RNA FOLDING DURING TRANSCRIPTION

faculty.biol.ttu.edu

RNA FOLDING DURING TRANSCRIPTION

FUTURE CHALLENGES AND PERSPECTIVES

Selection of RNA Targets

(like recently discovered ∼ human RNA transcripts longer than

150nt (~ 10 6 )

Better Experimental Methods

(like High-tech single-molecule methods, fluorescence

resonance energy transfer (FRET), fluorescence

correlation spectroscopy (FCS)

RNAPol and Elongation Factors

“cognate” RNA polymerase, such as varying transcription

speeds or pausing pattern

RNA Binding Proteins and Helicases

(understanding the role, specificity, and selectivity of their

authentic cellular RNA substrates)

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