adults: The ZENITH Study,

European Journal of Clinical Nutrition, 59, pp S26-S30, 2005

Sinclair AJ, Wallace J, Martin MJ, Attar-Bashi N, Weisinger RS and Li D, The

effects of eicosapentaenoic acid in various clinical conditions in Healthful Lipids,

chapter 16, pp 361- 394, 2005

39


Stewart-Knox B, Hamilton J, Parr H, Bunting B, Dietary Strategies and Uptake

of Reduced Fat Foods, Journal of Human Nutrition and Dietetics, 18, pp 121-

128, 2005

Stewart-Knox BJ, Simpson E, Parr H, Rae G, Polito A, Intorre F, Meunier N,

Andriollo M, O'Connor J, Coudray C, Strain JJ, Zinc status and taste acuity in

older Europeans, European Journal of Clinical Nutrition, 59, pp S31-S36, 2005

Stewart-Knox BJ, Sittlington J, Rugkasa J, Harrisson S, Treacy M, Abaunza PS.

Smoking and peer groups: Results from a longitudinal qualitative study of young

people in Northern Ireland. British Journal of Social Psychology 44, pp 397-414,

2005.

Strain JJ, Dowey L, Pentieva K, Ward M, McNulty H, B-vitamins, homocysteine

metabolism and cardiovascular disease, Proceedings of the Nutrition Society,

63, pp 597-603, 2005

Sweeney MR, McPartlin J, Weir DG, Daly S, Pentieva K and Scott JM, Evidence

of unmetabolised folic acid in cord-blood of new-born and serum of four-day old

infants, British Journal of Nutrition, 94, pp 727-730, 2005

Truby H, Baic S, deLooy A, Fox KR, Livingstone MBE, Logan CM, Macdonald

IA, Morgan LM, Taylor MA, Millward DJ; A randomised controlled trial of four

commercial weight loss programmes in the UK: initial findings from the BBC

"Diet Trials"; British Medical Journal 332, 1309-1311, 2006

Watkins DC, Murray LJ, McCarron P, Boreham CA, Cran GW, Young IS,

McGartland C, Robson PJ and Savage JM, Ten-year trends for fatness in

Northern Irish adolescents: the Young Hearts Projects – repeat cross-sectional

study, Int J Obesity, 29, pp 579-585, 2005

Welch RW, Cereal grains: dietary significance and nutritional value, in

Encyclopedia of Human Nutrition, 2nd Edition, ISBN 0-12-150110-8, pp 346-

357, Jan 2006

Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, Helander A and

McNulty H, Effect of folic acid supplementation and serotonin response in

healthy males, British Journal of Nutrition, 94, pp 602-608, 2005

Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, McConville C,

Helander A and McNulty H, Effect of folic acid supplementation on mood and

serotonin response in healthy males, British Journal of Nutrition, 94, pp 602-

608, 2005

Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, Helander A and

McNulty H, Effect of folic acid supplementation on mood and serotonin response

in healthy males, British Journal of Nutrition, 94, pp 602-608, 2005

40


Williams E, Stewart-Knox B, Helander A, McConville C, Bradbury I and Rowland

I, Associations between whole-blood serotonin and subjective mood in healthy

male volunteers, Biological Psychology, 71, pp 171-174, 2005

Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, McConville C,

Helander A and McNulty H, Effect of folic acid supplementation on mood and

serotonin response in healthy males, British Journal of Nutrition, 94, pp 602-

608, 2005

Wiseman H, Casey K, Bowey EA, Duffy R, Davies M, Rowland IR, Lloyd AS,

Murray A Thompson R and Clarke DB, Influence of 10 wk of soy consumption

on plasma concentrations and excretion of isoflavanoids and on gut microflora

metabolism in healthy adults, American Journal of Clinical Nutrition, 80, pp 692-

699, 2005

PHARMACEUTICAL TECHNOLOGY RESEARCH GROUP

Graham RL, Graham C, McClean S, Chen T, O'Rourke M, Hirst D, Theakston D

and Shaw C, Identification and functional analysis of a novel bradykinin

inhibitory peptide in the venoms of New World Crotalinae pit vipers, Biochemical

and Biophysical Research Communications, 338, pp 1587-1592, 2005

Janneh O, Owen A, Chandler B, Hartkoorn RC, Hart CA, Bray PG, Ward SA,

Back DJ and Khoo SH, Modulation of the intracellular accumulation of

saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2,

P-gp and BCRP AIDS, 19, pp 2097-2102, 2005

Jones SP, Janneh O, Back DJ and Pirmohamed M, Altered adipokine response

in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside

reverse transcriptase inhibitors. Antiviral Therapy, 10, pp 207-213, 2005

Leslie R, Graham J, McClean S, O'Kane EJ, Theakston D and Shaw C,

Adenosine in the venoms from viperinae snakes of the genus Bitis: Identification

and quantitation using LC/MS and CE/MS, Biochemical and Biophysical

Research Communications, 333, pp 88-94, 2005

Marenah L, Flatt PR, Orr DF, Shaw C and Abdel-Wahab YHA, Characterization

of naturally occurring peptides in the skin secretion of Rana pipiens frog reveal

pipinin-1 as the novel insulin-releasing agent, Journal of Peptide Research, 66,

pp 204-210, 2005

Marenah L, Flatt PR, Orr DF, Shaw C and Abdel-Wahab YHA, Isolation and

structural characterisation of novel Rugosin A-like insulinotropic peptide from

skin secretions of Rana saharica frog, Peptides, 26, pp 2117-2123, 2005

Marenah L, Flatt PR, Orr DF, Shaw C and Abdel-Wahab YHA, Skin secretions

of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and

41


evinins-1E and -2EC with novel insulin releasing activity, Journal of

Endocrinology, 188, pp 1-9, 2006

Nomikou N, Hughes P, McHale AP, An electric field-assisted biosorption

process: Potential for removal of hazardous or precious ionic species from

wastewater streams, 3rd. European Bioremediation Conference, Chania,

Greece, 2005

O'Donnell F, Smyth TJ, O'Kane E, Brooks P,The characterisation of synthetic

and natural-product pharmaceuticals by electrospray ionisation-mass

spectrometry (ESI-MS) and liquid chromatography (LC)-ESI-MS. TRAC-Trends

in Analytical Chemistry, 25, pp 572-582, 2006

O’Donnell F, Ramachandran VN, Smyth WF, Hack CJ, Patton E , A study of

the analytical behaviour of selected synthetic and naturally occurring quinolines

using electrospray ionisation ion trap mass spectrometry, liquid chromatography

and gas chromatography and the construction of an appropriate database for

quinoline characterization, Analytica Chimica Acta, 572, pp 63-76, 2006

Raymond G, Reid and Sarker SD, Isolation of natural products by low-pressure

column chromatography, in Natural Products Isolation (ed Sarker SD, Latif Z

and Gray AI), Humana Press, New Jersey, second edition, pp 117-158, 2005

Rollan Haro AM, Smyth A, Hughes P, Reid CN and McHale AP,

Electrosensitisation of mammalian cells and tissues to ultrasound: a novel

tumour treatment modality, Cancer Letters, 222, pp 49-55, 2005

Sarker SD and Nahar L, Hyphenated Techniques, in Natural Products (ed

Sarker SD, Latif Z and Gray AI), Humana Press, New Jersey, second edition, pp

233-268, 2005

Sarker SD and Nahar L, Supercritical Fluid Extraction, in Natural Products

Isolation (ed Sarker SD, Latif Z and Gray AI), Humana Press, New Jersey,

second edition, pp 47-76, 2005

Sarker SD, Latif Z and Gray AI, Natural Product Isolation: An Overview, in

Natural Products Isolation (ed Sarker SD, Latif Z and Gray AI), Humana Press,

New Jersey, second edition, pp 1-26, 2005

Shoeb M, Celik S, Jaspars M, Kumarasamy Y, MacManus SM, Nahar L, Paul

KTLD and Sarker SD, Isolation, structure elucidation and bioactivity of

schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii,

Tetrahedron, 61, pp 9001-9006, 2005

Smyth WF, Recent applications of capillary electrophoresis-electrospray

ionization-mass spectrometry in drug analysis, Electrophoresis, 26, pp 1334-

1357, 2005

Smyth WF, Leslie JC, McClean S, Hannigan BM, McKenna HP, Doherty B,

Joyce C and O’Kane E; The characterisation of selected antidepressant drugs

42


using electrospray ionisation with ion trap mass spectrometry and with

quadrupole time of flight mass spectrometry and their determination by HPLC-

ESI-MSn; Rapid Communications in Mass Spectrometry, 20, pp 1637-1642,

2006

Smyth WF, McClean S, Hack CJ, Ramachandran VN, Doherty B, Joyce C,

O'Donnell F, Smyth TJ, O'Kane E, Brooks P A study of the analytical behaviour

of selected synthetic and naturally occurring coumarins using liquid

chromatography, ion trap mass spectrometry, gas chromatography and

polarography and the construction of an appropriate database for coumarin

characterization. Analytica Chimica Acta, 564, pp 201-210, 2006

Smyth WF, McClean S, Hack CJ, Ramachandran VN, Doherty B, Joyce C,

O'Donnell F, Smyth TJ, O'Kane E, Brooks P,The characterisation of synthetic

and natural-product pharmaceuticals by electrospray ionisation-mass

spectrometry (ESI-MS) and liquid chromatography (LC)-ESI-MS. TRAC-Trends

in Analytical Chemistry, 25, pp 572-582, 2006

STEM CELL & EPIGENETICS RESEARCH GROUP

Annett K, Duggan O, Freeburn R, Hyland P, Pawelec G and Barnett Y, An

investigation of DNA mismatch repair capacity under normal culture conditions

and under conditions of supra-physiological challenge in human CD4+T cell

clones from donors of different ages, Experimental Gerontology, 40, pp 976-

981, 2005

Graham RL, Graham C, McClean S, Chen T, O'Rourke M, Hirst D, Theakston D

and Shaw C, Identification and functional analysis of a novel bradykinin

inhibitory peptide in the venoms of New World Crotalinae pit vipers, Biochemical

and Biophysical Research Communications, 338, pp 1587-1592, 2005

Hodkinson CF, Kelly M, Coudray C, Gilmore WS, Hannigan BM, O’Connor JM,

Strain JJ and Wallace JMW, Zinc status and age-related changes in peripheral

blood leukocyte sub-populations in healthy men and women aged 55-70 years:

The ZENITH study, European Journal of Clinical Nutrition, 59, pp S63-S67,

2005

Holmes VA, Wallace JM, Alexander HD, Gilmore WS, Bradbury I, Ward M,

Scott JM, McFaul P, McNulty H, Homocysteine is lower in the third trimester of

pregnancy in women with enhanced folate status from continued folic acid

supplementation, Clinical Chemistry, 51, pp 629-634, 2005

Lees-Murdock DJ, Shovlin TC, Gardiner T, De Felici M and Walsh CP, DNA

methyltransferase expression in the mouse germ line during periods of de novo

methylation, Development Dynamics, 232, pp 992-1002, 2005

43


Li J.-Y, Lees-Murdock DJ, Xu G.-L and Walsh CP, Timing of establishment of

paternal methylation imprints in the mouse, Genomics, 84, pp 952-960, 2005

Wheadon H, Molecular signals involved in leukaemic transformation by the

tyrosine kinase fusion protein Tel/PDFFR beta, Indo-UK Stem Cell Workshop,

Bangalore, India, 4-11 Apr 2005

SYSTEMS BIOLOGY RESEARCH GROUP

Berrar D, Bradbury I and Dubitzky W, Instance-based concept learning from

multiclass DNA microarray data, BMC Bioinformatics, 7, art. No. 73, 2006

Berrar D, Bradbury I and Dubitzky W, Avoiding model selection bias in smallsample

genomic data sets, Bioinformatics 22, pp 1245-1250, 2006.

Berrar D, Stahl F, Goncalves Silva CS, Rodrigues JR, Brito RM, Dubitzky W,

Towards data warehousing and mining of protein unfolding simulation data,

Journal of Clinical Monitoring and Computing, 19, pp307-317, 2005.

Berrar D, Sturgeon B, Bradbury I, Downes CS and Dubitzky W, Survival trees

for analyzing clinical outcome in lung adenocarcinomas based on gene

expression profile: identification of neogenin and diacyclglycerol kinase alpha

expression as critical factors, Journal of Computational Biology, 12, pp 534-544,

2005

Bi Y, Dubitzky W, An evidential approach in ensembles, in H. Haddad (Ed.) Proc

of the 2006 ACM Symposium on Applied Computing (SAC), Dijon, France, April

23-27, 2006. ISBN 1-59593-108-2, pp1-6, 2006.

Boreham CA, Dubitzky W, Robson PJ, Wallace Julie M, Bi Y, Three-dimension

model for developing a nutrition, lifestyle and health database, Proc of The 2005

International Conference on Information and Knowledge Engineering, pp151-

157, 2005Fuss H, Dubitzky W, Downes CS and Kurth MJ, Mathematical models

of cell cycle regulation, Briefings in Bioinformatics, 6, pp 163-177, 2005

Holmes VA, Wallace JM, Alexander HD, Gilmore WS, Bradbury I, Ward M,

Scott JM, McFaul P, McNulty H, Homocysteine is lower in the third trimester of

pregnancy in women with enhanced folate status from continued folic acid

supplementation, Clinical Chemistry, 51, pp 629-634, 2005

McEnery O, Lucas L, Ma YL, Morrow P, Mitchell C, Saetzler K, A fast, robust

and scale-independent approach to estimate vessel diameters in intravital

fluorescence microscopy images. Proc. IEEE Int. Symp. Biomedical Imaging:

From Nano to Macro, 101-104, 2006

McKillop DJ, McNulty H, Scott JM, McPartlin JM, Strain JJ, Bradbury I, Girvan J,

Hoey L, McCreedy R, Alexander J, Patterson K, Hannon-Fletcher M, Pentieva

44


K; The rate of intestinal absorption of natural food folates is not related to the

extent of folate conjugation; American Journal of Clinical Nutrition 84, pp 167-

173, 2006

Natarajan J, Berrar D, Dubitzky W, Hack C, Zhang Y, DeSesa C, Van Brocklyn

J, Bremer E, Text mining of full-text journal articles combined with gene

expression analysis reveals a relationship between sphingosine-1-phosphate

and invasivity of a glioblastoma cell line, BMC Bioinformatics, 7, pp 373, 2006.

Natarajan J, Haines C, Berglund B, DeSesa C, Hack CJ, Dubitzky W, Bremer

EG, GetItFull – a tool for downloading and pre-processing full-text journal

articles, in EG, Bremer, J Hakenberg, E-H S, Han, D Berrar, W Dubitzky

(editors) Knowledge Discovery in Life Science Literature, International

Workshop, KDLL 2006, Singapore, April 9, 2006, pp139-145, 2006

Natarajan J, Mulay N, DeSesa C, Hack CJ, Dubitzky W, and Bremer EG, A grid

infrastructure for text mining of full text articles and creation of a knowledge

base of gene relations, Proc of 6th Int’l Symposium on Biological and Medical

Data Analysis (ISBMDA’05), pp101-108, 2005

O’Donnell F, Ramachandran VN, Smyth WF, Hack CJ, Patton E , A study of

the analytical behaviour of selected synthetic and naturally occurring quinolines

using electrospray ionisation ion trap mass spectrometry, liquid chromatography

and gas chromatography and the construction of an appropriate database for

quinoline characterization, Analytica Chimica Acta, 572, pp 63-76, 2006

O'Donnell F, Smyth TJ, Hack CJ, O'Kane E, Brooks P,The characterisation of

synthetic and natural-product pharmaceuticals by electrospray ionisation-mass

spectrometry (ESI-MS) and liquid chromatography (LC)-ESI-MS. TRAC-Trends

in Analytical Chemistry, 25, pp 572-582, 2006

Smyth WF, McClean S, Hack CJ, Ramachandran VN, Doherty B, Joyce C,

O'Donnell F, Smyth TJ, O'Kane E, Brooks P A study of the analytical behaviour

of selected synthetic and naturally occurring coumarins using liquid

chromatography, ion trap mass spectrometry, gas chromatography and

polarography and the construction of an appropriate database for coumarin

characterization. Analytica Chimica Acta, 564, pp 201-210, 2006

Swain M, Hunniford T, Mandel J, Palfreyman N, Dubitzky W, Reverseengineering

gene-regulatory networks using evolutionary algorithms and grid

computing, Journal of Clinical Monitoring and Computing, 19, pp329-337, 2005.

Wang H, Dubitzky W A flexible and robust similarity measure based on

contextual probability. IJCAI-05 Proceedings, 27-34, 2005

Wang C, Krause A, Nugent C, Dubitzky W, Focal activity in simulated LQT2

models at rapid ventricular pacing: analysis of cardiac electrical activity using

grid-based computation, Proc of 6th Int’l Symposium on Biological and Medical

Data Analysis (ISBMDA’05), pp305-316, 2005

45


Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, Helander A and

McNulty H, Effect of folic acid supplementation and serotonin response in

healthy males, British Journal of Nutrition, 94, pp 602-608, 2005

Williams E, Stewart-Knox B, Bradbury I, Rowland I, Pentieva K, McConville C,

Helander A and McNulty H, Effect of folic acid supplementation on mood and

serotonin response in healthy males, British Journal of Nutrition, 94, pp 602-

608, 2005

Williams E, Stewart-Knox B, Helander A, McConville C, Bradbury I and Rowland

I, Associations between whole-blood serotonin and subjective mood in healthy

male volunteers, Biological Psychology, 71, pp 171-174, 2005

VISION SCIENCES RESEARCH GROUP

Anderson RS. The psychophysics of glaucoma: improving the structure/function

relationship. Prog Retin Eye Res. 25 pp 79-97, 2006.

Asejczyk-Widlicka M, Sródka DW, Kasprzak H, Pierscionek B.: Modelling the

elastic properties of the anterior eye and their contribution to maintenance of

image quality: the role of the limbus. Eye 1-8 (2006)

http://www.nature.com/eye/journal/vaop/ncurrent/pdf/6702464a.pdf

Beirne RO, Hogg RE, Stevenson MR, Zlatkova MB, Chakravarthy U & Anderson

RS Severity staging by early features of age-related maculopathy exhibits weak

relationships with functional deficits on SWS grating acuity. Investigative

Ophthalmology and Visual Science 47, pp 4624-4631, 2006.

Beirne RO, Zlatkova MB & Anderson RS Changes in human short-wavelengthsensitive

and achromatic resolution acuity with retinal eccentricity and meridian.

Visual Neuroscience 22, pp 79-86, 2005.

Evanger K, Haugen OH, Aanderud L, Thorsen E, Pierscionek BK.

Hypermetropia-succeeded myopia after hyperbaric oxygen therapy. Optometry

and Vision Science 83, pp195-198. 2006

Gilchrist JM, Pierscionek BK, Mann WM; Use of the Hermann grid illusion in the

measurement of contract perception in dyslexia, Vision Res, 45, pp 1-8, 2005

Hunter D. An alternative model for research ethics review at UK

universities Research Ethics Review 2, pp 47-51, 2006.

Hunter D: Placebos, and moral perils for participants Research Ethics Review

2, pp 71-72, 2006.

Hogg RE, Anderson RS, Stevenson M, Zlatkova MB, Chakravarthy U.

46


In vivo macular pigment measurements. A comparison of Resonance Raman

Spectroscopy and Heterochromatic Flicker Photometry. British Journal of

Ophthalmoogy. 2006 Jul 6; [Epub ahead of print]

Kwok LS, Pierscionek BK, Bullimore M, Swarbrick HA, Mountford J, Sutton G.

Orthokeratology for myopic children: wolf in sheep's clothing

Clinical and Experimental Ophthalmology 33, pp 343-347 2005

Lauritzen JS, Tolhurst D. Contrast constancy in natural scenes in shadow or

direct light: A proposed role for contrast-normalisation (non-specific suppression)

in visual cortex, Network-Computation In Neural Systems, 16, pp151-173, 2005

McClelland JF, Parkes J, Hill N, Jackson AJ, Saunders KJ; Accommodative

dysfunction in children with cerebral palsy; a population based study; Invest

Ophth Vis Sci, 47, pp 1824-1830, 2006.

Pierscionek BK, Belaidi A, Bruun HH. Refractive index gradient in the porcine

lens for 532 and 633 nm light. Eye, 4, pp 375-38, 2005

Pierscionek B K: Species variations in the refractive index of the eye lens and

patterns of change with ageing. In Focus on Eye Research, Ioseliani, O.R. (ed)

Nova Science publishers Inc, p 117-132, 2005

Schachar R, Pierscionek B, Abolmaali A, Le T.: The relationship between

accommodative amplitude and the ratio of central lens thickness to its equatorial

diameter in vertebrate eyes. British Journal of Ophthalmology

doi:10.1136/bjo.2006.107524

Vassilev A, Ivanov I, Zlatkova MB, Anderson RS. Human S-cone vision:

Relationship between perceptive field and ganglion cell dendritic field Journal of

Vision 5, pp:823-833, 2005

Zlatkova M, Coulter E, Anderson R, The effect of simulated lens yellowing and

opacification on blue-on-yellow acuity and contrast sensitivity; Vision Research,

46, pp 2432-2442, 2006

47


Research Funding

Staff Name(s) Title of Award Funding Body Value

Banat

Use of microbial surface

active molecules for

environmental pollution

remediation and as agents for

disruption of microbial

attachments to surfaces

INI Networking £1,216

Dowey IAESTE Studentships The British Council £1,520

Downes

Dubitzky

Flatt

McMullan

Rowland

Strain

Centre for Metabolomics DEL-SRIF3 £3,510,857

Downes

McKerr

Dubitzky

Dubitzky

FEI Philips centre for

advanced Bioimaging.

Advanced methods and

technologies for

bioinformatics.

Chemomentum: Grid services

based on environment to

enable innovative research

DEL-SRIF3 £1,457,340

CEC - ALFA £5,520

CEC FP 6 IST £147,802

Dubitzky

Bioinformatics Capability

Funding

DEL - Research

Capability Fund

£242,936

Gill

Rowland

Anti-cancer activities of soft

fruit

Scottish Crop

Research Institute

£29,943

Hannon-Fletcher

An investigation of the efficacy

of a novel holistic interventive

strategy to improve clinical

control in haemodialysis

patients.

The Irish Nephrology

Society: Amegen Res

Grant

£6,845

Holscher

Gault

Effects of Novel GIP Agonists

on the Beta-Amyloid-induced

block of synaptic plasticity and

memory formation impairment

Alzheimer's Research

Trust

£30,000

48


Staff Name(s) Title of Award Funding Body Value

Howard

Livingstone

Bonham

Hannon-Fletcher

Wallace

Investigation of chronic

NMDA antagonist (MK801)

brain toxicity

Dietary sodium: urinary

sodium analysis of 24 hour

urine samples in a

representative sample of

healthy adults aged 19-64

years in NI.

Astra Zeneca £74,190

Food Standards

Agency

£150,000

Lowery

SGM Vacation Studentship

2006

Soc. for General

Microbiology

£1,760

Lowery

Dooley

Snelling

Lowery

Marchant

Laboratory costs in support of

student Stephen Smyth.

Occurence of food borne and

food-poisioning bacterial

pathogens in domestically

composted household waste.

Integrated Management of

potato starch wastes

Water Service - DRD £8,000

The Wellcome Trust -

Vacation Scholarship

£1,360

The British Council £4,410

McKeown

The influence of tumour

hypoxia on malignant

progression in Prostate

Cancer.

The British Council -

IAESTE

£1,520

McKillop

Abdel-Wahab

Analysis of glycated intestinal

hormones in Glucose

metabolism and diabetes.

R&D Office HPSS

RRG Cohesion Fund

£6,923

Mitchell

Seminar in Cancer Research

II

R&D Office HPSS

RRG via Belfast City

Hospital

£5,000

Naughton

Rowland

Fungwatch extension

Food Safety

Promotion Board -

£10,010

O'Harte

Small equipment grant to

support diabetes research.

Diabetes UK support

group - Limavady

£2,000

Pierscionek

Structure/Function relationship

in the eye lens

The Royal Society £3,970

Pierscionek

Modelling of lens function

using Finite Element Analysis

Essilor International

(69,000

Euro, circa

£48,000)

(2004-2005)

Saetzler Automated tracing of filled Max Planck Institute £23,817

49


neurons in SBFSEM image

series

Rowland

Gill

NICHE Probiotics workshops INI Networking £6,209

Saetzler

Automated tracing of filled

neurons in SBFSEM image

series

Max Planck Institute £23,817

Saunders

Anderson

Epidemiology of myopia in a

UK child population

The College of

Optometrists

£48,030

Strain

Bonham

Duffy

Livingstone

Robson

Rowland

Wallace

PHIME: Public health impact

of long-term, low level mixed

element exposure in

susceptible population strata.

CEC - Framework 6

Food Quality & Safety

IP

£421,037

Thompson

Molecular characterization of

the transcription factor BTF3

as a modulator of the estrogen

signal pathway

Cancer Recognised

Research Group for NI

£4,570

Thurnham

Gift towards research on

Macular Disease.

The Howard

Foundation

£2,000

Wallace

Bonham

Duffy

Strain

Dietary Requirements for

Vitamin D: an investigation of

the Relative Significance of

dietary intake and Sunlight on

Vitamin D Status in young and

elderly adults.

Food Standards

Agency

£321,119

Walsh

Webba da Silva

Wheadon

Wheadon

Wheadon

Development of a novel

genetic screening test for

male infertility

Structure and Stability of

Architectures in Guanine -

Rich Gene Regulatory

Regions.

Proteomic analysis of the

signalling events involved in

Leukaemic transformation by

the tyrosine kinase fusion

protein Tel/PDGFBR.

Molecular signals involved in

the self renewal of

haemopoietic stem cells

Role of the Hox genes in stem

cells and cancer.

Invest Northern

£120,226

Ireland - Proof of

Concept

The Royal Society £13,200

NI Leukaemia

Research Fund

Haematology

Association of Ireland

R&D Office HPSS

RRG - Cohesion Fund

£155,702

£1,679

£2,500

50


6. Indicators of Esteem

Anderson

Membership of External Committees/Professional Bodies:

• Member of College of Experts, Medical Research Council (MRC) (since

2000)

• Member of Life Sciences Committee, Royal Irish Academy (since 2004)

• Member of Research Comittee, College of Optometrists (since 2006)

• Member, Northern Ireland Forum for Health & Social Care Research (since

2002)

• External Examiner, MSc Ophthalmology and Vision Science, University of

Manchester

• Honorary Principal Vision Scientist, Royal Victoria Hospital (RVH) (since Jan

2004)

Bjourson

Membership of External Committees/Professional Bodies:

• Member of N. Ireland HPSS R&D Clinical Doctorate Fellowship Grants

Review Panel

• Member of HPSS R&D Masters Grants Review Panel

• Founder member and steering-group member of NW Science & Technology

Partnership

• Member Irish cross-border horticulture steering group

• Invited Judge Sentinus Seagate Young Innovators

• Member N. Ireland HPSS R&D Nucleic Acid Users Committee

Invited Lectures:

• Bjourson AJ: Invited Lecture, 'Medical Technologies at University of Ulster'

IDA Ireland Medical Technology Division Meeting: March 2005

• Bjourson AJ: Invited Lecture, 'Medical Technologies at University of Ulster'

IDA Ireland Medical Technology Division Meeting: March 2005

Bonham

Invited Speaker:

• Rank Prize Conference, Lake District, UK; ‘Fatty acid status in pregnancy:

results from the Seychelles Child Development Nutrition Study’ (October

2005)

51


Bridgen

Membership of External Committees/Professional Bodies:

Editorial board, Journal of General Virology (since December 2003)

Downes

OBE for services to biomedical sciences, 2005

Membership of External Committees/Professional Bodies:

• Editorial Board, Cell Cycle

• Member, Action Cancer Scientific Advisory Committee (to 2005)

• Member, Royal Irish Academy Life Sciences Committee

• Member, Science Foundation Ireland Genetics Advisory Committee

• Member, HRB North-South Cooperation Clinical and Biochemical Sciences

Committee

Dubitzky

Membership of External Committees/Professional Bodies:

• Editorial Board, Journal of Computational Intelligence in Bioinformatics,

Research India Publications (2006 – present)

• Editorial Board, Int. J. of Data Mining and Bioinformatics (IJDMB),

InderScience Publishers (2005 – present)

• Editorial Board, BMC Bioinformatics, BioMed Central, The Open Access

Publisher (2005 – present)

• Editorial Board, OMICS A Journal of Integrative Biology, Mary Ann Liebert,

Inc., Publishers (2004 – present)

• Editorial Board, Briefings in Bioinformatics, Oxford University Press (2003 –

present)

Flatt

Biochemistry Medal of Irish Area Section of Biochemical Society, 2005

Membership of External Committees/Professional Bodies:

• Member of Royal Irish Academy (2006-)

• Member of Diabetes UK Research Advisory Group and Research

Committee (2005-2010)

• Member of Diabetes UK Advisory and Professional Advisory Councils

(2003-2009)

• Founder, Chief Scientific Officer and Director of Diabetica Ltd (2005)

52


Gill

Invited Speaker:

• "Crownalife and Syncan Implications for Probiotics and Prebiotics in

Cancer and Healthy Ageing". The Future of Functional Foods. London

March 2006

• "Synbiotics and Colon Cancer ". 156th Meeting Society for General

Microbiology, April 2006

• "Faecal water a risk biomarker for colon cancer"- Colon cancer in the

time of "omics" Nugo Conference,June 2006

Invited Expert:

• National Swedish VINN Excellence Centers review programme

Hannigan

Membership of External Committees/Professional Bodies:

• Executive Board member, Invest Northern Ireland (2002 - date)

• Director, UUTech Ltd (2004 - date)

• Director, UUScience Research Parks Ltd (2004 - date)

• Director, Northern Ireland Science Park Ltd (2004 - date)

• Chair, Heads of UK University Centres of Biomedical Sciences (2002 - 2005)

• Member, Association of Medical Research Charities (AMRC), Scientific

Advisory Committee (2003 - date)

Hannon-Fletcher

Membership of External Committees/Professional Bodies:

• Professional member, HPSS Research Ethical Committees, Northern

Ireland (OREC NI)

• Member, Institute of Biology Northern Ireland (NI) Committee

Committee Member of the Institute of Biology NI Branch (since 2004)

Secretary, Northern Ireland Obesity Research Group (NIORG) (since

2004

Howard

Membership of External Committees/Professional Bodies:

• Member of the Council of the Royal Microscopical Society

• Fellow of the Royal College of Pathologists

• Appointed to the Government’s Advisory Committee on Pesticides (March

2003)

• Member of the Steering Committee for PEX, Pesticide Exposure Sufferers

Group of the Pesticides Action Network (since 1999)

• On Board of Directors of International Society of Doctors for the

Environment (ISDE) (since 2001)

53


• Member of The Genetic Modification Group of the ISP, The Independent

Science Panel (ISP) is a panel of scientists from many disciplines,

committed to the Promotion of Science for the Public Good (since 2003)

• Appointed to the DEFRA Advisory Committee on Pesticides (since 2003)

• Editorial board, Journal of Microscopy

• Editorial board, Forma

• Editorial board, Electronic Journal of Pathology and Histology

Livingstone

Membership of External Committees/Professional Bodies:

• Member of the Board of Governors (Scientific), British Nutrition

Foundation (2003-present)

• Member of the Scientific Advisory Committee, Food Safety Promotion

Board (SafeFood), Ireland (since 2003)

• Member of the Northern Ireland Food Advisory Committee (FSA)

Marchant

Membership of External Committees/Professional Bodies:-

• Member of the Council of the British Mycological Society (since 2005)

• Member of the International Organizing Committee for the 2 nd International

Congress of Bioprocesses in Food Industries (June 2006)

Invited Speaker:

• 2 nd International Congress of Bioprocesses in Food Industries (June 2006)

McClean

Membership of External Committees/Professional Bodies:

• Member of the British Mass Spectrometry Society

• Member of the Royal Society of Chemistry

• Member of the Higher Education Academy (Registered Practitioner)

• Member of Review Panel for Grant Applications to Irish Health Research

Board (Dublin) - November 2004

• Technology & Knowledge Transfer:

• Ongoing Consultancy with Unilever, Port Sunlight, UK on the analysis of

human skin peptides.

McClenaghan

Membership of External Committees/Professional Bodies:

• Committee Member, NI Branch of Institute of Biology (since 2002)

• Principal Investigator/Publicity and WWW Co-ordinator, HPSS R&D Office

RRG in Endocrinology and Diabetes

Invited Speaker:

Physiological Society Sharpey-Schafer Prize Lecture, 2005

54


McDowell

Membership of External Committees/Professional Bodies:

• Member, NI Advisory Committee, Food Standards Agency (FSA) (since

2005)

• Member, UK Food Borne Disease Strategy Consultative Group, FSA (2001-

2006)

• Vice-Chair, Scientific Advisory Committee, Food Safety Promotion Board

(FSPB) (since 2002)

• External Advisor, Consumer Focused Review, FSPB (since 2005)

• Member NI E. coli O157:H7 Working Party, Department of Agriculture and

Rural Development (DARD) (2003-2004)

• Member, Antimicrobial Resistance Action Plan Implementation Group,

Department of Health and Social Services (DHSS) (since 2002)

• Member, Hospital Acquired Infection Subgroup, Department of Health

Regional Advisory Committee on Communicable Diseases (DHSS) (since

2001)

• EU “Expert” Evaluator for new proposals for Framework Programme (FP) 4,

5 and 6 (Quality of Life) (since 1998)

• EU “Expert” Reviewer for FP4, 5, and 6 projects (Quality of Life) (since 1998)

• EU Interim Review Panel Member – EU RAIN (2003-2005)

• Specialist Assessor - DEFRA Programme on Non-Food Borne Zoonoses

Research Project Evaluator (2003-2004)

• Food Institutional Research Measure (Department of Agriculture RoI) Food

Safety Promotion Board (2002-2004)

• Advanced Technologies Research Programme (BioResearch Ireland)

EPSRC (2000-2004)

• Editorial Board - Food Microbiology (since 2004)

McHale

• Founder of Gendel Ltd. and also primary inventor of its technologies.

• Founder of EFMB Ltd

McKelvey-Martin

Membership of External Committees/Professional Bodies:

• Member of Action Cancer Scientific and Research Committee (since Sept

2003)

• Principal Investigator on Cancer RRG, NI HPSS R&D Office (since 2004)

Invited Lectures/Presentations:

Comet Assay Workshop – Member of Expert panel, Warsaw, Poland (2005)

55


McKeown

Membership of External Committees/Professional Bodies:

• Chair, Association for Radiation Research

• Past Chair, Northern Ireland Cancer Recognised Research Group.

• Member of the Cancer and Radiation Biology Committee, British Institute of

Radiology

• Member of equipment grant review board, Health Research Board, Republic

of Ireland

• NI committee member, Institute of Biology

• Member of AQ4N scientific advisory board, KuDOS Pharmaceuticals,

Cambridge, UK

• Member of the Radiotherapy Trials Clinical Studies group. 2004 – 2007,

National Cancer Research Institute (London)

• Scientific committee member, International Association for Radiation

Research

Invited speaker:

Association for Radiation Research, Marstrand, Sweden (April 2006): “Have

bioreductive drugs fulfilled their potential”

McKerr

Membership of External Committees/Professional Bodies:

• Member of International Scientific Advisory Panel, The Royal Microscopical

Society

• Academic liaison panel, Unilever Research

• Member of the Nanotechnology Research Group within Northern Ireland

Bioengineering Centre (NIIBEC), University of Ulster

McKillop

Membership of External Committees/Professional Bodies:

• European Association for the Study of Diabetes (EASD)

• Irish Endocrine Society

• Fellow of The Institute of Biomedical Sciences (FIBMS)

• Principal Investigator of the HPSS Recognised Research Group in

Endocrinology and Diabetes (since 2002)

• Member of the Northern Ireland Forum for Health & Social Care

Research, the Biochemical Society

McMullan

Membership of External Committees/Professional Bodies:

• Member of EPSRC Peer Review College (since 2000)

• Member of EPSRC Funding Review Committee for Proteomics grant

applications (2005)

• Editor, BMC Biotechnology Journal

56


McNulty

Membership of External Committees/Professional Bodies:

• External examiner (degree programmes): BSc Hons Nutrition (Human) at

University of Nottingham (2002-2006); BSc Hons Nutritional Sciences at

University College Cork (2006 to 2009); BSc Hons Nutrition and Dietetics at

Dublin Institute of Technology/Trinity College Dublin (2006 to 2010)

• External examiner (PhD examinations): Since 2002, examined 8 PhD

students from 6 different universities in Ireland, UK and Europe.

• Member of the Nutrition Committee, Food Safety Authority of Ireland (FSAI)

(2000 to present)

• Chair of the Working Group on Supplements at the International Life

Sciences Institute (ILSI) Europe Workshop on New Horizons for Safe

Addition of Micronutrients to Foods (Bologna, Italy, September, 2005)

• Panel Member of the Northern Ireland Research & Development (R&D)

Office (HPSS) Fellowship Evaluation Panel (2002-2005)

Invited speaker:

• National Seminar on Folic Acid Food Fortification, Food Safety Authority of

Ireland (FSAI), Dublin: “Folate intake and status: evaluation of strategies to

prevent NTD”(June 2005).

Melcher

Invited speaker:

• Plenary speaker at ESF/EMBO meeting, 2006

Moore

Membership of External Committees/Professional Bodies:

• Member of Executive Committee for Vision RRG (Sept 2006-pres)

• Member of Committee for Infectious Diseases RRG (2004-pres)

• Member of European Vision & Eye Research group (2004-pres)

• Member of Association for Research in Vision & Ophthalmology (2000-pres)

Naughton

Membership of External Committees/Professional Bodies:

• Member of UK Council, Institute of Biology (since 2005)

O’Connor

Membership of External Committees/Professional Bodies:

• Fellow, Institute of Biomedical Sciences, UK

57


• Member of Nutrition Society, UK

• External Examiner University of West England, Bristol: MSc Biomedical

Sciences

• Member of Institute of Biomedical Sciences Northern Ireland Branch

Committee (since 2004)

• External Reviewer for MSc in Medical Sciences at University College Cork

• Member of the UK Heads of University Centres of Biomedical Sciences

Executive (HUCBMS) as the Northern Ireland representative from Sept 2006

O’Harte

Membership of External Committees/Professional Bodies:

• Member of HPSS RRG Committee for Endocrinology and Diabetes

• Member of HPSS Clinical Research Fellowship Review Panel (2004-2007)

• Member of the Editorial Board of British Journal of Pharmacology (2005-2009)

• Member of the Editorial Board of the Journal of Endocrinology (2004-2007)

• Invited Speaker for Nordisk Medal lecture entitled, “Use of incretin

hormone analogues for Type 2 diabetes therapy” at annual Irish

Endocrine Society meeting in Limerick (5th Nov. 2005)

Invited Speaker:

• National Diabetes UK annual Meeting in Glasgow 2005 for a special

symposium on "Gut hormones and Diabetes - Problem or Solution

Pierscionek

Membership of External Committees/Professional Bodies:

• Executive Member, Women in Optics

• Member, Engineering and Physical Sciences Research Council

(EPSRC) College

• Editorial Board, Journal of Biomedical Optics

• Editorial Board, Current Analytical Chemistry

• Session organizer, International Society for Eye Research Congress, Sydney

Australia, 2004

• Invited keynote speaker, Annual Conference for Irish Optometrists, April 2005

• Keynote speaker, Essilor Congress of optometry (Spain) 2004

• Invited speaker, British Society for Refractive Surgery Congress, Oxford, 2006

Rowland

Honorary Doctorate (Doctor Honoris Causa) for research in Nutrition and

Cancer, University of Gent, Belgium (March 2005)

Membership of External Committees/Professional Bodies:

• Member, Food Standards Agency (FSA) Committee on Novel Foods

and Processes (since 1997)

58


• Vice-Chairman, Food Standards Agency/Department of Health

Committee on Toxicity of Chemicals in Food, Consumer Products, and

the Environment (since 1998)

• Member, Molecular and Cellular Medicine Panel, Health Research

Board, Dublin (since November 2004)

• Organizing Committee, 1st - 6th International Conferences on

Nutrition and Health (2000 to 2005 )

• Invited lecture: Diet and cancer prevention'.Associate Parliamentary

Food and Health Forum - April 25 2006

Saetzler

Membership of External Committees/Professional Bodies:

• Member of the Society for Neuroscience (SfN,since 2002) and the IEEE

Signal Processing Society (since 2006)

Saunders

Membership of External Committees/Professional Bodies:

• Member of Research Committee, British College of Optometrists

Invited speaker

• Northern Irish Down Syndrome Association, Under 5’s conference, October 2006)

• Accommodative dysfunction in Cerebral Palsy. Royal College of Physicians and

Surgeons, Glasgow , December 2005

Stewart-Knox

Membership of External Committees/Professional Bodies:

• Expert Evaluator for EC DG12, on the Advisory Board for the Nutrition for

Older People Project

• Editorial Reviewer for the International Journal of Consumer Studies (Since

2001)

Strain

Membership of External Committees/Professional Bodies:

• Member of Medical Research Council College of Experts

Committee (since 2004)

• Member of Expert Consultative Committee, Children’s Nutrition

Research Center, USDA, Baylor College of Medicine, Houston,

Texas (since 2003)

• Member, Medical Research Council, Physiological Medicine and

Infections Board (2001-2004)

• Member, Joint Health Claims Initiative Expert Committee (since

2001)

59


• Chairman of the Scientific Advisory Committee of the Food

Safety Promotion Board (1999-2004) and member of the Food

Safety Promotion Board (since 1999)

• Member Panel on Dietetic Products, Nutrition and Allergies,

European Food Safety Authority (EFSA), Parma and Chair of

Working Group on Health Claims (since 2006)

Thurnham

Membership of External Committees/Professional Bodies:

• Member. Northern Ireland HPSS Research Ethics Committee 1

• Consultant, Food Standards Agency for Nutrition Programme

Invited Speaker

• VII International Congress on Nutrition, Longevity and Life Quality, Sao

Paulo, Brazil October 2006

• Workshop on Nutritional Anemia. 1st World Congress on Public Health

Nutrition, Barcelona 2006

• Monitoring and Evaluating the Impact of Biofortification, Harvest Plus

Methods Workshop, Washington USA (September 2005)

• International Vitamin A Consultative Group Meeting, Peru (November

2004)

Wallace

Membership of External Committees/Professional Bodies:

• Editorial Board, Current Nutrition and Food Science.

Walsh

Membership of External Committees/Professional Bodies:

• Northern Ireland Dept Health and Personal Social Services R&D office

Fellowship Committee 2002 – 2005

• Action Cancer Grant Review Committee 2005

• Review Panel, Genomics

Invited speaker:

• Seminar, Institute of Child Health, University College London, 2005

• Dublin Inst. Molecular Medicine International Workshop on Epigenetics

2006

Ward

Membership of External Committees/Professional Bodies:

• 2003 – 2006 Membership secretary of Irish section of The Nutrition Society

60


Welch

Membership of External Committees/Professional Bodies:

• 2002 onwards European Commission, on Expert Evaluator Panel for

proposals for Framework Programme 6 (Quality of Life).

Invited speaker:

• International Cereal Congress Jubilee Conference, Vienna, 3-6 July 2005.

“Effects of cereal food characteristics on satiety and subsequent intakes”

and “Uptake and antioxidant activity of oat and wheat phenolics in humans”.

Plenary session.

• World Grains Summit: Foods and Beverages, AACCI (American Association

of Cereal Chemists International and Master Brewers Association of the

Americas, San Francisco, September 17-20, 2006; “Strategies for

developing snack foods that enhance satiety and decrease subsequent

intakes”.

• confidential industry / producers / academia meeting organised by Dr Ingmar

Borjesson, Cerealia AB, Stockholm.

61

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