Progressive Supranuclear Palsy

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Clinical Features of PSP Slow vertical saccades, especially down, with a preserved range of movement, may be the first sign of the disorder; later, loss of vertical saccades and quick phases Horizontal saccades become slow and hypometric Disruption of steady gaze by horizontal saccadic intrusions (square-wave jerks) Impaired smooth pursuit, vertically (reduced range) and horizontally (with catch-up saccades)
Clinical Features of PSP Smooth eye-head tracking may be relatively preserved, especially vertically Preservation of vestibulo-ocular reflex Horizontal disconjugacy suggesting INO Loss of convergence Ultimately, all eye movements may be lost, but vestibular movements are the last to go
Page 1 and 2: HARVARD MEDICAL SCHOOL DEPARTMENT O
Page 3: Supportive Criteria for Dx PSP Symm
Page 7 and 8: Neuroimaging Figure 1: Sagittal T2-
Page 9: Figure 3. PET in a patient with PSP
Page 12 and 13: Pathology Figure 6: PSP-the-globose
Page 17 and 18: Tauopathies: Clinical Diseases Alzh
Page 19 and 20: Richardson JC, Steele J, Oszewski J

Progressive Supranuclear Palsy

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