Pharmacology

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Pain and Opioid Mechanisms Pain • Most common reason for seeking medical care • Everyone experiences pain…30% of Americans will suffer from chronic pain • Treatment of pain improves outcome; • Chronic pain is itself a disease which can and should be treated. Congenital Insensitivity to Pain
C & Aδ Fibers Pain Pathways Somatosensory Cortex Thalamus From Brain To Brain Spinal Cord Neural Steps in the Processing of Pain Signals 1. Transduction - Noxious stimuli → electrical signals 2. Transmission - Neural events from the periphery to the cortex 3. Modulation - Nervous system can selectively inhibit or enhance pain signals 4. Perception - subjective interpretation by the cortex Sensory component Affective component Nociceptive Transmission Pathway Sensory Receptor Periphery CNS Nociceptors: • C-polymodal small, non-myelinated • Aδ-mechanical thermal Medium, thinly-myelinated Spinal cord DRG Thalamus
Page 1 and 2: Pharmacology from the ancient Greek
Page 3 and 4: Dose Response Lock & Key Theory of
Page 5 and 6: L-Epinephrine D-Epinephrine L-Epine
Page 7 and 8: G-protein Coupled Receptors G-prote
Page 9 and 10: Tyrosine Kinase Receptors Kinase ca
Page 11 and 12: Quantal Dose Response Curve Graded
Page 13 and 14: Shift in Potency No loss of Efficac
Page 15: Review Agonists: Affinity, Selectiv
Page 19 and 20: Peripheral Nociceptor Activation
Page 21 and 22: Spinothalamic Projection to Thalamu
Page 23 and 24: δ Opioid Receptor κ Opioid Recept
Page 25 and 26: Addiction Liability Dopaminergic Di
Page 27 and 28: Fentanyl and Analogues Meperidine
Page 29: Naloxone Naltrexone • Prototypica

Pharmacology

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