Research on RNA folding 1. Studies on folding pathways and structure: to understand physicochemical principles of how RNA sequence dictates the formation of three dimensional structures. 2. Studies on dynamics and conformational switches: to illuminate how structural changes are related to RNA function. 3. Studies on folding during transcription and assembly of ribonucleoprotein complexes: to reveal how folding in cellular contexts leads to the formation of functional RNA structures and RNA-protein complexes.
Transcription is a crucial step in gene expression and its regulation. Carried out by DNA dependent RNA polymerase (RNAP).