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8.3 Biological Evolution 151<br />

A CLOSER LOOK 8.1<br />

Natural Selection: Mosquitoes and the Malaria Par<strong>as</strong>ite<br />

Malaria poses a great threat to 2.4 billion people—over onethird<br />

of the world’s population—living in more than 90 countries,<br />

most of them in the tropics. In the United States, in 2003,<br />

Palm Beach County, Florida, experienced a small but serious<br />

malaria outbreak, and of particular concern is that the malaria<br />

w<strong>as</strong> the result of bites from local mosquitoes, not brought in<br />

by travelers from nations where malaria is a continual problem.<br />

Worldwide, an estimated 300–400 million people are infected<br />

each year, and 1.1 million of them die (Figure 8.7). 6 It is the<br />

fourth largest cause of death of children in developing nations—<br />

in Africa alone, more than 3,000 children die daily from this<br />

dise<strong>as</strong>e. 7 Once thought to be caused by filth or bad air (hence<br />

the name malaria, from the Latin for “bad air”), malaria is actually<br />

caused by par<strong>as</strong>itic microbes (four species of the protozoon<br />

Pl<strong>as</strong>modium). These microbes affect and are carried by Anopheles<br />

mosquitoes, which then transfer the protozoa to people. One<br />

solution to the malaria problem, then, would be the eradication<br />

of Anopheles mosquitoes.<br />

By the end of World War II, scientists had discovered that<br />

the pesticide DDT w<strong>as</strong> extremely effective against Anopheles<br />

mosquitoes. They had also found chloroquine highly effective<br />

in killing Pl<strong>as</strong>modium par<strong>as</strong>ites. (Chloroquine is an artificial<br />

derivative of quinine, a chemical from the bark of the quinine<br />

tree that w<strong>as</strong> an early treatment for malaria.) In 1957 the<br />

World Health Organization (WHO) began a $6 billion campaign<br />

to rid the world of malaria using a combination of DDT<br />

and chloroquine.<br />

(a)<br />

FIGURE 8.7 (a) A child with malaria and (b) where malaria primarily<br />

occurs today. [Source: (b) U.S. Centers for Dise<strong>as</strong>e Control,<br />

http://www.cdc.gov/Malaria/distribution_epi/distribution.htm.]<br />

(b)<br />

Malaria transmission<br />

occurs throughout<br />

Malaria transmission<br />

occurs in some parts<br />

Malaria transmission<br />

is not known to occur

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