Modeling of a bioprocess Define goal & process boundaries Collect data (internal and external) Define bioreactions Identify process flow diagram (unit operations and streams) Define unit operation models Perform simulations Make inventory analysis and assessment adapted from: 50 Heinzle E., et al., (2006)Development of Sustainable Bioprocesses – Modelling and Assessment. John Wiley & Sons Ltd.
Modeling of a bioprocess • What are required amounts of raw materials and utilities? • What is the required size of process equipment and supporting utilities? • Can the product be produced in an existing facility or a new plant is required? • What is the total capital investments? • What is the manufacturing cost? • What is the optimum batch size? • How long does the single batch take? • How much product can be generated per year? • What is the demand for raw materials, labor, utilities, etc.? • Which process step can be a bottleneck? • What changes can increase throughout? • What is the environmental impact of the process? • Which design is the best among several possible alternatives? adapted from: Petrides D., Bioprocess Design and Economics. Oxford University Press, 2003. 51