Susceptibility Testing of Neisseria and Haemophilus ... - SWACM

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Haemophilus influenzae • Beta-lactamse testing (7) The result of ampicillin susceptibility tests should be used to predict the activity of amoxicillin. The majority of isolates or H. Influenzae that are resistant to ampicillin and amoxicillin produce a TEM-type beta-lactamase. In most cases, a direct beta-lactamase test can provide a rapid means of detecting resistance to ampicillin and amoxicillin. Beta-lactamase negative ampicillin resistant strains (BLNAR) of H. influenzae exist and should be considered resistant to amox/clav, amp/sulbactam, cefaclor, cefetamet, cefonicid, cefprozil, cefuroxime, loracarbef and pip/tazo despite apparent in vitro susceptibility of some BLNAR strains to these agents. CLSI M100-S21 Table 2E
Haemophilus influenzae in the United States 2001-2002 Phenotype Beta-lactamase negative ampicillin susceptible (BLNAS) Beta-lactamase positive ampicillin resistant(BLPAR) Beta-lactamase negative ampicillin resistant(BLNAR) Prevalence (n=1,434) 1019 (71.1%) 406 (28.3%) 9 (0.6%) This is the population that is missed by beta-lactamase testing. Karlowsky et al. 2001. JCM
Page 1 and 2: Susceptibility Testing of Neisseria
Page 3 and 4: Haemophilus influenzae “Amox-clav
Page 5: H. Influenzae Resistance Antibiotic
Page 9 and 10: Haemophilus influenzae Test Method
Page 12: Current Neisseria gonorrhoeae Treat
Page 15 and 16: http://www.cdc.gov/std/gisp2009/okc
Page 17 and 18: Neisseria gonorrhoeae: SWACM Region
Page 19 and 20: Current Neisseria meningitidis: Tre
Page 21 and 22: Neisseria meningitidis: MIC and Dis
Page 23 and 24: Neisseria meningitidis: Agents for

Susceptibility Testing of Neisseria and Haemophilus ... - SWACM

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