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Issue 31 – February 2008 <strong>Philips</strong> <strong>Research</strong> technology magazine<br />

Password<br />

How the compact fluorescent<br />

bulb can help fight climate change<br />

Seeing the light<br />

Bringing cinema into<br />

your living room<br />

A <strong>visionary</strong><br />

<strong>experience</strong><br />

Imaging gets<br />

personal<br />

When a stroke hits,<br />

every second counts<br />

Password February 2008


Page 4<br />

Password is a technology magazine published<br />

by <strong>Philips</strong> <strong>Research</strong>.<br />

<strong>Philips</strong> <strong>Research</strong>, part of Royal <strong>Philips</strong><br />

Electronics, has laboratories in three<br />

regions (Europe, Asia and North<br />

America) where around 1,800 people<br />

investigate promising options for<br />

innovation.<br />

Concept and realization<br />

MediaPartners LoyaliteitsCommunicatie<br />

Stroombaan 4<br />

1181 VX Amstelveen<br />

The Netherlands<br />

www.mediapartners.nl<br />

2 Password February 2008<br />

Editor-in-chief<br />

Peter van den Hurk<br />

peter.j.van.den.hurk@philips.com<br />

Project editor<br />

Brandy Vaughan<br />

Desk editor<br />

Brian Jones<br />

Design and Art Direction<br />

Jan Tiedo Huesse<br />

Antoin Buissink<br />

Production management<br />

Claudia van Roosmalen<br />

Erica Schrijvers<br />

Distribution management<br />

Erica Schrijvers<br />

A <strong>visionary</strong><br />

<strong>experience</strong><br />

The groundbreaking new Ambilight is<br />

making quite an impression – without<br />

ever leaving the living room.<br />

Contributors<br />

Roland Blokhuizen<br />

Stuart Cherry<br />

Cedric Collet<br />

Karin Engelbrecht<br />

Peter Harold<br />

Brandy Vaughan<br />

Susan Wild<br />

Printer<br />

Daneels Grafische Groep, Belgium<br />

Subscription<br />

www.research.philips.com/password<br />

More information<br />

<strong>Philips</strong> <strong>Research</strong><br />

Communications Department<br />

High Tech Campus 5 (MS04)<br />

5656 AE Eindhoven, The Netherlands<br />

Tel. +31-40-27 43403<br />

Fax. +31-40-27 44947<br />

E-mail: prpass@natlab.research.philips.com<br />

Articles and images may be reproduced only<br />

with permission from <strong>Philips</strong> <strong>Research</strong><br />

© KONINKLIJKE PHILIPS<br />

ELECTRONICS N.V. 2008<br />

All rights reserved


8<br />

13<br />

21<br />

24<br />

Contents<br />

Seeing the light<br />

As climate change and energy<br />

efficiency make headlines, the<br />

compact fluorescent lightbulb finds<br />

popularity again – more than 25 years<br />

after its debut.<br />

Imaging gets personal<br />

In life-threatening situations, doctors<br />

can easily become overwhelmed by<br />

the amount of information that needs<br />

to be processed in order to save lives.<br />

But new automated image analysis<br />

and 3D organ modeling can help<br />

doctors in the race to find a diagnosis.<br />

A natural choice<br />

Waking up to an alarm clock is a<br />

relatively modern activity. Biologically,<br />

humans are hardwired to wake up<br />

naturally with the rising sun. In winter,<br />

that’s not often an option but the new<br />

Wake-up Light from <strong>Philips</strong> offers a<br />

good alternative.<br />

Saving time,<br />

saving lives<br />

When someone suffers a stroke,<br />

every second counts. New tools are<br />

under development to help doctors<br />

make those life-saving decisions more<br />

quickly.<br />

16 ExperienceLab<br />

An interactive shop window<br />

can transform a shopper’s<br />

<strong>experience</strong> and boost sales.<br />

18 Making the impossible<br />

possible<br />

A 24-hour personal assistant<br />

and hospital-level medical<br />

service from the comfort of<br />

your own home – sound like<br />

a dream? Not so, says world-<br />

renown technology forecaster<br />

Daniel Burrus.<br />

28 Did you know...<br />

Interesting facts and figures at<br />

your fingertips.<br />

30 Behind the nano<br />

Password gets the inside story<br />

on Erik Bakkers, winner of<br />

Technology Review’s prestigious<br />

‘Young Innovator under 35’<br />

award.<br />

Password February 2008<br />

3


A <strong>visionary</strong><br />

<strong>experience</strong><br />

4 Password February 2008


y Stuart Cherry Images: <strong>Philips</strong><br />

Remember your parents telling you not to watch television in<br />

the dark? It turns out they were right. Simply turning on a light<br />

behind the screen makes watching easier on the eye and adds<br />

to the visual <strong>experience</strong>. So how did an idea as simple as this<br />

turn into a groundbreaking new viewing <strong>experience</strong> and one of<br />

the hottest products in today’s TV market?<br />

Once, product technology was the driving force in<br />

electronics development. Then the ‘<strong>experience</strong> economy’<br />

arrived, shifting the focus from selling clever products to<br />

selling sensations and emotions. In this new world, the<br />

Ambilight <strong>experience</strong> is a perfect example.<br />

You could describe Ambilight as a TV with built-in<br />

ambient lighting effects. But that doesn’t come anywhere<br />

close to the Ambilight <strong>experience</strong> – which is unique to<br />

<strong>Philips</strong>. Think of the difference surround sound makes and<br />

then consider Ambilight as the ‘surround color’ version. It<br />

completely immerses you in the action, makes the screen<br />

seem larger and relaxes your eyes. Even leading industry<br />

reviewers familiar with the whole gamut of new TV<br />

technologies are impressed.<br />

“Ambilight doesn’t simply look pretty, it really helps<br />

involve you in the picture,” says Clare Newsome, editor of<br />

the UK’s What Hi-fi? (Sound and Vision) magazine. “It does<br />

so by using a system of lights embedded in the set’s chassis,<br />

which react in symphony with the action on the screen<br />

to create a richer, more involving and ‘larger’ picture. The<br />

effect this has on three-dimensionality is incredible.”<br />

Big thinking<br />

As pioneering as the idea is, Ambilight owes its existence<br />

to an unknown <strong>Philips</strong> employee who remembered his or<br />

her parents’ advice – and to the fortuitous moment when<br />

that memory found its way into a realm of big thinking on<br />

Ambient Intelligence (the term used to describe electronic<br />

environments sensitive and responsive to people’s needs<br />

and emotions).<br />

“At the time, our researchers, together with design<br />

and human-science specialists, were developing ideas<br />

around Ambient Intelligence, asking big questions about<br />

the <strong>experience</strong>s people could really enjoy instead of just<br />

trying to make products better,” explains Emile Aarts, vicepresident<br />

of <strong>Philips</strong> <strong>Research</strong>.<br />

Indeed, Ambilight originally had nothing to do with<br />

television – it was born in <strong>Philips</strong>’ <strong>Research</strong> and Lighting<br />

divisions. “We were looking at how light could add value<br />

to people’s everyday lives,” says Elmo Diederiks, who<br />

was a member of the initial research project. “During a<br />

brainstorming session, someone must have remembered<br />

the warnings about watching TV in a dark room because<br />

we discovered the idea about using light to enhance TV<br />

viewing scribbled on a Post-it ® note.”<br />

Interactive research<br />

It normally takes years for an idea to make it to the<br />

marketplace, but Ambilight made that journey in just a year<br />

and a half. What’s more: behind this unique TV <strong>experience</strong><br />

and its rapid rise lies a unique story of testing and design<br />

based on ‘user-centric development’. It may sound like<br />

jargon, but user-centric development is eminently practical.<br />

It means involving real consumers in the development<br />

process right from the start through an interactive, step-bystep<br />

process. Asking not just “Is this concept interesting?”<br />

but also “What’s important to the <strong>experience</strong>?” and “How<br />

can we make it better?”.<br />

“Usually when a company develops a new product,<br />

it’s trying to extend the technology and only shows it to<br />

Password February 2008<br />

5


consumers at the prototype stage,” Diederiks says. “But<br />

involving potential users early on actually makes the whole<br />

process much more efficient. Once we knew what people<br />

wanted, finding the right technology was simple.”<br />

So what did people want? To find out, the team<br />

transformed the Post-it ® note idea into a complete<br />

scenario explaining how light could bring the onscreen<br />

action to life. Put to consumers along with a number<br />

of other scenarios, the Ambilight concept came out on<br />

top and rapidly moved from idea to prototype. Again,<br />

consumers were asked to assess the prototype in a battery<br />

of formal and informal tests. This time the testing was done<br />

at the ‘HomeLab’ (part of the ExperienceLab) – a research<br />

facility that’s more like a house than a laboratory.<br />

Not a disco<br />

For those who haven’t <strong>experience</strong>d it, Ambilight may sound<br />

too much like a ‘TV with disco lights’. But this impression<br />

doesn’t last long. Apparently some early testers thought<br />

this when they first read the concept description – that<br />

is until they settled back to watch an Ambilight TV in the<br />

Home Lab living room.<br />

“People came up to us afterwards demanding to be at<br />

the top of the list for beta testing. That’s how keen they<br />

were to have Ambilight in their own homes,” explains<br />

Jettie Hoonhout, the <strong>Philips</strong> psychologist who oversaw<br />

the testing. “We knew then that paper descriptions would<br />

never do Ambilight true justice.”<br />

A glowing success<br />

Indeed, Aarts admits that while <strong>Philips</strong> was quietly<br />

confident Ambilight could be a success, the company is<br />

still surprised at just how successful it has been. After the<br />

first sets hit the market in August 2004, Ambilight became<br />

6 Password February 2008<br />

a huge hit with consumers right away. So much so that in<br />

mid-2007, Ambilight TV sales passed the million mark – a<br />

notable achievement in a saturated market where truly<br />

innovative products are rare.<br />

Moreover, market surveys show that over 75%<br />

of respondents think Ambilight improves the viewing<br />

<strong>experience</strong>. That same research reveals that, although the<br />

consumer-testers asked for an off switch, most Ambilight<br />

TV owners never turn the effects off. One person even<br />

claimed, “If the Ambilight isn’t on, it’s like there’s a black<br />

hole around my TV.”<br />

Buoyed by the positive reactions, <strong>Philips</strong> continues<br />

to further develop the concept to deliver an even more<br />

intensive viewing <strong>experience</strong> through further consumer<br />

feedback. The fourth generation of the technology has<br />

just been launched as the Aurea range of TVs. Featuring<br />

126 separate LEDs arranged in an ‘active frame’ around<br />

the screen, Aurea offers the most immersive Ambilight<br />

<strong>experience</strong> to date.<br />

A winning formula<br />

The ‘<strong>experience</strong>’ thinking behind Ambilight has also led the<br />

company into new areas such as amBX which takes the<br />

Ambilight idea and makes it multi-sensory by adding sound,<br />

vibration, air movement and other effects. This ultimate<br />

immersive <strong>experience</strong> is available to gamers, filling their<br />

entire environment with physical sensation, and will be<br />

coming soon to other media.<br />

It’s been quite a journey for an idea discovered on a<br />

Post-it ®. It also reveals the value of the interplay between<br />

big conceptual ideas like Ambient Intelligence, specific<br />

technical know-how and a research approach that puts<br />

people at its heart. In Ambilight, <strong>Philips</strong> has found a winning<br />

formula. It’ll be interesting to watch the encore.


More<br />

Creating the Ambilight effect<br />

Only a small part of your eye, known as<br />

the macula, actually sees a sharp image.<br />

An even smaller portion, the fovea, is<br />

responsible for producing the even-<br />

sharper vision needed to watch television<br />

or read. For the rest of your retina, the<br />

image is blurred. Your brain then works<br />

efficiently to combine all the information<br />

into a coherent picture.<br />

Ambilight helps enlarge this picture<br />

through an innovative technology that<br />

can ‘read the screen’ to produce the<br />

surrounding color. It works by analyzing the<br />

input video signal in real time to determine<br />

the dominant color in each area of the<br />

screen, averaged over a number of frames.<br />

It then uses color-mapping transformations<br />

to extend these color signatures beyond<br />

the screen. While the fovea is looking at<br />

the screen, the ambient colors fall on the<br />

surrounding part of the retina convincing<br />

your brain that you are seeing a larger<br />

image. The result is a much more cinematic<br />

<strong>experience</strong> in your own home and a feeling<br />

that you are truly immersed in the action.<br />

Reducing eye strain<br />

In a dark room, the TV is the main source of<br />

light. Therefore, when the picture on the<br />

screen changes, there’s a big fluctuation<br />

on the light level in the room which causes<br />

your pupil to dilate or contract in response.<br />

TV images change rapidly, so the muscles<br />

controlling your pupil have to work hard to<br />

keep up, leading to eye fatigue. Ambilight<br />

evens out the changes in the ambient light<br />

levels, so your pupil – and the muscles that<br />

control it – don’t have to work as hard and<br />

therefore eyes feel less tired.<br />

Ambilight’s soothing effect has been<br />

confirmed in numerous studies. In 2004,<br />

Professor Begemann of the Technical<br />

University in Eindhoven, the Netherlands,<br />

showed that Ambilight can reduce eye<br />

strain in 60-90% of people under normal<br />

‘home theatre room lighting’ conditions. In<br />

2005, John Bullough and colleagues at the<br />

Rensselaer Polytechnic Institute in New<br />

York (USA) found a beneficial effect on<br />

visual discomfort, fatigue and eye strain.<br />

A 2007 report by Herbert Plischke and<br />

colleagues from the Ludwig-Maximilians<br />

University in Germany and the University<br />

of Applied Sciences in Austria concluded<br />

Ambilight improved relaxation and<br />

attention levels.<br />

http://www.flattv.ce.philips.com/<br />

http://www.aurea.philips.com/<br />

http://www.research.philips.com/<br />

Password February 2008<br />

7


8 Password February 2008


y Brandy Vaughan Images: <strong>Philips</strong>, Michel Klop, Getty Images<br />

Seeing the light<br />

With climate change moving from back-page news to frontpage<br />

headline, the compact fluorescent bulb has a new lease<br />

on life – 25 years after it first hit the market.<br />

Once an oddity in the world of lighting, energy-efficient<br />

compact fluorescent lamps (or CFLs) are making a<br />

comeback now that climate change is firmly on the agenda<br />

of politicians, CEOs and even celebrities.<br />

Changing the world one bulb at a time<br />

Why all the new attention? On average, CFLs use 70-80%<br />

less energy than the typical incandescent bulb to generate<br />

the same amount of light – making them an increasingly<br />

popular way to do something good for the environment<br />

and your wallet. Less energy means less carbon dioxide<br />

emitted into the environment from the burning of fossil<br />

fuels – the most common way to generate energy. Most<br />

experts believe carbon dioxide (CO 2) emissions are a<br />

major contributor to global warming (aka climate change).<br />

Although estimates vary, swapping just one<br />

incandescent bulb for a CFL could save up to 500<br />

pounds of CO2 emissions – equivalent to driving a few<br />

thousand miles in a car. <strong>Research</strong> also shows that CFLs last<br />

anywhere from four to eight times longer than the typical<br />

incandescent meaning fewer bulbs and far less packaging<br />

ends up in landfills.<br />

More efficient<br />

So how do CFLs manage to be so much more efficient than<br />

old-style bulbs? The simple answer is incandescent bulbs<br />

– with their 125-year-old technology – convert 95% of the<br />

energy used into heat while only 5% is released as visible<br />

light. In CFLs, the amount of light produced versus energy<br />

used is much higher.<br />

“Since first introduced over 100 years ago, the<br />

incandescent bulb has barely changed,” says Dr Matt<br />

Prescott, Director of www.banthebulb.org, an online<br />

campaign encouraging greater energy efficiency. “The bulb<br />

wastes so much energy that if it were invented today odds<br />

are that it wouldn’t even be allowed on the market.”<br />

According to Cees Ronda, from <strong>Philips</strong> <strong>Research</strong>,<br />

the efficiency is in the details. “Incandescents produce a<br />

Password February 2008<br />

9


10<br />

wide spectrum of radiation at numerous wavelengths but<br />

most of it is not visible because the temperature is too<br />

low. This non-visible light is then released in the form of<br />

heat,” he explains. “With CFLs, radiation is generated at<br />

specific wavelengths that are visible so less energy is lost<br />

as heat. Therefore, CFLs produce a much smaller range of<br />

wavelengths but more visible light.”<br />

Saving energy, saves money<br />

Along with fears of a soon-exhausted oil supply, energy<br />

demand is at an all-time high driving up energy costs.<br />

With this, CFLs make even more sense. In the USA alone,<br />

consumers could save around $6 billion a year in energy<br />

costs by installing more energy-efficient lighting, according<br />

to the US-based Alliance to Save Energy.<br />

But as Prescott points out: “Consumers tend to be<br />

short-sighted and focus on the higher upfront cost of an<br />

energy-saving bulb, which is disappointing because, in the<br />

long term, the running costs of a CFL are much lower.”<br />

In the beginning<br />

Much has changed since <strong>Philips</strong> brought the first CFLs to<br />

market in 1980, but the need for energy-efficient lighting<br />

is now more important than ever. The story of the CFL<br />

begins in the early 1970s when the 1973 oil crisis raised<br />

awareness of potential issues with energy consumption<br />

and inspired companies, like <strong>Philips</strong>, to take a more serious<br />

interest in energy-efficient lighting.<br />

Developments made in <strong>Philips</strong> <strong>Research</strong> in the late<br />

1960s with rare earth metals and luminescent materials<br />

made the CFL technology possible. Harry Verhaar, dubbed<br />

‘Mr Green Switch’ by his colleagues in <strong>Philips</strong> Lighting,<br />

explains: “During the oil crisis, we became aware of the<br />

need for more efficient lighting options. As consumers we<br />

were asked to save energy when OPEC cut off oil deliveries<br />

to Western Europe and the USA. The recent technological<br />

advancements allowed us to develop a new lighting<br />

technique that was more stable and more efficient.”<br />

But when the oil crisis died down so did consumers’<br />

dedication to energy efficiency. So in 1980, when <strong>Philips</strong><br />

introduced the first CFLs, people didn’t quite embrace<br />

them as hoped. The bulb price was high and consumers<br />

lacked understanding of the long-term energy and cost<br />

savings. Light quality was another issue as consumers<br />

thought the color was too harsh and had no patience for<br />

the time it took for CFLs to fully light.<br />

Password February 2008<br />

Times are changing<br />

Fortunately, in the 25 years since first hitting the market,<br />

CFLs have come a long way. They no longer flicker or buzz<br />

and the light quality has improved dramatically. Newer CFLs<br />

offer a warmer soft-white light, take less time to light up<br />

and have become significantly smaller. They’re also more<br />

versatile with different sockets and dimming capabilities.<br />

But research suggests that although the bulb has<br />

evolved, consumers are stuck in the past. “From market<br />

research we learned that still few people know about all the<br />

improvements made in CFLs over the last decade or so,”<br />

notes Verhaar.<br />

No longer a choice<br />

If recent legislation is anything to go by, consumers may<br />

soon have no choice but to switch to CFLs. In 1997,<br />

most developed countries signed the Kyoto Protocol – a<br />

groundbreaking agreement that attempts to mitigate<br />

climate change through mandatory reductions in<br />

greenhouse gases, particularly CO2 emissions. As the 2012<br />

target nears, governments are scrambling to make a real<br />

impact on their CO2 emissions, which for some includes<br />

the phasing out or eventual banning of incandescent bulbs.<br />

In early 2007, Australia announced a ban on incandescent


ulbs in favor of CFLs by 2010, after a government-initiated<br />

study found CFLs to be five times more energy efficient<br />

than incandescents.<br />

Canada announced in April 2007 that it will ban the sale<br />

of incandescent bulbs by 2012 in a bid to curb greenhouse<br />

More<br />

There are two main parts in a CFL:<br />

the gas-filled tube (also called bulb or<br />

burner) and the ballast. Electrical energy<br />

in the form of an electrical current from<br />

the ballast flows through the gas-filled<br />

tube containing mercury molecules<br />

which have a special property: when<br />

excited, they emit ultraviolet light.<br />

The ultraviolet light, in turn, excites a<br />

Inside the bulb<br />

phosphor coating on the inside of the<br />

tube and emits visible light, which shines<br />

out through the tube. This phosphor<br />

coating is a mixture of luminescent<br />

materials, each emitting a different<br />

color. By changing the composition of<br />

the mixture, lamps generating different<br />

grades of white light can be developed<br />

(daylight, soft white, etc).<br />

gas emissions. In October of the same year, the state of<br />

California (USA) announced that it will phase out the use<br />

of incandescent bulbs by 2018 as part of a bill aptly titled:<br />

‘How Many Legislators Does it Take to Change a Light<br />

Bulb’. Other US states have similar legislation pending.<br />

Making the CFL as reliable and high<br />

quality as the incandescent required a lot<br />

of research – and an electronics revolution.<br />

Early CFLs cost around $25 per bulb<br />

(although they still paid for themselves in<br />

electricity savings). The light they produced<br />

was bluish or pinkish so the phosphor<br />

coating had to be refined. The ballast<br />

hummed and didn’t cycle the electricity<br />

Password February 2008<br />

11


12<br />

The European Union (EU) is also preparing legislation<br />

requiring the use of energy-efficient lighting in offices,<br />

streets and private households, while many countries within<br />

the EU are drafting their own legislation.<br />

Greening the bulb<br />

Estimates show that 25% of global lighting emissions come<br />

from incandescent bulbs but they only produce 4% of<br />

quickly enough therefore leading to a<br />

re-design to make it more electronic and<br />

miniaturized. Eventually, costs came down<br />

as did size.<br />

A popular concern about CFLs is<br />

that the technology underpinning the<br />

efficiency relies on a small amount of<br />

mercury to produce light. And while the<br />

concern is legitimate – and all exhausted<br />

CFLs must be properly recycled – a<br />

Password February 2008<br />

government-initiated study in Australia<br />

found that when you consider the mercury<br />

produced from burning fossil fuels for<br />

electricity, the energy-hungry incandescent<br />

contributes five times more mercury into<br />

the environment than a CFL. According to<br />

the US Environmental Protection Agency,<br />

coal-fired power plants emit four times<br />

more mercury to power an incandescent<br />

bulb than to power a CFL.<br />

global artificial-light output. Yet still, the impact of compact<br />

fluorescents has been somewhat limited as consumers fail<br />

to look beyond the higher sticker price to the long-term<br />

savings in terms of both cost and energy.<br />

But as we learn more about the massive climate-change<br />

challenge we all face, it becomes clear that the question<br />

is no longer “How can we afford to switch to CFLs?” but<br />

instead “How can we afford not to?”<br />

<strong>Philips</strong> CFLs contain a record low<br />

amount of mercury – less than two<br />

milligrams, which is up to four times<br />

less than competitor CFLs. <strong>Philips</strong><br />

also utilizes pellet dosing versus liquid<br />

mercury to ensure safe and accurate<br />

levels of mercury per bulb and<br />

continually looks for ways to reduce the<br />

amount of mercury while still maintaining<br />

light quality and performance.


y Susan Wild Images: <strong>Philips</strong><br />

Imaging gets<br />

personal<br />

Fans of television medical dramas will recognize the scene:<br />

dedicated doctors examining hundreds of computed<br />

tomography (CT) images, racing to find a diagnosis<br />

and save lives. Ironically in the real world, medical<br />

scans now deliver so much data that<br />

doctors barely have enough time<br />

to use it to best effect. But that’s<br />

about to change thanks to new<br />

automated image analysis and<br />

3D organ modeling.<br />

When Wilhelm Röntgen made the first shadowy X-ray<br />

images of his wife’s hand in 1895, he could hardly fathom<br />

where those initial steps would lead. Today, medical imaging<br />

shows doctors the structures and organs inside the body in<br />

remarkable detail and clarity, using an array of non-invasive<br />

technologies of which the X-ray was the first.<br />

The X-ray is still at the heart of numerous imaging<br />

techniques including radiography, angiography, fluoroscopy<br />

and CT. Over time, this group has expanded to include<br />

others such as magnetic resonance imaging (MRI), positron<br />

emission tomography (PET), single photon emission<br />

computed tomography (SPECT) and ultrasound.<br />

As the number of modalities (the term used for types<br />

of imaging technology) has grown, so too has the number<br />

of scans conducted. In the USA alone, the number of CT<br />

scans grew from 30 million in 1999 to 60 million in 2006.<br />

The data bottleneck<br />

With the growth in computing power over the last 30<br />

years, systems capable of producing 3D and even 4D<br />

Password February 2008<br />

13


14<br />

<strong>Philips</strong> researchers working with <strong>Philips</strong>’ new cardiac modeling software that<br />

automatically matches its heart model to the patient’s multi-slice CT scan, and<br />

then creates a highly detailed patient-specific 3-D model from which a wide<br />

range of morphological and physiological measurements can be extracted.<br />

(adding time to show organ movement) representations of<br />

our insides are now common. The new imaging capabilities<br />

lead to more personalized organ models, better diagnosis<br />

and easier surgical interventions. Yet these advances have<br />

also led to a dilemma – clinicians now have access to so<br />

much data, they don’t have time to deal with it all.<br />

For instance, a single cardiac CT scan may generate<br />

a sequence of ten 3D images, each made up of 300 2D<br />

‘slices’. But analyzing all this data can take a highly trained<br />

specialist an hour or more, time which is better spent on<br />

face-to-face patient care.<br />

Rapid analysis<br />

According to Guido Pardo-Roques, Senior Director of<br />

Global CT <strong>Research</strong> at <strong>Philips</strong> Healthcare, there’s a twopart<br />

solution. “The first step is to decrease the time it takes<br />

to produce images in order to provide more reliable clinical<br />

information,” he says. “The second is to automate image<br />

analysis enabling faster and more accurate diagnosis and<br />

therefore treatment.”<br />

The latter is where <strong>Philips</strong> has recently taken a big step<br />

forward, as Jürgen Weese, Principal Scientist at <strong>Philips</strong><br />

<strong>Research</strong>, explains: “Speeding up image analysis is vital for<br />

Password February 2008<br />

the healthcare industry, especially in cardiac CT. To simplify<br />

the work of healthcare professionals, we’ve developed<br />

automated analysis techniques that provide an accurate<br />

model of a person’s heart in just ten seconds.”<br />

Besides its speed, the technology’s ability to provide<br />

personalized models is truly innovative. Previously, doctors<br />

planning a procedure or making a diagnosis had to rely<br />

on generic 3D models and 2D images. But by using<br />

advanced boundary-detection algorithms (see More),<br />

<strong>Philips</strong> technology overlays the patient’s CT scan data onto<br />

a standard reference model creating a patient-specific 3D<br />

representation that greatly aids diagnosis.<br />

A helping hand<br />

The technology is also intended to help doctors in the<br />

planning and execution of image-guided procedures such as<br />

minimally invasive heart repair. A prime example is cardiac<br />

radio-frequency ablation, a common intervention to correct<br />

irregular heartbeat involving the insertion of a catheter into<br />

the heart chambers. Until now, cardiologists relied on X-ray<br />

fluoroscopy to guide their instruments. However, while<br />

X-ray fluoroscopy shows bone and instruments clearly, it<br />

reveals little of the structures of the heart.


<strong>Philips</strong>’ new automated analysis and 3D organmodeling<br />

techniques allow a realistic model of the<br />

patient’s heart to be superimposed on the fluoroscopy<br />

images. As the model accurately describes the anatomy<br />

and includes important clinical information such as cardiac<br />

‘landmarks’ like heart valves, cardiologists can position<br />

instruments more easily. Weese likens the effect to<br />

switching the lights on in a dark room.<br />

The technology has already been integrated into<br />

<strong>Philips</strong>’ EP Navigator workstation and feedback from<br />

clinical tests supports the idea that it may lead to a<br />

significant breakthrough. Reza Razavi, Professor of<br />

Pediatric Cardiovascular Science at King’s College, London<br />

(UK), explains: “The software revolutionizes the ease<br />

with which we can analyze the very large datasets that<br />

are now being produced by our CT and MRI scanners.<br />

Not only is this a great value in diagnostics, but it also<br />

allows us to quickly integrate our 3D images into our Xray<br />

interventional program, which is of particular help in<br />

ablation of arrhythmias.”<br />

Not just for the heart<br />

<strong>Philips</strong> is not the only company pursuing ways to speed<br />

image analysis. But the ability of its technology to create<br />

More<br />

The process of identifying the various<br />

structures present in the image of an organ<br />

is known as ‘segmentation’. The heart is<br />

a challenging organ to segment because<br />

of its numerous substructures and its<br />

integration into the vascular system. Yet,<br />

<strong>Philips</strong>’ technology manages to segment<br />

the heart chambers and major vessels with<br />

boundaries delineated and the volumes<br />

www.medical.philips.com/main/clinicalsegments/ep<br />

Marking the boundaries<br />

annotated in just a few seconds.<br />

To do that, it uses a mesh of 17,358<br />

triangles to describe the heart’s geometry<br />

in a 3D computer model. First, the system<br />

goes through a learning phase, building<br />

a reference model from a set of 30 to<br />

40 reference segmentations enhanced<br />

with a wealth of technical and anatomical<br />

information.<br />

dynamic and accurate models of the heart – showing the<br />

four chambers, the myocardium and the major attached<br />

vessels – puts it at the forefront of innovation.<br />

Looking ahead, the team behind the technology is<br />

working on extending it to all modalities, adding even<br />

more detail and creating reference models for common<br />

anatomical variants (for instance, patients with five<br />

pulmonary veins rather than the normal four).<br />

Personalized diagnosis<br />

The team is also looking for ways to apply the techniques<br />

to the entire body. They’ve already developed an<br />

experimental system that extracts a 3D model of the lungs,<br />

the ribcage and the spine from CT scans. Long term, the<br />

hope is to help radiologists identify lung diseases and even<br />

model a patient’s entire breathing process. This would<br />

greatly improve accuracy and patient care in radiotherapy<br />

image-guided treatments of lung tumors.<br />

As these image-analysis and modeling techniques<br />

continue to evolve, it appears that they not only provide<br />

a way past the data bottleneck, but also open the door to<br />

new levels of personalized diagnosis and treatment.<br />

Next, the reference model is matched<br />

to the patient’s heart images to create<br />

a patient-specific model. This process<br />

employs highly sophisticated borderdetection<br />

algorithms that can identify<br />

complex structures, position the triangles<br />

and fix their vertices to give a robust and<br />

accurate match between the model and<br />

the image data.<br />

Password February 2008<br />

15


16 Password February 2008


ExperienceLab<br />

Using technology to create interactive<br />

window displays.<br />

To ensure that technological<br />

developments are easy to use,<br />

inventions need to be tested by<br />

consumers themselves. ExperienceLab<br />

is a unique laboratory where consumertested<br />

innovation is top priority.<br />

The lab, located at the High Tech<br />

Campus in Eindhoven, the Netherlands,<br />

provides the perfect setting for the<br />

discovery of the practical, social and<br />

psychological implications of upcoming<br />

technologies.<br />

In the lab, consumers use and<br />

interact with new technologies and<br />

applications, such as the Intelligent<br />

Shop Window (shown here). The<br />

Intelligent Shop Window concept<br />

provides shop owners with new ways<br />

to create interactive, higher-quality<br />

shopping <strong>experience</strong>s and attract<br />

more customers. It also allows<br />

shoppers to access information about<br />

the products on display – even when<br />

the shop is closed.<br />

Password February 2008<br />

17


18<br />

Making the<br />

impossible<br />

possible<br />

Modern technology, such as email and the Internet,<br />

has increased both our productivity and our workload.<br />

Wouldn’t it be great if we could use this technology to<br />

find a way to do twice as much in a day? It may sound like<br />

a dream but the reality is not far off, according to Daniel<br />

Burrus, a leading technology forecaster and author of the<br />

best-selling book Technotrends.<br />

As Burrus explains, the already speedy rate of technology<br />

is about to dwarf anything we’ve seen so far and give us<br />

some exciting options in the years ahead. “In the next five<br />

years, we’re going to <strong>experience</strong> more technology-driven<br />

change than we have in the last 15,” he notes. “Moore’s<br />

Law says that the technology behind most devices – such<br />

as processing power, bandwidth and storage capacity<br />

– doubles every 18 months. This has held up for 40 years<br />

but now things are moving incredibly faster.<br />

“For example, it took 20 years to go from a fivemegahertz<br />

chip to a 500-megahertz chip but to double<br />

that took just eight months. And that was five years ago,”<br />

Burrus emphasizes. “The curve is now going vertical, which<br />

Password February 2008<br />

means we can barely fathom the technology that will come<br />

our way in the future.”<br />

Twice the work in half the time<br />

It’s this advance in technology that will make things even<br />

more interesting – and give us our very own virtual<br />

personal assistant, says Burrus. Soon you could wake up,<br />

turn on the television and be greeted by your assistant<br />

– available 24 hours a day, seven days a week without<br />

complaints. After outlining your schedule for the day, your<br />

assistant then updates you on a change in your travel plans<br />

– your morning flight was cancelled. But not to worry: your<br />

personal assistant has already re-booked you on another


y Brandy Vaughan Image: Burrus <strong>Research</strong>. Illustration: Roland Blokhuizen<br />

flight and printed your boarding pass. At the airport, your<br />

assistant tells you where to find a free spot in the parking<br />

garage. Not enough time to research the company you’re<br />

visiting? Not a problem, your assistant does the research for<br />

you – in a nanosecond.<br />

Waiting for the right buy price on stock you’d like to<br />

own? The assistant can track stock prices and not only<br />

inform you when it’s hit the target price but also buy the<br />

stock for you – with a financial plug-in from your broker, of<br />

course. Anxiously awaiting lab test results? Just download<br />

the medical plug-in from your doctor and the wait will<br />

soon be over. As soon as the results are entered into your<br />

medical records, your assistant gives you the details.<br />

Eventually, your assistant will learn from your requests and<br />

begin to anticipate your needs, almost like thinking for itself.<br />

The best part: as our assistants take care of logistics, we<br />

can spend more time on the things we actually enjoy. “With<br />

this, we could do almost twice as much in one day,” Burrus<br />

notes. “And with the mountains of new information that<br />

will be available in the future, having an assistant will quickly<br />

become a necessity, much like owning a car.”<br />

Best yet to come<br />

In the healthcare field, there have also been tremendous<br />

advancements in technology but the best is yet to come,<br />

says Burrus. Besides e-enabled assisted living for patients<br />

Password February 2008<br />

19


20<br />

and routine genetics mapping, we could soon have access<br />

to a virtual hospital that performs tests from the comfort of<br />

our own home. He offers the example of late-night heart<br />

palpitations: is it a heart attack or just indigestion?<br />

Currently our options are limited, Burrus says. “If I<br />

<strong>experience</strong>d heart palpitations, I would have two options: I<br />

could call an ambulance to take me to the emergency room<br />

and after many hours and many tests, I could find out that<br />

I only have indigestion – and a large bill. But on the other<br />

hand, if I assume it’s indigestion and go back to sleep, I may<br />

never wake up.”<br />

But a virtual hospital opens up the options, he explains.<br />

“I just turn on my television and choose the virtual<br />

hospital’s admissions desk and give them my symptoms.<br />

After pulling up my medical records using multiple<br />

biometrics for identification, they then ask me to attach<br />

an inexpensive bio-sensor to my chest so they can take<br />

my vital signs, like blood pressure and pulse, and an EKG<br />

reading – all virtually,” Burrus notes.<br />

“The information instantly transfers to a real-life doctor<br />

for analysis, and the doctor either asks me to come in for<br />

further tests or suggests I take an indigestion pill,” he adds.<br />

Password February 2008<br />

Daniel Burrus<br />

Daniel Burrus is one of the world’s leading technology forecasters and business strategists. He’s written<br />

six books including the highly acclaimed Technotrends, which has been translated into more than a dozen<br />

languages. Burrus is the founder and CEO of Burrus <strong>Research</strong>, a US-based research and consulting firm that<br />

monitors global trends in science and technology. In 1983, Burrus became the first and only forecaster to<br />

accurately identify 20 technologies that would later become the driving forces of business and economic<br />

change for the coming decade.<br />

“Imagine the time, stress and money a system like this<br />

could save. With the rate of advancing technology, we<br />

could see this within the next 15 years.”<br />

Fraud-proof identification<br />

Both the virtual assistant and ‘at-home hospitaling’ would<br />

use biometrics for identification but Burrus insists that<br />

neither privacy nor fraud will be an issue. “Biometrics<br />

will soon become so advanced that fraud won’t be a<br />

problem. We’ll see defense-industry technology pour<br />

into the public domain and new biometrics will be<br />

coming out that are almost impossible to steal, like the<br />

blood vessel pattern embedded in our hands. We’ll also<br />

use multiple biometrics like this to establish identity<br />

depending on the level of security required.”<br />

Another hot topic these days is climate change. But<br />

will the new awareness impact technology? Actually, it<br />

could be the other way around, says Burrus. “Technology<br />

is only bound by the limits we give it as humans. If we<br />

decide to use technology to solve global problems such as<br />

climate change, then it can get us there. Technology has<br />

the ability to turn the impossible into the possible.”


y Brandy Vaughan Images: <strong>Philips</strong>, Getty Images<br />

A natural choice<br />

As with other modern inventions, most of us would find it hard<br />

to imagine life without an alarm clock. But it hasn’t always been<br />

this way. Until relatively recently, humans depended solely on<br />

the rising sun – and the natural light it produced – to wake up<br />

each morning.<br />

><br />

Password February 2008<br />

21


22<br />

So what happened? Our modern-day lifestyles often<br />

demand that we start our days before sunrise, especially<br />

during winter. Although it was deemed one of the most<br />

hated inventions in a 2004 MIT survey, the alarm clock is still<br />

the wake-up method of choice for most. As natural as this<br />

may seem today, biologically it’s clearly an unnatural choice.<br />

In the genes<br />

Waking up to gradual light, as with the sunrise, is not only a<br />

more gentle way to start the day, it’s actually deep-rooted<br />

in the brain via a biological ‘wake-up process’ that our<br />

bodies go through each morning – naturally initiated by light<br />

not sound.<br />

The process kicks off as our early-morning, lightsensitive<br />

retinas detect the first hint of light. This<br />

activates our internal biological ‘body clock’ located in the<br />

hypothalamus region of the brain. This body clock uses light<br />

and dark to regulate our daily wake-sleep patterns – a cycle<br />

known as the circadian rhythm – through the production<br />

of certain hormones and neurotransmitters that tell our<br />

bodies when to wake up and when to sleep.<br />

A hardwired response<br />

Studies suggest that the hormone melatonin, released in<br />

response to darkness, plays a key role in preparing our<br />

bodies for sleep. Conversely, increasing light levels trigger<br />

the production of ‘wake-up’ chemicals such as cortisol,<br />

which is heavily involved in helping the body become alert<br />

and energized after a night of sleep. As the main signal for<br />

our bodies to switch from producing melatonin to releasing<br />

cortisol, light is clearly an important aspect in our biological<br />

wake-up process.<br />

“Morning light is the most important light for<br />

synchronizing our circadian rhythms,” explains Dr David<br />

Password February 2008<br />

Avery, a specialist on the connection between light and<br />

sleep from the University of Washington, USA. “It’s not<br />

natural to wake up in the dark. Our ancestors woke up<br />

at dawn, whenever dawn came. It’s hardwired into our<br />

brains and this doesn’t change just because we decide to<br />

use an alarm clock.”<br />

Fight or flight<br />

While waking up to natural light is clearly best, it’s not<br />

always easy to adjust your daily schedule according to<br />

sunrise and sunset, especially in winter. Given many of<br />

us have to wake up well before the sun, an alarm clock<br />

is the most obvious solution. But when the alarm goes<br />

off suddenly, sometimes at a near-deafening volume, we<br />

jump from sound sleep to consciousness without giving<br />

our bodies the time, or light, needed to stimulate the<br />

natural wake-up cycle. Studies suggest this can cause us<br />

to feel drowsy and less alert during the day.<br />

There’s also evidence that waking up to the harsh and<br />

sudden sound of the alarm can throw our bodies into<br />

fight-or-flight mode, pumping our barely awake bodies<br />

full of adrenaline – also known as the stress chemical.<br />

While this may help you get to the office on time, it’s<br />

certainly not the best way to start the day.<br />

A more natural approach<br />

So if the loud alarm clock we typically wake up to isn’t<br />

such a good thing, what options are there? Other than<br />

teaching yourself to wake up without stimulus, the<br />

most talked about alternative is dawn simulation. It’s a<br />

relatively new technique that involves a device much like<br />

an alarm clock that uses gradually increasing light instead<br />

of sound to wake you up. Mimicking a natural sunrise,<br />

dawn simulation tricks the body into initiating the wake-


up process in a more natural way. Typically, light intensity<br />

will slowly increase for 30 minutes before the scheduled<br />

alarm goes off – often with a choice of sounds such as<br />

ocean waves, birds or the traditional beep.<br />

Recent studies show that participants using dawn<br />

simulation reported feeling more alert and less tired,<br />

which could be related to the proven increase in serotonin<br />

levels after light exposure. Serotonin has long been linked<br />

to improved moods and increased energy levels.<br />

Another factor in feeling energized after waking<br />

is cortisol release. Professor Angela Clow, from the<br />

University of Westminster (UK), explains, “Waking up<br />

with light helps the cortisol cycle efficiently regulate<br />

other bodily systems, which could explain why people<br />

find waking up with dawn simulation beneficial to how<br />

they feel during the day.”<br />

In sync<br />

Dawn simulation has also been shown to help keep our<br />

internal body clocks in sync. “All living organisms operate<br />

on night and day cycles and these physiological processes<br />

can become delayed, particularly in winter, meaning it<br />

takes longer for our bodies to switch from nighttime<br />

to daytime activities,” Clow says. “But dawn simulation<br />

helps trigger and regulate these cycles while slowly<br />

waking you up.”<br />

New evidence reveals that dawn simulation can<br />

also positively affect sleep, according to a recent study<br />

conducted at the University Medical Center Groningen<br />

in the Netherlands. Dr Ybe Meesters who headed<br />

the study notes, “The benefits of dawn simulation in a<br />

normal healthy population are easier awakening and an<br />

improvement in sleep quality, therefore improving quality<br />

of life, especially in the winter.”<br />

Putting <strong>experience</strong> into creation<br />

Although research on dawn simulation is a relatively<br />

new field of study, so far all studies show a beneficial<br />

correlation between dawn simulation and how users feel<br />

upon waking up. This was enough to inspire <strong>Philips</strong> to<br />

leverage more than 100 years of <strong>experience</strong> in lighting<br />

technology to develop a ‘Wake-up Light’ more advanced<br />

than all others in terms of light intensity (lux), a key factor<br />

in how well the wake-up process goes.<br />

As Dennis Schuilenburg, a business manager<br />

in <strong>Philips</strong>’ Consumer Lifestyle Sector, points out,<br />

“During development, we focused on real consumers in<br />

real-life situations. Through this we found that although<br />

everyone is different, many people need around 250-<br />

300 lux to awaken fully in the morning. But this lux level<br />

is difficult to achieve in a small unit because of heatdispersion<br />

issues.”<br />

He adds, “For this reason most companies still<br />

produce an alarm clock with a small light of around 50<br />

lux. We focused instead on developing an alarm clock<br />

that is a lamp first and foremost, therefore overcoming<br />

the heat-dispersion problem. It was only through<br />

intensive research that we discovered this was the best<br />

way forward.”<br />

Schuilenburg also explains that when determining<br />

the light curve, only the best prototype would do. “It’s<br />

important that light intensity increases very gradually,<br />

so users don’t wake up too early,” he says. “So we<br />

developed the light curve for the Wake-up Light to match<br />

the light curve of the rising sun.”<br />

The next best thing to a natural sunrise, the <strong>Philips</strong><br />

Wake-up Light has become so popular, the biggest<br />

challenge is keeping up with strong demand. All we need<br />

now is someone to make breakfast.<br />

Password February 2008<br />

23


24 Password February 2008<br />

Saving time,<br />

saving lives


y Brandy Vaughan and Peter Harold Images: <strong>Philips</strong>, Getty Images<br />

According to the World Health Organization, more than 15<br />

million people suffer from stroke each year worldwide. Of<br />

these, five million die and another five million are permanently<br />

disabled. When stroke hits, quick treatment can easily be the<br />

difference between life and death as oxygen-deprived brain<br />

cells begin to die at the alarming rate of 32,000 per second.<br />

Stroke is the third leading cause of death and the number<br />

one cause of disability in North America and Western<br />

Europe. But the number of healthy survivors could be<br />

much larger if treatment is administered more rapidly.<br />

Unless a stroke is treated within a few hours, victims are<br />

likely to suffer significant, and often permanent, disability<br />

– if not death.<br />

Rule of thirds<br />

According to Jon Barrick, Chief Executive of the UK-based<br />

Stroke Association, “Stroke clinicians talk about a ‘rule of<br />

thirds’ with stroke – a third are likely to die, a third become<br />

permanently disabled and a third recover. But we believe<br />

that this ‘rule of thirds’ can and should be broken. If the<br />

time between the onset of a stroke and diagnosis was no<br />

more than three hours, a significant number of people<br />

would have a much better chance of avoiding death or<br />

disability. But all too often, there are severe delays.”<br />

Many of the delays Barrick refers to are due to the<br />

varying symptoms of stroke that can differ widely from<br />

one patient to another, often mimicking other conditions.<br />

Adding to the difficulty of diagnosis, the signs of a<br />

stroke may begin suddenly or develop over many days<br />

– sometimes even temporarily improving – depending upon<br />

the type of stroke and area of the brain affected.<br />

To ensure that potential stroke patients get treatment<br />

as quickly as possible, emergency paramedics must make<br />

a preliminary diagnosis within minutes. To help them,<br />

screening tools, such as the Los Angeles Prehospital Stroke<br />

Screen (LAPSS), have been developed to give paramedics<br />

a set of questions and a corresponding decision ‘tree’ to<br />

help them determine if a stroke alert should be sent to an<br />

appropriate hospital.<br />

When time is critical<br />

The rapid rate of new healthcare technology begs the<br />

question: surely we can find a way to speed up the<br />

treatment process? It’s possible, but quick treatment<br />

demands quick diagnosis.<br />

The new ‘Stroke Angel’ software, developed by <strong>Philips</strong><br />

<strong>Research</strong> and the subject of several recent pilot studies in<br />

Germany, could help accelerate the process from the start.<br />

Running on a standard handheld computer, the Stroke Angel<br />

automates standard screening tools such as the LAPSS.<br />

Using information entered by the paramedic, it provides a<br />

recommendation on whether or not to send a stroke alert.<br />

It can even be programmed to identify nearby<br />

hospitals with suitable stroke-care units. This is key, as<br />

often paramedics under intense pressure have trouble<br />

remembering which hospitals are equipped to give stroke<br />

victims the life-saving treatment that some require.<br />

Several studies show that stroke patients fare significantly<br />

better when treated by dedicated stroke teams with<br />

specialized protocols.<br />

Password February 2008<br />

25


26<br />

Paramedics can also instruct the Stroke Angel to<br />

wirelessly transmit a stroke alert to the hospital together<br />

with the victim’s screening information. This gives the<br />

hospital time to prepare – such as alerting the stroke<br />

team and freeing up critical resources such as a CT or<br />

MRI scanner so that diagnosis and treatment can begin<br />

as soon as the patient arrives.<br />

The right diagnosis<br />

Once the patient arrives at the hospital, stroke diagnosis<br />

is still not easy – even for <strong>experience</strong>d stroke specialists.<br />

All too often, stroke patients suffer from disorientating<br />

symptoms that can cause confusion and disable the<br />

patient’s ability to communicate clearly with doctors.<br />

And a doctor must not only determine if the patient has<br />

suffered from a stroke but also which type of stroke from<br />

several possibilities – a life or death decision in itself.<br />

The two most common types of stroke are ischemic<br />

stroke and hemorrhagic stroke. Ischemic stroke, which<br />

accounts for around 80% of stroke cases, is typically<br />

A screenshot of the Stroke Navigator<br />

Password February 2008<br />

caused by a blood clot blocking blood flow to a certain<br />

part (or parts) of the brain. Blood clots can form either<br />

within the brain itself or travel to the brain from other<br />

areas of the body.<br />

The second most common type of stroke is<br />

hemorrhagic stroke caused by bleeding within the brain<br />

or surrounding tissues resulting from a ruptured blood<br />

vessel. This type of stroke not only prevents blood from<br />

reaching parts of the brain but can also damage brain<br />

tissue around the hemorrhage site and result in a build-up<br />

of pressure in the skull, causing extensive and often lifethreatening<br />

damage.<br />

Different treatments<br />

Making a differential diagnosis between these two types<br />

of stroke is extremely important because the treatments<br />

are radically different. In fact, the treatment for ischemic<br />

stroke can be fatal if administered to a hemorrhagic<br />

stroke victim. For this and other reasons, stroke is a<br />

potentially life-threatening condition that can deteriorate


quickly unless the right diagnosis and treatment decisions<br />

are made. With the pressure on, doctors have to be<br />

vigilant at every point in the care cycle.<br />

To help with this, <strong>Philips</strong> <strong>Research</strong> is developing<br />

the ‘Stroke Navigator’ that can provide hospital<br />

clinicians with a valuable tool to support and coordinate<br />

diagnosis and treatment. Linked to the hospital’s patient<br />

information system, it has been designed to create<br />

a complete patient profile based on the screening<br />

information and patient history, and then track every<br />

procedure performed, together with test results.<br />

This information is combined with pre-programmed<br />

expert knowledge, probability rates and clinical<br />

decision guidelines for the treatment of stroke. The<br />

Stroke Navigator then analyzes the information to give<br />

diagnostic and therapeutic suggestions.<br />

“With Stroke Angel and Stroke Navigator, we’re trying<br />

to bring more simplicity to stroke diagnosis by making it<br />

easier for paramedics and physicians to pull together all<br />

the information they need to make the best decisions,”<br />

More<br />

Around 25 million people worldwide suffer<br />

from dementia, and it’s estimated that<br />

this number could easily double by 2040.<br />

Dementia is the end result of a number of<br />

progressive degenerative diseases of the<br />

brain, the most common being Alzheimer’s<br />

disease. Most neurodegenerative diseases<br />

begin years before significant symptoms<br />

show up. But unfortunately, most current<br />

treatments only provide symptomatic<br />

relief in the mild to moderate stages of the<br />

disease but do not arrest its progression.<br />

Recognizing this, <strong>Philips</strong> <strong>Research</strong><br />

and the University Medical Center<br />

Hamburg-Eppendorf are jointly<br />

developing a computer-aided diagnostic<br />

system (CAD) that would use both<br />

positron emission tomography (PET)<br />

and magnetic resonance imaging (MRI)<br />

data to assist specialists in diagnosing<br />

neurodegenerative disease. As with<br />

stroke, a diagnosis not only determines<br />

whether the disease is present but also<br />

which type it is.<br />

Both PET and MRI are useful for<br />

revealing abnormalities in the brain and<br />

distinguishing between the different<br />

types of neurodegenerative disease. In<br />

explains Charles Lagor, Senior <strong>Research</strong> Member at the<br />

North American division of <strong>Philips</strong> <strong>Research</strong>.<br />

With the right information, the Stroke Navigator<br />

can provide a continuously updated probability of<br />

whether the patient has suffered an ischemic stroke, a<br />

hemorrhagic stroke or whether the patient is a so-called<br />

‘stroke mimic’ (someone suffering from a non-vascular<br />

disease that produces stroke-like symptoms). The Stroke<br />

Navigator can then suggest the next steps for treatment<br />

together with single-click operations to initiate them<br />

– such as a request for an urgent CT scan.<br />

“Such tools don’t require the development of<br />

new technology,” Lagor notes. “What they do require is<br />

a thorough understanding of clinician and patient<br />

needs so that you can apply existing technologies in<br />

innovative ways.”<br />

Following a stroke, victims cannot afford to lose time.<br />

Every minute that goes by is a matter of life or death.<br />

And in this fight for survival, combining technology and<br />

innovation can have a real impact: it can save lives.<br />

Advanced dementia diagnosis<br />

the early stages of the disease, however,<br />

the PET images are particularly difficult to<br />

interpret and CAD systems can be helpful<br />

to specialists.<br />

Dr Lothar Spies, head of the Digital<br />

Imaging <strong>Research</strong> Group at <strong>Philips</strong><br />

<strong>Research</strong>, describes what sets the<br />

new system apart: “This is not the first<br />

computer-aided system to provide<br />

assistance in diagnosing dementia. Other<br />

systems, however, rely on data from just<br />

one modality – typically PET. But this is a<br />

multi-modality CAD system integrating<br />

data from both PET and MRI scans.”<br />

Password February 2008<br />

27


Did you know...<br />

50 men<br />

“One machine can do the work of 50<br />

ordinary men. No machine can do<br />

the work of one extraordinary man”<br />

Elbert Hubbard, American writer and philosopher.<br />

8-ton lightbulb<br />

The world’s largest lightbulb stands 13 feet tall, weighs<br />

eight tons and is illuminated at night. It sits atop the<br />

Thomas Edison Memorial Tower in New Jersey, USA.<br />

The tower, which was built in 1937, is located on the spot<br />

where Edison invented the modern-day incandescent bulb.<br />

28 Password February 2008<br />

70% lifestyle<br />

In a recent BBC poll of 22,000<br />

people in 21 countries, 70% of<br />

respondents said they were<br />

prepared to change their<br />

lifestyles to help mitigate<br />

climate change – including<br />

people in the USA and<br />

China, the world’s two<br />

biggest emitters of<br />

carbon dioxide.<br />

Award winners<br />

First light<br />

The first city in the world<br />

to install electric street<br />

lighting was Godalming,<br />

UK, in 1881.<br />

At the 2007-2008 European<br />

Imaging and Sound Association<br />

(EISA) conference, <strong>Philips</strong> won two<br />

prestigious EISA awards in the ‘Full High Definition<br />

LCD TV’ and ‘Compact Home Theater System’<br />

categories. Winners were selected based on product<br />

innovation and design by editors from 49 leading<br />

European magazines specializing in multimedia.


No further<br />

“Inventions have long<br />

since reached their limit,<br />

and I see no hope for<br />

further developments”<br />

Julius Sextus Frontinus, Roman<br />

engineer in the year 10 AD.<br />

13,000 sheets<br />

<strong>Research</strong> conducted by IBM<br />

estimates that the average<br />

office-based employee<br />

generates as much as 13,000<br />

pieces of paper annually.<br />

LED palace<br />

It costs just € 0.45 per hour to light<br />

Buckingham Palace with the new LEDbased<br />

lighting system installed by <strong>Philips</strong>.<br />

$2.8 million lamp<br />

The highest amount paid for a lamp at<br />

a Christie’s auction was a Tiffany Lotus<br />

design that sold for $2.8 million in 1997.<br />

Marble marvel<br />

The first recorded patent<br />

for an industrial invention<br />

was granted in 1421<br />

to the engineer Filippo<br />

Brunelleschi in Florence,<br />

Italy. The patent gave him<br />

a three-year monopoly<br />

on the manufacturing of<br />

a barge with hoisting gear<br />

to transport marble.<br />

Password February 2008<br />

29


y Cedric Collet Images: <strong>Philips</strong>, Michel Klop<br />

30<br />

Behind the nano<br />

Life has been moving at warp speed for Erik Bakkers,<br />

senior scientist and project leader at <strong>Philips</strong> <strong>Research</strong>, ever<br />

since winning one of the industry’s most prestigious awards<br />

– Technology Review’s ‘Young Innovator under 35’.<br />

With just 35 winners out of a pool of 300, the competition<br />

for the award was intense. So what’s the secret behind<br />

Erik’s success? The answer lies in his groundbreaking<br />

nanotechnology research. After years of work, Erik finally<br />

found a way to do something previously unheard of when he<br />

discovered a method for combining semiconductors made<br />

of different materials on the same microchip – allowing for<br />

faster, more efficient semiconductor technology. Here Erik<br />

opens up about what he does inside and outside the lab.<br />

What’s a typical day like for you?<br />

Actually, every day is different. After checking emails, I make<br />

rounds through the labs and check on how the projects<br />

are progressing. As a project leader, I guide doctoral and<br />

post-doc students through the research process. Maybe then<br />

I’ll work on a peer review for a journal or meet with some<br />

project collaborators, like university professors, to discuss<br />

our joint projects. Since every project now has to have a<br />

business plan, I spend time doing market research, keeping<br />

track of what others are working on, seeing where our<br />

research will fit in and how we should approach it.<br />

Password February 2008<br />

Can you describe an interesting project that you are<br />

working on?<br />

Right now, I’m looking at nanowire sensors to detect<br />

things like proteins and DNA. The sensor is very small and<br />

sensitive yet has a large surface so it’s good for bacteria<br />

testing. For instance, if you have a bacterial infection and<br />

go to the hospital, it’s important to know exactly what it is<br />

as soon as possible in order to treat it properly. But with<br />

current technology it takes three to four days to determine<br />

the specific type of infection.<br />

To reduce this time and allow for earlier treatment,<br />

we’re working on a lab-on-a-chip solution that has<br />

necessary chemical processes embedded in the chip, which<br />

makes it easier to use saliva or blood on the spot to detect<br />

exactly which bacteria or virus is causing the infection. The<br />

first generation is already out, so we’re focusing on the<br />

second generation to reduce the analysis time even further.<br />

What do you like best about your job?<br />

I really like the multidisciplinary approach we take with<br />

research projects. We’re constantly thinking of new ways


Erik Bakkers, seen here with a colleague,<br />

is currently working on lab-on-a-chip<br />

solutions.<br />

to expand and apply our research. It helps that there’s a<br />

cooperative mindset here as well as world-class facilities.<br />

And when we finish a project, it’s great to see the final<br />

results in practice, no longer in theory.<br />

What was the best thing about winning the Technology<br />

Review award?<br />

All the winners were invited to a follow-up conference<br />

at MIT where I gave two presentations on my research.<br />

I also participated in a panel discussion on the future of<br />

microchip technology. There was a great debate about the<br />

way forward as features get smaller and clock frequencies<br />

More<br />

Because of variations in expansion<br />

rates when heated, combining different<br />

materials in one semiconductor device<br />

was almost a mission impossible. When<br />

attempted, the incredible physical<br />

strain led to reduced performance. But<br />

thinking outside the box, Erik Bakkers<br />

Outside the box<br />

and his team created the circuits out of<br />

nanowires, which decreased the strain<br />

as the point of contact between the<br />

semiconductors was minimized to mere<br />

tens of nanometers.<br />

This technique of mixing semiconductors<br />

on the same chip paves the<br />

increase. Overall, the conference was very interactive and<br />

forward thinking.<br />

What would you be doing if you weren’t working in the lab?<br />

I can think of two things: traveling around the world or<br />

working for a company that specializes in mergers and<br />

takeovers – being involved in such a dynamic and fast-paced<br />

field would be quite exciting.<br />

How do you spend your time outside the lab?<br />

I love to cycle and play squash. But there’s less time for those<br />

activities now that my two children keep me busy.<br />

way for multipurpose chips that could<br />

revolutionize mobile and computer<br />

technology through less power usage yet<br />

faster processing speeds. Even better: it<br />

could easily translate into cheaper – and<br />

more technologically advanced – mobile<br />

phones and computers in the near future.<br />

Password February 2008<br />

31


A new day, a new career...<br />

<strong>Philips</strong> is the leading Dutch company in terms of products and innovation,<br />

according to the Global Reputation Top 200 ranking, published in May 2007<br />

by the US-based Reputation Institute. <strong>Philips</strong> <strong>Research</strong> has 1,800 technology<br />

researchers worldwide creating the future today. Join us and make a difference.<br />

www.philips.com

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