Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
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Summary<br />
Outlook<br />
<strong>Mesothelin</strong> is overexpressed in various carcinomas<br />
<strong>Mesothelin</strong>-<strong>ADC</strong> binds with high affinity and specificity and<br />
is efficiently internalized<br />
In vitro high potency and selectivity <strong>for</strong> proliferating,<br />
mesothelin positive cells<br />
In vivo high efficacy in mesothelin positive xenografts and<br />
pronounced bystander effect<br />
Phase 1 clinical trial with <strong>Mesothelin</strong>-<strong>ADC</strong> is underway<br />
Development of a Companion Diagnostic initiated<br />
Page 16 • <strong>Mesothelin</strong> <strong>ADC</strong> BAY 94-9343, MipTec 2011 Basel, Sven Golfier
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