ANNUAL REPORT 2012 - TiGenix

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206 TiGenix I annual report 2012 Title Country Application number Methods and compositions for use in cellular therapies. (PCT Publication WO 2011/004264) Stem cell culture media and methods (PCT Publication WO/2012/032112) Methods and compositions for use in cellular therapies. (PCT Publication WO/2012/095743) Cell populations having imunoregulatory activity, methods for the preparation and uses thereof. (PCT Publication WO/2012/123401) Cell populations having imunoregulatory activity, methods for the preparation and uses thereof. (PCT Publication WO/2012/123401) In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selecting cell populations for autologous transplantation (PCT Publication WO01/24833) Brazil BR112012000534 Canada 2,767,300 Mexico MX/a/2012/000396 Singapore 201200157-4 USA 13/382,426 China 201080030890 Japan Pending Israel 25/02/2495 South Korea 2012-7003364 Australia 2010269962 India 241/KOLNP/2012 New Zealand 13/03/3537 Russian Fed 2012104529 Europe 10752171.8 WO WO WO WO CA EP.DIV PCT/EP2011/065540 PCT/IB2012/000097 PCT/EP2012/054251 PCT/EP2012/059313 CA2397610 EP04077642.9 AT AT 285797 BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE EP1218037 EP1218037 EP1218037 DE60017159 DK1218037 ES2234673 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 EP1218037 PT1218037 EP00967443 HK HK 05106052.7 US US-CIP1 US10/089932 US12/323185 US-CIP2 10/422,475
Title Country Application number Isolation of precursor cells and their use for tissue repair (PCT Publication WO/2001/025402) Use of CXCL6 chemokine in the prevention or repair of cartilage defects (PCT Publication WO2005/014026) CA AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE US US US-CIP1 AU CA AT BE CH DE DK ES FI FR GB GR HU IE IT LI LU MC NL PL SE TR HK IL CA2386506 AT283349T EP1288690 EP1288690 EP1288690 DE20023640U/ DE60016288 DK1288690 ES2230157T EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 EP1288690 PT1288690 EP1288690 US10/422,475 US12/176256 US12/983,658 AU2004262451 CA2,533,124 AT449608T EP1653994 EP1653994 DE602004024312D DK1653994 ES2337469T EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1653994 EP1288690 EP1288690 EP1288690 HK06105628.3 IL173,544 207
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ANNUAL REPORT 2012
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9. MAJOR SHAREHOLDERS 103 9.1. OVER
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There can be no assurance that TiGe
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educing their ultimate value to the
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eimbursement in certain instances s
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or the relevant manufacturing proce
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In recent years, it expanded its op
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making this change may be costly an
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TiGenix’s development stage produ
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qualified employees and consultants
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1. Introduction Annual report 2012
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2. Persons Responsible for the Cont
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4. Selected Financial Information Y
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5.3. ORGANISATIONAL STRUCTURE TiGen
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Date Transaction Number and class o
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Date Transaction Number and class o
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(12) The shares were subscribed to
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5.5. DESCRIPTION OF RIGHTS AND BENE
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Formalities to attend the sharehold
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amendments to the Articles of Assoc
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the existing shareholders have a pr
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Issue date Term Number of warrants
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6. Business Overview Most of the in
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6.2. COMPETITIVE STRENGTHS The Comp
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6.3. IMPORTANT EVENTS IN THE DEVELO
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6.3.5. Funding history Since its in
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non-weight bearing area of the join
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6.4.5. Commercial launch ChondroCel
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und Behandlungsmethode”) in sever
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Therapeutics (product Hyalograft C)
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Different routes of administration
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Clinical development In January 201
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evenues from this pipeline within t
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that the average cost of treatment
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TiGenix has obtained cGMP status fo
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Biologics for treatment of Rheumato
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of the patents and patent applicati
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- “Marker genes for use in the id
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manufacturing process and therapeut
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Invalidation of US patent US6777231
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7. Corporate Governance 7.1. GENERA
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7.2.3. Independent directors As to
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7.2.4. Composition of the Board of
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of Ravago NV, Vanbreda Risk & Benef
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Litigation statement concerning the
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As proof of the independence and an
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for their healthcare and biotechnol
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7.5. SCIENTIFIC ADVISORY BOARD AND
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As of the date of publication of th
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(rounded down to the nearest intege
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usiness at customary market conditi
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9. Major Shareholders 9.1. OVERVIEW
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10. Financial Statements : General
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11. Consolidated Financial Statemen
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11.3. CONSOLIDATED STATEMENT OF CAS
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The consolidated financial statemen
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11.5.2.2. Basis of consolidation Th
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are provided and costs are incurred
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of interest on the remaining balanc
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Deferred tax assets and liabilities
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- Partnering of Cx601 (i.e. finding
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The Group is mainly exposed to the
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fiscal year 2010, reference is made
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Sales and marketing expenses Years
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The number of employees in the R&D
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Analysis of profit/(loss) for the p
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(8) Disposal group held for sale Th
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(10) Property, plant and equipment
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The decrease of stock in 2012 compa
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dividends will be based upon the Co
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alance. As a consequence, the Compa
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(23) Other current liabilities The
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TiGenix SAU - Stock options Prior t
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(25) Business combination Descripti
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(26) Related party transactions Tra
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(28) Commitments and contingencies
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(30) Consolidation scope Name Subsi
Page 155 and 156: We believe that the audit evidence
Page 157 and 158: assets and liabilities, its financi
Page 159 and 160: the results of its operations and c
Page 161 and 162: 12.2. STATUTORY BALANCE SHEET 2010-
Page 163 and 164: The value of receivables is reduced
Page 165 and 166: 13. Annual Report of the Board of D
Page 167 and 168: 2013. The facility will provide the
Page 169 and 170: year ended December 31, 2011, and T
Page 171 and 172: Operating result (EBIT) and net res
Page 173 and 174: Statement of financial position The
Page 175 and 176: - The total personnel costs of EUR
Page 177 and 178: - TiGenix may fail in successfully
Page 179 and 180: continue as a going concern and to
Page 181 and 182: Functioning of the Board of Directo
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Page 185 and 186: Apart from the above remuneration f
Page 187 and 188: Shares and warrants held by indepen
Page 189 and 190: - Long-term incentive plan : warran
Page 191 and 192: Shares and warrants held by executi
Page 193 and 194: - identifying and implementing busi
Page 195 and 196: actual bonus equal to 78 % of her p
Page 197 and 198: was reduced to a half-time role com
Page 199 and 200: 14. Business and Financial Update a
Page 201 and 202: Financial results for the full year
Page 203 and 204: 15. Available Documents The Company
Page 205: Title Country Application number Ce
Page 209 and 210: Country Trademark Classes USA CELLE
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