Stability of Drugs and Dosage Forms Sumie Yoshioka

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Preface
As stated earlier, this book attempts to present a reasonably systematic and comprehensive
approach to the subject of chemical and physical drug stability. Efforts have also been
made to provide a fairly comprehensive listing ofreferences that could be used by the reader
to access the primary literature. Our understanding of the chemical and physical stability of
drugs in solid dosage forms is still quite incomplete, and good comprehensive studies on the
stability ofproteins are only now providing the type of information from which the prediction
of physical and chemical stability of proteins might be possible. Additionally, we do not
know what the stability problems of the drugs of the future, especially the products of
genomic research, will be. Therefore, no book on the subject of drug stability should be
considered complete. Opinions and interpretations of any scientific study also differ. The
emphases presented here represent the biases of the authors, who welcome constructive
comments and criticisms on any of the work presented in this text.
Finally, the authors would like to thank their colleagues for their contributions to the
studies presented in this book. They would like to especially thank Drs. Aso and Izutsu, who
contributed significantly to a number of the studies presented from Dr. Yoshioka’s laboratory.
Contributors from Professor Stella’s laboratory include various students, technicians (especially
Ms. Waugh), and postdoctoral and visiting scientists. The authors would also like to
thank Ms. Kawai and Ms. Nakamura of Nankoudo Publishers, who helped with the original
Japanese version of this book.
Sumie Yoshioka
Valentino J. Stella