Teratogen-Induced Eye Malformations

cvm.ncsu.edu

Teratogen-Induced Eye Malformations

Conclusions -- Teratogens

• Many ocular features of human teratologic

syndromes can be reproduced in animal

models.

• Gastrulation (third week post fertilization in

human) is a critical period for induction of

ocular malformations.

• Although anterior segment dysgenesis

syndromes involve neural crest derivatives,

they may result from a primary effect on the

neural plate rather than on the crest cells.