directors - Institute of Molecular and Cell Biology - A*Star

imcb.a.star.edu.sg

directors - Institute of Molecular and Cell Biology - A*Star

Contacts

January 2010

Institute of Molecular and Cell Biology

61 Biopolis Drive

Proteos

Singapore 138673

Fax: +65 6779 1117

Postgraduate Studentships

postgrad@imcb.a-star.edu.sg

Postdoctoral Enquiries

recruit@imcb.a-star.edu.sg

Scholarship Information

scholarship@imcb.a-star.edu.sg

School Outreach Program

stuor@imcb.a-star.edu.sg

General Enquiries

enquiry@imcb.a-star.edu.sg

www.imcb.a-star.edu.sg

Graphic elements from the poster

“Study of Cell cycle control in neural stem cells”

by Shuhui Lim & Philipp Kaldis

A


S T A R

Institute of

Molecular and

Cell Biology


Message from the Executive Director

IMCB is one of Asia’s leading basic science research institutes, with more than 50 different nationalities represented among

a staff of more than 350. IMCB is located at the state-of-the-art research complex at Biopolis that is home to several other

research institutes and pharmaceutical and biotechnology companies. Our mission is to better understand the causes of

common human diseases, such as cancer, using all of the tools of modern medical science, with the aim of using that

knowledge to develop better treatments for human disorders.

Neal COPELAND

RESEARCH

Cancer Genetics

GROUPS

Dmitry BULAVIN

Cell Cycle Control & Tumourigenesis

dvbulavin@imcb.a-star.edu.sg

Genomics

IMCB

DIRECTORS

Professors Nancy JENKINS and Neal

COPELAND are an internationally

renowned husband-wife duo who have

worked together for 30 years and are

among the 50 most-cited biomedical

research scientists in the world, with more

than 750 published papers. For the last 2

decades, Professors Jenkins and

Copeland have studied human conditions

Neal COPELAND such as cancer, immunity, fertility and

learning with mouse models, but their

current research is predominantly

focused on cancer. Their laboratory was

among the first to show that Sleeping

Beauty transposition can be employed as

a cancer gene discovery tool, and more

recently, the laboratory has begun to

focus on the PiggyBac transposon for

modeling cancer. Professors Jenkins and

Copeland were recently elected to the

Nancy JENKINS United States National Academy of

Sciences for their continuing contribution and dedication to

furthering scientific knowledge in the field of Genetics.

Professor Philip INGHAM’s laboratory

has pioneered the genetic analysis of

Hedgehog signalling, identifying and

characterizing the key components of

the pathway in Drosophila, and

discovering the Sonic Hedgehog gene in

vertebrates. His group continues to

study Hedgehog signalling and human

disease related processes in the

Philip INGHAM zebrafish. Professor Ingham was elected

a Fellow of the Royal Society in 2002 and an Honorary

Fellow of the Royal College of Physicians in 2007.

Professor Wanjin HONG’s

laboratory is widely credited for

identifying and characterizing

numerous proteins (such as

SNAREs, sorting nexins and

small GTPases) involved in

vesicle-mediated transport in

mammalian cells. The group has

recently established a role for TAZ,

Wanjin HONG a target of the Hippo tumour

suppressor pathway, in breast cancer cell migration

and tumorigenesis. He is currently the Editor-in-Chief

of Bioscience Reports (BsR) and is on the editorial

board for several other journals.

Professor Jean Paul THIERY’s

laboratory combines biophysical,

transcriptomic and proteomic

methods as well as the use of

advanced imaging techniques to

investigate cell adhesion in

epithelial–mesenchymal transition.

His group is also characterizing

murine neural crest cell pluripotency

and cell migration, as well as Jean Paul THIERY

breast development and oncogenesis. Prior to

joining IMCB, Professor Thiery was the Director of

the Department of Translational Research at the

Curie Institute Cancer Center in Paris. He was

recently received into the Legion of Honour for his

outstanding contributions to science.

Professor Pernille RØRTH’s group

focuses on studying live cell

migration using Drosophila as a

genetically tractable in vivo model

system. The laboratory explores how

border cell and cluster movements

are controlled and guided in vivo.

They are currently examining how

cells become migratory and

Pernille RØRTH invasive, how spatial and temporal

regulation of signalling affects cellular behaviour, as

well as regulation of adhesion and possible links

to mechanobiology.

Nancy JENKINS & Neal COPELAND

Cancer Genetics

njenkins@imcb.a-star.edu.sg

ncopeland@imcb.a-star.edu.sg

Yoshiaki ITO (Adjunct)

RUNX Genes in Development & Cancer

NUS CSI

itoy@imcb.a-star.edu.sg

Cell Cycle Control

Philipp KALDIS

Cell Division & Cancer

kaldis@imcb.a-star.edu.sg

Yan LUO

S-phase Histone Expression Regulation

yluo@imcb.a-star.edu.sg

Uttam SURANA

Regulation of the Cell Division Cycle

mcbucs@imcb.a-star.edu.sg

Cell Structure and Function

Frederic BARD

Regulation of Membrane Traffic

fbard@imcb.a-star.edu.sg

Wanjin HONG

Protein Trafficking in Mammalian Cells

mcbhwj@imcb.a-star.edu.sg

Walter HUNZIKER

Epithelial Cell Polarity

hunziker@imcb.a-star.edu.sg

Structural Biology

Robert ROBINSON

Actin Structure & Cell Movement

rrobinson@imcb.a-star.edu.sg

Haiwei SONG

Translation Termination & mRNA Decay

haiwei@imcb.a-star.edu.sg

Ernesto GUCCIONE

Chromatin, Epigenetics & Differentiation

eguccione@imcb.a-star.edu.sg

Byrappa VENKATESH & Sydney BRENNER

Comparative Genomics

mcbbv@imcb.a-star.edu.sg

sydney_brenner@a-star.edu.sg

Infectious Diseases

Dingxiang LIU

Molecular Virology & Viral Pathogenesis

dxliu@imcb.a-star.edu.sg

Yee Joo TAN

Collaborative Anti-Viral Research

mcbtanyj@imcb.a-star.edu.sg

Yue WANG

Candida albicans Molecular & Cellular Biology

mcbwangy@imcb.a-star.edu.sg

Lianhui ZHANG

Microbial Quorum Sensing

lianhui@imcb.a-star.edu.sg

Signal Transduction

Xinmin CAO

Functions of GRIM-19/Mitochondrial Complex I

mcbcaoxm@imcb.a-star.edu.sg

Graeme GUY

Modulators of the RTK/Ras/ERK Pathway

mcbgg@imcb.a-star.edu.sg

Vinay TERGAONKAR

Deregulated Activity of NFκB

vinayt@imcb.a-star.edu.sg

Qi ZENG

PRL-3 Phosphatase & Cancer Metastasis

mcbzengq@imcb.a-star.edu.sg

Edward MANSER & Thomas LEUNG (Adjunct)

sGSK Laboratory at IMCB

A*STAR Neuroscience Research Partnership

ed.manser@nrp.a-star.edu.sg

thomas.leung@nrp.a-star.edu.sg

Translational Research

Walter BLACKSTOCK

Mass Spectrometry & Systems Biology

wblackstock@imcb.a-star.edu.sg

Jean Paul THIERY

Mechanisms in Development & Cancer

jpthiery@imcb.a-star.edu.sg

Developmental Biology

Tom CARNEY

Protease Mediated Regulation of

Epithelial Biology

tcarney@imcb.a-star.edu.sg

Philip INGHAM

Developmental Biomedical Genetics

pingham@imcb.a-star.edu.sg

Vladimir KORZH

Fish Developmental Biology

vlad@imcb.a-star.edu.sg

Baojie LI

Signal Transduction & Developmental Biology

libj@imcb.a-star.edu.sg

Pernille RØRTH

Dynamics of Collective Cell Migration

prorth@imcb.a-star.edu.sg

Sudipto ROY

Genetic Control of Development & Regeneration

sudipto@imcb.a-star.edu.sg

Jacqueline VELTMAAT

Mammary Gland Biology & Pathology

jmveltmaat@imcb.a-star.edu.sg

Xiaohang YANG

Developmental Neurobiology

mcbyangn@imcb.a-star.edu.sg

Colin STEWART (Adjunct)

Developmental and Regenerative Biology

Institute of Medical Biology

colin.stewart@imb.a-star.edu.sg

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