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Preparation and Spectral Characteristic of Molecularly Imprinted
Polymers for Sulfamethazine
L IU Hui2jun 1 , XU Wei2jian 2 , L IU Yao2chi 1 , XION G Yuan2qin 2
1. College of Chemistry and Chemical Engineering , University of South China , Hengyang 421001 , China
2. College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , China
Abstract Molecularly imprinted polymers (MIPs) were synthesized , which was initiated by UV photo2induction at low tempera2
ture , with sulfamethazine (SM2 ) was used as template , methacrylic acid (MAA) as monomer , and ethylene glycol dimethylacry2
late ( EGDMA) as crosslinker. By UV spectrometry the authors compared the combination action on sulfamethazine with MAA
and researched the static adsorption ability and selective recognition of the molecularly imprinted polymers. The results showed
that the combination action of functional monomer with template molecules was produced , sulfamethazine imprinted polymers u2
sing methacrylic acid as monomer had higher affinity capability than NMIP and comparatively similar structure substrate of sul2
fisoxazole (SIZ) , while SM2 imprinted polymers could specifically recognize the corresponding imprinted molecules. The static
adsorption modulus of SM2 imprinted polymer was 2821 3 mg mL - 1 and the separate factor was 31 9. Then , the prediction im2
printing principle of sulfamethazine template polymer was given. The infrared spectra of methacrylic acid (MAA) and ethylene
glycol dimethylacrylate ( EGDMA) and MIPs of SM2 were analysed. It was found that the absorbability peak of C C function
group in the IMPs turned out to be very low , but the function group of carboxylic acid in the IMPs did not markedly change. The
results showed that there were some functional groups in MIPs which could interact with the template.
Keywords Sulfamethazine ; Molecularly imprinted polymers ; Spectrum analysis ; Molecular recognition
(Received May 10 , 2006 ; accepted Aug. 20 , 2006)