A visionary experience - Philips Research
A visionary experience - Philips Research
A visionary experience - Philips Research
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Issue 31 – February 2008 <strong>Philips</strong> <strong>Research</strong> technology magazine<br />
Password<br />
How the compact fluorescent<br />
bulb can help fight climate change<br />
Seeing the light<br />
Bringing cinema into<br />
your living room<br />
A <strong>visionary</strong><br />
<strong>experience</strong><br />
Imaging gets<br />
personal<br />
When a stroke hits,<br />
every second counts<br />
Password February 2008
Page 4<br />
Password is a technology magazine published<br />
by <strong>Philips</strong> <strong>Research</strong>.<br />
<strong>Philips</strong> <strong>Research</strong>, part of Royal <strong>Philips</strong><br />
Electronics, has laboratories in three<br />
regions (Europe, Asia and North<br />
America) where around 1,800 people<br />
investigate promising options for<br />
innovation.<br />
Concept and realization<br />
MediaPartners LoyaliteitsCommunicatie<br />
Stroombaan 4<br />
1181 VX Amstelveen<br />
The Netherlands<br />
www.mediapartners.nl<br />
2 Password February 2008<br />
Editor-in-chief<br />
Peter van den Hurk<br />
peter.j.van.den.hurk@philips.com<br />
Project editor<br />
Brandy Vaughan<br />
Desk editor<br />
Brian Jones<br />
Design and Art Direction<br />
Jan Tiedo Huesse<br />
Antoin Buissink<br />
Production management<br />
Claudia van Roosmalen<br />
Erica Schrijvers<br />
Distribution management<br />
Erica Schrijvers<br />
A <strong>visionary</strong><br />
<strong>experience</strong><br />
The groundbreaking new Ambilight is<br />
making quite an impression – without<br />
ever leaving the living room.<br />
Contributors<br />
Roland Blokhuizen<br />
Stuart Cherry<br />
Cedric Collet<br />
Karin Engelbrecht<br />
Peter Harold<br />
Brandy Vaughan<br />
Susan Wild<br />
Printer<br />
Daneels Grafische Groep, Belgium<br />
Subscription<br />
www.research.philips.com/password<br />
More information<br />
<strong>Philips</strong> <strong>Research</strong><br />
Communications Department<br />
High Tech Campus 5 (MS04)<br />
5656 AE Eindhoven, The Netherlands<br />
Tel. +31-40-27 43403<br />
Fax. +31-40-27 44947<br />
E-mail: prpass@natlab.research.philips.com<br />
Articles and images may be reproduced only<br />
with permission from <strong>Philips</strong> <strong>Research</strong><br />
© KONINKLIJKE PHILIPS<br />
ELECTRONICS N.V. 2008<br />
All rights reserved
8<br />
13<br />
21<br />
24<br />
Contents<br />
Seeing the light<br />
As climate change and energy<br />
efficiency make headlines, the<br />
compact fluorescent lightbulb finds<br />
popularity again – more than 25 years<br />
after its debut.<br />
Imaging gets personal<br />
In life-threatening situations, doctors<br />
can easily become overwhelmed by<br />
the amount of information that needs<br />
to be processed in order to save lives.<br />
But new automated image analysis<br />
and 3D organ modeling can help<br />
doctors in the race to find a diagnosis.<br />
A natural choice<br />
Waking up to an alarm clock is a<br />
relatively modern activity. Biologically,<br />
humans are hardwired to wake up<br />
naturally with the rising sun. In winter,<br />
that’s not often an option but the new<br />
Wake-up Light from <strong>Philips</strong> offers a<br />
good alternative.<br />
Saving time,<br />
saving lives<br />
When someone suffers a stroke,<br />
every second counts. New tools are<br />
under development to help doctors<br />
make those life-saving decisions more<br />
quickly.<br />
16 ExperienceLab<br />
An interactive shop window<br />
can transform a shopper’s<br />
<strong>experience</strong> and boost sales.<br />
18 Making the impossible<br />
possible<br />
A 24-hour personal assistant<br />
and hospital-level medical<br />
service from the comfort of<br />
your own home – sound like<br />
a dream? Not so, says world-<br />
renown technology forecaster<br />
Daniel Burrus.<br />
28 Did you know...<br />
Interesting facts and figures at<br />
your fingertips.<br />
30 Behind the nano<br />
Password gets the inside story<br />
on Erik Bakkers, winner of<br />
Technology Review’s prestigious<br />
‘Young Innovator under 35’<br />
award.<br />
Password February 2008<br />
3
A <strong>visionary</strong><br />
<strong>experience</strong><br />
4 Password February 2008
y Stuart Cherry Images: <strong>Philips</strong><br />
Remember your parents telling you not to watch television in<br />
the dark? It turns out they were right. Simply turning on a light<br />
behind the screen makes watching easier on the eye and adds<br />
to the visual <strong>experience</strong>. So how did an idea as simple as this<br />
turn into a groundbreaking new viewing <strong>experience</strong> and one of<br />
the hottest products in today’s TV market?<br />
Once, product technology was the driving force in<br />
electronics development. Then the ‘<strong>experience</strong> economy’<br />
arrived, shifting the focus from selling clever products to<br />
selling sensations and emotions. In this new world, the<br />
Ambilight <strong>experience</strong> is a perfect example.<br />
You could describe Ambilight as a TV with built-in<br />
ambient lighting effects. But that doesn’t come anywhere<br />
close to the Ambilight <strong>experience</strong> – which is unique to<br />
<strong>Philips</strong>. Think of the difference surround sound makes and<br />
then consider Ambilight as the ‘surround color’ version. It<br />
completely immerses you in the action, makes the screen<br />
seem larger and relaxes your eyes. Even leading industry<br />
reviewers familiar with the whole gamut of new TV<br />
technologies are impressed.<br />
“Ambilight doesn’t simply look pretty, it really helps<br />
involve you in the picture,” says Clare Newsome, editor of<br />
the UK’s What Hi-fi? (Sound and Vision) magazine. “It does<br />
so by using a system of lights embedded in the set’s chassis,<br />
which react in symphony with the action on the screen<br />
to create a richer, more involving and ‘larger’ picture. The<br />
effect this has on three-dimensionality is incredible.”<br />
Big thinking<br />
As pioneering as the idea is, Ambilight owes its existence<br />
to an unknown <strong>Philips</strong> employee who remembered his or<br />
her parents’ advice – and to the fortuitous moment when<br />
that memory found its way into a realm of big thinking on<br />
Ambient Intelligence (the term used to describe electronic<br />
environments sensitive and responsive to people’s needs<br />
and emotions).<br />
“At the time, our researchers, together with design<br />
and human-science specialists, were developing ideas<br />
around Ambient Intelligence, asking big questions about<br />
the <strong>experience</strong>s people could really enjoy instead of just<br />
trying to make products better,” explains Emile Aarts, vicepresident<br />
of <strong>Philips</strong> <strong>Research</strong>.<br />
Indeed, Ambilight originally had nothing to do with<br />
television – it was born in <strong>Philips</strong>’ <strong>Research</strong> and Lighting<br />
divisions. “We were looking at how light could add value<br />
to people’s everyday lives,” says Elmo Diederiks, who<br />
was a member of the initial research project. “During a<br />
brainstorming session, someone must have remembered<br />
the warnings about watching TV in a dark room because<br />
we discovered the idea about using light to enhance TV<br />
viewing scribbled on a Post-it ® note.”<br />
Interactive research<br />
It normally takes years for an idea to make it to the<br />
marketplace, but Ambilight made that journey in just a year<br />
and a half. What’s more: behind this unique TV <strong>experience</strong><br />
and its rapid rise lies a unique story of testing and design<br />
based on ‘user-centric development’. It may sound like<br />
jargon, but user-centric development is eminently practical.<br />
It means involving real consumers in the development<br />
process right from the start through an interactive, step-bystep<br />
process. Asking not just “Is this concept interesting?”<br />
but also “What’s important to the <strong>experience</strong>?” and “How<br />
can we make it better?”.<br />
“Usually when a company develops a new product,<br />
it’s trying to extend the technology and only shows it to<br />
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5
consumers at the prototype stage,” Diederiks says. “But<br />
involving potential users early on actually makes the whole<br />
process much more efficient. Once we knew what people<br />
wanted, finding the right technology was simple.”<br />
So what did people want? To find out, the team<br />
transformed the Post-it ® note idea into a complete<br />
scenario explaining how light could bring the onscreen<br />
action to life. Put to consumers along with a number<br />
of other scenarios, the Ambilight concept came out on<br />
top and rapidly moved from idea to prototype. Again,<br />
consumers were asked to assess the prototype in a battery<br />
of formal and informal tests. This time the testing was done<br />
at the ‘HomeLab’ (part of the ExperienceLab) – a research<br />
facility that’s more like a house than a laboratory.<br />
Not a disco<br />
For those who haven’t <strong>experience</strong>d it, Ambilight may sound<br />
too much like a ‘TV with disco lights’. But this impression<br />
doesn’t last long. Apparently some early testers thought<br />
this when they first read the concept description – that<br />
is until they settled back to watch an Ambilight TV in the<br />
Home Lab living room.<br />
“People came up to us afterwards demanding to be at<br />
the top of the list for beta testing. That’s how keen they<br />
were to have Ambilight in their own homes,” explains<br />
Jettie Hoonhout, the <strong>Philips</strong> psychologist who oversaw<br />
the testing. “We knew then that paper descriptions would<br />
never do Ambilight true justice.”<br />
A glowing success<br />
Indeed, Aarts admits that while <strong>Philips</strong> was quietly<br />
confident Ambilight could be a success, the company is<br />
still surprised at just how successful it has been. After the<br />
first sets hit the market in August 2004, Ambilight became<br />
6 Password February 2008<br />
a huge hit with consumers right away. So much so that in<br />
mid-2007, Ambilight TV sales passed the million mark – a<br />
notable achievement in a saturated market where truly<br />
innovative products are rare.<br />
Moreover, market surveys show that over 75%<br />
of respondents think Ambilight improves the viewing<br />
<strong>experience</strong>. That same research reveals that, although the<br />
consumer-testers asked for an off switch, most Ambilight<br />
TV owners never turn the effects off. One person even<br />
claimed, “If the Ambilight isn’t on, it’s like there’s a black<br />
hole around my TV.”<br />
Buoyed by the positive reactions, <strong>Philips</strong> continues<br />
to further develop the concept to deliver an even more<br />
intensive viewing <strong>experience</strong> through further consumer<br />
feedback. The fourth generation of the technology has<br />
just been launched as the Aurea range of TVs. Featuring<br />
126 separate LEDs arranged in an ‘active frame’ around<br />
the screen, Aurea offers the most immersive Ambilight<br />
<strong>experience</strong> to date.<br />
A winning formula<br />
The ‘<strong>experience</strong>’ thinking behind Ambilight has also led the<br />
company into new areas such as amBX which takes the<br />
Ambilight idea and makes it multi-sensory by adding sound,<br />
vibration, air movement and other effects. This ultimate<br />
immersive <strong>experience</strong> is available to gamers, filling their<br />
entire environment with physical sensation, and will be<br />
coming soon to other media.<br />
It’s been quite a journey for an idea discovered on a<br />
Post-it ®. It also reveals the value of the interplay between<br />
big conceptual ideas like Ambient Intelligence, specific<br />
technical know-how and a research approach that puts<br />
people at its heart. In Ambilight, <strong>Philips</strong> has found a winning<br />
formula. It’ll be interesting to watch the encore.
More<br />
Creating the Ambilight effect<br />
Only a small part of your eye, known as<br />
the macula, actually sees a sharp image.<br />
An even smaller portion, the fovea, is<br />
responsible for producing the even-<br />
sharper vision needed to watch television<br />
or read. For the rest of your retina, the<br />
image is blurred. Your brain then works<br />
efficiently to combine all the information<br />
into a coherent picture.<br />
Ambilight helps enlarge this picture<br />
through an innovative technology that<br />
can ‘read the screen’ to produce the<br />
surrounding color. It works by analyzing the<br />
input video signal in real time to determine<br />
the dominant color in each area of the<br />
screen, averaged over a number of frames.<br />
It then uses color-mapping transformations<br />
to extend these color signatures beyond<br />
the screen. While the fovea is looking at<br />
the screen, the ambient colors fall on the<br />
surrounding part of the retina convincing<br />
your brain that you are seeing a larger<br />
image. The result is a much more cinematic<br />
<strong>experience</strong> in your own home and a feeling<br />
that you are truly immersed in the action.<br />
Reducing eye strain<br />
In a dark room, the TV is the main source of<br />
light. Therefore, when the picture on the<br />
screen changes, there’s a big fluctuation<br />
on the light level in the room which causes<br />
your pupil to dilate or contract in response.<br />
TV images change rapidly, so the muscles<br />
controlling your pupil have to work hard to<br />
keep up, leading to eye fatigue. Ambilight<br />
evens out the changes in the ambient light<br />
levels, so your pupil – and the muscles that<br />
control it – don’t have to work as hard and<br />
therefore eyes feel less tired.<br />
Ambilight’s soothing effect has been<br />
confirmed in numerous studies. In 2004,<br />
Professor Begemann of the Technical<br />
University in Eindhoven, the Netherlands,<br />
showed that Ambilight can reduce eye<br />
strain in 60-90% of people under normal<br />
‘home theatre room lighting’ conditions. In<br />
2005, John Bullough and colleagues at the<br />
Rensselaer Polytechnic Institute in New<br />
York (USA) found a beneficial effect on<br />
visual discomfort, fatigue and eye strain.<br />
A 2007 report by Herbert Plischke and<br />
colleagues from the Ludwig-Maximilians<br />
University in Germany and the University<br />
of Applied Sciences in Austria concluded<br />
Ambilight improved relaxation and<br />
attention levels.<br />
http://www.flattv.ce.philips.com/<br />
http://www.aurea.philips.com/<br />
http://www.research.philips.com/<br />
Password February 2008<br />
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8 Password February 2008
y Brandy Vaughan Images: <strong>Philips</strong>, Michel Klop, Getty Images<br />
Seeing the light<br />
With climate change moving from back-page news to frontpage<br />
headline, the compact fluorescent bulb has a new lease<br />
on life – 25 years after it first hit the market.<br />
Once an oddity in the world of lighting, energy-efficient<br />
compact fluorescent lamps (or CFLs) are making a<br />
comeback now that climate change is firmly on the agenda<br />
of politicians, CEOs and even celebrities.<br />
Changing the world one bulb at a time<br />
Why all the new attention? On average, CFLs use 70-80%<br />
less energy than the typical incandescent bulb to generate<br />
the same amount of light – making them an increasingly<br />
popular way to do something good for the environment<br />
and your wallet. Less energy means less carbon dioxide<br />
emitted into the environment from the burning of fossil<br />
fuels – the most common way to generate energy. Most<br />
experts believe carbon dioxide (CO 2) emissions are a<br />
major contributor to global warming (aka climate change).<br />
Although estimates vary, swapping just one<br />
incandescent bulb for a CFL could save up to 500<br />
pounds of CO2 emissions – equivalent to driving a few<br />
thousand miles in a car. <strong>Research</strong> also shows that CFLs last<br />
anywhere from four to eight times longer than the typical<br />
incandescent meaning fewer bulbs and far less packaging<br />
ends up in landfills.<br />
More efficient<br />
So how do CFLs manage to be so much more efficient than<br />
old-style bulbs? The simple answer is incandescent bulbs<br />
– with their 125-year-old technology – convert 95% of the<br />
energy used into heat while only 5% is released as visible<br />
light. In CFLs, the amount of light produced versus energy<br />
used is much higher.<br />
“Since first introduced over 100 years ago, the<br />
incandescent bulb has barely changed,” says Dr Matt<br />
Prescott, Director of www.banthebulb.org, an online<br />
campaign encouraging greater energy efficiency. “The bulb<br />
wastes so much energy that if it were invented today odds<br />
are that it wouldn’t even be allowed on the market.”<br />
According to Cees Ronda, from <strong>Philips</strong> <strong>Research</strong>,<br />
the efficiency is in the details. “Incandescents produce a<br />
Password February 2008<br />
9
10<br />
wide spectrum of radiation at numerous wavelengths but<br />
most of it is not visible because the temperature is too<br />
low. This non-visible light is then released in the form of<br />
heat,” he explains. “With CFLs, radiation is generated at<br />
specific wavelengths that are visible so less energy is lost<br />
as heat. Therefore, CFLs produce a much smaller range of<br />
wavelengths but more visible light.”<br />
Saving energy, saves money<br />
Along with fears of a soon-exhausted oil supply, energy<br />
demand is at an all-time high driving up energy costs.<br />
With this, CFLs make even more sense. In the USA alone,<br />
consumers could save around $6 billion a year in energy<br />
costs by installing more energy-efficient lighting, according<br />
to the US-based Alliance to Save Energy.<br />
But as Prescott points out: “Consumers tend to be<br />
short-sighted and focus on the higher upfront cost of an<br />
energy-saving bulb, which is disappointing because, in the<br />
long term, the running costs of a CFL are much lower.”<br />
In the beginning<br />
Much has changed since <strong>Philips</strong> brought the first CFLs to<br />
market in 1980, but the need for energy-efficient lighting<br />
is now more important than ever. The story of the CFL<br />
begins in the early 1970s when the 1973 oil crisis raised<br />
awareness of potential issues with energy consumption<br />
and inspired companies, like <strong>Philips</strong>, to take a more serious<br />
interest in energy-efficient lighting.<br />
Developments made in <strong>Philips</strong> <strong>Research</strong> in the late<br />
1960s with rare earth metals and luminescent materials<br />
made the CFL technology possible. Harry Verhaar, dubbed<br />
‘Mr Green Switch’ by his colleagues in <strong>Philips</strong> Lighting,<br />
explains: “During the oil crisis, we became aware of the<br />
need for more efficient lighting options. As consumers we<br />
were asked to save energy when OPEC cut off oil deliveries<br />
to Western Europe and the USA. The recent technological<br />
advancements allowed us to develop a new lighting<br />
technique that was more stable and more efficient.”<br />
But when the oil crisis died down so did consumers’<br />
dedication to energy efficiency. So in 1980, when <strong>Philips</strong><br />
introduced the first CFLs, people didn’t quite embrace<br />
them as hoped. The bulb price was high and consumers<br />
lacked understanding of the long-term energy and cost<br />
savings. Light quality was another issue as consumers<br />
thought the color was too harsh and had no patience for<br />
the time it took for CFLs to fully light.<br />
Password February 2008<br />
Times are changing<br />
Fortunately, in the 25 years since first hitting the market,<br />
CFLs have come a long way. They no longer flicker or buzz<br />
and the light quality has improved dramatically. Newer CFLs<br />
offer a warmer soft-white light, take less time to light up<br />
and have become significantly smaller. They’re also more<br />
versatile with different sockets and dimming capabilities.<br />
But research suggests that although the bulb has<br />
evolved, consumers are stuck in the past. “From market<br />
research we learned that still few people know about all the<br />
improvements made in CFLs over the last decade or so,”<br />
notes Verhaar.<br />
No longer a choice<br />
If recent legislation is anything to go by, consumers may<br />
soon have no choice but to switch to CFLs. In 1997,<br />
most developed countries signed the Kyoto Protocol – a<br />
groundbreaking agreement that attempts to mitigate<br />
climate change through mandatory reductions in<br />
greenhouse gases, particularly CO2 emissions. As the 2012<br />
target nears, governments are scrambling to make a real<br />
impact on their CO2 emissions, which for some includes<br />
the phasing out or eventual banning of incandescent bulbs.<br />
In early 2007, Australia announced a ban on incandescent
ulbs in favor of CFLs by 2010, after a government-initiated<br />
study found CFLs to be five times more energy efficient<br />
than incandescents.<br />
Canada announced in April 2007 that it will ban the sale<br />
of incandescent bulbs by 2012 in a bid to curb greenhouse<br />
More<br />
There are two main parts in a CFL:<br />
the gas-filled tube (also called bulb or<br />
burner) and the ballast. Electrical energy<br />
in the form of an electrical current from<br />
the ballast flows through the gas-filled<br />
tube containing mercury molecules<br />
which have a special property: when<br />
excited, they emit ultraviolet light.<br />
The ultraviolet light, in turn, excites a<br />
Inside the bulb<br />
phosphor coating on the inside of the<br />
tube and emits visible light, which shines<br />
out through the tube. This phosphor<br />
coating is a mixture of luminescent<br />
materials, each emitting a different<br />
color. By changing the composition of<br />
the mixture, lamps generating different<br />
grades of white light can be developed<br />
(daylight, soft white, etc).<br />
gas emissions. In October of the same year, the state of<br />
California (USA) announced that it will phase out the use<br />
of incandescent bulbs by 2018 as part of a bill aptly titled:<br />
‘How Many Legislators Does it Take to Change a Light<br />
Bulb’. Other US states have similar legislation pending.<br />
Making the CFL as reliable and high<br />
quality as the incandescent required a lot<br />
of research – and an electronics revolution.<br />
Early CFLs cost around $25 per bulb<br />
(although they still paid for themselves in<br />
electricity savings). The light they produced<br />
was bluish or pinkish so the phosphor<br />
coating had to be refined. The ballast<br />
hummed and didn’t cycle the electricity<br />
Password February 2008<br />
11
12<br />
The European Union (EU) is also preparing legislation<br />
requiring the use of energy-efficient lighting in offices,<br />
streets and private households, while many countries within<br />
the EU are drafting their own legislation.<br />
Greening the bulb<br />
Estimates show that 25% of global lighting emissions come<br />
from incandescent bulbs but they only produce 4% of<br />
quickly enough therefore leading to a<br />
re-design to make it more electronic and<br />
miniaturized. Eventually, costs came down<br />
as did size.<br />
A popular concern about CFLs is<br />
that the technology underpinning the<br />
efficiency relies on a small amount of<br />
mercury to produce light. And while the<br />
concern is legitimate – and all exhausted<br />
CFLs must be properly recycled – a<br />
Password February 2008<br />
government-initiated study in Australia<br />
found that when you consider the mercury<br />
produced from burning fossil fuels for<br />
electricity, the energy-hungry incandescent<br />
contributes five times more mercury into<br />
the environment than a CFL. According to<br />
the US Environmental Protection Agency,<br />
coal-fired power plants emit four times<br />
more mercury to power an incandescent<br />
bulb than to power a CFL.<br />
global artificial-light output. Yet still, the impact of compact<br />
fluorescents has been somewhat limited as consumers fail<br />
to look beyond the higher sticker price to the long-term<br />
savings in terms of both cost and energy.<br />
But as we learn more about the massive climate-change<br />
challenge we all face, it becomes clear that the question<br />
is no longer “How can we afford to switch to CFLs?” but<br />
instead “How can we afford not to?”<br />
<strong>Philips</strong> CFLs contain a record low<br />
amount of mercury – less than two<br />
milligrams, which is up to four times<br />
less than competitor CFLs. <strong>Philips</strong><br />
also utilizes pellet dosing versus liquid<br />
mercury to ensure safe and accurate<br />
levels of mercury per bulb and<br />
continually looks for ways to reduce the<br />
amount of mercury while still maintaining<br />
light quality and performance.
y Susan Wild Images: <strong>Philips</strong><br />
Imaging gets<br />
personal<br />
Fans of television medical dramas will recognize the scene:<br />
dedicated doctors examining hundreds of computed<br />
tomography (CT) images, racing to find a diagnosis<br />
and save lives. Ironically in the real world, medical<br />
scans now deliver so much data that<br />
doctors barely have enough time<br />
to use it to best effect. But that’s<br />
about to change thanks to new<br />
automated image analysis and<br />
3D organ modeling.<br />
When Wilhelm Röntgen made the first shadowy X-ray<br />
images of his wife’s hand in 1895, he could hardly fathom<br />
where those initial steps would lead. Today, medical imaging<br />
shows doctors the structures and organs inside the body in<br />
remarkable detail and clarity, using an array of non-invasive<br />
technologies of which the X-ray was the first.<br />
The X-ray is still at the heart of numerous imaging<br />
techniques including radiography, angiography, fluoroscopy<br />
and CT. Over time, this group has expanded to include<br />
others such as magnetic resonance imaging (MRI), positron<br />
emission tomography (PET), single photon emission<br />
computed tomography (SPECT) and ultrasound.<br />
As the number of modalities (the term used for types<br />
of imaging technology) has grown, so too has the number<br />
of scans conducted. In the USA alone, the number of CT<br />
scans grew from 30 million in 1999 to 60 million in 2006.<br />
The data bottleneck<br />
With the growth in computing power over the last 30<br />
years, systems capable of producing 3D and even 4D<br />
Password February 2008<br />
13
14<br />
<strong>Philips</strong> researchers working with <strong>Philips</strong>’ new cardiac modeling software that<br />
automatically matches its heart model to the patient’s multi-slice CT scan, and<br />
then creates a highly detailed patient-specific 3-D model from which a wide<br />
range of morphological and physiological measurements can be extracted.<br />
(adding time to show organ movement) representations of<br />
our insides are now common. The new imaging capabilities<br />
lead to more personalized organ models, better diagnosis<br />
and easier surgical interventions. Yet these advances have<br />
also led to a dilemma – clinicians now have access to so<br />
much data, they don’t have time to deal with it all.<br />
For instance, a single cardiac CT scan may generate<br />
a sequence of ten 3D images, each made up of 300 2D<br />
‘slices’. But analyzing all this data can take a highly trained<br />
specialist an hour or more, time which is better spent on<br />
face-to-face patient care.<br />
Rapid analysis<br />
According to Guido Pardo-Roques, Senior Director of<br />
Global CT <strong>Research</strong> at <strong>Philips</strong> Healthcare, there’s a twopart<br />
solution. “The first step is to decrease the time it takes<br />
to produce images in order to provide more reliable clinical<br />
information,” he says. “The second is to automate image<br />
analysis enabling faster and more accurate diagnosis and<br />
therefore treatment.”<br />
The latter is where <strong>Philips</strong> has recently taken a big step<br />
forward, as Jürgen Weese, Principal Scientist at <strong>Philips</strong><br />
<strong>Research</strong>, explains: “Speeding up image analysis is vital for<br />
Password February 2008<br />
the healthcare industry, especially in cardiac CT. To simplify<br />
the work of healthcare professionals, we’ve developed<br />
automated analysis techniques that provide an accurate<br />
model of a person’s heart in just ten seconds.”<br />
Besides its speed, the technology’s ability to provide<br />
personalized models is truly innovative. Previously, doctors<br />
planning a procedure or making a diagnosis had to rely<br />
on generic 3D models and 2D images. But by using<br />
advanced boundary-detection algorithms (see More),<br />
<strong>Philips</strong> technology overlays the patient’s CT scan data onto<br />
a standard reference model creating a patient-specific 3D<br />
representation that greatly aids diagnosis.<br />
A helping hand<br />
The technology is also intended to help doctors in the<br />
planning and execution of image-guided procedures such as<br />
minimally invasive heart repair. A prime example is cardiac<br />
radio-frequency ablation, a common intervention to correct<br />
irregular heartbeat involving the insertion of a catheter into<br />
the heart chambers. Until now, cardiologists relied on X-ray<br />
fluoroscopy to guide their instruments. However, while<br />
X-ray fluoroscopy shows bone and instruments clearly, it<br />
reveals little of the structures of the heart.
<strong>Philips</strong>’ new automated analysis and 3D organmodeling<br />
techniques allow a realistic model of the<br />
patient’s heart to be superimposed on the fluoroscopy<br />
images. As the model accurately describes the anatomy<br />
and includes important clinical information such as cardiac<br />
‘landmarks’ like heart valves, cardiologists can position<br />
instruments more easily. Weese likens the effect to<br />
switching the lights on in a dark room.<br />
The technology has already been integrated into<br />
<strong>Philips</strong>’ EP Navigator workstation and feedback from<br />
clinical tests supports the idea that it may lead to a<br />
significant breakthrough. Reza Razavi, Professor of<br />
Pediatric Cardiovascular Science at King’s College, London<br />
(UK), explains: “The software revolutionizes the ease<br />
with which we can analyze the very large datasets that<br />
are now being produced by our CT and MRI scanners.<br />
Not only is this a great value in diagnostics, but it also<br />
allows us to quickly integrate our 3D images into our Xray<br />
interventional program, which is of particular help in<br />
ablation of arrhythmias.”<br />
Not just for the heart<br />
<strong>Philips</strong> is not the only company pursuing ways to speed<br />
image analysis. But the ability of its technology to create<br />
More<br />
The process of identifying the various<br />
structures present in the image of an organ<br />
is known as ‘segmentation’. The heart is<br />
a challenging organ to segment because<br />
of its numerous substructures and its<br />
integration into the vascular system. Yet,<br />
<strong>Philips</strong>’ technology manages to segment<br />
the heart chambers and major vessels with<br />
boundaries delineated and the volumes<br />
www.medical.philips.com/main/clinicalsegments/ep<br />
Marking the boundaries<br />
annotated in just a few seconds.<br />
To do that, it uses a mesh of 17,358<br />
triangles to describe the heart’s geometry<br />
in a 3D computer model. First, the system<br />
goes through a learning phase, building<br />
a reference model from a set of 30 to<br />
40 reference segmentations enhanced<br />
with a wealth of technical and anatomical<br />
information.<br />
dynamic and accurate models of the heart – showing the<br />
four chambers, the myocardium and the major attached<br />
vessels – puts it at the forefront of innovation.<br />
Looking ahead, the team behind the technology is<br />
working on extending it to all modalities, adding even<br />
more detail and creating reference models for common<br />
anatomical variants (for instance, patients with five<br />
pulmonary veins rather than the normal four).<br />
Personalized diagnosis<br />
The team is also looking for ways to apply the techniques<br />
to the entire body. They’ve already developed an<br />
experimental system that extracts a 3D model of the lungs,<br />
the ribcage and the spine from CT scans. Long term, the<br />
hope is to help radiologists identify lung diseases and even<br />
model a patient’s entire breathing process. This would<br />
greatly improve accuracy and patient care in radiotherapy<br />
image-guided treatments of lung tumors.<br />
As these image-analysis and modeling techniques<br />
continue to evolve, it appears that they not only provide<br />
a way past the data bottleneck, but also open the door to<br />
new levels of personalized diagnosis and treatment.<br />
Next, the reference model is matched<br />
to the patient’s heart images to create<br />
a patient-specific model. This process<br />
employs highly sophisticated borderdetection<br />
algorithms that can identify<br />
complex structures, position the triangles<br />
and fix their vertices to give a robust and<br />
accurate match between the model and<br />
the image data.<br />
Password February 2008<br />
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16 Password February 2008
ExperienceLab<br />
Using technology to create interactive<br />
window displays.<br />
To ensure that technological<br />
developments are easy to use,<br />
inventions need to be tested by<br />
consumers themselves. ExperienceLab<br />
is a unique laboratory where consumertested<br />
innovation is top priority.<br />
The lab, located at the High Tech<br />
Campus in Eindhoven, the Netherlands,<br />
provides the perfect setting for the<br />
discovery of the practical, social and<br />
psychological implications of upcoming<br />
technologies.<br />
In the lab, consumers use and<br />
interact with new technologies and<br />
applications, such as the Intelligent<br />
Shop Window (shown here). The<br />
Intelligent Shop Window concept<br />
provides shop owners with new ways<br />
to create interactive, higher-quality<br />
shopping <strong>experience</strong>s and attract<br />
more customers. It also allows<br />
shoppers to access information about<br />
the products on display – even when<br />
the shop is closed.<br />
Password February 2008<br />
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18<br />
Making the<br />
impossible<br />
possible<br />
Modern technology, such as email and the Internet,<br />
has increased both our productivity and our workload.<br />
Wouldn’t it be great if we could use this technology to<br />
find a way to do twice as much in a day? It may sound like<br />
a dream but the reality is not far off, according to Daniel<br />
Burrus, a leading technology forecaster and author of the<br />
best-selling book Technotrends.<br />
As Burrus explains, the already speedy rate of technology<br />
is about to dwarf anything we’ve seen so far and give us<br />
some exciting options in the years ahead. “In the next five<br />
years, we’re going to <strong>experience</strong> more technology-driven<br />
change than we have in the last 15,” he notes. “Moore’s<br />
Law says that the technology behind most devices – such<br />
as processing power, bandwidth and storage capacity<br />
– doubles every 18 months. This has held up for 40 years<br />
but now things are moving incredibly faster.<br />
“For example, it took 20 years to go from a fivemegahertz<br />
chip to a 500-megahertz chip but to double<br />
that took just eight months. And that was five years ago,”<br />
Burrus emphasizes. “The curve is now going vertical, which<br />
Password February 2008<br />
means we can barely fathom the technology that will come<br />
our way in the future.”<br />
Twice the work in half the time<br />
It’s this advance in technology that will make things even<br />
more interesting – and give us our very own virtual<br />
personal assistant, says Burrus. Soon you could wake up,<br />
turn on the television and be greeted by your assistant<br />
– available 24 hours a day, seven days a week without<br />
complaints. After outlining your schedule for the day, your<br />
assistant then updates you on a change in your travel plans<br />
– your morning flight was cancelled. But not to worry: your<br />
personal assistant has already re-booked you on another
y Brandy Vaughan Image: Burrus <strong>Research</strong>. Illustration: Roland Blokhuizen<br />
flight and printed your boarding pass. At the airport, your<br />
assistant tells you where to find a free spot in the parking<br />
garage. Not enough time to research the company you’re<br />
visiting? Not a problem, your assistant does the research for<br />
you – in a nanosecond.<br />
Waiting for the right buy price on stock you’d like to<br />
own? The assistant can track stock prices and not only<br />
inform you when it’s hit the target price but also buy the<br />
stock for you – with a financial plug-in from your broker, of<br />
course. Anxiously awaiting lab test results? Just download<br />
the medical plug-in from your doctor and the wait will<br />
soon be over. As soon as the results are entered into your<br />
medical records, your assistant gives you the details.<br />
Eventually, your assistant will learn from your requests and<br />
begin to anticipate your needs, almost like thinking for itself.<br />
The best part: as our assistants take care of logistics, we<br />
can spend more time on the things we actually enjoy. “With<br />
this, we could do almost twice as much in one day,” Burrus<br />
notes. “And with the mountains of new information that<br />
will be available in the future, having an assistant will quickly<br />
become a necessity, much like owning a car.”<br />
Best yet to come<br />
In the healthcare field, there have also been tremendous<br />
advancements in technology but the best is yet to come,<br />
says Burrus. Besides e-enabled assisted living for patients<br />
Password February 2008<br />
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20<br />
and routine genetics mapping, we could soon have access<br />
to a virtual hospital that performs tests from the comfort of<br />
our own home. He offers the example of late-night heart<br />
palpitations: is it a heart attack or just indigestion?<br />
Currently our options are limited, Burrus says. “If I<br />
<strong>experience</strong>d heart palpitations, I would have two options: I<br />
could call an ambulance to take me to the emergency room<br />
and after many hours and many tests, I could find out that<br />
I only have indigestion – and a large bill. But on the other<br />
hand, if I assume it’s indigestion and go back to sleep, I may<br />
never wake up.”<br />
But a virtual hospital opens up the options, he explains.<br />
“I just turn on my television and choose the virtual<br />
hospital’s admissions desk and give them my symptoms.<br />
After pulling up my medical records using multiple<br />
biometrics for identification, they then ask me to attach<br />
an inexpensive bio-sensor to my chest so they can take<br />
my vital signs, like blood pressure and pulse, and an EKG<br />
reading – all virtually,” Burrus notes.<br />
“The information instantly transfers to a real-life doctor<br />
for analysis, and the doctor either asks me to come in for<br />
further tests or suggests I take an indigestion pill,” he adds.<br />
Password February 2008<br />
Daniel Burrus<br />
Daniel Burrus is one of the world’s leading technology forecasters and business strategists. He’s written<br />
six books including the highly acclaimed Technotrends, which has been translated into more than a dozen<br />
languages. Burrus is the founder and CEO of Burrus <strong>Research</strong>, a US-based research and consulting firm that<br />
monitors global trends in science and technology. In 1983, Burrus became the first and only forecaster to<br />
accurately identify 20 technologies that would later become the driving forces of business and economic<br />
change for the coming decade.<br />
“Imagine the time, stress and money a system like this<br />
could save. With the rate of advancing technology, we<br />
could see this within the next 15 years.”<br />
Fraud-proof identification<br />
Both the virtual assistant and ‘at-home hospitaling’ would<br />
use biometrics for identification but Burrus insists that<br />
neither privacy nor fraud will be an issue. “Biometrics<br />
will soon become so advanced that fraud won’t be a<br />
problem. We’ll see defense-industry technology pour<br />
into the public domain and new biometrics will be<br />
coming out that are almost impossible to steal, like the<br />
blood vessel pattern embedded in our hands. We’ll also<br />
use multiple biometrics like this to establish identity<br />
depending on the level of security required.”<br />
Another hot topic these days is climate change. But<br />
will the new awareness impact technology? Actually, it<br />
could be the other way around, says Burrus. “Technology<br />
is only bound by the limits we give it as humans. If we<br />
decide to use technology to solve global problems such as<br />
climate change, then it can get us there. Technology has<br />
the ability to turn the impossible into the possible.”
y Brandy Vaughan Images: <strong>Philips</strong>, Getty Images<br />
A natural choice<br />
As with other modern inventions, most of us would find it hard<br />
to imagine life without an alarm clock. But it hasn’t always been<br />
this way. Until relatively recently, humans depended solely on<br />
the rising sun – and the natural light it produced – to wake up<br />
each morning.<br />
><br />
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22<br />
So what happened? Our modern-day lifestyles often<br />
demand that we start our days before sunrise, especially<br />
during winter. Although it was deemed one of the most<br />
hated inventions in a 2004 MIT survey, the alarm clock is still<br />
the wake-up method of choice for most. As natural as this<br />
may seem today, biologically it’s clearly an unnatural choice.<br />
In the genes<br />
Waking up to gradual light, as with the sunrise, is not only a<br />
more gentle way to start the day, it’s actually deep-rooted<br />
in the brain via a biological ‘wake-up process’ that our<br />
bodies go through each morning – naturally initiated by light<br />
not sound.<br />
The process kicks off as our early-morning, lightsensitive<br />
retinas detect the first hint of light. This<br />
activates our internal biological ‘body clock’ located in the<br />
hypothalamus region of the brain. This body clock uses light<br />
and dark to regulate our daily wake-sleep patterns – a cycle<br />
known as the circadian rhythm – through the production<br />
of certain hormones and neurotransmitters that tell our<br />
bodies when to wake up and when to sleep.<br />
A hardwired response<br />
Studies suggest that the hormone melatonin, released in<br />
response to darkness, plays a key role in preparing our<br />
bodies for sleep. Conversely, increasing light levels trigger<br />
the production of ‘wake-up’ chemicals such as cortisol,<br />
which is heavily involved in helping the body become alert<br />
and energized after a night of sleep. As the main signal for<br />
our bodies to switch from producing melatonin to releasing<br />
cortisol, light is clearly an important aspect in our biological<br />
wake-up process.<br />
“Morning light is the most important light for<br />
synchronizing our circadian rhythms,” explains Dr David<br />
Password February 2008<br />
Avery, a specialist on the connection between light and<br />
sleep from the University of Washington, USA. “It’s not<br />
natural to wake up in the dark. Our ancestors woke up<br />
at dawn, whenever dawn came. It’s hardwired into our<br />
brains and this doesn’t change just because we decide to<br />
use an alarm clock.”<br />
Fight or flight<br />
While waking up to natural light is clearly best, it’s not<br />
always easy to adjust your daily schedule according to<br />
sunrise and sunset, especially in winter. Given many of<br />
us have to wake up well before the sun, an alarm clock<br />
is the most obvious solution. But when the alarm goes<br />
off suddenly, sometimes at a near-deafening volume, we<br />
jump from sound sleep to consciousness without giving<br />
our bodies the time, or light, needed to stimulate the<br />
natural wake-up cycle. Studies suggest this can cause us<br />
to feel drowsy and less alert during the day.<br />
There’s also evidence that waking up to the harsh and<br />
sudden sound of the alarm can throw our bodies into<br />
fight-or-flight mode, pumping our barely awake bodies<br />
full of adrenaline – also known as the stress chemical.<br />
While this may help you get to the office on time, it’s<br />
certainly not the best way to start the day.<br />
A more natural approach<br />
So if the loud alarm clock we typically wake up to isn’t<br />
such a good thing, what options are there? Other than<br />
teaching yourself to wake up without stimulus, the<br />
most talked about alternative is dawn simulation. It’s a<br />
relatively new technique that involves a device much like<br />
an alarm clock that uses gradually increasing light instead<br />
of sound to wake you up. Mimicking a natural sunrise,<br />
dawn simulation tricks the body into initiating the wake-
up process in a more natural way. Typically, light intensity<br />
will slowly increase for 30 minutes before the scheduled<br />
alarm goes off – often with a choice of sounds such as<br />
ocean waves, birds or the traditional beep.<br />
Recent studies show that participants using dawn<br />
simulation reported feeling more alert and less tired,<br />
which could be related to the proven increase in serotonin<br />
levels after light exposure. Serotonin has long been linked<br />
to improved moods and increased energy levels.<br />
Another factor in feeling energized after waking<br />
is cortisol release. Professor Angela Clow, from the<br />
University of Westminster (UK), explains, “Waking up<br />
with light helps the cortisol cycle efficiently regulate<br />
other bodily systems, which could explain why people<br />
find waking up with dawn simulation beneficial to how<br />
they feel during the day.”<br />
In sync<br />
Dawn simulation has also been shown to help keep our<br />
internal body clocks in sync. “All living organisms operate<br />
on night and day cycles and these physiological processes<br />
can become delayed, particularly in winter, meaning it<br />
takes longer for our bodies to switch from nighttime<br />
to daytime activities,” Clow says. “But dawn simulation<br />
helps trigger and regulate these cycles while slowly<br />
waking you up.”<br />
New evidence reveals that dawn simulation can<br />
also positively affect sleep, according to a recent study<br />
conducted at the University Medical Center Groningen<br />
in the Netherlands. Dr Ybe Meesters who headed<br />
the study notes, “The benefits of dawn simulation in a<br />
normal healthy population are easier awakening and an<br />
improvement in sleep quality, therefore improving quality<br />
of life, especially in the winter.”<br />
Putting <strong>experience</strong> into creation<br />
Although research on dawn simulation is a relatively<br />
new field of study, so far all studies show a beneficial<br />
correlation between dawn simulation and how users feel<br />
upon waking up. This was enough to inspire <strong>Philips</strong> to<br />
leverage more than 100 years of <strong>experience</strong> in lighting<br />
technology to develop a ‘Wake-up Light’ more advanced<br />
than all others in terms of light intensity (lux), a key factor<br />
in how well the wake-up process goes.<br />
As Dennis Schuilenburg, a business manager<br />
in <strong>Philips</strong>’ Consumer Lifestyle Sector, points out,<br />
“During development, we focused on real consumers in<br />
real-life situations. Through this we found that although<br />
everyone is different, many people need around 250-<br />
300 lux to awaken fully in the morning. But this lux level<br />
is difficult to achieve in a small unit because of heatdispersion<br />
issues.”<br />
He adds, “For this reason most companies still<br />
produce an alarm clock with a small light of around 50<br />
lux. We focused instead on developing an alarm clock<br />
that is a lamp first and foremost, therefore overcoming<br />
the heat-dispersion problem. It was only through<br />
intensive research that we discovered this was the best<br />
way forward.”<br />
Schuilenburg also explains that when determining<br />
the light curve, only the best prototype would do. “It’s<br />
important that light intensity increases very gradually,<br />
so users don’t wake up too early,” he says. “So we<br />
developed the light curve for the Wake-up Light to match<br />
the light curve of the rising sun.”<br />
The next best thing to a natural sunrise, the <strong>Philips</strong><br />
Wake-up Light has become so popular, the biggest<br />
challenge is keeping up with strong demand. All we need<br />
now is someone to make breakfast.<br />
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24 Password February 2008<br />
Saving time,<br />
saving lives
y Brandy Vaughan and Peter Harold Images: <strong>Philips</strong>, Getty Images<br />
According to the World Health Organization, more than 15<br />
million people suffer from stroke each year worldwide. Of<br />
these, five million die and another five million are permanently<br />
disabled. When stroke hits, quick treatment can easily be the<br />
difference between life and death as oxygen-deprived brain<br />
cells begin to die at the alarming rate of 32,000 per second.<br />
Stroke is the third leading cause of death and the number<br />
one cause of disability in North America and Western<br />
Europe. But the number of healthy survivors could be<br />
much larger if treatment is administered more rapidly.<br />
Unless a stroke is treated within a few hours, victims are<br />
likely to suffer significant, and often permanent, disability<br />
– if not death.<br />
Rule of thirds<br />
According to Jon Barrick, Chief Executive of the UK-based<br />
Stroke Association, “Stroke clinicians talk about a ‘rule of<br />
thirds’ with stroke – a third are likely to die, a third become<br />
permanently disabled and a third recover. But we believe<br />
that this ‘rule of thirds’ can and should be broken. If the<br />
time between the onset of a stroke and diagnosis was no<br />
more than three hours, a significant number of people<br />
would have a much better chance of avoiding death or<br />
disability. But all too often, there are severe delays.”<br />
Many of the delays Barrick refers to are due to the<br />
varying symptoms of stroke that can differ widely from<br />
one patient to another, often mimicking other conditions.<br />
Adding to the difficulty of diagnosis, the signs of a<br />
stroke may begin suddenly or develop over many days<br />
– sometimes even temporarily improving – depending upon<br />
the type of stroke and area of the brain affected.<br />
To ensure that potential stroke patients get treatment<br />
as quickly as possible, emergency paramedics must make<br />
a preliminary diagnosis within minutes. To help them,<br />
screening tools, such as the Los Angeles Prehospital Stroke<br />
Screen (LAPSS), have been developed to give paramedics<br />
a set of questions and a corresponding decision ‘tree’ to<br />
help them determine if a stroke alert should be sent to an<br />
appropriate hospital.<br />
When time is critical<br />
The rapid rate of new healthcare technology begs the<br />
question: surely we can find a way to speed up the<br />
treatment process? It’s possible, but quick treatment<br />
demands quick diagnosis.<br />
The new ‘Stroke Angel’ software, developed by <strong>Philips</strong><br />
<strong>Research</strong> and the subject of several recent pilot studies in<br />
Germany, could help accelerate the process from the start.<br />
Running on a standard handheld computer, the Stroke Angel<br />
automates standard screening tools such as the LAPSS.<br />
Using information entered by the paramedic, it provides a<br />
recommendation on whether or not to send a stroke alert.<br />
It can even be programmed to identify nearby<br />
hospitals with suitable stroke-care units. This is key, as<br />
often paramedics under intense pressure have trouble<br />
remembering which hospitals are equipped to give stroke<br />
victims the life-saving treatment that some require.<br />
Several studies show that stroke patients fare significantly<br />
better when treated by dedicated stroke teams with<br />
specialized protocols.<br />
Password February 2008<br />
25
26<br />
Paramedics can also instruct the Stroke Angel to<br />
wirelessly transmit a stroke alert to the hospital together<br />
with the victim’s screening information. This gives the<br />
hospital time to prepare – such as alerting the stroke<br />
team and freeing up critical resources such as a CT or<br />
MRI scanner so that diagnosis and treatment can begin<br />
as soon as the patient arrives.<br />
The right diagnosis<br />
Once the patient arrives at the hospital, stroke diagnosis<br />
is still not easy – even for <strong>experience</strong>d stroke specialists.<br />
All too often, stroke patients suffer from disorientating<br />
symptoms that can cause confusion and disable the<br />
patient’s ability to communicate clearly with doctors.<br />
And a doctor must not only determine if the patient has<br />
suffered from a stroke but also which type of stroke from<br />
several possibilities – a life or death decision in itself.<br />
The two most common types of stroke are ischemic<br />
stroke and hemorrhagic stroke. Ischemic stroke, which<br />
accounts for around 80% of stroke cases, is typically<br />
A screenshot of the Stroke Navigator<br />
Password February 2008<br />
caused by a blood clot blocking blood flow to a certain<br />
part (or parts) of the brain. Blood clots can form either<br />
within the brain itself or travel to the brain from other<br />
areas of the body.<br />
The second most common type of stroke is<br />
hemorrhagic stroke caused by bleeding within the brain<br />
or surrounding tissues resulting from a ruptured blood<br />
vessel. This type of stroke not only prevents blood from<br />
reaching parts of the brain but can also damage brain<br />
tissue around the hemorrhage site and result in a build-up<br />
of pressure in the skull, causing extensive and often lifethreatening<br />
damage.<br />
Different treatments<br />
Making a differential diagnosis between these two types<br />
of stroke is extremely important because the treatments<br />
are radically different. In fact, the treatment for ischemic<br />
stroke can be fatal if administered to a hemorrhagic<br />
stroke victim. For this and other reasons, stroke is a<br />
potentially life-threatening condition that can deteriorate
quickly unless the right diagnosis and treatment decisions<br />
are made. With the pressure on, doctors have to be<br />
vigilant at every point in the care cycle.<br />
To help with this, <strong>Philips</strong> <strong>Research</strong> is developing<br />
the ‘Stroke Navigator’ that can provide hospital<br />
clinicians with a valuable tool to support and coordinate<br />
diagnosis and treatment. Linked to the hospital’s patient<br />
information system, it has been designed to create<br />
a complete patient profile based on the screening<br />
information and patient history, and then track every<br />
procedure performed, together with test results.<br />
This information is combined with pre-programmed<br />
expert knowledge, probability rates and clinical<br />
decision guidelines for the treatment of stroke. The<br />
Stroke Navigator then analyzes the information to give<br />
diagnostic and therapeutic suggestions.<br />
“With Stroke Angel and Stroke Navigator, we’re trying<br />
to bring more simplicity to stroke diagnosis by making it<br />
easier for paramedics and physicians to pull together all<br />
the information they need to make the best decisions,”<br />
More<br />
Around 25 million people worldwide suffer<br />
from dementia, and it’s estimated that<br />
this number could easily double by 2040.<br />
Dementia is the end result of a number of<br />
progressive degenerative diseases of the<br />
brain, the most common being Alzheimer’s<br />
disease. Most neurodegenerative diseases<br />
begin years before significant symptoms<br />
show up. But unfortunately, most current<br />
treatments only provide symptomatic<br />
relief in the mild to moderate stages of the<br />
disease but do not arrest its progression.<br />
Recognizing this, <strong>Philips</strong> <strong>Research</strong><br />
and the University Medical Center<br />
Hamburg-Eppendorf are jointly<br />
developing a computer-aided diagnostic<br />
system (CAD) that would use both<br />
positron emission tomography (PET)<br />
and magnetic resonance imaging (MRI)<br />
data to assist specialists in diagnosing<br />
neurodegenerative disease. As with<br />
stroke, a diagnosis not only determines<br />
whether the disease is present but also<br />
which type it is.<br />
Both PET and MRI are useful for<br />
revealing abnormalities in the brain and<br />
distinguishing between the different<br />
types of neurodegenerative disease. In<br />
explains Charles Lagor, Senior <strong>Research</strong> Member at the<br />
North American division of <strong>Philips</strong> <strong>Research</strong>.<br />
With the right information, the Stroke Navigator<br />
can provide a continuously updated probability of<br />
whether the patient has suffered an ischemic stroke, a<br />
hemorrhagic stroke or whether the patient is a so-called<br />
‘stroke mimic’ (someone suffering from a non-vascular<br />
disease that produces stroke-like symptoms). The Stroke<br />
Navigator can then suggest the next steps for treatment<br />
together with single-click operations to initiate them<br />
– such as a request for an urgent CT scan.<br />
“Such tools don’t require the development of<br />
new technology,” Lagor notes. “What they do require is<br />
a thorough understanding of clinician and patient<br />
needs so that you can apply existing technologies in<br />
innovative ways.”<br />
Following a stroke, victims cannot afford to lose time.<br />
Every minute that goes by is a matter of life or death.<br />
And in this fight for survival, combining technology and<br />
innovation can have a real impact: it can save lives.<br />
Advanced dementia diagnosis<br />
the early stages of the disease, however,<br />
the PET images are particularly difficult to<br />
interpret and CAD systems can be helpful<br />
to specialists.<br />
Dr Lothar Spies, head of the Digital<br />
Imaging <strong>Research</strong> Group at <strong>Philips</strong><br />
<strong>Research</strong>, describes what sets the<br />
new system apart: “This is not the first<br />
computer-aided system to provide<br />
assistance in diagnosing dementia. Other<br />
systems, however, rely on data from just<br />
one modality – typically PET. But this is a<br />
multi-modality CAD system integrating<br />
data from both PET and MRI scans.”<br />
Password February 2008<br />
27
Did you know...<br />
50 men<br />
“One machine can do the work of 50<br />
ordinary men. No machine can do<br />
the work of one extraordinary man”<br />
Elbert Hubbard, American writer and philosopher.<br />
8-ton lightbulb<br />
The world’s largest lightbulb stands 13 feet tall, weighs<br />
eight tons and is illuminated at night. It sits atop the<br />
Thomas Edison Memorial Tower in New Jersey, USA.<br />
The tower, which was built in 1937, is located on the spot<br />
where Edison invented the modern-day incandescent bulb.<br />
28 Password February 2008<br />
70% lifestyle<br />
In a recent BBC poll of 22,000<br />
people in 21 countries, 70% of<br />
respondents said they were<br />
prepared to change their<br />
lifestyles to help mitigate<br />
climate change – including<br />
people in the USA and<br />
China, the world’s two<br />
biggest emitters of<br />
carbon dioxide.<br />
Award winners<br />
First light<br />
The first city in the world<br />
to install electric street<br />
lighting was Godalming,<br />
UK, in 1881.<br />
At the 2007-2008 European<br />
Imaging and Sound Association<br />
(EISA) conference, <strong>Philips</strong> won two<br />
prestigious EISA awards in the ‘Full High Definition<br />
LCD TV’ and ‘Compact Home Theater System’<br />
categories. Winners were selected based on product<br />
innovation and design by editors from 49 leading<br />
European magazines specializing in multimedia.
No further<br />
“Inventions have long<br />
since reached their limit,<br />
and I see no hope for<br />
further developments”<br />
Julius Sextus Frontinus, Roman<br />
engineer in the year 10 AD.<br />
13,000 sheets<br />
<strong>Research</strong> conducted by IBM<br />
estimates that the average<br />
office-based employee<br />
generates as much as 13,000<br />
pieces of paper annually.<br />
LED palace<br />
It costs just € 0.45 per hour to light<br />
Buckingham Palace with the new LEDbased<br />
lighting system installed by <strong>Philips</strong>.<br />
$2.8 million lamp<br />
The highest amount paid for a lamp at<br />
a Christie’s auction was a Tiffany Lotus<br />
design that sold for $2.8 million in 1997.<br />
Marble marvel<br />
The first recorded patent<br />
for an industrial invention<br />
was granted in 1421<br />
to the engineer Filippo<br />
Brunelleschi in Florence,<br />
Italy. The patent gave him<br />
a three-year monopoly<br />
on the manufacturing of<br />
a barge with hoisting gear<br />
to transport marble.<br />
Password February 2008<br />
29
y Cedric Collet Images: <strong>Philips</strong>, Michel Klop<br />
30<br />
Behind the nano<br />
Life has been moving at warp speed for Erik Bakkers,<br />
senior scientist and project leader at <strong>Philips</strong> <strong>Research</strong>, ever<br />
since winning one of the industry’s most prestigious awards<br />
– Technology Review’s ‘Young Innovator under 35’.<br />
With just 35 winners out of a pool of 300, the competition<br />
for the award was intense. So what’s the secret behind<br />
Erik’s success? The answer lies in his groundbreaking<br />
nanotechnology research. After years of work, Erik finally<br />
found a way to do something previously unheard of when he<br />
discovered a method for combining semiconductors made<br />
of different materials on the same microchip – allowing for<br />
faster, more efficient semiconductor technology. Here Erik<br />
opens up about what he does inside and outside the lab.<br />
What’s a typical day like for you?<br />
Actually, every day is different. After checking emails, I make<br />
rounds through the labs and check on how the projects<br />
are progressing. As a project leader, I guide doctoral and<br />
post-doc students through the research process. Maybe then<br />
I’ll work on a peer review for a journal or meet with some<br />
project collaborators, like university professors, to discuss<br />
our joint projects. Since every project now has to have a<br />
business plan, I spend time doing market research, keeping<br />
track of what others are working on, seeing where our<br />
research will fit in and how we should approach it.<br />
Password February 2008<br />
Can you describe an interesting project that you are<br />
working on?<br />
Right now, I’m looking at nanowire sensors to detect<br />
things like proteins and DNA. The sensor is very small and<br />
sensitive yet has a large surface so it’s good for bacteria<br />
testing. For instance, if you have a bacterial infection and<br />
go to the hospital, it’s important to know exactly what it is<br />
as soon as possible in order to treat it properly. But with<br />
current technology it takes three to four days to determine<br />
the specific type of infection.<br />
To reduce this time and allow for earlier treatment,<br />
we’re working on a lab-on-a-chip solution that has<br />
necessary chemical processes embedded in the chip, which<br />
makes it easier to use saliva or blood on the spot to detect<br />
exactly which bacteria or virus is causing the infection. The<br />
first generation is already out, so we’re focusing on the<br />
second generation to reduce the analysis time even further.<br />
What do you like best about your job?<br />
I really like the multidisciplinary approach we take with<br />
research projects. We’re constantly thinking of new ways
Erik Bakkers, seen here with a colleague,<br />
is currently working on lab-on-a-chip<br />
solutions.<br />
to expand and apply our research. It helps that there’s a<br />
cooperative mindset here as well as world-class facilities.<br />
And when we finish a project, it’s great to see the final<br />
results in practice, no longer in theory.<br />
What was the best thing about winning the Technology<br />
Review award?<br />
All the winners were invited to a follow-up conference<br />
at MIT where I gave two presentations on my research.<br />
I also participated in a panel discussion on the future of<br />
microchip technology. There was a great debate about the<br />
way forward as features get smaller and clock frequencies<br />
More<br />
Because of variations in expansion<br />
rates when heated, combining different<br />
materials in one semiconductor device<br />
was almost a mission impossible. When<br />
attempted, the incredible physical<br />
strain led to reduced performance. But<br />
thinking outside the box, Erik Bakkers<br />
Outside the box<br />
and his team created the circuits out of<br />
nanowires, which decreased the strain<br />
as the point of contact between the<br />
semiconductors was minimized to mere<br />
tens of nanometers.<br />
This technique of mixing semiconductors<br />
on the same chip paves the<br />
increase. Overall, the conference was very interactive and<br />
forward thinking.<br />
What would you be doing if you weren’t working in the lab?<br />
I can think of two things: traveling around the world or<br />
working for a company that specializes in mergers and<br />
takeovers – being involved in such a dynamic and fast-paced<br />
field would be quite exciting.<br />
How do you spend your time outside the lab?<br />
I love to cycle and play squash. But there’s less time for those<br />
activities now that my two children keep me busy.<br />
way for multipurpose chips that could<br />
revolutionize mobile and computer<br />
technology through less power usage yet<br />
faster processing speeds. Even better: it<br />
could easily translate into cheaper – and<br />
more technologically advanced – mobile<br />
phones and computers in the near future.<br />
Password February 2008<br />
31
A new day, a new career...<br />
<strong>Philips</strong> is the leading Dutch company in terms of products and innovation,<br />
according to the Global Reputation Top 200 ranking, published in May 2007<br />
by the US-based Reputation Institute. <strong>Philips</strong> <strong>Research</strong> has 1,800 technology<br />
researchers worldwide creating the future today. Join us and make a difference.<br />
www.philips.com