The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...
The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...
The Molecular Pathogenesis of Cancer Joan Brugge Cell Biology ...
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How Many Genes/Proteins are Altered in Human <strong>Cancer</strong>s<br />
Initially looked at individual genes/proteins that<br />
were known to be involved in regulating cell growth or<br />
that were associated with hereditary breast cancer.<br />
Multiple proteins were identified as being altered in<br />
human breast tumors<br />
p53<br />
BRCA1<br />
BRCA2<br />
Cyclin D<br />
Myc<br />
HER-2<br />
Estrogen receptor<br />
lost/mutated<br />
lost/mutated<br />
lost/mutated<br />
increased production<br />
increased production<br />
gene amplified<br />
misregulated
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