Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
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Select<strong>in</strong>g Optimal Antimicrobial Therapy<br />
(adapted from <strong>Pr<strong>in</strong>ciples</strong> of Anti-<strong>in</strong>fective Therapy by John Bradley and Sarah Long <strong>in</strong><br />
<strong>Pr<strong>in</strong>ciples</strong> & Practice of <strong>Pediatric</strong> <strong>Infectious</strong> <strong>Disease</strong>s)<br />
Questions pert<strong>in</strong>ent to choos<strong>in</strong>g <strong>antimicrobial</strong> <strong>therapy</strong> appropriately<br />
1. What is the cl<strong>in</strong>ical syndrome/site of <strong>in</strong>fection? Pathogens are predictable by site<br />
2. Does the child have normal defense mechanisms (<strong>in</strong> which case causative agents<br />
are predictable) OR are they impaired by underly<strong>in</strong>g conditions, trauma, surgery, or a<br />
medical device (<strong>in</strong> which case causative agents are less reliably predictable)?<br />
3. What is the child’s age? Pathogens are predictable by age<br />
4. What cl<strong>in</strong>ical specimen(s) should be obta<strong>in</strong>ed to guide empirical/def<strong>in</strong>itive <strong>therapy</strong>?<br />
5. Which <strong>antimicrobial</strong> agents have activity aga<strong>in</strong>st the pathogens considered, and<br />
what is the current range of susceptibilities for each antibiotic aga<strong>in</strong>st these pathogens<br />
<strong>in</strong> the practitioner’s hospital or cl<strong>in</strong>ic?
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