Teratogen-Induced Eye Malformations

cvm.ncsu.edu

Teratogen-Induced Eye Malformations

Conclusions

• The clinical features of human fetal alcohol syndrome

are accurately reflected in this mouse model of early,

acute exposure.

• Ethanol is teratogenic when administered at a time

equivalent to the third week of human gestation.

• A narrow critical period exists during ocular

development for teratogenic effects to be expressed.

Teratogen exposure prior to the appearance of

identifiable ocular primordia results in developmental

defects which are not apparent until much later in

gestation.

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