Cardiovascular Trials Review Cardiovascular Trials Review - Diegori.it

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Page Acronym/Title 1176 XSOLVD – Extended Studies of Left Ventricular Dysfunction Preliminary Report 1178 COMPANION – Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure 14e. Preliminary Reports — Arrhythmia 1182 PAFAC (Preliminary Report) – Prevention of Atrial Fibrillation After Cardioversion 1184 SPORTIF III – Stroke Prevention Using Oral Thrombin Inhibitor in Atrial Fibrillation 1186 AF-CHF – The Atrial Fibrillation and Congestive Heart Failure Trial 14f. Preliminary Reports — Interventional Cardiology 1190 X-TRACT – X-Sizer for Treatment of Thrombus and Atherosclerosis in Coronary Interventions Trial 1192 BRITE II – Beta Radiation to Reduce In-Stent Restenosis II 1194 OctoStent 1196 Abciximab in Patients Undergoing Stenting After Loading with High- Dose Clopidogrel 1198 DELIVER – The RX ACHIEVE Drug-Eluting Coronary Stent System in the Treatment of Patients with de novo Native Coronary Lesions 1200 TAXUS II – Paclitaxel-Eluting Stent Study 1202 FACIT – Folate After Coronary Intervention Trial xxxii Contents
Introduction The purpose of Cardiovascular Trials Review, Eighth Edition, is to review those trials that have made a major impact on the practice of clinical cardiology within the last 5 years. We have included only studies that were published in English and concentrated mainly on publications that have appeared since 1999 and have studied either pharmacological or device therapy. The text is divided into major headings of diseases such as myocardial infarction and unstable angina. In general, we gave priority to prospective randomized trials with preference to multicenter studies. In this eighth edition, we have added more than 130 new entries and concentrated on trials from 2002–2003. We have included some smaller studies that describe the new drug-eluting stents. The front section of the book concentrates on articles already in print. The preliminary reports section concentrates on studies that have been presented or discussed in abstract or other form at major cardiology meetings within the last year. Some of these studies are ongoing clinical trials. The Trials Listing sets forth studies by disease categories, which are in the Subjects section. The Trials Index at the back of the book alphabetically lists acronyms and the corresponding pages on which the trials can be found, followed by the names of trials without acronyms. We continue to be amazed by the increasing number of new, large clinical trials in the literature. Since the early ’90s there has been a virtual explosion of growth in the number of these trials. An article by Cheng (Am Heart J. 1999;137:726–765) listed more than 2250 cardiology trials with acronyms. It is common for some acronyms to be used for more than one study (example: PREVENT). Because the seventh edition exceeded 1500 pages, we had to eliminate many studies prior to 1999 to make room for those published in the last 1–2 years. These earlier studies can be found in the seventh edition of Cardiovascular Trials Review. Unfortunately, we were not able to include all studies in this text. There are many excellent studies that may not appear in this book. However, a review of the trials included in this book should give readers a flavor of the types and designs of major clinical trials that have influenced the practice of clinical cardiology. The drugs, indications for drugs, and drug dosages may or may not be approved for general use by the US Food and Drug Administration. Physicians should consult the package inserts and/or the Physicians’ Desk Reference for drug indications, contraindications, side effects, and dosages as recommended. Robert A. Kloner, MD, PhD Los Angeles, July 2003 Yochai Birnbaum, MD Jason S. Chi, BS xxxiii
Page 1 and 2: Cardiovascular Trials Review Eighth
Page 3 and 4: Dedicated to the memory of Philip K
Page 5 and 6: Subjects Contents Section Page 1. A
Page 7 and 8: Page Acronym/Title Trials Listing C
Page 9 and 10: Page Acronym/Title Contents 85 HIT-
Page 11 and 12: Page Acronym/Title Contents 176 ESC
Page 13 and 14: Page Acronym/Title Contents 260 APL
Page 15 and 16: Page Acronym/Title Contents 348 EAS
Page 17 and 18: Page Acronym/Title Contents 443 PRE
Page 19 and 20: Page Acronym/Title Contents 543 Int
Page 21 and 22: Page Acronym/Title Contents 641 CAN
Page 23 and 24: Page Acronym/Title Contents 741 COP
Page 25 and 26: Page Acronym/Title Contents 837 MIR
Page 27 and 28: Page Acronym/Title Contents 939 CTO
Page 29 and 30: Page Acronym/Title Contents 1038 PE
Page 31: Page Acronym/Title Contents 13. Val
Page 35 and 36: MIRACL Myocardial Ischemia Reductio
Page 37 and 38: ASCOT-LLA Anglo-Scandinavian Cardia
Page 39 and 40: Comparison of the Effects of Atorva
Page 41 and 42: CAPE II Trial Circadian Anti-Ischem
Page 43: CAPE II Trial Circadian Anti-Ischem

Cardiovascular Trials Review Cardiovascular Trials Review - Diegori.it

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