2012 Scientific Report - Queensland Children's Medical Research ...

QCMRI Director’s Report ........................................................................................................... 3
Cancer and Cell Biology ............................................................................................................ 4
Children’s Cancer Research Laboratory ........................................................................... 5
The Developing Brain, Growth and a Healthy Start to life ......................................................... 10
Endocrinology and Diabetes Research Group ................................................................. 11
Feeding and Development Therapies Group ................................................................... 17
Infection, Inflammation and the Environment .......................................................................... 20
Cough, Asthma and Airways Research Group ................................................................. 21
Respiratory infection Outreach and Research Team ........................................................ 29
Children’s Lung, Environment and Asthma Research Group ............................................. 38
Airways Infections, Inflammation and Cystic Fibrosis Group ............................................ 50
Queensland Paediatric Infectious Diseases (QPID) Laboratory ......................................... 54
Burns, Trauma and the Critically Ill ........................................................................................... 65
Centre for Children’s Burns and Trauma Research ........................................................ 66
Innovative, Evidence Based Health Care and Delivery ................................................................ 74
Department of Nursing Research, Royal Children’s Hospital ........................................... 75
Centre for Online Health ............................................................................................... 80
Children’s Allied Health Research ................................................................................... 92
Biostatistics and Epidemiology Unit ............................................................................. 100

Director’s Message
The Queensland Children’s Medical Research Institute (QCMRI) had a highly productive year in 2011,
expanding to nearly 200 researchers, research higher degree students and support staff. QCMRI
researchers achieved outstanding success in the 2011 NHMRC project and fellowship funding
rounds, with our researchers involved in projects totalling more than $8.8 million. QCMRI
researchers 2012 was another are now productive lead investigators year for on the projects QCMRI. totalling The Institute
Director’s
more than grew $4.8m, in numbers
Message
with Dr again Kerry-Ann in 2012,
O’Grady with over awarded 230 researchers, the single largest research project higher grant degree of any students University and of support Queensland staff researcher, now members a of
fantastic the Institute. outcome.
The Researchers Institute had from a 100% QCMRI success achieved rate outstanding applications success to the in NHMRC’s the 2012 fellowship NHMRC was another schemes, funding productive rounds. with year In for the QCMR
particularly the project pleasing and fellowship outcomes categories, for our early our career researchers researchers. were In involved 2011, with over QCMRI in successful 230 researchers, applications research higher degr
produced totalling $8.59 170 peer million. reviewed QCMRI manuscripts, researchers books are and lead book investigators chapters. the Several Institute. on projects were published totalling high over
impact $3.68m, journals with special including mention the New to England Professor Journal Claire of Wainwright Medicine, Lancet, who Nature was successful Genetics in and 2 the project
Journal
grant applications
of the American
as CIA,
Medical
worth
Association.
a combined
QCMRI
total of
researchers
$1.71 million.
were Researchers also involved from in QCMRI the achieved outstanding
supervision of 73 research higher degree students in 2011 and a further project 10 students and fellowship graduated categories, our resear
during Also of the note year. was the awarding of a $2.5 million NHMRC Centre totalling of Research $8.59 million. Excellence QCMRI to researchers are le
QCMRI’s Professor Anne Chang in the area of Indigenous Children’s $3.68m, Health. with special mention to Professor Claire
QCMRI also launched its Children’s Health and Environment Program (CHEP) in 2011. Under
grant applications as CIA, worth a combined tota
Professor QCMRI students Peter Sly’s were directorship, also highly CHEP successful aims to in become obtaining one prestigious of Australia’s NHMRC major Scholarships, research bodies with for 3
environmental scholarships awarded issues affecting to QCMRI children’s in the 2012 health. round. This $5m UQ were initiative awarded Also is a of collaboration 7 note of these was the scholarships between awarding the in of a $2.5 million N
QCMRI, total, so UQ’s QCMRI School students of Population and their Health, supervisory Global teams Change should Institute, be QCMRI’s National very proud Research Professor their Centre Anne efforts for Chang when in the area of Ind
Environmental put into this context. Toxicology and Faculty of Health Science.
QCMRI students were also highly successful in o
The In terms Institute of also research saw research income successfully more broadly, translated QCMRI to outcomes researchers scholarships in 2011. were Examples Chief awarded Investigators include to QCMRI the on in the 2012 rou
uptake projects of totalling recommendations more than for $40 the optimal million (life first-aid of project), in burns developed with total, 2012 by so income QCMRI of Burns students approximately and their supervisory t
researchers $11.5m and by in the excess Australia of $8.5m and New where Zealand QCMRI Burns researchers Association, were St lead put John’s into investigator. Ambulance this context. and other
organisations; research that has helped to further define the clinical role of bronchoalveolar lavage
In 2012, QCMRI researchers produced 184 peer reviewed manuscripts,
(BAL) in cystic fibrosis; development of new National and International In terms guidelines of with research an additional
on the income treatment more 22 broadly, QCM
books and book chapters. A number of these manuscripts
of bronchiectisis; and the demonstration of safety and efficacy of Influenza projects were published
vaccines. totalling in more high than impact $40 million (life of p
journals including the Lancet, Nature Genetics and the Journal $11.5m of and the in American excess of Medical $8.5m where QCMRI re
Association.
I would also like to thank the Children’s Health Foundation Queensland (CHFQ) and their donors for
their QCMRI continued researchers support were of involved our Institute. in the The supervision CHFQ works of tirelessly 70 research to In 2012, raise higher the QCMRI degree funds researchers we students need to (PhD produced XXX p
invest and MPhil) in research. in 2012 and a further 8 students completed their studies XX books during and book the course chapters. of the A number of these
year.
journals including the Lancet, Nature Genetics a
While the QCMRI is only two years young, it has very quickly cemented its place as a leader in
Association.
children’s QCMRI continues health research. to receive None of wonderful the achievements support or from opportunities the Children’s I have discussed Health would Foundation have
been Queensland possible and without their the donors. hard work Much and of dedication the Institute’s of our success team of is QCMRI passionate based researchers this support were and and involved their
in the supervi
support entire QCMRI staff. QCMRI community researchers is greatly continue appreciative to push boundaries of the Foundation’s and and achieve MPhil) ongoing real outcomes 2012 commitment and for a further to 8 students com
health supporting and well-being research at of QCMRI. children in Queensland and further afield. year.
Professor Keith Grimwood
Director
2011 was an extremely successful year for the QCMRI and has
provided us with solid foundations for an even greater 2012.
Professor Keith Grimwood
Professor Keith Grimwood Director - Director
QCMRI Scientific Report 2011 3

QCMRI Scientific Report 2011 4

Children’s Cancer Research Laboratory
The Cancer and Cell Biology Team at the QCMRI is a multidisciplinary group focused on
improving our biologic understanding and treatment of childhood cancer. The team is closely
integrated with the Queensland Children’s Cancer Centre/Division of Oncology of Children’s
Health Queensland. The past year has seen the establishment of an exciting Paediatric
Leukaemia Drug Development Program with new national and international collaborations. The
Queensland Children’s Tumour Bank has established multiple collaborative studies that are
progressing well. In addition the team provides key support necessary for clinical trials for
children with cancer.
Summary of Research Activities and Achievements
Paediatric Leukaemia Drug Development Program
2012 saw a new focus on childhood leukaemia in the Children’s Cancer Research Laboratory,
with the establishment of the Paediatric Leukaemia Drug Development Program, led by Dr
Andrew Moore. A Paediatric Oncologist and Clinician-Scientist, Dr Moore returned to Brisbane in
March after completing his PhD at the Institute of Cancer Research in London. Dr Moore has
been investigating the mechanisms of cell death in childhood acute myeloid leukaemia (AML), a
relatively uncommon but aggressive form of childhood leukaemia with a poor prognosis. His
research is also evaluating a novel drug, targeting one of the proteins that may be involved in
causing resistance to conventional chemotherapy.
Thanks to competitive research funding secured by Dr Moore, the Paediatric Leukaemia Drug
Development Program employed a full-time research assistant (Ms Anjelidja Zivanovic) and
purchased specialised equipment necessary to find and evaluate new therapeutic targets in
childhood leukaemia. During 2012, Dr Moore also secured further research funding, enabling
two additional research projects to be commenced in 2013, both evaluating novel therapeutics
for childhood AML.
Queensland Children’s Tumour Bank
The Queensland Children’s Tumour Bank (QCTB) aims to assist as many quality scientific projects
as possible, in order to increase knowledge about childhood cancer and thereby improve
diagnosis and treatment. To achieve this we collect, process and store tissue and bodily fluids
from patients at the Royal Children’s Hospital and facilitate distribution of these valuable
resources to other researchers, both nationally and internationally.
Our bio-resource collection continues to expand, and now includes a number of rare variants
and sub-types of cancer in addition to more commonly seen cases. During 2012 the QCTB
obtained specimens from over 160 collection events involving 129 individual ethically consented
patients with cancer and related disorders. This included banking of surgically removed tissue
from patients with solid lesions, bone marrow from patients diagnosed with leukaemia, and
other additional specimen types. Tissue and cells are stored in a range of formats to allow
maximum flexibility for future research, be that at the DNA, RNA, protein or live cell level. During
2012 we began collecting extensive follow-up specimens from patients with acute myeloid
leukaemia over the course of their treatment, to support our in-house research program on this
QCMRI Scientific Report 2012 5

disease lead by Dr. Andrew Moore. Over 12,000 vials containing patient samples are currently
held in the QCTB collection, stored at ultra-low temperatures in multiple geographic locations.
In addition to continued involvement in the projects of local and national collaborators (studying
both solid tumour and leukemic disorders), 2012 saw the QCTB begin supporting international
cancer biology projects. New collaborations were established with two independent research
groups in the U.S.A. (both studying the brain tumour medulloblastoma), a large research
consortium based in Canada (studying medulloblastoma and ependymoma), and two research
groups in the U.K. (studying high grade glioma and rhabdomyosarcoma). The tumour bank
provides such researchers not just with biological resources such as tissue, DNA and RNA, but
works actively with the project coordinators to provide valuable matched clinical data tailored to
the needs of each individual project.
A number of our collaborative projects will run long-term over coming years, with the QCTB
providing further bio-specimens and scientific support as new patients of interest are diagnosed
at the Royal Children’s Hospital. Such projects highlight the important long term role that biobanks
play in adding power to investigations of the most common paediatric cancers and
enabling meaningful study of rare disease types. Such studies will ultimately lead to better
outcomes for future children with cancer.
The QCTB continues to maintain a close working relationship with the Clinical Research Office in
the Division of Oncology at the Royal Children’s Hospital, providing laboratory services that
allow the hospital to take part in a large number of clinical trials. These are typically large multicentre
trials that aim to assess the safety and efficacy of new treatments for haematological
disorders and cancer.
Awards
Dr Andrew Moore
‣ Australian and New Zealand Children’s Haematology and Oncology Group (ANZCHOG)
Annual Scientific Meeting 2012. Awarded one of two best oral abstract prizes.
‣ Leukaemia Foundation Young Investigator Award 2012. This was the major prize for the
2012 New Directions in Leukaemia Research Meeting, awarded to the best research
contribution based on assessment of abstract and poster or presentation by the judging
panel at the meeting.
QCMRI Scientific Report 2012 6

Research Grants and Contracts
Years Grant Agency Chief
Investigators
2010- QCMRI/ Children’s A/Prof. A
2015 Health Foundation Hallahan
Queensland
Title
Tumour Bank - Infrastructure
Funding
Amount
$401,911
2012-
2013
The BrainChild
Foundation
Dr. W Ingram
Towards Better Outcomes For
Children With Brain Tumours –
Advancement Of Multiple Research
Studies Using Banked Specimens
$25,000
2012-
2016
NHMRC Dr A Moore The role of Survivin and XIAP (Xlinked
inhibitor of apoptosis
protein) as biomarkers and
therapeutic targets in paediatric
acute myeloid leukamia
$248,424
2012-
2016
Children’s Health
Foundation
Queensland / QCMRI
Dr A Moore
A study to assess the mechanisms
of cell death in acute myeloid
leukaemia.
$506,615
2012 Pfizer Australia Dr A Moore The role of Survivin and XIAP (Xlinked
inhibitor of apoptosis
protein) as biomarkers and
therapeutic targets in paediatric
acute myeloid leukamia
2012 ANZ Trustees Dr A Moore The role of Survivin and XIAP (Xlinked
inhibitor of apoptosis
protein) as biomarkers and
therapeutic targets in paediatric
acute myeloid leukamia
$50,000
$50,000
Publications
Peer Reviewed Manuscripts
1. Bavetsias V, Crumpler S, Sun C, Avery S, Atrash B, Faisal A, Moore AS, Kosmopoulou M,
Brown N, Sheldrake PW, Bush K, Henley A, Box G, Valenti M, de Haven Brandon A,
Raynaud FI, Workman P, Eccles SA, Bayliss R, Linardopoulos S, Blagg J. Optimization of
imidazo [4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora
kinase inhibitor as an orally bioavailable preclinical development candidate for the
treatment of acute myeloid leukemia. J Med Chem2012; 55: 8721-34
QCMRI Scientific Report 2012 7

2. Keating J, Tsoli M., Hallahan A.R., Ingram W.J., Haber, M. Ziegler D.S. (2012) Targeting
the Inhibitor of Apoptosis Proteins as a novel therapeutic strategy in
medulloblastoma. Molecular Cancer Theraputics. 11(12): 2654-63.
3. Moore AS, Faisal A, Gonzalez de Castro D, Bavetsias V, Sun C, Atrash B, Valenti M, de
Haven Brandon A, Avery S, Mair D, Mirabella F, Swansbury J, Pearson ADJ, Workman P,
Blagg J, Raynaud FI, Eccles SA and Linardopoulos S. Selective FLT3 inhibition of FLT3-
ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for
emerging clinical resistance patterns. Leukemia 2012; 26: 1462-1470.
4. Norris RLG, Paul M, George R, Moore AS, Pinkerton R, Haywood A, Charles B. A stableisotope
HPLC-MS/MS method to simplify storage of human whole blood samples for
glutathione assay. J Chromatography B 2012; 898: 136-140.
5. White M, Murphy AJ,Hallahan A, Ware RS, Fraser C, Davies PS. Survival in overweight
and underweight children undergoing hematopoietic stem cell transplantation. Eur J
Clin Nutr. 2012 Aug 15. doi: 10.1038/ejcn.2012.109
Staff Profile
Name
A/Prof. Andrew Hallahan
Dr Wendy Ingram
Dr Andrew Moore
Ms Erica Little
Ms Angela Zivanovic
Position
Director
Scientist/Tumour Bank Manager
NHMRC Early Career Fellow
Senior Research Assistant
Senior Research Technician
QCMRI Scientific Report 2012 8

National and International Collaborators
National
‣ Queensland Institute of Medical Research, Brisbane: Prof. Andrew Boyd & Dr. Steven Lane
‣ Children’s Cancer Institute Australia, Sydney: Dr. David Ziegler
‣ Murdoch Children’s Research Institute, Melbourne: Dr. Richard Saffery
‣ Monash Medical Centre, Melbourne: A/Prof. Elizabeth Algar
‣ Monash Institute of Medical Research, Melbourne: Prof. Terry Johns
‣ Telethon Institute for Child Health Research, Perth: Dr. Peter Dallas & Dr. Nicolas Gottardo
International
‣ University of Iowa, USA: Prof. Sue O'Dorisio
‣ Children's National Medical Center, Washington DC, USA: A/Prof. Brian Rood
‣ The Hospital for Sick Children, Toronto, Canada: Prof. Michael Taylor
‣ Institute of Cancer Research, London, UK: Dr. Chris Jones & Dr. Janet Shipley
Paediatric Leukaemia Drug Development Program
‣ Professor Andy Pearson, The Institute of Cancer Research & Royal Marsden Hospital,
London, UK
‣ Dr Spiros Linardopoulos, The Institute of Cancer Research, London, UK
‣ Dr Soheil Meshinchi, Children’s Oncology Group and Fred Hutchinson Cancer Research
Center, Seattle, USA.
Research Group Contact Details
Queensland Children’s Tumour Bank
Queensland Children’s Medical Research Institute
Level 4, Foundation Building
Royal Children’s Hospital
Herston Road, Herston
Queensland 4029
p: (07) 3636 9211
e: tumourbank@qcmri.org.au
QCMRI Website:
http://www.qcmri.org.au/Research/CancerandCellBiology/ChildrensCancerResearchGroup/
CCRGTheTeam.aspx
QCMRI Scientific Report 2012 9

QCMRI Scientific Report 2011 9

Endocrinology and Diabetes Research Group
Summary of Research Activities and Achievements
Cardiovascular Risk in Children and Adolescents with Diabetes and Obesity
Research Programme (Louise Conwell)
‣ Characterisation of the metabonomic profile of adolescents with type 1 diabetes and
assessment of association with cardiovascular risk factors.
This project aims to explore the utility of metabonomics in young people with diabetes.
Metabonomics aims to profile all the small molecule metabolites found within cells, tissues
and biofluids in a given physiological and environmental context. It is an innovative
technique that may provide information about alterations in metabolism by monitoring
changes in the composition of biofluids (blood / urine) i.e. a ‘metabolic fingerprint’. The
project aims to compare the metabonomic profile of adolescents (14-19 years inclusive)
with type 1 diabetes for at least 5 years to controls using two analytical tools (i) Gas
chromatography – mass spectrometry (GC-MS) and (ii) Nuclear magnetic resonance NMR
spectroscopy. It also aims to compare putative cardiovascular risk factors in adolescents
with type 1 diabetes for at least 5 years to controls i.e. biochemical risk markers of
atherosclerosis and vascular dysfunction (dyslipidaemia, inflammation, oxidative stress); and
adverse vascular and echocardiographic measures. The metabonomic profile of adolescents
with type 1 diabetes will be correlated to other cardiovascular risk factors.
‣ Young Heart Study
A collaboration has been established with A/Prof Gary Leong, Dr Rachana Dayiha
(Department of Endocrinology and Diabetes, Mater Children’s Hospital) and their coinvestigator.
The study is exploring cardiometabolic links in obese young people, considering
insulin resistance, inflammation, adipocytokines, vascular measures and echocardiographic
measures.
Beta-cell Disorders (Congenital Hyperinsulinism and Monogenic Diabetes)
Clinical and Research Programme (Louise Conwell)
Dr Stephanie Johnson is conducting a PhD at the University of Queensland (supervised by
A/Prof Emma Duncan, RBWH; A/Prof Louise Conwell and Dr Mark Harris, Mater Children’s
Hospital). She is evaluating the efficacy of next generation DNA sequencing in the diagnosis
of disorders of beta cell function, including congenital hyperinsulinism and monogenic
diabetes. This research compliments clinical activities including development of a clinical
national framework for care of infants and children with congenital hyperinsulinism,
integrating genetics, 18F-DOPA Positron Emission Tomography (PET) / Computed
Tomography (CT) and medical and/or surgical management for best patient outcome. 18F-
DOPA PET/CT became uniquely available at the RBWH in 2010 which is a diagnostic tool to
distinguish focal from diffuse disease pre-operatively, important in planning the extent of
pancreatic resection.
QCMRI Scientific Report 2012 11

Eat Smart for Success: Investigating the use of pharmacotherapy in adolescents
for weight loss maintenance: The role of appetite (Jennifer Batch)
Eat Smart for Success aims to assist obese adolescents maintain weight loss after a dietary
intervention. One of the major issues in obesity management is that patients who lose weight
often regain all the weight in the following 1-2 years. This study is specifically designed to try to
find a solution to this problem by adding metformin. We will study metformin’s effect on
fullness (satiety) such that the drive to eat and the amount of food eaten are reduced. We will
also study the effect of metformin on gut hormones produced in response to food in obese and
healthy weight adolescents. We know that obese adolescents have a high risk of becoming
obese adults with early cardiovascular disease. Assisting adolescents to maintain weight loss will
help prevent cardiovascular disease in adult life.
Awards
‣ Karen Shann, Best New Poster Presenter, Australian Diabetes Educator Association
2012
Research Grants and Contracts
Years Grant Agency Chief
Investigators
2011-
2013
Children’s Health
Foundation,
Brisbane
A/Prof L
Conwell, Dr R
Greer
Title
A clinical national framework for
care of infants and children with
hyperinsulinism of infancy (HI)
Amount
$77,000
2009-
2013
Australian
Paediatric
Endocrine Group
(APEG) / Merck
Serono
A/Prof L Conwell
Characterisation of the
metabonomic profile of
adolescents with type 1 diabetes
and assessment of association
with cardiovascular risk factors.
$15,000
2009-
2013
Children’s Health
Foundation,
Brisbane / QCMRI
A/Prof L Conwell
Metabonomics, heart and blood
vessel risk in teenagers with type 1
diabetes.
$64,280
2009-
2013
Children’s Health
Foundation,
Brisbane / QCMRI
A/Prof L Conwell
Metabonomics, heart and blood
vessel risk in teenagers with type 1
diabetes.
$21,000
2011-
ongoing
Juvenile Diabetes
Research
Foundation
A/Prof L Conwell,
Prof J Batch
(Associate
Investigators)
Australasian Paediatric Endocrine
Group Clinical Trials Network
$910,463
QCMRI Scientific Report 2012 12

Years Grant Agency Chief
Investigators
2012 Royal Brisbane Prof E Duncan,
and Women’s Dr A Cotterill, A/Prof
Hospital (RBWH) L Conwell
and RBWH
Foundation
Research Project
Grant
Title
The Genetic Basis of Maturity
Onset Diabetes of the Young
Amount
$50,000
2012-
2013
University of
Queensland
Prof J Coombes, Dr
D Green, Dr L
Naylor, Prof P
Davies, A/Prof L
Conwell, S Trost
Developing a national
collaboration for the prevention
and management of childhood
obesity and exercise
$16,000
Publications
Peer Reviewed Manuscripts
1. Barrett HL, Dekker Nitert M, Conwell LS, Callaway LK. Probiotics for preventing
gestational diabetes (Protocol). Cochrane Database of Systematic Reviews 2012, Issue
7. Art. No.: CD009951. DOI: 10.1002/14651858.CD009951.
2. Conwell LS, Chang AB. Bisphosphonates for osteoporosis in people with cystic fibrosis.
Cochrane Database Syst Rev. 2012 Apr 18;4:CD002010. doi:
10.1002/14651858.CD002010.pub3. Review.
3. Greer RM, Portelli SL, Hung BS, Cleghorn GJ, McMahon SK, Batch JA, Conwell LS. Serum
vitamin D levels are lower I Australia children and adolescents with type 1 diabetes
than in children without diabetes. Pediatr Diabetes 2012 Aug 23. doi: 10.1111/j.1399-
5448.2012.00890.x. [Epub ahead of print]
4. Maon S, Edirippulige S, Ware R, Batch J. The use of web-based interventions to
prevent excessive weight gain. Journal of Telemedicine And Telecare, 2012; 18(1): 37-
41.
Book Chapters
1. McMahon S (2012). “Growth and Variations of Growth” in Practical Paediatrics
Seventh Edition. M South, D Isaacs (Editors).
2. McMahon S, Kecskes Z (2012). “Maternal Thyroid Disease” in Antenatal Consuls, A
Guide for Neonatologists and Paediatricians. MW Davies, GT Inglis, LA Jardine, PJ
Koorts (Editors).
QCMRI Scientific Report 2012 13

Staff Profile
Name
Prof Jennifer Batch
A/Prof Louise Conwell
Dr Sarah McMahon
Dr Diane Jensen
Dr Ristan Greer
Dr Amanda Scott
Carol Willis
Helen Kearney
Karen Shann
Jennifer La Cour
Position
Staff Endocrinologist
Staff Endocrinologist
Staff Endocrinologist
Research Fellow
Senior Research Fellow
Clinical Fellow
Data Manager
Clinical Nurse Consultant
Clinical Nurse
Clinical Nurse
Our Students
Research Degrees Ongoing
Name Supervisors Degree
Dr Diane Jensen
Prof JA Batch
Prof H Truby
A/Prof N King
PhD
Ms Siti Maon
Dr Stephanie Johnson
Dr S Edirippulige
A/Prof R Ware
Prof JA Batch
A/Prof E Duncan
A/Prof LS Conwell
Dr M Harris
PhD
PhD
QCMRI Scientific Report 2012 14

National and International Collaborators
Congenital Hyperinsulinism Clinical and Research Programme
Department of Endocrinology and Diabetes, Mater Children’s Hospital, Brisbane
‣ A/Prof Andrew Cotterill, Director, Staff Endocrinologist
‣ Dr Mark Harris, Staff Endocrinologist
Departments of Surgery, Royal and Mater Children’s Hospital, Brisbane
‣ Dr Rosslyn Walker, Executive Director of Surgical Division, RCH
‣ Dr Kelvin Choo, Paediatric Surgeon
Department of Nuclear Medicine, Radioisotope Laboratory, Queensland PET Service, Royal
Brisbane and Women’s Hospital
‣ Prof David McFarlane and Dr Frank Fiumara, Nuclear Medicine Physicians
‣ Louise Campbell, Director PET Technology / Deputy Director Nuclear Medicine
Technology
‣ Damion Stimson and Dr Matthew Griffiths
Department of Pathology, Mater Health Services, Brisbane
‣ Dr David Cowley, Director of Chemical Pathology
‣ Ivan McGown, Supervising Scientist, Molecular Genetics
Department of Endocrinology, Royal Brisbane and Women’s Hospital; UQ Centre for Clinical
Research; UQ Diamantina Institute
‣ A/Prof Emma Duncan, Staff Endocrinologist
Evidence Based Medicine / Systematic Reviews
Mothers and Babies Research Group, Royal Brisbane and Women’s Hospital
‣ Dr Helen Barrett, Dr Marloes Dekker Nitert and A/Prof Leonie Callaway
University of Limerick and Limerick Regional Hospital
‣ Professor Clodagh O’Gorman, Professor of Paediatrics and Consultant Paediatrician
Eat Smart Adolescent Obesity Research Programme
‣ Professor Helen Truby, Dietetics and Nutrition, Monash University
‣ A/Prof R Ware, QCMRI
‣ A/Prof Neil King, QUT
‣ Dr S Edirippulige, Centre for Online Health, UQ
QCMRI Scientific Report 2012 15

Research Group Contact Details
Department of Endocrinology and Diabetes
Royal Children’s Hospital
Herston Rd, Herston
Brisbane, QLD 4029
p: (07) 3636 5492
f: (07) 3636 9102
QCMRI Website:
http://www.qcmri.org.au/Research/TheDevelopingBrain,GrowthandaHealthyStartt/Endocrin
ologyandDiabetesResearchGroup.aspx
QCMRI Scientific Report 2012 16

Feeding and Developmental Therapies Group
The Feeding and Developmental Therapies group is a multi-disciplinary group focusing on
two main areas of research: Therapy options for children with feeding difficulties, as well as
the use of telehealth to provide therapy services to sick children at home. All team
members hold clinical positions at the Royal Children’s Hospital or Mater Children’s Hospital.
The past year has seen team members present at a number of national and international
conferences. Group leader, Dr Pamela Dodrill, has also been an invited key note speaker at
two international conferences in the United States. The group hosted a number of
workshops for paediatric health professionals in 2012, with over 600 clinicians from across
Australia and New Zealand attending.
Research Activities and Achievements
Keynote addresses at international conferences
‣ Dodrill P. Management of feeding difficulties in preterm neonates: Using plasticity to
drive function. Dysphagia Research Society Meeting. Toronto, March 2012
‣ Dodrill P. Managing early feeding difficulties: Getting it right for later life. Feeding
Disturbances Conference. Phoenix, January 2012.
Research Grants and Contracts
Years Grant Agency Chief
Investigators
2012-
2013
Australia New
Zealand Children’s
Haematology and
Oncology Group
Dr P Dodrill,
Ms O Taylor,
Dr N Armfield,
A/Prof A Smith,
A/Prof A
Hallahan
Title
Telehealth Therapy: Delivering
therapy services to children with
cancer via telehealth
Amount
$30,000
2011 -
2013
QCMRI/ Children’s
Health Foundation
Dr P Dodrill
Clinical PhD Scholarship,
Ms J Marshall
$122,500
2013 QCMRI/ Children’s
Health Foundation
Dr P Dodrill
QCMRI Allied Health Near Miss
Grant
$15,000
QCMRI Scientific Report 2012 17

Publications
Peer Reviewed Manuscript
1. Morgan AT, Dodrill P, Ward EC. Interventions for oropharyngeal dysphagia in children with
neurological impairment. Cochrane Database Syst Rev. 2012 Oct 17;10:CD009456.
2. Marshall J, Hill R, Dodrill P. A survey of practice for clinicians working with children
with autism spectrum disorders and feeding difficulties. International Journal of
Speech-Language Pathology, 2012 (in press).
3. Marshall J, Hill R, Ziviani J, Dodrill P. Features of feeding difficulty in children with
autism spectrum disorders: A review. International Journal of Speech-Language
Pathology, 2012 (in press).
Staff Profile
Name
Dr Pamela Dodrill
Nadine Frederiksen
Kahli Sanders
Position
Honorary Appointment
Project Officer
Project Officer
Our Students
Research Degrees Ongoing
Name Supervisors Degree
Jeanne Marshall
Pamela Dodrill, Rebecca Hill, PhD
Jenny Ziviani
Jane Morgan
Olivia Taylor
Pamela Dodrill, Peter
Frederiksen
Pamela Dodrill, Anthony
Smith, Andrew Hallahan
PhD
MPhil
QCMRI Scientific Report 2012 18

Community and Professional Activities
Teaching/ training
‣ Dodrill P. The basics of pediatric feeding. Labonheur Children’s Hospital, Memphis,
September 2012.
‣ Dodrill P. Topical issues in pediatric feeding. Labonheur Children’s Hospital, Memphis,
September 2012.
‣ Dodrill P. Advances in neonatal feeding. Tuffs University, Boston, October 2012.
‣ Dodrill P. Paediatric feeding management. University of Canterbury, April 2012.
‣ Dodrill P. Managing feeding in medically complex infants - advanced practice for
experienced clinicians. University of Canterbury, April 2012.
‣ Dodrill P. Management of childhood feeding difficulties. Nestle Nutrition Update, April
2012.
‣ Dodrill P. Special Feeding Equipment. RCH Paediatric Nurse Education Program, July 2012.
‣ Dodrill P. Feeding the high-risk neonate. RBWH Neonatal Nurse Education Program,
March, June, September, December 2012.
Hosting of national/ international workshops
‣ Dr Kay Toomey and Dr Erin Ross (Colorado, USA). The SOS approach to feeding.
Workshops hosted by Dr Pamela Dodrill from QCMRI in Brisbane (June 2012), Sydney (July
2012), Auckland (August 2012). Over 400 practicing paediatric clinicians attended these
workshops.
‣ Dr Suzanne Evans Morris (Virginia, USA). Working with the gastrostomy dependent child
and Working with children with severe feeding disturbances. Workshops hosted by Dr
Pamela Dodrill from QCMRI in Brisbane (November 2012) and Perth (December 2012).
Over 200 practicing paediatric clinicians attended these workshops.
Research Group Contact Details
Healthy Eating Learning Program (HELP) Study
QCMRI
Level 4, RCH Foundation Building
Royal Children’s Hospital
Herston Queensland 4029
p: (07) 3636 6100
e: helpstudy@uq.edu.au
QCMRI Website:
http://www.qcmri.org.au/Research/TheDevelopingBrain,GrowthandaHealthyStartt/Healthy
EatingLearningProgram.aspx
QCMRI Scientific Report 2012 19

QCMRI Scientific Report 2011 40

Cough, Asthma and Airways Research Group
2012 commenced as a busy year for the Cough, Asthma and Airways Research Group
(CAARG). Late in 2011 we were pleased to learn that a number of Investigators in the
CAARG team had been successful in the NHMRC 2012 grant round, and this year we were
able to commence several exciting new projects in the field of cough, asthma and airway
disorders in children. The majority of these studies are multi-centre studies being conducted
across Australia, continuing our strong collaborations with respiratory centres and clinical
trialists both nationally and internationally.
The major achievement for the CAARG team in 2012 was the announcement of a successful
grant through the NHMRC Centre of Research Excellence scheme. The Centre of Research
Excellence (CRE) scheme provides funding to establish collaborative research centres to
pursue research excellence and develop capacity in clinical, population health and health
services research. The successful grant that CAARG received, in conjunction with Menzies
School of Health Research, will establish the CRE in Respiratory Health of Aboriginal and
Torres Strait Islander Children.
CAARG researchers Professor Anne Chang, Dr Danielle Wurzel, Dr Nitin Kapur, Sophie
Anderson-James and Carol Willis attended and presented research findings at the annual
scientific meeting of the Thoracic Society of Australia and New Zealand, held in Canberra in
April 2012.
Three new research projects commenced in 2012:
‣ A randomised, placebo-controlled trial of oral antibiotics for treatment of mild and
moderate exacerbations in children with non-CF Bronchiectasis
‣ A prospective, observational cohort study examining the costs (direct and in-direct)
associated with non-CF bronchiectasis
‣ A study to validate a 16-item questionnaire measuring the quality of life of children
with chronic cough
Our projects in the areas of protracted bacterial bronchitis and bronchoscopy, acute cough
quality of life, and trials of inhaled steroids for treatment of acute and chronic cough have
continued throughout 2012.
We have maintained our successful partnership with the RCH Department of Emergency
Medicine (EM+RRG: Emergency Medicine + Respiratory Research Group), with a high level of
collaboration between the CAARG team and the Paediatric Emergency Research Unit (PERU)
on a number of studies centring around cough, which remains one of the most common
causes of childhood medical presentations in Australia. Similarly, the many of our studies
continue to involve the substantial contribution of the Queensland Paediatric Infectious
Diseases Laboratory (QPID).
QCMRI Scientific Report 2012 21

Awards & Achievements
‣ Helen Petksy (PhD candidate) was awarded Best Oral presentation (late candidature)
at the QCMRI student expo
‣ Danielle Wurzel (PhD candidate) was awarded Best Poster presentation (late
candidature) at the QCMRI student expo, and a NHMRC Postgraduate Scholarship
‣ Stacey Spencer (CAARG staff member) was awarded a full-fee scholarship from
University of Southern Queensland for continuation of her Bachelor of Health Science
studies
‣ Emily Bailey (MPhil candidate) was awarded an APSR Travel Scholarship to attend
Hong Kong conference in December 2012.
Research Grants and Contracts
Years
2009-
2013
Grant
Agency
NHMRC
Grant #
545216
Chief Investigators Title Amount
AB Chang NHMRC Practitioner Fellowship $505,000
2010-
2015
QCMRI AB Chang, J Acworth Qld Children’s Medical
Research Institute Centre for
Excellence program grant.
$2,250,000
2012 -
2016
NHMRC
AB Chang, N Brown,
EK Mulholland, KA
O’Grady, K Grimwood,
PS Morris, AJ Leach,
JW Upham,PJ Torzillo,
H D’Antoine
Centre of Research Excellence
in Lung Health of Aboriginal
and Torres Strait Islander
Children
$2,490,000
2012-
2014
NHMRC
AB Chang, P Morris, C
Robertson, K
Grimwood, P Van
Asperen, A Wilson, KA
O'Grady, TP Sloots, PJ
Torzillo
Multicentre randomised
controlled trial to improve the
management of exacerbations
in children with bronchiectasis
$1,148,522
2009-
2012
NHMRC
D Thomas, V Johnston,
N Brown, AB Chang, C
Segan
A randomised controlled trial of
a family tobacco control
program to reduce respiratory
illness in Indigenous infants
$1,100,875
QCMRI Scientific Report 2012 22

Years
2010-
2012
Grant
Agency
NHMRC
Chief Investigators Title Amount
AB Chang, PS Morris, K
Grimwood, T Sloots, A
White, C Maclennan
Randomised controlled trial of
Azithromycin to reduce the
morbidity of severe
bronchiolitis in Indigenous
infants
$1,407,075
2012-
2014
NHMRC
H Smith-Vaughan, A
Cheng, AB Chang, I
Mackay, PJ Torzillo, D
Wurzel
Identifying the microbiological
risk factors for acute lower
respiratory infection in
Indigenous children to inform
future intervention strategies
$ 479,734
Publications
Peer Reviewed Manuscripts
1. Goyal V, Masters IB, Chang AB. Interventions for primary (intrinsic) tracheomalacia in
children. Cochrane Database Syst Rev. 2012 Oct 17;10:CD005304.
2. Weir K, McMahon S, Chang AB. Restriction of oral intake of water for aspiration lung
disease in children. Cochrane Database Syst Rev. 2012 Sep 12;9:CD005303.
3. Mulholland S, Gavranich JB, Gillies MB, Chang AB. Antibiotics for community-acquired
lower respiratory tract infections secondary to Mycoplasma pneumoniae in children.
Cochrane Database Syst Rev. 2012 Sep 12;9:CD004875.
4. McCallum GB, Morris PS, Wilson CC, Versteegh LA, Ward LM, Chatfield MD, Chang AB.
Severity scoring systems: Are they internally valid, reliable and predictive of oxygen
use in children with acute bronchiolitis? Pediatr Pulmonol. 2012 Sep 4.[Epub ahead of
print]
5. Chang AB, Grimwood K, Robertson CF, Wilson AC, van Asperen PP, O'Grady KA, Sloots
TP, Torzillo PJ, Bailey EJ, McCallum GB, Masters IB, Byrnes CA, Chatfield MD, Buntain
HM, Mackay IM, Morris PS. Antibiotics for bronchiectasis exacerbations in children:
rationale and study protocol for a randomised placebo-controlled trial. Trials. 2012
Aug 31;13:156.
6. Carson KV, Brinn MP, Labiszewski NA, Peters M, Chang AB, Veale A, Esterman AJ,
Smith BJ. Interventions for tobacco use prevention in Indigenous youth. Cochrane
Database Syst Rev. 2012 Aug 15;8:CD009325.
7. Bonifant CM, Shevill E, Chang AB. Vitamin A supplementation for cystic fibrosis.
Cochrane Database Syst Rev. 2012 Aug 15;8:CD006751.
8. Valery PC, Morris PS, Grimwood K, Torzillo PJ, Byrnes CA, Masters IB, Bauert PA,
McCallum GB, Mobberly C, Chang AB. Azithromycin for Indigenous children with
QCMRI Scientific Report 2012 23

onchiectasis: study protocol for a multi-centre randomized controlled trial. BMC
Pediatr. 2012 Aug 14;12:122.
9. Hare KM, Leach AJ, Morris PS, Smith-Vaughan H, Torzillo P, Bauert P, Cheng AC,
McDonald MI, Brown N, Chang AB, Grimwood K. Impact of recent antibiotics on
nasopharyngeal carriage and lower airway infection in Indigenous Australian children
with non-cystic fibrosis bronchiectasis. Int J Antimicrob Agents. 2012 Oct;40(4):365-9.
Epub 2012 Jul 20.
10. Chang AB, Marsh RL, Smith-Vaughan HC, Hoffman LR. Emerging drugs for
bronchiectasis. Expert Opin Emerg Drugs. 2012 Sep;17(3):361-78. Epub 2012 Jul 19.
11. Marchant J, Masters IB, Champion A, Petsky H, Chang AB. Randomised controlled trial
of amoxycillin clavulanate in children with chronic wet cough. Thorax. 2012
Aug;67(8):689-93. Epub 2012 May 24.
12. Chang AB, Yerkovich ST, Gibson PG, Anderson-James S, Petsky HL, Carroll ML, Masters
IB, Marchant JM, Wurzel D, Upham JW. Pulmonary innate immunity in children with
protracted bacterial bronchitis. J Pediatr. 2012 Oct;161(4):621-5.e1. Epub 2012 May 9.
13. Hare KM, Binks MJ, Grimwood K, Chang AB, Leach AJ, Smith-Vaughan H. Culture and
PCR detection of Haemophilus influenzae and Haemophilus haemolyticus in Australian
Indigenous children with bronchiectasis. J Clin Microbiol. 2012 Jul;50(7):2444-5. Epub
2012 May 2.
14. Ferguson JH, Chang AB. Vitamin D supplementation for cystic fibrosis. Cochrane
Database Syst Rev. 2012 Apr 18;4:CD007298.
15. Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB. Anticholinergic
therapy for acute asthma in children. Cochrane Database Syst Rev. 2012 Apr
18;4:CD003797.
16. Conwell LS, Chang AB. Bisphosphonates for osteoporosis in people with cystic fibrosis.
Cochrane Database Syst Rev. 2012 Apr 18;4:CD002010.
17. Chang AB, Robertson CF, Van Asperen PP, Glasgow NJ, Mellis CM, Masters IB, Teoh L,
Tjhung I, Morris PS, Petsky HL, Willis C, Landau LI. A multicenter study on chronic
cough in children : burden and etiologies based on a standardized management
pathway. Chest. 2012 Oct;142(4):943-50.
18. Yerkovich ST, Chang AB, Carroll ML, Petsky HL, Scrivener G, Upham JW. Soluble
receptor for advanced glycation end products (sRAGE) is present at high
concentrations in the lungs of children and varies with age and the pattern of lung
inflammation. Respirology. 2012 Jul;17(5):841-6.
19. Burgess C, Masters IB, Francis P, Grimwood K, Chang AB. Flexible bronchoscopy in
managing a child with pulmonary hydatid disease. Pediatr Pulmonol. 2012
Nov;47(11):1140-2. Epub 2012 Mar 19.
20. Newcombe PA, Dunn TL, Casey LM, Sheffield JK, Petsky H, Anderson-James S, Chang
AB. Breathe Easier Online: evaluation of a randomized controlled pilot trial of an
Internet-based intervention to improve well-being in children and adolescents with a
chronic respiratory condition. J Med Internet Res. 2012 Feb 8;14(1):e23.
QCMRI Scientific Report 2012 24

21. Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough
as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane
Database Syst Rev. 2012 Feb 15;2:CD006088.
22. Dunn TL, Casey LM, Sheffield J, Newcombe P, Chang AB. Dropout from computerbased
interventions for children and adolescents with chronic health conditions. J
Health Psychol. 2012 Apr;17(3):429-42.
23. Kapur N, Grimwood K, Masters IB, Morris PS, Chang AB. Lower airway microbiology
and cellularity in children with newly diagnosed non-CF bronchiectasis. Pediatr
Pulmonol. 2012 Mar;47(3):300-7.
24. Kapur N, Masters IB, Newcombe P, Chang AB. The burden of disease in pediatric noncystic
fibrosis bronchiectasis. Chest. 2012 Apr;141(4):1018-24.
25. Kapur N, Masters IB, Morris PS, Galligan J, Ware R, Chang AB. Defining pulmonary
exacerbation in children with non-cystic fibrosis bronchiectasis. Pediatr Pulmonol.
2012 Jan;47(1):68-75.
26. O'Grady KA, Torzillo PJ, Ruben AR, Taylor-Thomson D, Valery PC, Chang AB.
Identification of radiological alveolar pneumonia in children with high rates of
hospitalized respiratory infections: comparison of WHO-defined and pediatric
pulmonologist diagnosis in the clinical context. Pediatr Pulmonol. 2012 Apr;47(4):386-
92.
27. Petsky HL, Cates CJ, Lasserson TJ, Li AM, Turner C, Kynaston JA, Chang AB. A systematic
review and meta-analysis: tailoring asthma treatment on eosinophilic markers
(exhaled nitric oxide or sputum eosinophils). Thorax. 2012 Mar;67(3):199-208.
28. Sanchez MO, Greer MC, Masters IB, Chang AB. A comparison of fluoroscopic airway
screening with flexible bronchoscopy for diagnosing tracheomalacia. Pediatr Pulmonol.
2012 Jan;47(1):63-7.
Book Chapters
1. Buntain H, Chang AB. Chapter 13: Vitamin D and Cystic Fibrosis. In: Litonjua A (ed).
Vitamin D and the Lung: Mechanisms and Disease Associations. Humana Press/Springer.
In press: scheduled publication date: 30 June 2012.
2. Chang AB, Redding GJ. Bronchiectasis. In: Kendig's disorders of the respiratory tract in
children. V Chernick, TF Boat, eds. 8th edn. Philadelphia:W.B. Saunders: in press,
scheduled publication date 13 April 2012.
3. Chang AB. Bronchitis. In: Kendig's disorders of the respiratory tract in children. V
Chernick, TF Boat, eds. 8th edn. Philadelphia:W.B. Saunders: in press, scheduled
publication date 13 April 2012.
QCMRI Scientific Report 2012 25

Staff Profile
Name
Prof Anne Chang
A/Prof Brent Masters
Dr Julie Marchant
Dr Helen Buntain
Dr Danielle Wurzel
Dr Nitin Kapur
Ms Sophie Anderson-James
Ms Carol Willis
Ms Stacey Spencer
Ms Joanne Tuppin
Ms Helen Petsky
Ms Emily Bailey
Position
Group Director
Paediatric Respiratory and Sleep Physician
Paediatric Respiratory and Sleep Physician
Post doctoral Fellow
Senior Lecturer
Paediatric Respiratory VMO
Paediatric Respiratory Physician
Respiratory Fellow
PhD Candidate
Respiratory Fellow
Project Coordinator
PhD Candidate
Project Manager
Administration Officer
Study Coordinator
Study Coordinator (part time)
PhD Candidate
Study Coordinator (part time)
MPhil Candidate
Our Students
Research Degrees Ongoing
Name Supervisors Degree
Kelly Weir
A Chang
PhD
S McMahon
Helen Petsky
Simon Wilson
A Chang
C Turner
A Kynaston
B Lovell
A Chang
I Masters
PhD
PhD
QCMRI Scientific Report 2012 26

Danielle Wurzel
Sophie Anderson-James
Thuy Frakking
Vikas Goyal
A Chang
J Upham
S Yerkovich
I Masters
J Marchant
A Chang
J Marchant
K O’Grady
C Turner
A Chang
K O’Grady
K Weir
A Chang
IB Masters
K Grimwood
J Marchant
PhD
PhD
PhD
PhD
National and International Collaborators
‣ Child Health Group of Menzies School of Health Research (A/Prof Peter Morris, A/Prof
Amanda Leach, Dr Heidi Vaughan-Smith)
‣ Prof John Upham, Princess Alexandra Hospital and University of Queensland
‣ Prof Albert Li, Prince of Wales Hospital and Chinese University of Hong Kong
‣ Prof Peter Gibson, John Hunter Hospital, Newcastle
‣ Assoc/Prof Peter Newcombe and Dr Jeanie Sheffield, School of Psychology and
Behavioural Sciences, University of Queensland
‣ Dr Jason Acworth and Dr Natalie Philips, Dept of Emergency Medicine, Royal Children’s
Hospital (QCMRI Paediatric Emergency Research Unit – PERU)
‣ Menzies School of Health Research, Child Health Division (Prof Anne Chang holds joint
appointment).
‣ Prof Paul Torzillo – Royal Prince Alfred Hospital, the University of Sydney and the
Nganampa Health Service
‣ Dr Stephanie Yerkovich, Lung Transplant Unit, The Prince Charles Hospital
‣ Queensland Health Statewide Respiratory Clinical Network
‣ Department of Thoracic Medicine, The Prince Charles Hospital
‣ Australian Lung Foundation
‣ Prof Greg Redding, A/Prof Lucas Hoffman, Seattle Children’s Hospital
‣ Dr Catherine Byrnes, Starlight Children’s Hospital, NZ
QCMRI Scientific Report 2012 27

Research Group Contact Details
Queensland Children’s Respiratory Centre
Royal Children’s Hospital
Herston Road, Herston
Queensland 4029
p: (07) 3636 9149
f: (07) 3636 1958
e: anne_b_chang@health.qld.gov.au
QCMRI Website:
http://www.qcmri.org.au/Research/Infection,InflammationandtheEnvironment/CoughandA
sthmaResearchGroup(CAARG).aspx
QCMRI Scientific Report 2012 28

Respiratory infection Outreach and Research Team
OVERVIEW
The Respiratory infection Outreach and Research (RiOAR) Team is a new group established
in QCMRI in 2012 under the leadership of Dr Kerry-Ann O’Grady. RiOAR is a subgroup of the
Cough, Asthma and Airways Research Group led by Professor Anne Chang and the two
teams work closely together on a number of projects.
RiOAR’s research focus is acute respiratory infections in children with an emphasis on
epidemiology, clinical outcomes and prevention at the primary and secondary levels. A major
component is acute respiratory illnesses in Aboriginal and Torres Strait Islander children with
capacity building of Aboriginal and Torres Strait Islander health professionals in research.
The year has been dedicated to establishing the group and a number of large research projects.
An exciting initiative has been the establishment of an Indigenous Research Reference Group to
oversee the team’s research with Aboriginal and Torres Strait Islander peoples.
Figure 1. Indigenous Representation of the RiOAR Team’s Goals and Objectives. Artist: Indala
(Mrs Linda Medlin)
QCMRI Scientific Report 2012 29

Research Activities and Achievements
ED Cough Study: The ED Cough Study is a cohort study of children aged less than 15 years
attending the Royal Children’s Hospital Emergency Department with a respiratory illness that
has cough as a symptom. It aims to explore the predictors and outcomes of acute respiratory
illness in children and the development of chronic cough over the four weeks post presentation.
The study is being conducted in partnership with the Departments of Respiratory Medicine and
Emergency Medicine at the Royal Children’s Hospital Brisbane and the Queensland Paediatric
Infectious Diseases Laboratory.
TLSiMKids Study (Tooth and Lung Sickness in Murri Kids): TLSiMKids is a cohort study of urban
Aboriginal and Torres Strait Islander children in Brisbane registered with an Indigenous specific
primary health care service. It aims to comprehensively explore the incidence, predictors and
outcomes of acute respiratory illness and dental disease, including clinical, epidemiological,
microbiological, social, cultural and economic factors. In addition, Indigenous methodologies are
being employed to explore risk and impact from an Indigenous perspective. The study is being
conducted in partnership with Murri Health Group, the Department of Respiratory Medicine at
the Royal Children’s Hospital Brisbane, the Poche Centre for Indigenous Health at the University
of Sydney and the Queensland Paediatric Infectious Diseases Laboratory.
Figure 2: Indigenous Representation of TLSiMKids. Artist: Indala (Mrs Linda Medlin)
CHiRRP: Combating Haemophilus influenzae related respiratory pathology: CHiRRP is a multicentre,
double blind randomised controlled trial that aims to determine the efficacy of a 10-
valent pneumococcal-Protein D conjugate vaccine in preventing respiratory exacerbations (flareups)
in children with bronchiectasis, chronic suppuratives lung disease and recurrent protracted
QCMRI Scientific Report 2012 30

acterial bronchitis. The study is being conducted in partnership with the University of Sydney,
the University of Western Australia, Griffith University and Menzies School of Health Research.
FluMum: Influenza vaccine in pregnancy and the benefit to infants: FluMum is a national
cohort study that aims to determine whether the infants of mothers who received influenza
vaccine in pregnancy as less likely to get influenza infection in the first six months of life
compared to the infants of mothers who were not vaccinated. Nationally, the study aims to
recruit over 10,000 women from Darwin, Brisbane, Sydney, Melbourne, Adelaide and Perth over
a four year period. The study is being conducted in partnership with the Menzies School of
Health Research, the University of Sydney, Melbourne University, the University of Adelaide and
the University of Western Australia. The RiOAR team hosts the National Study Coordinator and
has played a major role in national data management.
IROC: Indigenous Respiratory Outreach Care: IROC is an initiative of Queensland Health’s
Statewide Respiratory Clinical Network and aims to deliver and evaluate specialist respiratory
clinical services to rural and remote Aboriginal and Torres Strait Islander communities in
Queensland. Dr O’Grady and Linda Medlin have both played a major role in the implementation
of the service and Linda continues to serve on the IROC Governance Group
Figure 3: IROC Artwork. Artist: Indala (Mrs Linda Medlin)
AKAPRI: Aboriginal Knowledge, Attitudes and Perceptions of Respiratory Illnesses. AKAPRI
aims to determine whether IROC is impacting on knowledge, attitudes and perceptions of
respiratory illnesses, with a particular emphasis on evaluating the service from within an
Indigenous framework using Indigenous methodologies. The study is comparing two rural and
remote communities in Queensland, one receiving IROC and one that has had no specialist
respiratory services.
QCMRI Scientific Report 2012 31

Figure 4: AKAPRI Artwork. Artist: Indala (Mrs Linda Medlin)
Indigenous Research Reference Group (IRRG)
The RiOAR Team’s IRRG was established in 2012 and its members include Senior Aboriginal
and/or Torres Strait Islander Research Fellows, Aboriginal clinicians, Traditional Owners of the
Brisbane region, Aboriginal and Torres Strait Islander elders and other community members.
The Group meets quarterly and its aim is to ensure the cultural integrity and safety of our
research, support our Aboriginal and Torres Strait Islander higher research degree candidates
and act as an important conduit for consultation and feedback with Aboriginal and Torres Strait
Islander communities in Brisbane. The IRRG is chaired by Dr Janet Hammill from the UQ Centre
for Clinical Research.
Awards
‣ O’Grady KF. The University of Queensland Foundation Research Excellence Award
‣ Medlin LM.
QCMRI Student Expo Best Early Candidate Poster Presentation
QCMRI Scientific Report 2012 32

Years Grant Agency Chief
Investigators
2012 - 2014 NHMRC Project Grant O’Grady KF, Chang
AB, Grimwood K,
Morris P,
Mulholland EK,
Torzillo PJ, Cripps
A, Woods N,
Smith-Vaughan H,
Revell A
2012 – 2016 NHMRC Project Grant Andrews RM,
O’Grady KF, Nolan
T, Lambert SB,
Woods N,
Marshall H,
Richmond P,
Chatfield M
Title
Reducing
respiratory
exacerbations in
children with
suppurative lung
disease by
vaccination
against
Haemophilus
influenzae
FluMum: Influenza
vaccine in
pregnancy and the
benefits to infants
Amount
$1,122,500
$2,281,065
2012 – 2014 Queensland
Government/Queensl
and Children’s Health
Foundation Smart
Futures Fellowship
O’Grady KF
Lung Sickness in
Murri Kids: what’s
the story?
$360,000
2012 - 2014 Queensland Children’s
Health Foundation
(QCMRI Project Grant)
O’Grady KF, Chang
AB, Sloots TP,
Otim M.
The
epidemiology,
aetiology &
outcomes of
respiratory
illnesses in urban
Indigenous
children
$195,000
2012-2013 The University of
Queensland
Foundation Research
Excellence Award
O’Grady KF
Respiratory
illnesses in
urban Aboriginal
and Torres Strait
Islander children
$77,000
2009 - 2012 NHMRC Post-Doctoral
Training Fellowship in
Aboriginal and Torres
Strait Islander Health
O’Grady KF
The aetiology and
prevention of
pneumonia in
Indigenous
children in
Northern
Australia.
$283,500
2012 – 2014 QCMRI (QCHF) Clinical
PhD Scholarship
Bell, AM
Lung Sickness in
Murri Kids: our
story
$120,000
QCMRI Scientific Report 2012 33

Research Publications
Full Peer Reviewed Manuscripts
O’Grady KF, Torzillo PJ, Taylor-Thomson D, Ruben A, Valery P, Chang AB. Identification of
radiological alveolar pneumonia in children with high rates of hospitalized respiratory
infections: Comparison of WHO-defined and pediatric pulmonologist diagnosis in the clinical
context. Pediatr Pulmon. 2012 Apr;47(4):386-92
Chang AB, Grimwood K, Robertson CF, Wilson AC, van Asperen PP, O'Grady KF, Sloots TP,
Torzillo PJ, Bailey EJ, McCallum GB, Masters IB, Byrnes CA, Chatfield MD, Buntain HM, Mackay
IM, Morris PS. Antibiotics for bronchiectasis exacerbations in children: rationale and study
protocol for a randomised placebo-controlled trial. Trials. 2012 Aug 31;13:156. doi:
10.1186/1745-6215-13-156
Staff Profile
Name
Dr Kerry-Ann O’Grady
Mr Ben Arnold
Ms Lisa Mulhearn
Ms Sheree Rablin
Ms Sallyanne Le Gros-Wilson
Ms Kerry Hall
Mr Ben Drescher
Dr Vikas Goyal
Ms Jennifer Waldstett
Ms Laura Rehner
Position
Senior Research Fellow
Research Assistant
FluMum National Study Coordinator
CHiRRP National Study Coordinator
Research Officer
Research Officer
Research Officer
Study Doctor
UQ Summer Research Scholar
UQ Summer Research Scholar
QCMRI Scientific Report 2012 34

Our Students
Research Degrees On-going
Name Supervisors Degree
Linda Medlin
O’Grady KF, Chang AB,
Toombs M, Brown A.
Aboriginal knowledge,
attitudes and perceptions of
respiratory illnesses
Anna Bell
Ben Drescher
O’Grady KF, Chang AB,
Newcombe P, Morseu-Diop N.
O’Grady KF, Chang AB,
Lambert SB, Bogassian F, Otim
M.
Lung Sickness in Murri Kids:
Our Story
Chronic cough amongst
children presenting to a
paediatric emergency
department
Community and Professional Activities
Dr O’Grady continued to coordinate and teach the QCMRI Research Education and Training
Series with Dr Robert Ware throughout 2012, including the QCMRI Student Expo. She was a
member of the QCMRI Director’s Advisory Committee and the QCMRI Higher Research Degree
Student Committee, and is on the Leadership Group of the Centre for Research Excellence for
Lung Health of Aboriginal and Torres Strait Islander Children led by Professor Chang.
Several of our staff and students have been active in community engagement activities in
the Aboriginal and Torres Strait Islander community in Brisbane, including major promotion
of respiratory health during NAIDOC week. Linda Medlin is a member of the Governance
Group for the Queensland Health Statewide Respiratory Clinical Network’s Indigenous
Respiratory Outreach Care program.
QCMRI Scientific Report 2012 35

Major Partners
‣ The National Centre for Immunisation Research and Surveillance, the University of
Sydney
‣ The Children’s Hospital, Westmead, NSW
‣ Princess Margaret Hospital for Children, Perth, WA
‣ Vaccine & Immunisation Research Group, Melbourne University and Murdoch Children’s
Medical Research Institute
‣ Griffith University
‣ Telethon Institute for Child Health Research, University of Western Australia
‣ Menzies School of Health Research, Charles Darwin University, Northern Territory
‣ Murri Health Group, Caboolture, QLD
‣ Queensland Paediatric Infectious Diseases Laboratory and Sir Albert Saczewski Virus
Research Centre, Herston, QLD
‣ Royal Children’s Hospital, Brisbane, QLD
‣ Royal Brisbane and Women’s Hospital, Brisbane, QLD
‣ Mater Women’s Hospital, South Brisbane, QLD
‣ Mater Redlands Hospital, Redlands, QLD
‣ NorthWest Private Hospital, Everton Hills, QLD
‣ Sunnybank Private Hospital, Sunnybank, QLD
‣ Redlands Hospital, Redlands, QLD
‣ Nganampa Health Council, Anangu Pitjantjatjara Yankunytjatjara, South Australia
‣ The Prince Charles Hospital, Chermside, QLD
‣ Statewide Respiratory Clinical Network, Queensland Health, QLD
QCMRI Scientific Report 2012 36

Centre Contact Details
Respiratory infection Outreach and Research Team
Dr Kerry-Ann O’Grady
Level 2, Edith Cavell Building
Royal Brisbane & Women’s Hospital Campus
Herston QLD 4029
p: (07) 3636 1296
e: k.ogrady@uq.edu.au
QCMRI Website:
http://www.qcmri.org.au/Research/Infection,InflammationandtheEnvironment/Respiratoryi
nfectionOutreachAndResearchTeam/RiOARTheTeam.aspx
QCMRI Scientific Report 2012 37

Children’s Lung, Environment and Asthma Research (CLEAR) Group
OVERVIEW
Asthma
In Australia, asthma is the most common respiratory disease and it is one of the most
frequent reasons for hospitalisations among children aged 0–4 years, especially boys.
Asthma is triggered by a number of factors including viral infections, allergy/atopy and
environmental exposures, but don’t know exactly how it works at a cell level.
Understanding how asthma develops
With collaboration with the RAINE group in Perth we were able to conduct some analyses in
2012 to find out what factors in early life lead to the development of asthma. We looked at
factors like growth and environmental toxins. Mothers smoking during pregnancy and
exposing young children to cigarette smoke in the homes and in cars increase the risk of
asthma and increase the “twitchiness” of the child’s airways. Some these data were
presented at conferences in 2012, but we will publish the final results in 2013.
In 2012 we also continued our research into understanding how lung disease starts at the
cell level. In this study we take lining (epithelial) cells from children’s airways when they are
asleep for surgery by gently brushing the inside of their throat and nose. We grow these
cells in the laboratory and we see how the cells repair themselves and respond to “insults”.
These insults are things like viruses which are common in asthma and may start the process
of lung damage.
Interventions to treat asthma
In 2012 the CLEAR group began recruitment for a clinical trial called RELAX, funded by the
NH&MRC. This study uses an injectable drug called omalizumab to investigate whether it
can prevent asthma exacerbations in adolescents. This drug blocks allergy-related IgE
antibodies and should help break the cycle of interaction between allergens and viruses that
contribute to acute asthma. This study involves sites in Brisbane, Melbourne and Perth. The
study will continue recruiting in 2013 and 2014. The results of this study should be available
in 2017.
2012 also saw the beginnings of another trial to prevent asthma in infants. This study, also
funded by the NH&MRC will start recruiting in 2013. This study uses a powder called OM-85,
which is made from the outer walls of comment bacteria, is put into the drinks of infants
who are at high risk of developing asthma. We are investigating if treatment with this drug
for two winters, will prime the immune system to prevent viruses causing wheezing illnesses
and help prevent asthma from developing in early life.
Cystic fibrosis and bronchiectasis
Cystic fibrosis (CF) is a fairly common genetic condition which affects one in 2, 500 people in
Australia. CF affects many of the body’s organs, but of all the organs affected lung disease is
the most serious complication for most patients.
QCMRI Scientific Report 2012 38

Bronchiectasis is a lung disease that affects the airways, causing airway obstruction and
airway collapse. Bronchiectasis is common is CF, but it can also affect people without CF.
Understanding how lung disease works in cystic fibrosis and bronchiectasis
To understand how lung disease and bronchiectasis begins we undertook an analysis of data
collected in collaboration with the Australian Respiratory Early Surveillance Team for Cystic
Fibrosis. As part of this analysis we determined which biomarkers (cells or molecules that
cells produce) are raised in children with CF who go onto develop bronchiectasis. We found
that when markers of neutrophilic inflammation are present, the risk of developing
bronchiectasis is increased considerably. In conjunction with this study we are trying to find
other biomarkers that may be more sensitive to detecting disease. The results of these
studies will be published in 2013, with continued efforts to find new biomarker in 2013 and
beyond.
Similar to the study in asthma looking at how disease starts, we are also looking at how
bronchiectasis develops at the cell level. We grow the epithelial cells, like in the asthma
study, so that they represent what an airway might look like, and then we test to see how
the cells react and what they produce so we can find out how lung damage starts.
Interventions to prevent lung disease in cystic fibrosis
2012 saw the first participant recruited for the first national study in Australia and New
Zealand to try and prevent bronchiectasis in infants with CF. This study, COMBAT CF, is
funded through the Cystic Fibrosis Foundation Therapeutics. Infants are recruited before
they are 3 months old and are given either a drug called azithromycin or a placebo for three
years. We think that azithromycin acts by modifying neutrophilic inflammation and we hope
that this study will show this happens. This study will continue for the next four years will
results available in 2017.
Viruses and impacts on lung health
Respiratory viruses, which present as the common cold, can be a major problem for infants
and children with respiratory disease like asthma and cystic fibrosis.
The results of a study investigating viruses children with cystic fibrosis carry in the first three
years of life were finalised, with the results to be published in 2013.
In 2012 we began investigating how viruses play a role in the symptoms of children who are
admitted to hospital, and also how infections with both bacteria and viruses have an effect
on symptoms. This study is ongoing into 2013 and will continue for the next few years we
investigate the impact on symptoms, lung function, disease progression and the cells in the
lung.
Lung function in special groups
The CLEAR group, together with the Department of Respiratory Medicine at Royal Children’s
Hospital, measures lung function using specially designed equipment in infants and preschoolers.
These measurements of lung function help us better understand how the lungs
work, and help us link what is happening at the cell level to what is happening at the organ
level.
QCMRI Scientific Report 2012 39

Collaborating with oncology
This study involves a collaboration that began in 2012 between the CLEAR group and the
Oncology Department at Royal Children’s Hospital. Children with blood cancers or other
conditions who are treated with high dose chemotherapy, radiation and stem cell
transplantation may develop significant and life-threatening chronic lung diseases even after
their cancer has been cured. The aim of this project is to identify a better test of breathing
function to identify the children likely to develop problems earlier to enable earlier
treatment and better monitoring of response to treatment. This study began in 2012 and
will continue into 2013.
Lung function in children from Mexico
Collaboration between the CLEAR group and the National Institute of Public Health,
Department of Environmental Health, Mexico aimed to develop reference values for the
Forced Oscillation Technique (FOT) suitable for use in Mexican preschool aged children.
Current FOT reference ranges are based on a Caucasian population, limiting the clinical
utility of the FOT in other ethnic populations. This collaboration developed ethnic
appropriate FOT reference ranges for Mexican children and allows for the appropriate
interpretation of lung function measurements for Mexican children. These data have been
published in Spanish for use in Latin American countries.
Environmental health
How the environment affects health
Through a retrospective analysis of data from the RAINE group in Perth, in 2012 we were
able to identify associations with environmental toxins and worse health outcomes in
children. These health outcomes were related to mental health, like ADHD, and physical
health, like growth and asthma. While these results have been presented at conferences in
2012, the data will be available in 2013.
Summary of Research Activities and Achievements
The Children’s Health and Environment Program (CHEP)
In line with the (World Health Organisation) WHO Global Plan for Action for Children’s
Health CHEP aims to promote and improve children’s environmental health through
multidisciplinary research. Its terms of reference (TOR) specifically address strategies 1, 2 &
5 of the World Health Organisation (WHO) Global Plan:
CHEP TOR1: To conduct research aimed at understanding the mechanisms underlying the
development of childhood diseases of environmental origin;
CHEP TOR2: To strengthen international and intersectoral collaborative research on
children’s environmental health.
QCMRI Scientific Report 2012 40

CHEP TOR3: To Educate and raise awareness about prevention of environmental exposures
and environmentally-related diseases in children.
CHEP is administratively located within the QCMRI. The Program consists of:
‣ A Director
‣ An external Scientific Advisory Board, with representation from QCMRI, UQ Faculty of
Health Sciences and from key stakeholders
‣ Senior Centre Staff
‣ Project leaders and staff
Environmental Contributions to Burden of Disease: Rosana Norman, James Scott, Peter Sly
An important aim of the Children's Health and Environment Program is to establish a
framework for understanding the environmental contribution to burden of disease among
children in Australia. The focus is on non-communicable disease outcomes including
asthma/respiratory disease, neurodevelopmental, mental and behavioural disorders,
obesity and diabetes and childhood cancers. The research is part of a collaborative effort
with researchers at the UQ School of Population Health (Lennert Veerman) and School of
Medicine (Geoffrey Cleghorn) as well as QUT (Fiona Harden and Leisa-Maree Toms),
Menzies School of Health Research (Ross Bailie), NSW Cancer Council (Freddy Sitas) and
ENTOX (Jochen Mueller) and has included reviews on the consequences of exposure to
brominated flame retardants and on the environmental contribution to autism, childhood
cancers and obesity and diabetes. This work has already resulted in a series of publications
including an invited commentary. Other related research activities are described in more
detail below.
The long-term consequences of child maltreatment: Rosana Norman, James Scott
The project team is led by Dr Rosana Norman and also includes Dr James Scott from the
University of Queensland Centre for Clinical Research and Alexander Butchart from the
World Health Organization. The researchers reviewed all published studies that included
health outcomes for individuals who had been physically or emotionally abused or neglected
in childhood. The researchers found that individuals who had been emotionally abused as
children were about three times more likely to develop depression, while individuals who
had been physically abused or neglected were one-and-a-half to two times more likely to
develop depression than people who had not been abused or neglected. They also
established a link between anxiety disorders, drug abuse, and suicidal behaviour and
childhood abuse and found that children who had been maltreated had a higher risk of
sexually transmitted infections and risky sexual behaviour as adults than people who had
not experienced abuse. The study confirms that all forms of child maltreatment should be
considered important risks to health with a sizeable impact on major contributors to the
burden of disease in all parts of the world. This work was recently published in PLoS
Medicine. The next phase of the research aims to quantify the cost of child maltreatment
and to identify cost-effective interventions.
QCMRI Scientific Report 2012 41

Bullying in Childhood and Adolescence: Sophie Moore, Rosana Norman, James Scott
The researchers examined demographic, family and parental factors as well as childhood
characteristics from age 2 that are associated with self-reported bullying in adolescence in
the Western Australian Pregnancy Cohort (RAINE) study. Bullying was associated with family
structure, maternal mental health problems and low family income but no sex differences
were observed both in terms of risk factors for being bullied and prevalence of bullying in
adolescence. This study is one of the first to show that children with emotional and
behavioural problems as early as 2 and 5 years of age, well before bullying occurs, can be
identified as being at an increased risk of bullying in later life. The researchers are currently
working with the Raine cohort data to investigate associations between bullying (victim,
bully and bully-victim) at age 14 years and mental health outcomes at age 17 years.
Furthermore they are conducting a systematic review and meta-analysis of bullying
outcomes, aiming to summarise the evidence for associations between bullying and a broad
range of outcomes related to education, employment, mental health, physical health, and
violence and criminal behaviour. The next part of their research will focus on identifying
interventions for reducing bullying in Australian schools.
Consequences of exposure to e-waste: Kristen Grant, Fiona Goldizen, Rosana Norman,
Peter Sly
The researchers are undertaking a systematic literature review on the health impacts of e-
waste exposure. The review has examined research relating to the physical health
outcomes, mental health outcomes, educational outcomes and alterations in cellular levels
and function associated with exposure to e-waste. To our knowledge this is the first
systematic review examining the direct health impacts of e-waste exposure and will provide
valuable information on what is currently a very small body of research. The review will
serve as a component of a larger World Health Organisation project on the impacts of e-
waste exposure on children’s health and form part of the background documents for an
international expert meeting, to be attended by toxicologists, environmental chemists,
epidemiologists, paediatricians, occupational health specialists, risk assessors and policy
experts. This international project aims to assess the overall position of research and policy
by identifying exposure scenarios, identifying individual chemical components and mixtures
commonly found in e-waste, investigating proven and potential health effects and assessing
opportunities for intervention.
PhD Project of Amy Heffernan:
Supervisory team: Professors Mueller and Sly, Dr Leisa-Maree Toms
This project aims to assess the exposure of Australian infants to organic pollutants and the
relationship to body burden. Low-volume analytical methods have been developed for the
analysis of a range of environmental phenols by LCMS/MS. Urine samples have been
collected, pooled and analysed for selected age, sex and socioeconomic strata from the
Australian population. Future work will assess inter- and intra-individual variability, and
expand the suite of analytes.
QCMRI Scientific Report 2012 42

PhD Project of Yiqin Chen
Supervisors (Mueller & Sly): Assessing body burden of POPs in infants of Australia through
systematic collection and analysis of faeces. The collection, extraction, and clean-up of
faeces have been investigated. The main target compounds to date have been PCBs and
PBDEs with initial results demonstrating that these chemicals can be measured in faeces of
infants and young children. The project is collaboration between QCMRI and Entox. This
project also formed the basis for a new ARC Discovery Project.
Postdoc Project of Maria Jose Gomez Ramos.
Supervisory team: Professors Mueller & Sly.
The aim of the project is to develop fast and sensitive analytical methods for the analysis of
environmental contaminants in infants and young children. An automatic analytical method
has been developed for the analysis of 12 phthalate metabolites in urine by on-line SPE
coupled to LCMS/MS. New extraction methods are being tested for the analysis of pesticides
and other organic contaminants in mother milk.
Awards
Professor Peter Sly
‣ NHMRC Senior Principal; Research Fellowship
‣ Senior Clinical Research Fellowship
Research Grants and Contracts
Years Grant
Agency
2012 QCMRI near
miss grant
Chief Investigators Title Amount
PD Sly
Does Azithromycin prevent viral
respiratory infections in Cystic
fibrosis patients
50,000
2012 UWA-UQ
Bilateral
Research
Collaboration
Award
2012 ARC Linkage
Infrastructure
Equipment and
Facilities
PD Sly, E Fantino, SM
Stick, A Kicic
P Hugenholtz, TP
Stinear, GW Tyson, BP
Howden, MJ Walker,
RM Robins-Browne,
MA Schembri, PD Sly,
EL Hartland, JW
Moreau
The airway epithelium in paediatric
respiratory diseases
A high-throughput screening and
sequencing facility for single cell
genomics
16,300
$380,000
QCMRI Scientific Report 2012 43

2012-
2014
National Health
and Research
Council Project
Grant
PD Sly, P Holt, P
LeSouef, M Tang
Winter-only treatment with
omalizumab to prevent asthma
exacerbations in children
$718,335
2011-
2013
Australian
Research
Council
Discovery
Program
PD Sly, P Stumbles, A
Lacombe, Z Hantos, A
Kicic, D Strickland
Rhinovirus impairs physiological
and immunological lung
development and causes
exacerbation of allergic airways
disease
$550,000
2011-
2015
Cystic Fibrosis
Foundation
THERAPEUTICS
Inc
PD Sly, SM Stick, L
Saiman, H Tiddens, N
deKlerk
COMBAT CF. Multi-centre
randomized placebo-controlled
study of azithromycin in the
primary prevention of radiogicallydefined
bronchiectasis in infants
with Cystic Fibrosis
US$794,339
2010-
2015
RCHF/QCMRI
PD Sly, S Bell, C
Wainwright
Inflammatory airways disease in
children with a focus on Cystic
Fibrosis
$2,475,000
2010-
2015
The University
of Queensland
PD Sly
Children’s Health and Environment
Program
$2,403,000
2010-
2015
Centres of
Research
Excellence
(CRE) cheme
SM Stick, PD Sly, S
Ranganathan, P
Robinson, C
Robertson, G Hall, N
de Klerk, R Robins-
Browne, L Shields
Centre for research in early lung
disease
$2,495,000
Publications
Peer Reviewed Manuscripts
1. Ahanchian H, Jones CM, Chen Y, Sly PD. Respiratory viral infections in children with
asthma: do they matter and can we prevent them? BMC Pediatr. 2012;12:147
2. Busi LE, Sly PD, Restuccia S, Llancaman L. Validation of a school-based written
questionnaire for asthma case identification in Argentina. Pediatr Pulmonol 2012;47:1-7
3. Ferrari AJ, Somerville AJ, Baxter AJ, Norman R, Patten SB, Vos T, et al. Global variation
in the prevalence and incidence of major depressive disorder: a systematic review of
the epidemiological literature. Psychological Medicine 2012; 43(3):471-81.
4. Ferrari, Alize J., Saha, Sukanta, McGrath, John J., Norman, Rosana, Baxter, Amanda,
Vos, Eric Theo and Whiteford, Harvey. Health states for schizophrenia and bipolar
QCMRI Scientific Report 2012 44

disorder within the Global Burden of Disease 2010 Study. Population Health Metrics
2012; 10:16.1-16.7.
5. Garratt LW, Wright AKA, Ranganathan SC, Grigg J, Sly PD, on behalf of AREST CF. Small
macrophages are present in early childhood respiratory disease. J Cyst Fibros.
2012;11:201-208
6. Hales BJ, Chai LY, Elliot CE, Pearce LJ, Zhang G, Heinrich TK, Smith W, Kusel MM, Holt
PG, Sly PD, Thomas WR. Anti-bacterial antibody responses associated with the
development of asthma in house dust mite-sensitised and non-sensitised children.
Thorax 2012;67:321-327
7. Kimman M, Norman R, Jan S, Kingston D, Woodward M. The burden of cancer in
member countries of the Association of Southeast Asian Nations (ASEAN). Asia Pac J
Can Prev 2012; 13:411-420.
8. Kusel MH, Kebadze T, Johnston SL, Holt PG, Sly PD. Febrile respiratory illnesses in
infancy & atopy are risk factors for persistent asthma & wheeze. Eur Respir J
2012;39:876-882.
9. Lau C, Jagals P. A framework for assessing and predicting the environmental health
impact of infectious diseases: a case study of leptospirosis. Rev Environ Health
2012;27(2–3):
10. Lim, S.S, Vos, T, Norman, R et al. A comparative risk assessment of burden of disease
and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-
2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet
2012; 380: 2224-2260.
11. Liu K, Franke M, Fantino E, Sly PD. Influence Of Growth Factors And Glucocorticoids In
Media On Epithelial Cell Responses. Am J Respir Crit Care Med 185;2012:A4268
12. Mott LS, Park J, Murray CP, Gangell CL, de Klerk NH, Robinson PJ, Robertson CF,
Ranganathan SC, Sly PD, Stick SM; on behalf of AREST CF. Progression of early
structural lung disease in young children with cystic fibrosis assessed using CT. Thorax.
2012;67:509-516
13. Murray, C.J.L., Vos, T., Lozano. R, Norman, R et al. Disability-adjusted life years (DALYs)
for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the
Global Burden of Disease Study 2010. The Lancet 2012; 380: 2197-2223.
14. Norman RE, Byambaa M, De R, Butchart A, Scott J and Vos T. The long-term health
consequences of child physical abuse, emotional abuse, and neglect: a systematic
review and meta-analysis. PLoS Medicine 2012; 98 11: e1001349.1-e1001349.31.
15. Paternoster L, Standl M, Chen CM et al. Meta-analysis of genome-wide association
studies identifies three new risk loci for atopic dermatitis. Nat Genet 2012;44:187-192
16. Riedl S, Hughes I, Leong GM, Beilby J, Sly P, Choong C.GH secretagogue receptor gene
polymorphisms are associated with stature throughout childhood. Eur J Endocrinol
2012;166:1079-1085
QCMRI Scientific Report 2012 45

17. Robinson P, Schechter M, Winfield K, Smith J, Brennan S, Shinkai M, Henke M, Sly PD,
Clarithromycin therapy for patients with cystic fibrosis: a randomized controlled trial. J
Cyst Fibros. 2012;47:551-557
18. Salomon, J.A., Vos, T., Hogan, D.R., Norman, R, et al. Common values in assessing
health outcomes from disease and injury: disability weights measurement study for
the Global Burden of Disease Study 2010. The Lancet 2012; 380:2129-2143.
19. Schultz A, Sly PD, Zhang G, Venter A, Devadason SG, le Souëf PN. Usefulness of
parental response to questions about adherence to prescribed inhaled corticosteroids
in young children. Arch Dis Child. 2012;97:1092-1096
20. Schultz A, Sly PD, Zhang G, Venter A, Le Souef P, Devadason S. Incentive device
improves spacer technique but not clinical outcome in preschool children with asthma.
J Paediatr Child Health 2012;48:52-56
21. Simpson SJ, Straszek SP, Sly PD, Stick SM, Hall GL. Clinical investigation of respiratory
system admittance in preschool children. Pediatr Pulmonol 2012;47:53-58
22. Sly JL, Carpenter DO. (2012) Special vulnerability of children to environmental
exposures. Rev Environ Health. Sep 4:1-7. doi: 10.1515/reveh-2012-0024.
23. Strickland DH, Thomas JA, Mok D, Blank F, McKenna KL, Larcombe AN, Sly PD, Holt PG.
Defective aeroallergen surveillance by airway mucosal dendritic cells as a
determininant of risk for persistent airways hyper-responsiveness in experimental
asthma. Mucosal Immunol 2012;5:332-341
24. Suresh S, Manun A, O’Callaghan M, Sly P. The impact of birth weight on peak lung
function in young adults. CHEST. December 2012;142:1603-1610
25. Vieira SE, Stein RT, Ferraro AA, Pastro LD, Pedro SS, Lemos M, da Silva ER, Sly PD,
Saldiva PH. Urban pollutants are significant risk factors for asthma and pneumonia in
children: The influence of location on the measurement of pollutants. Arch
Bronconeumol. 2012;48:389-395
26. Vos, T., Flaxman, A.D., Naghavi, M., Norman, et al. Years lived with disability (YLDs) for
1160 sequelae of 289 diseases and injuries 1990?2010: a systematic analysis for the
Global Burden of Disease Study 2010. The Lancet 2012; 380: 2163-2196.
Book Chapters
1. Holt PG, Sly PD, Prescott S. Early life origins of allergy and asthma. In: Holgate ST,
Broide DH, Church MK, Martinez FD (Eds.) Allergy 4 th Edition 2012:3;51-62 Edinburgh,
Elsevier Limited.
2. Sly PD, Jones C. New and future developments of therapy for asthma in children. In:
Carlsen K, Gerritsen J(Ed) Paediatric Asthma. 2012:56;224-234 European Respiratory
Society Monographs
3. Suresh S, Sly PD. Stridor. In: South M, Isaacs D (Eds) Practical Paediatrics 7 th Edition
with Student Consult Online Access. 2012 Churchill Livingston
QCMRI Scientific Report 2012 46

Staff Profile
Name
Professor Peter Sly
Dr Emmanuelle Fantino
Dr Catherine Gangell
Dr Leith Sly
Dr Rosana Norman
Dr Ken Liu
Dr Keith Chappell
Claire Shackleton
Lyn Chen
Carmen Jones
Sophie Moore
Kristen Grant
Julie Varghese
Johanna Schagen
Jayden Logan
Emma Thomas
Leigh Hamilton
Position
Senior Clinical Research Fellow
Senior Research Scientist
Clinical Trials Manager
Communications Strategies Coordinator, CHEP
Senior Lecturer- Children’s Environmental Health
Postdoctoral Research Fellow
Postdoctoral Research Fellow
Respiratory Scientist
Biostatistician
Research Assistant
Senior Research Technician
Senior Research Technician
Clinical Trials Coordinator
Laboratory Technician
Laboratory Technician
Laboratory Technician
Research Team Coordinator
Our Students
Research Degrees Completed
Name
Jayden Logan
Degree
BSc (Hons)
QCMRI Scientific Report 2012 47

Research Degrees Ongoing
Name Supervisors Degree
Amy Heffernan
Prof Jochen Mueller
PhD
Prof Peter Sly
Stuart Paynter
Sadasivam Suresh
Khang Duong
Jaisy Eacharath
Yiqin Chen
Abdullah Tarique
Prof Peter Sly
Dr Robert Ware
Prof Philip Weinstein
Prof Gail Williams
Dr Abdullah A Mamun
Professor Peter Sly A/Prof
Michael O'Callaghan
Professor Kerry Atkinson,
Professor Peter Sly
Dr Simon Phipps
Mr Tung-Liang Chung
Dr Simon Phipps
Dr Stuart Mazzone
Professor Peter Sly
Dr John Upham
Prof Jochen Mueller
Prof Peter Sly
Prof Peter Sly
Dr Emmanuelle Fantino
PhD
PhD
PhD
PhD
PhD
PhD
National and International Collaborators
‣ Queensland Health
‣ National Research Centre for Environmental Toxicology
‣ Queensland Paediatric Infectious Diseases Group
‣ Australian Infectious Diseases Research Group
‣ Global Change Institute
‣ School of Biomedical Sciences
‣ School of Population Health, UQ
‣ Telethon Institute for Child Health Research, WA
‣ Murdoch Children’s Research Institute, Vic
‣ University of Szeged, Hungary
‣ University of Cape Town, South Africa
QCMRI Scientific Report 2012 48

‣ University of Arizona, USA
‣ University of Albany, New York State, USA
‣ University of Otago, Christchurch, NZ
Research Group Contact Details
Children’s Lung, Environment and Asthma Research Group
Level 4, Foundation Building
Royal Children’s Hospital
Herston Road, Herston
Queensland 4029
p: (07) 3636 9690
f: (07) 3636 5578
QCMRI Website:
http://www.qcmri.org.au/Research/Infection,InflammationandtheEnvironment/ChildrensLu
ng,EnvironmentandAsthmaResearch.aspx
QCMRI Scientific Report 2012 49

Airways Infections, Inflammation & Cystic Fibrosis Group
Overview and Highlights from 2012
Our comprehensive program of multidisciplinary research is continuing with a number of
key areas making significant progress:
Ongoing analysis of data from the NHMRC funded multicentre randomized controlled trial of
bronchoalveolar lavage (BAL) directed therapy in infants with CF has led to interesting
insights into the importance of early respiratory exacerbations in young children with CF and
the development of structural and functional lung disease (CA. Byrnes et al Thorax 2013).
The group is currently analysing the longitudinal microbiology data from the original study
as well as the molecular aspects of early infection with P.aeruginosa and the effects of early
infection and inflammation on long term structural and functional measures of lung disease.
The final analysis of health economic outcomes is close to submission to one of the
paediatric journals. The follow up study of this cohort of patients to examine the
progression of lung disease through adolescence in relation to early life determinants over 3
years 2013-2015 is now starting and is funded through an NHMRC project grant starting in
2013.
We have been funded through another NHMRC project grant starting in 2013 to investigate
the effects of exposure to early general anaesthesia in children with CF using the clinical trial
structure from the original ACFBAL study.
There is continuing evaluation of airway microbiology in children and young people with
suppurative lung disease with specimen and data collection finalised on the bronchoalveolar
lavage fluid of young children with respiratory disorders.
A pilot study was completed during 2012 on the measurement of particle size distribution,
distances covered and duration of viability of cough aerosols from both paediatric and adult
patients with CF. This work has major implications for infection control and has formed the
basis of a project grant application to NHMRC for the 2013 funding round. This work is a
multidisciplinary project undertaken collaboratively with staff at RCH, TPCH and QUT.
The Australian Standards of Care (SOC) for patients with CF were updated in 2012 and the
SOC form the basis for independent peer reviews of CF specialist centres across Australia.
The Brisbane sites, including RCH, TPCH and the Mater Hospitals were reviewed in
November 2012 with recommendations pending.
Validation of our pre-school QOL questionnaire is continuing with interviews of parents and
pre-schoolers with CF about to be conducted.
Our team continues to be involved in clinical trials both investigator led and pharmaceutical
company sponsored trials - this has been in areas related to both asthma and cystic fibrosis.
Professor Wainwright has been invited to act a Lead Investigator on the international
Steering Committee for 2 new Vertex corrector/potentiator Phase 3 studies commencing in
2013. This pharmaceutical study research could potentially have an enormous effect on the
clinical management of patients who are homozygous for the DF508 genotype which
includes the majority of patients with CF.
QCMRI Scientific Report 2012 50

Awards and Achievements
‣ Professor Wainwright was appointed as Chair of the Health Care Principal Committee
NHMRC 2012-15 and a member of the NHMRC Council 2012-15.
Research Grants and Contracts
Years
2013 -
2014
2013 -
2015
Grant
Agency
NHMRC
Project Grant
NHMRC
Project Grant
2013 Vertex
Pharmaceuti
cals
Chief Investigators Title Amount
Wainwright, Davidson,
Armstrong, Quittner,
Salvado, Robertson,
Byrnes, Cooper
Wainwright,
Grimwood, Sly,
Tiddens, Hugenholtz,
Massie, Robertson,
Cooper, Byrnes,
Vidmar
Wainwright
2012 Regional
Diabetes
Support
Scheme
Novo
Nordisk
Pharmaceuti
cals P/L
Wainwright
2012 AID (UQ) Hugenholz,
Wainwright
2011 -
2014
2011 -
2014
A randomised controlled trial of
effects of early life exposure to
general anaesthesia on
neurobehavioural outcomes in
children with cystic fibrosis (CF)
Clinical and psychosocial changes
over late childhood and
adolescence and early life
determinants of long term clinical
outcomes in cystic fibrosis
$572,727
$1,135,570
A Phase 3, Randomized, Double- $ per pt
Blind, Placebo-Controlled, Parallel- funding
Group Study to Evaluate the Efficacy and Safety of Lumacaftor in C
and Safety of Lumacaftor in
Combination With Ivacaftor in
Subjects Aged 12 Years and Older
With Cystic Fibrosis, Homozygous
for the F508del-CFTR Mutation
(VX12-809-104)
CF-IDEA (Cystic Fibrosis – Insulin $15,000
Deficiency, Early Action) Study
Sequencing strains emerging
bacteria and fungi in patients with
CF
NIH Sly, Wainwright A phase 3 multi-centre randomized
placebo-controlled study of
azithromycin in the primary
prevention of radiologicallydefined
bronchiectasis in infants
with cystic fibrosis.
Westmead Wainwrig Wainwright
Hospital,
Sydney
Filamentous Fungi in cystic fibrosis:
clinical risk factors and impact on
lung disease
$10,000
$ per pt
funding
$7000 pa
QCMRI Scientific Report 2012 51

Publications
Peer Reviewed Manuscripts
1. Döring G, Flume P, Heijerman H, Elborn JS; Consensus Study Group. Treatment of lung
infection in patients with cystic fibrosis: current and future strategies. J. Cyst Fibros.
2012 Dec;11(6):461-79
2. Kidd TJ, Ramsay KA, Hu H, Marks GB, Wainwright CE, Bye PT, Elkins MR, Robinson PJ,
Rose BR, Wilson JW, Grimwood K, Bell SC, and the ACPinCF Investigator Group. Shared
Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres.
Eur Respir J. 2012 Aug 9. [Epub ahead of print] doi: 10.1183/09031936.00060512
3. Ratjen F, Durham T, Navratil T, Schaberg A, Accursom FJ, Wainwright C, Barnes M,
Moss RB. Long terms effects of denufosol tetrasodium in patients with cystic fibrosis.
Journal of Cystic Fibrosis 06/2012; DOI:10.1016/j.jcf.2012.05.003.
4. Rose B, Hu Harmer C, Anuj S, Manos J, Wainwright C, Cheney J, Harbour C, Zablotska I,
Turnbull L, Whitchurch C, Grimwood K. Type 3 secretion system effector genotype and
secretion phenotype of longitudinally-collected P. aeruginosa isolates from young
children diagnosed with cystic fibrosis following newborn screening. Clinical
Microbiology and Infection 2012 Jan; doi: 10.1111/j.1469-0691.2012.03770.x.
5. Wainwright C. Treatment of cystic fibrosis following infant screening. Therapy 2012; 8
6: 613-622
6. Willner D, Daly J, Whiley D, Grimwood K, Wainwright C, Hugenholtz P. Comparison of
DNA extraction methods for microbial community profiling with an application to
pediatric bronchoalveolar lavage samples. PLoS One 2012 April; Volume 7, Issue 4 |
e34605.
Staff Profile
Name
Prof Claire Wainwright
Ms Joyce Cheney
Ms Sue Edwards
Mrs Heather Saddington
Miss Emma Sanderson
Mr Nicholas Gailer
Position
Paediatric Respiratory Specialist
Project Manager/Nurse Researcher
Clinical Nurse – Research
Clinical Nurse – Research
Clinical Nurse – Research
Database Manager
QCMRI Scientific Report 2012 52

Our Students
Research Degrees Completed
Name
Snehal Anuj
Mandana Arshi
Degree
PhD
PhD
Research Degrees Ongoing
Name Supervisors Degree
Sonya Stacey
K Whitfield
PhD
C Wainwright
I Coombed
Mr Maximilian Stephens C Wainwright
Ms Kate Lilley C Wainwright M.Phil
Research Group Contact Details
Professor Claire Wainwright
Head of CF Services
Queensland Children’s Respiratory Centre
Level 5, Woolworths Building
Royal Children’s Hospital
Herston Road, Herston
Queensland 4029
p: (07) 3636 1932
f: (07) 3636 4230
e: claire_wainwright@health.qld.gov.au
Ms Joyce Cheney
Project Manager
p: (07) 3636 3760
e: joyce_cheney@health.qld.gov.au
QCMRI Website:
http://www.qcmri.org.au/Research/Infection,InflammationandtheEnvironment/AirwaysInfe
ctions,InflammationCysticFibrosis.aspx
QCMRI Scientific Report 2012 53

Queensland Paediatric Infectious Diseases (QPID) Laboratory
Summary of Research Activities and Achievements
Highlights of 2012 Research Outcomes were:
‣ The completion of the first two years of the NHMRC-sponsored birth cohort study
examining the acquisition and clinical impact of respiratory viruses during the first 2
years of life. Recruitment rate for this study has been completed, and preliminary
results have identified human rhinoviruses as a major contributor to infection in this
patient group.
‣ A research study found that human rhinoviruses are widespread and frequent
pathogens of children undergoing serious asthma exacerbations and should be
considered in clinical management. The laboratory diagnosis of HRVs should be
considered very important when supporting children with exacerbated asthma.
‣ The development and deployment of real-time PCR assays to detect human
parechoviruses, enteroviruses, klasseviruses, cosaviruses and cardioviruses. Screening
respiratory samples from 2009, 2010, 2011 and 2012 identified presence of these viruses
in our population except for klasseviruses and cosaviruses. Clinical correlates with viral
presence will be assessed.
‣ A real-time RT-PCR for scaffold virus was developed and showed the co-circulation of
two genotypes in the respiratory tracts of young children during 2011 in and around
Brisbane, Australia. It identified a local variant of a SAFV-2 genotype (SAFV-2/QCW),
the genome of which was subsequently sequenced.
‣ Matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF
MS), on the Sequenom Mass Array iPLEX SNP typing platform was applied to perform
high-throughput multiplex SNP detection, with up to 40 SNPs per single reaction. This
methodology was validated for methicillin-resistant Staphylococcus aureus (MRSA) which
comprises 17 targets in one reaction and provides optimal throughput for MRSA
genotyping.
‣ MALDI-TOF MS was also used to develop an assay for characterisation of influenza virus
type A, including the pandemic influenza A (2009) “swine flu”. Notably, the assay
simultaneous identified the H275Y mutation that confers resistance to Tamiflu, and is
therefore important in the clinical management of critically ill patients.
‣ The development of sensitive and specific rapid diagnostic tests for the human
polyomaviruses has facilitated extensive molecular epidemiological investigations to
identify a role of these viruses in specific disease. Preliminary data show BK polyomavirus
involvement and integration into tumour cells from kidney transplant patients with
aggressive bladder cancer. Work in collaboration with local and national researchers and
physicians is proceeding to elucidate the role of polyomaviruses in breast cancer
formation.
QCMRI Scientific Report 2012 54

‣ The Clinical Trials Unit in the QPID laboratory has continued to conduct a number of
externally-funded clinical and new drug trials. The primary interest of the CTU is
infectious diseases, particularly vaccine preventable diseases. Often this involves early
phase trials in children and older age groups, to identify improved, safer, and more
effective prevention and treatment options. The unit has developed an international
reputation and continues be recognised for its significant contribution made in this
area of the Children’s Health Queensland Hospitals and Health Service activities.
Research Grants and Contracts
Years
2012-
2014
Grant Chief Investigators Title Amount
Agency
QCMRI Seweryn Bialasiewicz QCMRI Early Career Fellowship $450,000
2012 QCMRI Seweryn Bialasiewicz NHMRC Near-Miss Funding $50,000
2010-
2012
ARC
Ian Mackay, Theo P
Sloots
Seeking causes of unexplained
respiratory illness in children by
identifying new respiratory
viruses
$245,000
2010-
2012
QCMRI Ian Mackay Identification and clinical impact
of non-rhinovirus picornaviruses
in respiratory disease
$300,000
2012-
2015
NHMRC
Chang, Morris,
O’Grady, Grimwood,
Sloots, Van Asperen,
Wilson, Robertson
Multicentre randomised
controlled trial to improve the
management of exacerbations
in children with bronchiectasis
$1,148,522
($155,000
QPID)
2012-
2015
NHMRC
1019834
Chang, Morris,
Robertson, Grimwood,
Van Asperen, Sloots,
Torzillo, O’Grady,
Wilson
BREATH: Bronchiectasis
Randomised controlled trial-
Evaluation of Azithromycin and
inhaled hypertonic saline for
lung Health maintenance
$2,686,000
(85,000 QPID)
2010-
2015
QCMRI
Sloots T, Nissen MD,
Lambert S, Grimwood
K.
Molecular Microbiology and
Epidemiology of Respiratory
Infections in Children
$2,250,000
2010-
2012
NHMRC Chang A, Morris P,
Grimwood K, Sloots T,
White A, MacLennan
C.
Randomised controlled trial of
azithromycin to reduce the
morbidity of severe
bronchiolitis in Indigenous
infants.
$1,407,075
2011-
2012
The Prince
Charles
Bell S, Morawski L,
Wainwright C,
Quantification of infectious
aerosol transport in the air for
$99,828
QCMRI Scientific Report 2012 55

2011-
2015
Hospital
Foundation
NHMRC
Grimwood K,
Hargreaves M,
Johnson G,
O’Rourke P, Sly P
Grimwood K, Lambert
SB, Ware R, Sloots T,
Nissen MD
application towards prevention
of infection spread
Burden of respiratory infection
in the first 2 years of life
$1,135,000
2010-
2015
NIH (USA)
Stanley S (Program
Director)
Virgin H, Wang D,
Sloots TP, Nissen MD
Discovery and characterization
of emerging, engineered and
unrecognized pathogens
$US1,426,860
($100,000
QPID)
2012 -
2016
NHMRC
AB Chang, N Brown,
EK Mulholland, KA
O’Grady, K Grimwood,
PS Morris, AJ Leach,
JW Upham,PJ Torzillo,
H D’Antoine
Centre of Research Excellence
in Lung Health of Aboriginal
and Torres Strait Islander
Children
$2,490,000
2011-
2013
Health
Research
Council of NZ
Ingham T, Camargo C,
Jones B, Cormack D,
Kirman J, Davies C,
Crane J,
Grimwood K
Bronchiolitis disparities among
Maori and Pacific children.
Health Research Council of New
Zealand
$NZ
1,146,720
2011-
2012
2012-
2015
2012-
2015
The
University of
Queensland
Australian
Infectious
Disease
Research
Centre
Development
Grant
Young P, Sly P,
Schembri M,
Hugenholtz P, Sloots T,
Paterson D, Kappler
U,Grimwood K,
McEwan A,
Wainwright C, Nissen
M, MacKay I, Walker
M, Spann K
Polymicrobial interactions in
inducing and exacerbating
respiratory diseases
QCMRI Whiley D The genetic properties of clonal
P. aeruginosa strains in Brisbane
patients with CF
QCMRI Whiley D Molecular surveillance methods
for Neisseria gonorrhoeae
antimicrobial resistance
$180,000
$450,000
$156,500
2012 The
University of
Queensland
Australian
Infectious
Disease
Research
Centre
Development
Hugenholtz P,
Wainwright CE, Bell
SC, Grimwood K,
Fraser J, Reid D, Sly PD
A comparative genomic analysis
of emerging multiple antibiotic
resistant non Pseudomonal
bacteria and fungi in the
airways of children and adults
with cystic fibrosis
$10,000
QCMRI Scientific Report 2012 56

2012-
2014
2012-
2015
NHMRC O’Grady KA, Chang A,
Grimwood K, Morris P,
Smith-Vaughan H,
Mulholland K, Torzillo
P, Cripps A, Wood N,
Revell A
NHMRC Whiley D, Regan D,
Donovan B, Chen M,
Guy R, Lahra M
A multi-centre, double blid,
randomised controlled trial to
evaluate the efficacy of 10
valent-pneumococcal-
Haemophilus influenzae-Protein
D conjugate vaccine in reducing
respiratory exacerbations in
children aged >18 months with
chronic suppurative lung
disease
Neisseria gonorrhoeae
antmicrobial resistance:
detection and propagation
$1,122,492
$419,900
($316,000
QPID)
2013-
2015
NHMRC Upham, Mackay Understanding the mechanisms
responsible for anti-viral
immune dysfunction in asthma
$285,000
2011-
2015
NHMRC Early
Career
Fellowships
Whiley D
Acquisition and transmission of
respiratory pathogens in
persons with cystic fibrosis (CF):
development and
implementation of novel
molecular tools
$ 300,000
2011-
2013
Novartis, Sloots TP Estimating Australian strain
coverage of a multicomponent
vaccine targeting serogroup B
meningococci
$487,340
2013 Novartis, Sloots TP Evaluating anti-malarial drug
efficacy in wild-type infections
$184,750
QCMRI Scientific Report 2012 57

Publications
Peer Reviewed Manuscripts
1. Antonsson A, Bialasiewicz S, Rockett RJ, Jacob K, Bennett IC, Sloots TP. 2012. Exploring
the Prevalence of Ten Polyomaviruses and Two Herpes Viruses in Breast Cancer. Plos
One 7(8): e39842
2. Bryant K, McVernon J, Marchant C, Nolan T, Marshall G, Richmond P, Marshall H,
Nissen M, Lambert S, Aris E, Mesaros N, Miller J (2012). Immunogenicity and Safety of
Measles-Mumps-Rubella and Varicella Vaccines Coadministered with a Fourth dose of
Haemophilus influenzae Type b and Neisseria meningitidis Serogroups C and Y-Tetanus
Toxoid Conjugate Vaccine in Toddlers: A Pooled Analysis of Randomized Trials. Hum
Vaccin Immunother. 2012 . 8(8):1036-41.
3. Burgess C, Masters IB, Francis P, Grimwood K, Chang AB. Flexible bronchoscopy in
managing a child with pulmonary hydatid disease. Pediatr Pulmonol 2012: 47: 1140-
1142.
4. Chang AB, Grimwood K, Robertson CF, Wilson AC, van Asperen PP, O’Grady KF, Sloots
TP, Torzillo PJ, Bailey EJ, McCallum GB, Masters IB, Byrnes CA, Chatfield MD, Buntain
H, Mackay IM, Morris PS. 2012. Antibiotics for bronchiectasis exacerbations in
children: rationale and study protocol for a randomised placebo-controlled trial. Trials.
13:156
5. Chang AB, Grimwood K, Wilson AC, van Asperen PP, Byrnes CA, O’Grady KF, Sloots TP,
Robertson CF, Torzillo PJ, McCallum GB, Masters IB, Buntain HM, Mackay IM, Ungerer
J, Tuppin J, Morris PS. Bronchiectasis exacerbation study on azithromycin and
amoxicillin-clavulanate for respiratory exacerbations in children (BEST-2): study
protocol for a randomised controlled trial. Trials 2012; epub ahead of time
6. Clifford V, Garland SM, Grimwood K. Prevention of neonatal GBS disease in the 21 st
century. J Paediatr Child Health 2012; 48: 808-815.
7. Cox H, Jacob K, Whiley DM, Bletchly C, Nimmo GR, Nissen MD, Sloots TP. 2013. Further
evidence that the IS481 target is suitable for real-time PCR detection of Bordetella
pertussis. Pathology. 45(2), 202–203.
8. Ferguson PE, Gilroy NM, Faux CE, Mackay IM, Sloots TP, Nissen MD, Dwyer DE, Sorrell
TC. 2013. Human rhinovirus C in adult haematopoietic stem cell transplant recipients
with respiratory illness. J Clin Virol. 56(3):339-43.
9. Goire N, Freeman K, Lambert SB, Nimmo GR, Limnios AE, Lahra MM, Nissen MD, Sloots
TP, Whiley DM. 2012. The influence of target population on nonculture-based
detection of markers of Neisseria gonorrhoeae antimicrobial resistance. Sex Health.
2012 Oct 5. doi: 10.1071/SH12026.
10. Goire N, Ohnishi M, Limnios AE, Lahra MM, Lambert SB, Nimmo GR, Nissen MD, Sloots
TP, Whiley DM. 2012. Enhanced gonococcal antimicrobial surveillance in the era of
ceftriaxone resistance: a real-time PCR assay for direct detection of the Neisseria
gonorrhoeae H041 strain. J Antimicrob Chemother. 67(4):902-5.
QCMRI Scientific Report 2012 58

11. Goire N, Sloots TP, Nissen MD, Whiley DM, 2012, Protocol for the Molecular Detection
of Antibiotic Resistance Mechanisms in Neisseria gonorrhoeae Methods Mol Biol.
903:319-28.
12. Hare KM, Binks MJ, Grimwood K, Chang AB, Leach AJ, Smith-Vaughan H. Culture and
PCR detection of Haemophilus influenzae and Haemophilus haemolyticus in Australian
Indigenous children with bronchiectasis. J Clin Microbiol 2012; 50: 2444-2445
13. Hare KM, Leach AJ, Morris PS, Vaughan-Smith H, Torzillo P, Bauert P, Cheng AC,
McDonald MI, Brown N, Chang AB, Grimwood K. Impact of recent antibiotics on
nasopharyngeal carriage and lower airway infection in Indigenous Australian children
with non-cystic fibrosis bronchiectasis. Int J Antimicrob Agents 2012; 40: 365-369.
14. Hare KM, Marsh RL, Binks MJ, Grimwood K, Pizzutto SJ, Leach AJ, Chang AB, Smith-
Vaughan HC. Quantitative PCR confirms culture as the gold standard for detection of
lower airway infection by nontypeable Haemophilus influenzae in Australian
Indigenous children with bronchiectasis. J Microbiol Methods 2012; epub ahead of
time.
15. Howard PF, McCaw JM, Richmond PC, Nissen M, Sloots T, Lambert SB, Lai M,
Greenberg M, Nolan T, McVernon J. 2012. Virus detection and its association with
symptoms during influenza-like illness in a sample of healthy adults enrolled in a
randomised controlled vaccine trial. Influenza Other Respiratory Viruses. Jun 19. doi:
10.1111/j.1750-2659.2012.00395.x. [Epub ahead of print]
16. Kapur N, Grimwood K, Masters IB, Morris PS, Chang AB. Lower airway microbiology
and cellularity in children with newly diagnosed non-CF bronchiectasis. Pediatr
Pulmonol 2012; 47: 300-307.
17. Kidd TJ, Ritchie SR, Ramsay KA, Grimwood K, Bell SC, Rainey PB. Pseudomonas
aeruginosa exhibits frequent recombination, but only a limited association between
genotype and ecological setting. PLoS One 2012; 7: e44199.
18. Kidd TJ, Ramsay KA, Hu H, Marks GB, Wainwright CE, Bye PT, Elkins MR, Robinson PJ,
Rose BR, Wilson JW, Grimwood K, Bell SC, and the ACPinCF Investigator Group. Shared
Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres.
Eur Respir J 2012; epub ahead of time.
19. Khor CC, S Davila, C Shimizu, S Sheng, T Matsubara, Y Suzuki, JW Newburger, A Baker,
D Burgner, W Breunis, T Kuijpers, VJ Wright, M Levin, ML Hibberd, JC Burns, on behalf
of the US and International Kawasaki Disease Genetics Consortia (2011).Genome-wide
linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki
disease. J. Medical Genetics (2011). doi:10.1136/jmg.2010.086611.
20. Kunac DL, Tatley MV, Grimwood K, Reith DM. Active surveillance of serious adverse
drug reactions in New Zealand children. Arch Dis Child 2012; 97: 761-762
21. Lai R, Liang F, Pearson D, Barnett G, Whiley DM, Sloots TP, Barnard R, Corrie SR. 2012.
PrimRglo: A multiplexable quantitative real-time polymerase chain reaction system for
nucleic acid detection. Anal. Biochem. 422(2):89-95.
QCMRI Scientific Report 2012 59

22. Lambert SB, Ware RS, Cook AL, Maguire FA, Whiley DM, Bialasiewicz S, Mackay IM,
Wang D, Sloots TP, Nissen MD, Grimwood K. 2012. Observational Research in
Childhood Infectious Diseases (ORChID): a dynamic birth cohort study. BMJ Open.2(6).
doi:pii: e002134. 10.1136/bmjopen-2012-002134.
23. Mackay IM, Arden KE, Speicher D, O'neill N, Mcerlean P, Greer R, Nissen MD, Sloots
TP. 2012. Co-circulation of four human coronaviruses (HCoVs) in Queensland children
with acute respiratory tract illnesses in 2004. Viruses 4(4):637-53
24. Mackay IM, Lambert SB, Faux CE, Arden KE, Nissen MD, Sloots TP, Nolan TM.
Community-wide, contemporaneous circulation of a broad spectrum of human
rhinoviruses in healthy Australian preschool-aged children during a 12-month period. J
Infect Dis. 2012 Jul 24. [Epub ahead of print]
25. Madhi SA, De Wals P, Grijalava CG, Grimwood K, Grossman R, Ishiwada N, Lee
P-I, Nascimento-Carvalho C, Nohynek H, O’Brien KL, Vergison A,Wolter J. The burden
of childhood pneumonia in the developed world: a review of the literature. Pediatr
Infect Dis J 2012; epub ahead of time.
26. Marshall HS, Richmond PC, Nissen MD, Jiang Q, Anderson AS, Jansen KU, Reynolds G,
Ziegler JB, Harris SL, Jones TR, Perez JL (2012). Safety and Immunogenicity of a
Meningococcal B Bivalent rLP2086 Vaccine in Healthy Toddlers Aged 18 to 36 Months:
A Phase 1 Randomized Controlled Clinical Trial. Pediatr Infect Dis J. 2012 Jun 20.
27. McCaw JM, Howard PF, Richmond PC, Nissen M, Sloots T, Lambert SB, Lai M,
Greenberg M, Nolan T, McVernon J. 2012. Household transmission of respiratory
viruses - assessment of viral, individual and household characteristics in a population
study of healthy Australian adults. BMC Infect Dis.12: 345.
28. McVernon J, Nolan T, Richmond P, Reynolds G, Nissen M, Lambert SB, Marshall H,
Papa T, Rehm C. 2012. A randomized trial to assess safety and immunogenicity of
alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus
protein conjugate vaccine in toddlers. Pediatr Infect Dis J. 31(1):e15-23
29. Moore R, Kyd JM, Carzino R, Armstrong D, Grimwood K, Otcyk DC, Cripps AW.
Mucosal and systemic antibody responses to potential Pseudomonas aeruginosa
vaccine protein antigens in young children with cystic fibrosis following colonization
and infection. Hum Vaccin Immunother 2012; epub ahead of time.
30. Pizzuto SJ, Grimwood K, Bauert P, Schultz KL, Yerkovich ST, Upham JW, Chang AB.
Bronchoscopy contributes to the clinical management of Indigenous children newly
diagnosed with bronchiectasis. Pediatr Pulmonol 2012; epub ahead of time.
31. Richmond PC, Marshall HS, Nissen MD, Jiang Q, Jansen KU, Garcés-Sánchez M,
Martinón-Torres F, Beeslaar J, Szenborn L, Wysocki J, Eiden J, Harris SL, Jones TR, Perez
JL; on behalf of the 2001 Study Investigators (2012). Safety, immunogenicity, and
tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086
vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2
trial. Lancet Infect Dis. 2012 May 4. [Epub ahead of print]
QCMRI Scientific Report 2012 60

32. Richmond PC, Nissen MD, Marshall HS, Lambert SL, Roberton D, Gruber WC, Jones TR,
Arora A (2012). A bivalent Neisseria meningitidis recombinant lipidated factor H
binding protein vaccine in young adults: Results of a randomised, controlled, doseescalation
phase 1 trial. Vaccine. 2012.07.065 [Epub ahead of print]
33. Sheridan S, Lambert S, Grimwood K.Impact of rotavirus vaccination on childhood
gastroenteritis. Microbiology Australia 2012; 33: 56-60.
34. Sheridan SL, Ware RS, Grimwood K, Lambert SB. Number and order of whole cell
pertussis vaccines in infancy and disease protection. JAMA 2012; 308: 454-456.
35. Sheridan SL, Ware RS, Grimwood K, Lambert SB. Unexpectedly limited duration of
immunity following acellular pertussis vaccination in preadolescents in a North
American outbreak. Clin Infect Dis 2012; 55: 1434-1435 (letter)
36. Syrmis MW, Moser R, Kidd TJ, Hunt P, Ramsay KA, Bell SC, Wainwright CE, Grimwood
K, Nissen MD, Sloots TP, Whiley DM. High-throughput single nucleotide
polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic
fibrosis patients using the Sequenom iPLEX platform. J Med Microbiol 2012; epub
ahead of time.
37. Vaska V, K Grimwood, GA Gole, GR Nimmo, DL Paterson, MD Nissen (2011).
Community-associated Methicillin-resistant Staphylococcus aureus causing orbital
cellulitis in Australian children. Pediatr. Infect. Dis. J. Jun 15 [Epub ahead of print].
38. Vaska V, Nimmo GR, Jones M, Grimwood K, Paterson DL. Increases in Australian
cutaneous abscess hospitalizations: 1999-2008. Eur J Clin Microbiol Infect Dis 2012; 31:
93-96.
39. Valery PC, Morris PS, Grimwood K, Torzillo PJ, Byrnes CA, Masters IB, Bauert PA,
McCallum GB, Mobberly C, Chang AB. Azithromycin for Indigenous children with
bronchiectasis: study protocol for a multi-centre randomized controlled trial. BMC
Pediatrics 2012; 12: 122.
40. Wang CY, Arden KE, Greer R, Sloots TP, Mackay IM. 2012. A novel duplex real-time PCR
for HPIV-4 detects co-circulation of both viral subtypes among ill children during 2008.
J Clin Virol. 54(1):83-5.
41. Wang CYT, Greer RM, Delwart E, Sloots TP, Mackay IM. 2012. A newly designed realtime
RT-PCR for SAFV detects SAFV-2 and SAFV-3 in the respiratory tracts of ill children
during 2011. J Clin Virol 55:173-176
42. Whiley DM, Goire N, Lahra MM, Donovan B, Limnios AE, Nissen MD, Sloots TP. 2012.
The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a
public health disaster in waiting. J Antimicrob Chemother. May 17. [Epub ahead of
print]
43. Whiley DM, Goire N, Rahimi F, Lahra MM, Limnios AE, Nissen MD, Sloots TP. 2013.
Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative
single nucleotide polymorphisms on gonococcal housekeeping genes. J Antimicrob
Chemother. 68(2):322-8.
QCMRI Scientific Report 2012 61

44. Whiley DM, Jacob K, Nakos J, Bletchly C, Nimmo GR, Nissen MD, Sloots TP. 2012.
Improved detection of genetic markers of antimicrobial resistance by hybridization
probe-based melting curve analysis using primers to mask proximal mutations:
examples include the influenza H275Y substitution. J Antimicrob Chemother. 67(6):
1375-9
45. Willner D, Daly J, Whiley D, Grimwood K, Wainwright CE, Hugenholtz P. Comparison of
DNA extraction methods for microbial community profiling with an application to
pediatric bronchoalveolar lavage samples. PLoS One 2012; 7: e34605
Letters to the Editor
1. Lambert SB, Sheridan S, Grimwood K. Effectiveness of rotavirus vaccine in preventing
severe acute gastroenteritis in children. Can Fam Physician 2012; 58: 1081 (letter)
Books and Book Chapters
1. Bialasiewicz S , Mackay IM, Whiley DM, Sloots TP (2012). “Protocol for the Use of
Enzyme-Linked Hybridization Assays for Genital Ulcer Disease” in Diagnosis of Sexually
Transmitted Diseases Methods and Protocols. CR MacKenzie, B Henrich (Editors),
Humana Press, New York, USA.
2. Davis JW, Nissen M (2012). “Human immunodeficiency virus” in Antenatal Consults: a
guide for neonatologists and paediatricians. MW Davies, GDT Inglis, LA Jardine, PJ
Koorts (Editors), Churchill Livingstone Elsevier, Sydney, Australia.
Staff Profile
Name
A/Prof Michael Nissen
A/Prof Theo Sloots
Dianne Maestracci
Prof Keith Grimwood
A/Prof Stephen Lambert
A/Prof Ian Mackay
A/Prof David Whiley
Dr Katherine Arden
Dr Seweryn Bialasiewicz
Dr Kevin Jacob
Timothy Kidd
Anne Cook
H Cox
Jane Gaydon
H Hackett
R Holding
Position
Unit Director
Unit Director
Administration Officer
Senior Researcher
Senior Researcher
Senior Researcher
Senior Researcher
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
QCMRI Scientific Report 2012 62

L Mhango
Kaye Ramsay
Rebecca Rockett
Dr Melanie Syrmis
Sarah Tozer
C Y T Wang
Sophia Ye
Uyen Duong
K Ellis
Jaqui Langton
Frances Maguire
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Research Staff
Clinical Trials Staff
Clinical Trials Staff
Clinical Trials Staff
Clinical Trials Staff
Our Students
Research Degrees Completed
Name
Snehal Anuj
Namraj Goire
Timothy Kidd
F Rahimi
Degree
PhD
PhD
PhD
MSc Coursework
Research Degrees Ongoing
Name Supervisors Degree
Sarah Tozer Nissen, Lambert, Sloots PhD
Rebecca Rockett Sloots, Whiley, Nissen PhD
Asma Al-Saleh Grimwood, Whiley, Sloots PhD
Sophia Ye Whiley, Grimwood, Lambert PhD
Elina Trembizki Whiley, Grimwood PhD
K Madden Arden, Mackay Hons
Anna Tai Beatson, Bell, Whiley PhD
QCMRI Scientific Report 2012 63

National and International Collaborators
National
‣ Inflammatory Airways Diseases Research Group, QCMRI
‣ Cough and Asthma Research Group, QCMRI
‣ Departments of Respiratory Medicine, CHS, and The Prince Charles Hospital, Brisbane
‣ The Queensland Institute of Medical Research, Brisbane
‣ The Australian Infectious Diseases Research Centre, University of Queensland
‣ James Cook University, Townsville, Australia
‣ Menzies School of Health Research. Darwin, Australia.
‣ University of Melbourne School of Population Health, Melbourne.
‣ National Centre for Immunology and Surveillance, Sydney
‣ Macquarie University, Sydney, Australia
‣ Department of Nephrology, Princess Alexandra Hospital, Brisbane
International
‣ Department of Pathology and Immunology, Washington University, St. Louis, USA.
‣ Laboratory of Medical Microbiology and Immunology, St Elisabeth Hospital, Tilburg, The
Netherlands
‣ New Zealand Institute for Advanced Study and Allan Wilson Centre for Molecular
Ecology and Evolution, Massey University at Albany, Auckland, New Zealand.
‣ University of Otago, New Zealand
Research Group Contact Details
Queensland Paediatric Infectious Diseases Laboratory
Level 7, Building C28, Royal Children's Hospital
Children’s Health Queensland Hospital and Health Service
Herston Road, Herston
Queensland 4029
p: (07) 3636 8833
f: (07) 3636 1401
e: t.sloots@uq.edu.au
QCMRI Website:
http://www.qcmri.org.au/Research/Infection,InflammationandtheEnvironment/QldPaediatr
icInfectiousDiseasesLaboratory.aspx
QCMRI Scientific Report 2012 64

QCMRI Scientific Report 2011 79

Centre for Children’s Burns and Trauma Research
MESSAGE FROM GROUP LEADER
The research conducted by the Centre for Children’s Burns and Trauma Research (CCBTR)
focuses on paediatric burns, paediatric trauma and acute wound healing. The centre was
established in 1999 by Professor Roy Kimble and aims to -
‣ Understand the causes of paediatric trauma, identify ways to decrease the number
of children with burns and traumatic injuries, and implement these changes.
‣ Provide scientific evidence for existing treatments and development of novel wound
healing treatments for better burn care of children suffering from burns.
‣ To improve the lives of all children suffering from burns or trauma.
The CCBTR is one of the leading burns and trauma research groups in Australia and is lead by
Professor Kimble, who is a burn surgeon and Director of Paediatric Trauma on the QLD
Trauma Network. The CCBTR is a multidisciplinary team, comprised of QCMRI researchers
who are located in laboratories and offices at the Queensland Children’s Medical Research
Institute (QCMRI), in the University of QLD Department of Paediatrics and Child Health and
in the Stuart Pegg Paediatric Burns Centre (SPPBC) at the Royal Children’s Hospital (RCH) -
one of the largest paediatric Burns Centres in Australasia.
The laboratory is situated next to the Burns Centre in the Royal Children’s Hospital and the
clinical and laboratory aspects of the research are well integrated. Problems seen in the
clinical setting are driving quality laboratory and clinical-trial research which then are used
to inform evidence-based treatment of children with burns and trauma.
Summary of Research Activities and Achievements
2012 has been a very positive year for CCBTR. The team were successful in securing a QCMRI
program grant. The objective of this program is to develop and establish an extensive
network of research aimed at improving the health and wellbeing of children with burns and
other traumatic injuries. This program is an exciting collaboration between established
researchers from UQ, QUT, James Cook University and Queensland Health with strengths in
different areas, to tackle wound healing and other sequelae associated with burns and
traumatic injuries.
Professor Kimble was an invited speaker at a number of international conferences in the
United Kingdom including the International Society for Burn Injury in Edinburgh in
September. Dr Cuttle and Ms Brown also presented oral papers at this International Burns
QCMRI Scientific Report 2012 66

Forum. A number of posters and oral papers were presented by CCBTR researchers at The
Australian New Zealand Burns Association Annual Conference in Hobart, October 2012.
The QCMRI Program Grant enabled CCBTR to establish a new position: Clinical Research
Manager, CCBTR. Dr Stockton commenced with the team in October 2012. This appointment
will enable more research projects to be undertaken within the unit.
Awards
Catherine Tanzer – Prize for runner up poster
‣ Tanzer C, Cuttle L, Kimble RM, Upton Z, Parker TJ. Identification of biomarkers for poor
healing and increased scarring in paediatric burn patients. In: Australian Society for
Medical Research; Brisbane June 2012 (Honours student poster presentation)
Catherine Tanzer – Prize for best oral presentation (early candidature)
‣ Tanzer C, Parker TJ, Broadbent J, Upton Z, Kimble RM, Cuttle L. Identification of
biomarkers for poor healing and increased scarring in paediatric burn patients. In:
QCMRI student expo; Brisbane Aug 2012
Research Grants and Contracts
Years
2012-
2016
Grant
Agency
QCMRI
Chief Investigators Title Amount
LCuttle
R Kimble
J Paratz
J Kennardy
K Watt
Z Upton
Improving the physical and
psychological healing of children
with burns and trauma
$2,224,750
2013-
2015
NHMRC
Project APP
1047744
A Cowin
R Murray
R Kimble
Dampening inflammation with
Flightless
$385,139
2012-
2016
NHMRC Early
Career
Fellowship
L Cuttle
The acute treatment of children’s
burns: optimising repair
$294,892
2012-
2014
Molnlycke
Health
R Kimble
RCT of three different burns
dressings on
partial thickness burns in children
$150,000
QCMRI Scientific Report 2012 67

Years Grant
Agency
2012 RCH
Foundation –
John T Reid
Charitable
Trust
Chief Investigators Title Amount
B Wallis
J Maskell
L Cuttle
Kidsafe referral program $52,000
2012 Children’s
Health
Foundation
R Kimble (QHealth)
2 x 3D Cameras for wound and scar
analysis, exercise equipment for
outpatient burns and ditto devices
for statewide distribution,
anaesthetic machine
$250,000
2010-
2012
QLD
Government
R Sale
R Kimble
The development and testing of a
distraction device to reduce pain and
anxiety in children undergoing
hospital procedures
$900,000
2010-
2012
2010-
2012
2011-
2014
QIPC R Kimble 6 year review of drowning in children
0-17 years in Queensland
QIPC R Kimble Driveway reverse-over injuries in
children
QCMRI J James Chadwick Children coping with burn scarring:
an intervention to improve quality of
life and self concept
$180,364
$150,000
$21,000
2011-
2012
UQ Uniquest
M Lavin
L Cuttle
Kong-Nan
R Kimble
Use of a serine protease inhibitor for
wound healing/treatment of burns
$21,000
2011-
2012
QIPC L Cuttle Burn First-aid education campaign $34,000
2011-
2013
2011-
2013
QCMRI R Kimble QCMRI established researcher
project grant and trauma prevention
QCMRI L Cuttle Early career research scholarship:
improving the pre-hospital
treatment and acute management
of burned children
$300,000
$375,000
QCMRI Scientific Report 2012 68

Publications
Peer Reviewed Manuscripts
1. Brown NJ, Rodger S, Ware RS, Kimble RM, Cuttle L. Efficacy of a children's procedural
preparation and distraction device on healing in acute burn wound care procedures:
study protocol for a randomized controlled trial. Trials. 2012;13:238-50.
2. Choi WW, McBride CA, Bourke C, Borzi P, Choo K, Walker R, et al. Long-term review of
sutureless ward reduction in neonates with gastroschisis in the neonatal unit. J Pediatr
Surg. 2012;47(8):1516-20.
3. De Young AC, Kenardy JA, Cobham VE, Kimble R. Prevalence, comorbidity and course
of trauma reactions in young burn-injured children. J Child Psychol Psychiatry.
2012;53(1):56-63.
4. James-Chadwick J, Newcombe P, Martin G, Kimble R. Children living with burn
scarring: Can cosmetic camouflage improve psychosocial well-being? Journal of
Wound Technology. 2012 Jan;15:75-6
5. Kipping B, Rodger S, Miller K, Kimble RM. Virtual reality for acute pain reduction in
adolescents undergoing burn wound care: a prospective randomized controlled trial.
Burns. 2012;38(5):650-7.
6. Maskell J, Newcombe P, Martin G, Kimble R. Conducting a paediatric multi-centre RCT
with an industry partner: challenges and lessons learned. J Paediatr Child Health.
2012;48(11):974-7.
7. Paratz JD, Stockton K, Plaza A, Muller M, Boots RJ. Intensive exercise after thermal
injury improves physical, functional, and psychological outcomes. J Trauma Acute Care
Surg. 2012;73(1):186-94.
8. Pym A, Franklin R, Wallis B, Kimble R. Unregulated and unsafe: the impact of
motorcycle riding on Queensland Children. J Paeds Child Health (in press)
9. Sinnya S, Curtis K, Walsh M, Wong D, Kimble R. Late presentation of anal canal
duplication in an adolescent female – a rare diagnosis. Int J Colorectal Dis. 2012 (in
press)
10. Smith AC, White MM, McBride CA, Kimble RM, Armfield NR, Ware RS, et al. Multi-site
videoconference tutorials for medical students in Australia. ANZ J Surg.
2012;82(10):714-9.
11. Stockton KA, Davis MJ, Brown MG, Boots R, Paratz JD. Physiological responses to
maximal exercise testing and the modified incremental shuttle walk test in adults after
thermal injury: a pilot study. J Burn Care Res. 2012;33(2):252-8.
12. Stockton KA, Kandiah DA, Paratz JD, Bennell KL. Fatigue, muscle strength and vitamin D
status in women with systemic lupus erythematosus compared with healthy controls.
Lupus. 2012;21(3):271-8.
13. Watterson D, Gabbe BJ, et al. Developing the first Bi-National clinical quality registry
for burns-Lessons learned so far.Burns. 2012; 38(1): 52-60
Book Chapters
1. Mildenhall L, Kimble R. Dilated bladder. In: Antenatal consults: A guide for
paediatricians and neonatologists. Editor Mark Davies. Elsevier Australia. Chapter 45,
pp142-5, 2012
QCMRI Scientific Report 2012 69

Staff Profile
Name
Prof Roy Kimble
Dr Leila Cuttle
Dr Kellie Stockton
Ms Tona Gillen
Ms Belinda Wallis
Ms Margit Kempf
Ms Catherine Tanzer
Dr Kate Miller
Dr Megan Simons
Dr Craig McBride
Ms Kristen Storey
Dr Alex De Young
Dr Gael Phillips
Dionne Essenstam
Lauren Harvey
Dr Galina Gramotnev
Robyn Goodall
Position
Director
Laboratory Researcher
Clinical Researcher
Trauma Researcher
Burns Prevention Officer
Laboratory Researcher
Research Assistant
Clinical Researcher
Clinical Researcher
Clinical Researcher
Clinical Researcher
Clinical Researcher
Pathologist
Database Manager
Database Manager
Statistician
Administration Assistant
QCMRI Scientific Report 2012 70

Our Students
Research Degrees Completed
Name
Belinda Kipping
Andrea Kitay
Catherine Tanzer
Degree
Maters
MBBS Honours
BBiomedSci (Hons)
Research Degrees Ongoing
Name Supervisors Degree
Bronwyn Griffin
R Kimble
PhD
K Watt
L Shields
Nadia Brown
L Cuttle
PhD
R Kimble
S Rogers
Jessica Maskell
R Kimble
PhD
Newcombe P
Martin G
Foster M
Belinda Wallis
R Kimble
PhD
J Nixon
K Watt
Emma Gee Kee
K Stockton
R Kimble
L Cuttle
Masters
National and International Collaborators
‣ 2011-present: Q Health Pathology Services, RBWH. The study of stress hormones and
enzymes in paediatric burn patients.
‣ 2011-present: Mölnlycke Health Care: An RCT studying dressings for partial thickness
paediatric burns.
‣ 2010-present: Professor Martin Lavin, QIMR: Use of a serine protease inhibitor for
wound healing /treatment of burns.
‣ 2010-present: Dr Kerrianne Watt: School of Population Health, UQ: Decreasing the
incidence of children’s burns and trauma.
‣ 2009- present: Dr Jennifer Paratz. Collaboration between an adult and paediatric burn
centre.
QCMRI Scientific Report 2012 71

‣ 2009-present: Professor Zee Upton, QUT: Investigating the molecular basis and patient
factors in hypertrophic scarring.
‣ 2009-present: Professor Anthony Weiss, University of Sydney: Studying the effect of
the addition of elastin in dermal substitutes.
‣ 2009-present: Rye Phamaceuticals: Studying the effect of tea tree oil products in
paediatric burns
‣ 2007-present: Professor Sylvia Rodger, School of Health & Rehabilitation Sciences:
Decreasing pain and anxiety in children undergoing procedures in hospital.
‣ 2007 – present: Mr Steven Jeffrey, Burns & Reconstructive Surgeon, Birmingham, UK
& Professor Hans Oliver Rennekampff, Department of Plastic & Reconstructive
Surgery, BG Trauma Centre, Tubingen, Germany.
‣ 2006-present: Microskin International: The study of a cosmetic camouflage in the
psycho-social wellbeing of children with mature burn scarring. Microskin is a computer
colour matched spray-on skin camouflage which is durable, lasting for up to five days
after application. Professor Kimble and his team in collaboration with Professor
Graham Martin from UQ Dept of Psychiatry have studied this locally developed
product to determine whether it offers lasting psychosocial benefit to paediatric burns
patients. Two RCTs have been completed, the second involving all major paediatric
burn centres in Australia and New Zealand. This award winning research indicates that
Microskin improves psychosocial functioning in paediatric burn patients and is welltolerated
and acceptable.
‣ 2006-present: Professor Justin Kenardy, CONROD. The study of short and long term
psychological sequelae in paediatric burns patients.
‣ 2006-present: Professor Meyer Tenenhaus, Division of Plastic Surgery, University of
California, San Diego, California, USA. Collaboration in studying several new techniques
in burn surgery including the use of a vacuum suction device over full thickness grafts
for burn scar reconstruction.
‣ 2006-present: Assoc Prof Rob Sale and Diversionary Therapy Technologies:
Development and Studying the use of an Electronic Interactive Hand Held Device to
Deliver Procedural Preparation and Distraction Therapy to Children undergoing
Medical Procedures.
QCMRI Scientific Report 2012 72

Research Group Contact Details
Professor Roy Kimble, Director
The Centre for Children’s Burns & Trauma Research
University of Queensland Department of Paediatrics and Child Health Level 3, Foundation
Building Royal Children’s Hospital Herston Rd, Herston,
Queensland 4029
p: (07) 3636 9241
f: (07) 3365 5455
Dr Leila Cuttle, Laboratory Research Manager
The Centre for Children’s Burns & Trauma Research
University of Queensland, Queensland Children's Medical Research Institute,
Level 4, Foundation Building, Royal Children's Hospital, Herston Rd, Herston, QLD Australia,
4029
p: (07) 3636 9067
f: (07) 3636 5578
e: l.cuttle@uq.edu.au
Dr Kellie Stockton, Clinical Research Manager
The Centre for Children’s Burns & Trauma Research
University of Queensland, Queensland Children's Medical Research Institute,
Level 4, Foundation Building, Royal Children's Hospital, Herston Rd, Herston, QLD Australia,
4029
p: (07) 3636 1278
f: (07) 3636 5578
e: k.stockton@uq.edu.au
QCMRI Website:
http://www.qcmri.org.au/Research/Burns,TraumaandtheCriticallyIll/CentreforChildrensBurn
sandTraumaResearch.aspx
QCMRI Scientific Report 2012 73

QCMRI Scientific Report 2011 88
QCMRI Scientific Report 2012 74

Department Nursing Research, Royal Children’s Hospital
Summary of Research Activities and Achievements
The primary aim of the nursing research program was to promote, initiate and develop
nursing research relevant to the health care needs of children and their families. The
Children’s Health Queensland Hospital and Health Service nursing research program was
comprised of three main streams: a) research education; b) coordination and conduct of
research projects; c) support of postgraduate research study by clinical nurses to build a
critical mass for evidence based practice change in the organisation. During 2012, 6 nursing
research projects, have been conducted or continue to be in progress. Major research
themes for these funded studies included:
‣ Retrieval of critically ill children
‣ Development and utilisation of Indigenous safe infant sleeping e-learning modes for
Indigenous Health Workers
‣ Capacity building, and partnerships and safe infant health promotion in Aboriginal and
Torres Strait Islander communities
‣ Intravascular device administration sets: URUeplacement after USUtandard UVUersus
UPUrolonged use (The RSVP Trial)
‣ Health Professionals’ attitude, knowledge and beliefs regarding Lesbian, Gay, Bisexual
and Transgender parents seeking health care for their children. (LGBT Study)
‣ USUecurement UAUnd UDUuration of paediatric UPUeripheral UIUntraUvUenous
UDUevices (SAD PIVD): an observational cohort study.
Project ideas developed for 2013:
‣ Trial of a safe sleep enabler to reduce the risk of sudden unexpected deaths in infancy
in high risk environments.
‣ The SAVE Trial: USUecuring UAUll intraUVUenous devices UEUffectively in hospitals. A
randomised controlled rial
Please Note:
In February 2013, the Nursing Director – Research and the Nurse Researcher – Community
Child Health, were abolished as part of Children’s Health Queensland workforce reductions.
As of the 10 th February 2013 the Nursing Research Unit in its current form no longer exists.
Future research activity by nurses at CHQH&HS will come under a new model. At the time of
completing and submitting this final report for Nursing Research (11 th March, 2013), this
model was yet to be determined. Shelley Nowlan, CHQ Executive Director of Nursing
Services, will lead the new model once it is determined.
QCMRI Scientific Report 2012 75

Professor Jeanine Young, appointed Professor of Nursing, University of the Sunshine Coast
(to commence August 2013), will continue the support of currently funded projects during
2013 for which she is chief or co-investigator. These projects include two NH&MRC funded
trials in collaboration with the Centre for Health Practice Innovation, Griffith University,
where she holds an appointment as an Adjunct Professor. The trial of the safe sleep enabler
to reduce the risk of sudden unexpected deaths in infancy in high risk environments in self
selected Indigenous communities, is supported by Professor Young’s role as Chair of the
SIDS and Kids National Scientific Advisory Group and Member, International Society for the
Study and Prevention of Infant Death and her supervision of Leanne Craigie, Project Officer
as RHD supervisor. Lorelle Malyon will continue to support the completion of the SAD PIVD
study in her role as Nurse Educator – DEM.
Awards
Adj Professor Jeanine Young
‣ Best Paper, 2 nd International Conference on Global Telehealth.
Research Grants and Contracts
Years
2011-
2013
Grant
Agency
NHMRC
Chief Investigators Title Amount
C Rickard, M Wallis, J
Young, J Gowardman,
M Whitby, D
McMillan, J Fraser, L
Zhang, M McGrail, R
Chan
Intravascular device
administration sets: Replacement
after Standard Versus Prolonged
use (The RSVP Trial).
$1,555,305
2012-
2013
Indigenous
Early
Childhood
Development
Commonweal
th Grants
J Young, L Craigie, K
Watson, L Raven
Health Promotion Initiative for
Raising Awareness of ways to
reduce the risk of sudden infant
death in Aboriginal and Torres
Strait Islander communities:
capacity building and partnership
in safe infant sleeping health
promotion.
$140,000
2011-
2012
Collaborative
for
Healthcare
Improvement
J Young, N Higgins, L
Raven, M Watson
Keeping Indigenous mortality
reductions on-track with on-line
solutions: Innovative ways of
supporting health professional to
deliver safe sleeping information
that meets the culturally specific
needs of Aboriginal and Torres
Strait Islander families.
$88,000
QCMRI Scientific Report 2012 76

Years
2011-
2012
Grant
Agency
Queensland
Health
Nursing and
Midwifery
Novice
Researcher
Grant
Chief Investigators Title Amount
K Watson, S Keogh
Exploring parental experience of
retrieval of a critically ill child
$10,000
2011-
2012
Nurses
Memorial
Trust
Western
Australia
L Shields, J Young, R
Chapman, T Zappia, R
Watkins, P Nicol, K
Berry
Health Professionals’ attitude,
knowledge and beliefs regarding
Lesbian, Gay, Bisexual and
Transgender parents seeking
health care for their children.
$10,000
2006-
2012
Australia &
New Zealand
Children’s
Haematology
/ Oncology
Group
Y Hastings, L
Lockwood, J Young, R
Ware
‘Parents’ and adolescents’
perceptions of the Informed
Consent and initial treatment
processes in the paediatric
cancer setting
$12,640
2009-
2011
NHMRC
J Kenardy, V Cobham, R
Nixon, B McDermott, S
Keogh
Treating children with PTSD
following an accidental injury: A
multi-site RCT
$346,425
Publications
Peer Reviewed Manuscripts
1. Bradford N, Armfield NR, Young J, Ehmer M, Smith AC. Safety for home care: the use of
internet video calls to double-check interventions. J Telemed Telecare.
2012;18(8):434-7. doi: 10.1258/jtt.2012.GTH102. Epub 2012 Dec 3.
2. Bradford N, Armfield NR, Young J, Smith AC. Feasibility and accuracy of medication
checks via Internet video. J Telemed Telecare. 2012;18(3):128-32. doi:
10.1258/jtt.2012.SFT102. Epub 2012 Feb 23.
3. Bradford N, Irving H, Smith AC, Pedersen LA, Herbert A. Palliative care afterhours: a
review of a phone support service. J Pediatr Oncol Nurs. 2012 May-Jun;29(3):141-50.
4. Bradford N, Young J, Armfield NR, Bensink ME, Pedersen LA, Herbert A, Smith AC. A
pilot study of the effectiveness of home teleconsultations in paediatric palliative care.
J Telemed Telecare. 2012;18(8):438-42. Epub 2012 Nov 15
5. Long D, Young J, Rickard CM, Mitchell ML. (2012) Measuring paediatric intensive care
nursing knowledge in Australia and New Zealand: How the Basic Knowledge
Assessment Tool for pediatric critical care nurses (PEDS-BKAT4) performs. Australian
Critical Care Article first published online 18 th April 2012:
http://dx.doi.org/10.1016/j.aucc.2012.02.004U
QCMRI Scientific Report 2012 77

6. Watson K, Young J, Barnes M. (2012) What constitutes ‘support’ for the role of
Aboriginal and Torres Strait Islander Child Health Workforce? Australian Health Review
Accepted May 2013, Published on-line 21 st December 2012,
HUhttp://dx.doi.org/10.1071/AH11079U
7. Young J, Mannix T. (2012) Cochrane Review Summary: Non-pharmacological
management of infant and young chil procedural pain – Clinical Context. Neonatal,
Paediatric and Child Health Nursing July 2012 15(2): 26-27.
8. Young J, Watson K, Ellis L, Raven L. (2012) Responding to evidence: Breastfeed baby if
you can – the sixth public health recommendation to reduce the risk of sudden and
unexpected death in infancy. Breastfeeding Review 20(1): 7-15.
9. Young J, Watson K, Ellis L, Raven L.(2012) Response to Gifford, J. (2012) Safe Sleeping
Recommendations, Letter to the Editor Breastfeeding Review 20(2): 52.
10. Young J, Watson K, Ellis L, Raven L. (2012) Response to Letter to the Editor by Leach S
& Fetherston C. (2012) Safe Sleeping Recommendations in Breastfeeding Review
20(1): 7-15. Breastfeeding Review November 20(3): 50.
Staff Profile
Name
Adj Prof Jeanine Young
Dr Samantha Keogh
Karen Watson
Lorelle Malyon
Lauren Kearney
Alison Williams
Linda Crowe
Robin Hardy
Kirsten Franzen
Leanne Craigie
Position
Nursing Director – Research
Nurse Researcher
Nurse Researcher
Nurse Researcher
Nurse Researcher
Community Child Health
Community Child Health
Research Assistant
Research Assistant
Research Assistant
QCMRI Scientific Report 2012 78

Our Students
Research Degrees Ongoing
Name Supervisors Degree
Mrs Debbie Long
J Young
C Rickard
M Mitchell
PhD
Rebecca Saul
Lorelle Malyon
Natalie Bradford
Elizabeth Crowe
J Kenardy
S Keogh
A Williams
R Ware
J Young
A Smith
J Young
N Armfield
MSc
MPhil
MPhil - PhD
MPhil
National and International Collaborators
‣ A/Professor Angela Cooke-Jackson, Emerson College, Boston USA
‣ Stephanie Cowan, Change for our Children, Christchurch NZ
Research Group Contact Details
Nursing Research
Ground Floor, North Tower
Royal Children’s Hospital
Herston Road, Herston
Queensland 4029
p: (07) 3636 1962
f: (07) 3636 1224
QCMRI Website:
http://www.qcmri.org.au/Research/InnovativeEvidenceBasedHealthCareandDelivery/Nursin
gResearch.aspx
QCMRI Scientific Report 2012 79

Centre for Online Health
Message from the Director of the Centre
Introduction
The Centre for Online Health (COH) has had a very productive year on all fronts - covering its
unique role in research, teaching and in telehealth service provision.
Research themes involving telemedicine have broadened to include paediatrics, adult and
residential aged care. A diverse range of research projects has generated special focus areas
including critical care, home telehealth, primary health care, Indigenous health and
specialist geriatric support within nursing homes.
The COH maintains responsibility for two major telehealth operations in Queensland - the
Queensland Telepaediatric Service (QTS) – established more than 12 years ago at the Royal
Children's Hospital; and the PA Telehealth Centre – which was officially launched at the
Princess Alexandra Hospital in November 2012. The QTS is one of the largest reported
services of its kind worldwide having delivered over 15,000 consultations in 37 paediatric
specialty areas. The PA Telehealth Centre which contains state-of-the-art telehealth
facilities has been developed in collaboration with Queensland Health and the
Commonwealth Government.
The COH has strengthened its position as the leading academic telehealth centre in
Australia, by winning a significant tender through the Department of Health and Ageing for
$1.3m (under the Telehealth Support Program) to provide training and educational support
to existing health practitioners, as well as those entering the workforce, to enable them to
deliver health services via online video conference consultations.
A strength of our work has been the growing partnership with colleagues within UQ who
have an interest in telehealth. We are actively contributing to a collaboration badged
“Telehealth @ UQ”. This arrangement has resulted in several major grant achievements.
In partnership with the Centre for Research in Geriatric Medicine (CRGM) and Uniquest, the
COH conceived and developed a commercial enterprise called “RES-e-CARE” to deliver
specialist care to aged care homes through telehealth. This has generated high levels of
interest among service providers.
In partnership with the CRGM and the Telerehabilitation Research Unit at St. Lucia, the COH
secured over $4.5m in funds to operate demonstrations in telehealth with a large emphasis
on care delivery in small rural hospitals and residential aged care facilities.
The COH output in terms of publications and presentations was regular – with a total of 21
peer-reviewed papers; two published abstracts; two edited books; three book chapters
published; and a total of 26 conference presentations at national and international
QCMRI Scientific Report 2012 80

conferences. A textbook on Telemedicine and Dermatology – a joint initiative of the
Dermatology Research Centre (Prof Peter Soyer) and the Centre for Online Health (A/Prof
Anthony Smith) was published in 2012.
The COH led the scientific program committee for the International Global Telehealth
conference held in Sydney in November 2012. The conference comprised a two day
program with three workshops and 35 presentations; and was attended by 170 delegates
from 14 countries. Selected papers were published in a special issue of the Journal of
Telemedicine and Telecare.
Telehealth is attracting plenty of interest in Australia and abroad, as a key strategy to help
overcome the logistical challenges associated with health service delivery. The emerging
investments in the national broadband infrastructure in Australia and the recently
introduced Commonwealth (Medicare) funding for video consultations are creating many
exciting opportunities for the COH to contribute to the development of telehealth in
Australia. The next five to ten years will be both challenging and rewarding for the COH as
we work closely with clinicians through the necessary change processes required for
telehealth adoption on a widespread scale.
Professor Len Gray, Director
QCMRI Scientific Report 2012 81

Summary of Research Activities and Achievements
‣ Telepaediatrics – establishment, coordination and evaluation of telemedicine services
delivered through Children’s Health Services, Queensland Health. (Smith, AC) – T2 and
T3
The Queensland Telepaediatric Service provides the foundation for the centre's research
into service delivery models of health care delivery for children and their families in rural
and regional areas of Queensland. During 2012, the service reached an important
milestone, delivering over 15,000 consultations from the COH at the Royal Children’s
Hospital. The COH have been contracted to develop a similar model of telehealth service
development at the Princess Alexandra Hospital (PA Telehealth Centre).
‣ Evaluation of a novel health screening service for children in a remote Indigenous
community. (Smith AC, Armfield NR, Scuffham P) – T3
The aim of this project is to examine the feasibility of a novel health screening service and to
obtain scientific evidence to demonstrate feasibility, clinical usefulness and costeffectiveness.
The screening program formally commenced in 2009. A longitudinal study is
underway to examine clinical utilization, health service benefits and factors which influence
organisational uptake. A review of the service was published in 2012. Lesson learnt through
this experience in Cherbourg are being observed by other Aboriginal and Torres Strait
Islander health service providers in Australia.
‣ A randomized controlled trial to evaluate paediatric critical care telemedicine in
Queensland (Smith AC, Coulthard M, Slater A, Armfield NR) – T1 and T2
This three year study involves a randomised controlled trial to investigate the efficacy and
economics of paediatric critical care telemedicine with selected regional Queensland
hospitals. Four sites are currently being established. All equipment has been built and
tested ready for deployment. Ethics has been approved by the appropriate committees.
‣ Using conversational computer technology to improve diabetes management: A
randomised controlled trial. (Oldenburg B, Courtney M, Friedman R, Wootton R, Ash S,
Smith AC) – T2 and T3.
The aim of this study was to evaluate the cost-effectiveness of a telehealth service for
patients with diabetes. Telephone linked Care (TLC) is a system used to share information
between patients and clinicians. A study which evaluated the feasibility of this system in
regional Queensland was completed in 2012. Two papers have been published and one
publication is in press.
QCMRI Scientific Report 2012 82

‣ Health-e-REGIONS (Smith AC, Gray L) – T2 and T3
The Health e-REGIONS Project aims to establish and evaluate a prototype for the provision
of specialist telehealth services in the Western Downs region of Queensland. The first phase
(scoping study) was completed in 2012 and the findings were published. Additional funding
of $1.4m was awarded in December 2012 for a comprehensive two year project to
implement and evaluate the telehealth strategy. A new ‘whole of community’ telehealth
model will be tested in three small rural towns including Dalby, Chinchilla and Miles.
‣ Telepaediatric Palliative Care Research Project - Phase 2 (Smith AC) – T2 and T3
This long-standing project involves the development and evaluation of a range of telehealth
services designed for patients and families receiving long-term and/or palliative care. The
majority of the services involve consultations and clinical support in the home setting. Four
papers were published during 2012 describing the effectiveness of the program from a
clinical and efficacy perspective.
‣ A telehealth coordination service for the nursing home: Needs Assessment and Proof
of concept (Gray LC, Smith AC, Edirippulige S) – T2 and T3
This project explored the interactions between specialists and residents of a large residential
aged care facility in Brisbane, to estimate the potential to substitute some of the encounters
with a telehealth solution. In phase 2, trials of several specialty consultations were trialled
using telemedicine solutions. This work was concluded in early 2012, and led to the
development of RES-e-CARE and the large NHMRC evaluation referred to in our report.
Three papers have been published.
‣ Move it to improve it (MitiiTM): A randomised controlled trial of a novel web-based
multi-modal training program for children and adolescents with cerebral palsy (Boyd R,
Mitchell L, James S, Ziviani J, Sakzewski L, Smith AC, Rose S et al) – T1 and T2
Move it to improve it (MitiiTM) is an internet based multi-modal training program
comprising upper-limb and cognitive training within the context of meaningful physical
activity. It requires no specialist or costly equipment and can be accessed in the client’s
home at their convenience. This study aims to test the efficacy of MitiiTM in improving
upper-limb function, motor planning, executive function, visual perception and physical
activity capacity and performance.
‣ The development, delivery, promotion and evaluation of a clinical telehealth
educational and training programs for clinicians (Smith AC, Armfield NR, Edirippulige S,
Gray L) – T3
QCMRI Scientific Report 2012 83

This project represents a significant contribution to the development, delivery, promotion
and evaluation of a clinical telehealth education and training program for clinicians. The aim
of the project is to develop a CPD course in clinical telehealth; a UQ Grad Certificate course
in Clinical Telehealth and an Elective for undergraduate students. The development phase is
on schedule and implementation is due to commence in May 2013. A formal evaluation
plan has been developed to measure effectiveness. Components of this project will be
commercialised under the COH business ProACT.
Awards
Research Grants and Contracts
Years Grant Agency Chief
Investigators
2010-2012 Sporting Chance Smith, AC.
Foundation
Title
Telepaediatric Palliative
care Research Project
Amount
$210,000
2011-2012 QGC Smith, AC., Gray,L Health-e-REGIONS $237,062
2012-2013 DoHA via UniQUest Smith, AC.,
Edirippulige, S.,
Armfield, NR.,
Gray, L
The development,
delivery, promotion and
evaluation of a clinical
telehealth educational
and training programs for
clinicians
$1,298,078
2012 Service Level
Agreement: Childrens
Health Service District
(Queensland Health)
Smith AC. Telepaediatrics $223,630
QCMRI Scientific Report 2012 84

Publications
Journal Articles
1. Armfield, N. R., L. C. Gray and A. C. Smith (2012). "Clinical use of Skype: a review of the
evidence base." Journal of Telemedicine and Telecare 18(3): 125-127.
2. Armfield Nr Fau - Donovan, T., M. E. Donovan T Fau - Bensink, A. C. Bensink Me Fau -
Smith and A. C. Smith (2012). "The costs and potential savings of telemedicine for
acute care neonatal consultation: preliminary findings." Journal of Telemedicine and
Telecare 18: 429-433.
3. Bensink, M., P. Scuffham and A. Smith (2012). Health economics. Telemedicine in
Dermatology. B. M. Soyer HP, Smith AC and Wurm EM. . Germany, Springer Press:
167-186.
4. Bradford, N., N. R. Armfield, J. Young, M. Ehmer and A. C. Smith (2012). "Safety for
home care: the use of internet video calls to double-check interventions." J Telemed
Telecare 18(8): 434-437.
5. Bradford, N., N. R. Armfield, J. Young and A. C. Smith (2012). "Feasibility and accuracy
of medication checks via Internet video." J Telemed Telecare 18(3): 128-132.
6. Bradford, N., M. Bensink, H. Irving, J. Murray, L.-A. Pedersen, J. Roylance, L. Crowe and
A. Herbert (2012). "Paediatric palliative care services in Queensland: An exploration of
the barriers, gaps and plans for service development." Neonatal, Paediatric & Child
Health Nursing 15(1): 2-7.
7. Bradford, N., H. Irving, A. C. Smith, L. A. Pedersen and A. Herbert (2012). "Palliative
care afterhours: a review of a phone support service." J Pediatr Oncol Nurs 29(3): 141-
150.
8. Bradford N Fau - Young, J., N. R. Young J Fau - Armfield, M. E. Armfield Nr Fau -
Bensink, L.-A. Bensink Me Fau - Pedersen, A. Pedersen La Fau - Herbert, A. C. Herbert A
Fau - Smith and A. C. Smith (2012). "A pilot study of the effectiveness of home
teleconsultations in paediatric palliative care." Journal of Telemedicine and Telecare
18(8): 438-442.
9. Bradford N, S. J., Armfield NR, Smith AC, Young J. (2012). "Connecting with the outside
world: use of computers and Internet during prolonged hospitalisation." Pediatr Blood
Cancer.
10. Croll, J., C. J. Norton, L. C. Gray, A. Bryett and A. C. Smith (2012). "Telehealth
opportunities in regional Queensland: a scoping study." Journal of Telemedicine and
Telecare 18: 451-454.
11. Edirippulige, S., N. R. Armfield and A. C. Smith (2012). "A qualitative study of the
careers and professional practices of graduates from an e-health postgraduate
programme." Journal of Telemedicine and Telecare 18: 455-459.
12. Edirippulige, S., C. A. Smith, R. N. Armfield, M. Bensink and R. Wootton (2012).
"Student Perceptions of a Hands-on Practicum to Supplement an Online eHealth
Course." J Med Internet Res 14(6): e182.
QCMRI Scientific Report 2012 85

13. Fatehi, F. and R. Wootton (2012). "Telemedicine, telehealth or e-health? A bibliometric
analysis of the trends in the use of these terms." Journal of Telemedicine and Telecare
18: 460-464.
14. Gray, L. C., S. Edirippulige, A. C. Smith, E. Beattie, D. Theodoros, T. Russell and M.
Martin-Khan (2012). "Telehealth for nursing homes: the utilization of specialist
services for residential care." Journal of Telemedicine and Telecare 18(3): 142-146.
15. Maon, S., S. Edirippulige, R. Ware and J. Batch (2012). "The use of web-based
interventions to prevent excessive weight gain." J Telemed Telecare 18(1): 37-41.
16. Marasinghe, R. B., S. Edirippulige, D. Kavanagh, A. Smith and M. T. Jiffry (2012). "Effect
of mobile phone-based psychotherapy in suicide prevention: a randomized controlled
trial in Sri Lanka." J Telemed Telecare 18(3): 151-155.
17. Martin-Khan M, B. E., Edirippulige S, Gray LC, Russell T, Smith AC and Theodoros D.
(2012). "Telehealth for nursing homes: utilisation of specialist services." Australasian
Journal on Ageing. 31(Suppl 1): 37.
18. Rodrigo, E. S., S. R. Wimalaratne, R. B. Marasinghe and S. Edirippulige (2012). "A pilot
health information management system for public health midwives serving in a
remote area of Sri Lanka." J Telemed Telecare 18(3): 159-163.
19. Smith, A. C., N. R. Armfield, J. Croll and L. C. Gray (2012). "A review of Medicare
expenditure in Australia for psychiatric consultations delivered in person and via
videoconference." Journal of Telemedicine and Telecare 18(3): 169-171.
20. Smith, A. C., N. R. Armfield, W.-I. Wu, C. A. Brown and C. Perry (2012). "A mobile
telemedicine-enabled ear screening service for Indigenous children in Queensland:
activity and outcomes in the first three years." Journal of Telemedicine and Telecare:
485-489.
21. Smith, A. C., M. M. White, C. A. McBride, R. M. Kimble, N. R. Armfield, R. S. Ware and
M. G. Coulthard (2012). "Multi-site videoconference tutorials for medical students in
Australia." ANZ J Surg 82(10): 714-719.
22. T, D., A. NR, C. K, S. A, V. d. W. J, H. T and R. D (2012). "Remote management of ill
infants by telemedicine: improving access and outcome in a vulnerable patient group."
Journal of Paediatrics and Child Health 48(Suppl. 1).
23. Wong, L., M. Martin-Khan, J. Rowland, P. Varghese and L. C. Gray (2012). "The
Rowland Universal Dementia Assessment Scale (RUDAS) as a reliable screening tool for
dementia when administered via videoconferencing in elderly post-acute hospital
patients." Journal of Telemedicine and Telecare 18(3): 176-179.
24. Wood, J., S. Stathis, A. Smith and J. Krause (2012). "E-CYMHS: an expansion of a child
and youth telepsychiatry model in Queensland." Australas Psychiatry 20(4): 333-337.
QCMRI Scientific Report 2012 86

Book and Edited Books
1. Smith, A., N. Armfield and R. Eikelboom (2012). Global Telehealth.
2. Soyer, H., M. Binder, A. Smith and W. EMT, Eds. (2012). Telemedicine in Dermatology
Springer Press.
Book Chapters
1. Jakowenko, J., M. Smith and A. Smith (2012). Photographic imaging essentials
Telemedicine in Dermatology. B. M. Soyer HP, Smith AC and Wurm EM. . Germany
Springer Press: 143-146.
2. Wurm, E., H. Soyer and A. Smith (2012). Introduction to Teledermatology.
Telemedicine in Dermatology. B. M. Soyer HP, Smith AC and Wurm EM. Germany,
Springer Press: 1-8.
Staff Profile
Research Staff
Title First Name Last Name Position Hospital
Appointment
University/School
Appointment
Prof Len Gray Director Consultant Academic
Geriatrician
A/Prof Anthony Smith Deputy Director Academic
Dr Sisira Edirippulige Lecturer and Course
Academic
Coordinator
Dr Nigel Armfield Research Fellow Academic
Dr Nancye Peel Research Fellow Academic
Dr Jasmine Croll Research Fellow Academic
Ms Karen Lucas Service Manager Research
Ms Megan White Telepaediatric
Research
Coordinator
Ms Lisa Garner Telepaediatric
Research
Coordinator
Ms Brooke Mickan Telepaediatric
Research
Coordinator
Mr Sean Halloran Telehealth
Research
Coordinator
Ms Ruth Saunders Curriculum Designer
Research
and Developer
Ms Linda MacDonald Curriculum Designer
and Developer
Research
QCMRI Scientific Report 2012 87

Ms Joanne Grey Senior
Research
Communications and
Media Officer
Ms Chrissie Norton Buisness
Research
Development
Manager
Ms Nathalie Bradford Clinical Research
Research
Nurse
Ms Joanna Kho Senior Research
Research
Administration
Officer
Mr Adam Mothershaw Graduate Technical
Research
Engineer
Mr Wing Kit Fung IT Officer Research
(Kenneth)
Mr Wei-I (Will) Wu IT Officer Research
Ms Eliza Burke Centre Administrator Research
Ms Dominique Bird Research Consultant Honorary
Appointment
Ms Liam Caffery Lecturer Honorary
Appointment
Mr Bernard Crowe Visiting Research
Fellow
Honorary
Appointment
Mr David Hailey Visiting Research
Fellow
Honorary
Appointment
Mr James Marcin Professor Honorary
Appointment
Mr Robert McCrossin Visiting Research
Fellow
Honorary
Appointment
Mr Leif Nohr Research Fellow Honorary
Appointment
Ms Megan Rollo Conjoint Associate
Lecturer
Conjoint
Appointment
Mr Trevor Russell Lecturer Affiliate
Mr Paul Scuffham Visiting Research
Honorary
Fellow
Appointment
Ms Deborah Theodoros Associate Professor Affiliate
Dr Richard Wootton Professor Honorary
Appointment
Our Students
Research Degrees Completed
Name
Higgins, Niall
Degree
PhD
QCMRI Scientific Report 2012 88

Research Degrees Ongoing
Name Supervisors Degree
Thompson, Lauren Armfield, NR Mphil
Taylor, Olivia Smith, AC Mphil
Marasinghe, Rohana Smith, AC and Edirippulige PhD
Siti, Maon Edirippulige, S PhD
Fatehi, Farhad Gray, L PhD
Bradford, Natalie Smith, AC and Armfield, NR PhD
Major Partners and Linkages
National and International
Hospitals/Institutes/Centres
‣ Royal Children’s Hospital/Children’s Health Services District, Queensland Health
The COH has maintained a strong partnership with the RCH for more than ten years –
establishing and managing paediatric telehealth services. This telepaediatric service delivers
around 2000 consultations per year for a broad range of specialties. Routine telehealth
clinics are held in the COH, which is located centrally within the RCH.
‣ Princess Alexandra Hospital, Queensland Health
The COH have a service level agreement to manage the PA Telehealth Centre at the PA
Hospital. The COH was instrumental in the design and planning of the facility during
2011/12. The COH currently has responsibility for the coordination and management of
new telehealth services provided through the centre.
‣ Department of Paediatrics and Child Health, The University of Queensland
The COH is working with Professor Mark Coulthard - Department of Paediatrics and Child
Health to expand the delivery of MBBS student lectures to students (via videoconference)
whilst on clinical placement at remote locations. The multi-site videoconference tutorials
are held weekly in the COH.
QCMRI Scientific Report 2012 89

‣ Queensland Cerebral Palsy and Rehabilitation Research Centre
A/Prof Anthony Smith is a chief investigator on several major grants held by the QCPRRC.
A/Prof Smith collaborates with Prof Ros Boyd and supports the telehealth aspects of her
studies involving remote therapy and telemedicine devices.
National Academic Collaborations
‣ Australasian Telehealth Society (ATHS)
A/Prof Anthony Smith wass the inaugural Queensland representative of the Australasian
Telehealth Society, established in 2008. He was elected Vice-President of the ATHS in
November 2012.
International Academic Collaborations
‣ Norwegian Centre for Integrated Care and Telemedicine
The COH hosted Mr Leif Nohr for a six month sabbatical. Leif is a lawyer with special
interests and expertise in the field of telemedicine.
‣ UC Davis – Center for Health and Technology, UC Davis Children's Hospital Sacramento
USA
Links established with Professor Jim Marcin (now an honorary Professor at the COH) – with
common interests in paediatric critical care telemedicine completed his sabbatical at the
COH.
QCMRI Scientific Report 2012 90

Research Group Contact Details
Dr Anthony Smith
Deputy Director and Associate Professor
Centre for Online Health
The University of Queensland l CRICOS Provider No: 00025B
Appts: (07) 3346 4707
QCMRI Web
http://www.qcmri.org.au/Research/InnovativeEvidenceBasedHealthCareandDelivery/Centre
forOnlineHealth%28COH%29.aspx
Queensland Telepaediatric Service
Level 3 Foundation Building
Royal Children’s Hospital
Herston QLD 4029
p: (07) 3346 4754 l Toll-free 1800 35 46 57 (Australia Wide)
f: (07) 3346 4705
PA Telehealth Centre
Ground Floor, Main Building
Princess Alexandra Hospital
Woolloongabba QLD 4102
p: (07) 3176 8181
f: (07) 3176 8190
QCMRI Scientific Report 2012 91

Children’s Allied Health Research
MESSAGE FROM GROUP LEADER
During 2012 a number of new allied health research initiatives have occurred focusing on
current service provisions within Children’s Health Queensland Hospital and Health Service.
Many of these have been small scale project with individual disciplines others have been on
a larger scale and involved cross disciplinary and external partners. As well Established
research groups have continued to flourish with the support of grant funding. Fundamental
to these activities has been the support received from numerous organisations particularly
Queensland Health and the School of Health and Rehabilitation Sciences at The University of
Queensland.
The activities represented in this report reflect those directly associated with the Professor
of Children’s Allied Health Research. There are numerous other achievements by individuals
and groups across both Children’s Health Queensland Hospital and Health Service which are
not recorded here.
Professor Jenny Ziviani
Summary of Research Activities and Achievements
‣ Allied health practitioners were successful in receiving 2 of the Queensland Health HP
Research Grants and additional support was secured from QCMRI for seeding funds for
2 additional applications which were judged to be near misses.
‣ Professor Ziviani was awarded a University of Queensland Excellence in Research Higher
Degree Supervision Award.
‣ Doctoral awardee Margaret Wallen was nominated for the highly competitive Pursuit
Award in Childhood Disability Research for her thesis “Modified constraint induced
movement therapy for children with CP hemiplegia”. She presented this work to a
panel at Bloorview Children’s Hospital in Toronto.
‣ Doctoral awardee Craig Greber was awarded a Dean’s Commendation for his thesis
“The four quadrant model of facilitated learning”.
‣ Doctoral awardee Fiona Jones has had resources developed from her thesis “Transition
to high school for children with cerebral palsy” made available on the CanChild website.
‣ Four honours students completed projects in Children’s Health Queensland all with First
Class honours.
‣ Dr Peter Steer launched the book “The art and science of motivation: a therapist guide
to working with children” edited by Jenny Ziviani, Anne Poulsen and Monica Cuskelly at
the Riverbend Bookshop, Bulimba
QCMRI Scientific Report 2012 92

‣ Twenty two international conference papers have been presented with one (Wallen et
al) being awarded both best intervention and best paper at the Biennial Conference of
the Australasian Academy of Cerebral Palsy and Developmental Medicine.
Research Grants and Contracts
Years Grant Agency Chief Investigators Titles Amount
2012 Learning and
Enhancement
Grant UQ
J Ziviani
S Schabrun
P Hodges
D Copland
Fostering and Inspiring Research
Engagement (FIRE): an incubator
scheme for undergraduate
students
$19,475
2012 HP Research
Grants (Qld
Health)
M Simons
Z Tyack
J Ziviani
R Plaza
R Kimble
L Cuttle
Brisbane Scar Rating Scale:
Improving the evidence base for
burns management
$30,764
2012-
2014
HWA – Qld
Health
Simulated
Learning
Environment
Project Funding
M Moller
J Ziviani
D Best
G Jull
E Ward
S Bennett
S Morris
N Low Choy
Simulated Learning in Paediatrics
for Allied Health Practitioners
$750,790
2012-
2014
Smart Future
Fund Qld
R Boyd
P Colditz
S Rose
A Smith
T Scuffham
L McKinlay
Neurorestorative Rehabilitation for
Queensland Children
$1,000,000
2012 Perpetual Trusts R Boyd
J Ziviani
Mitii: A novel virtual reality
intervention for children with
acquired brain injury
$79,910
2012 HP Research
Grants (Qld
Health)
R Boyd
J Ziviani
Move it to improve it (Mitii)
Australia: Efficacy of a web based
multimodal intervention for
children with cerebral palsy
$39,487
QCMRI Scientific Report 2012 93

2011-
2013
Foundation for
Children
R Boyd
J Ziviani
A Smith
Move it to improve it (Mitii)
Australia: Efficacy of a web based
multimedia intervention for
children with CP
$180,000
2011-
2013
ARC
R Boyd
J Ziviani
A Guzzetta
UPBEAT: Effect of infant hand
observation training on the early
development of hand reaching and
grasping in healthy infants and
those with early brain damage
$400,000
2011-
2013
NHMRC
R Boyd
J Ziviani
D Abbot
S Rose
COMBIT: Randomised controlled
trial of a novel upper limb
neurorebilitation for congenital
hemiplegia
$450,000
Publications
Peer Reviewed Manuscripts
1. Simons, M., Ziviani, J., Thorley, M., McNee, J. & Tyack, Z (2012). Exploring reliability of
scar rating scales using photographs of burns from children aged up to 15 years.
Journal of Burn Care and Research, 12/2012; DOI:10.1097/BCR.Ob013e3182700054
2. Boyd, R., Mitchell, L., James, S., Ziviani, J., Sakzewski, L., Smith, A., Rose, S.,Cunnington,
R., Whittingham, K., Bodimeade, H., Ware, R., Neilson, J., Bilde, P., Comans, T. &
Scuffham, P (2013). Move it to improve it (Mitii TM ): A randomised controlled trial of a
novel web-based multi-modal training program for children and adolescents with
cerebral palsy, BMJ Open 2013;3:e002853. doi:10.1136/bmjopen-2013-002853
3. Miller, L., Ziviani, J. & Boyd, R. (2013) A systematic review of clinimetric properties of
measurements of motivation for children aged 5-16 years with a physical disability or
motor delay, Physical and Occupational Therapy in Pediatrics
DOI:10.3109/01942638.2013.771720
4. Ziviani, J., Darlington, Y., Feeney, R., Meredith, P. & Head, B. (2013). Children with
disabilities in out-of-home care: Perspectives on organisational collaboration. Children
and Youth Services Review, 35, 797-805
5. Ziviani, J., Feeney, R., Darlington, Y., Rodger, S., & Watter, P. (2013) Service delivery
complexities: Early intervention for children with physical disabilities. Infants and
Young Children, 26, 2, 147-163
6. Guzzetta, A., Boyd, R., Perez, M., Ziviani, J., Burzi,V., Slaughter, V., Rose, S., Provan, K.,
Finlay, L., Fisher, I. et al. (2013) UP-BEAT (Upper Limb Baby Early Action-observation
Training) – Two parallel randomised controlled trials of action observation training for
QCMRI Scientific Report 2012 94

typically developing infants and infants with asymmetric brain lesions. BMJ Open
2013;3:e002512. doi:10.1136/bmjopen-2012-002512
7. Wallen, M. & Ziviani, J. (2013) Letter to the editor: Caution regarding the Pediatric
Motor Activity Log (PMAL) to measure upper limb intervention outcomes for children
with unilateral cerebral palsy. Developmental Medicine and Child Neurology Online
early doi: 10.1111/dmcn.12057
8. Graham, F., Rodger, S. & Ziviani, J. (2013) The effectiveness of Occupational
Performance Coaching in improving children’s and mother’s performance and
mother’s self competence. American Journal of Occupational Therapy. 67, 1, 10-18 DOI
10.5014/ajot.2013.004648
9. Ashburner, J., Ziviani, J. & Pennington, A. (2012). The introduction of keyboarding to
children with Autism Spectrum Disorders: A help or a hindrance. Australasian Journal
of Special Education, 36, 1, 32-61
10. Jones, F., Rodger, S., Ziviani, J. & Boyd, R. (2012) Applying a hermeneutic
phenomenological approach in allied health sciences research. International Journal of
Therapy and Rehabilitation, 19, 7, 2-10
11. Ziviani, J. & Wallen, M. (2012). Family-centred care, service or therapy: Its all in the
name! Physical Therapy Review, 17, 4, 252-253
12. Perez, M., Carlson, G., Ziviani, J. & Cuskelly, M. (2012) The contribution of occupational
therapists in positive behaviour support. Australian Occupational Therapy Journal. 59,
428–436 DOI: 10.1111/j.1440-1630.2012.01036.
13. Wallen, M., Ziviani, J., Naylor, O., Evans, R., Novak, I. & Herbert, R. (2012). Wallen et
al., Reply to Ramsey et al. Developmental Medicine and Child Neurology. 54, 479-480.
DOI: 10.1111/j.1469-8749.2012.04263.x
14. Sakzewski, L., Carlon, S., Shields, N., Ziviani, J., Ware, R & Boyd, R.N. (2012) Impact of
intensive upper limb rehabilitation on quality of life in a randomised trial for children
with unilateral cerebral palsy. Developmental Medicine and Child Neurology, 54, 415-
423. DOI: 10.1111/j.1469-8749.2012.04272.x
15. Mitchell, L., Ziviani, J., Oftedal, S. & Boyd, R. (2012). The effect of virtual-reality
interventions on physical activity in children and adolescents with early brain injuries
including cerebral palsy: A systematic review. Developmental Medicine and Child
Neurology. 54, 7, 667-671. DOI: 10.1111/j.1469-8749.2011.04199.x
16. Ziviani, J., Feeney, R., Cuskelly, M., Meredith, P. & Hunt, K. (2012). Effectiveness of
support services for children and young people with challenging behaviours related to
or secondary to disabilities, who live in out-of-home care: A systematic review.
Children and Youth Services Review. 34, 758-770 doi:10.1016/j.childyouth.2012.01.002
17. Yu, M., Ziviani, J., Baxter, J. & Haynes, M. (2012). Time use differences in activity
participation among children 4 to 5 years old with and without the risk of developing
conduct problems. Research in Developmental Disabilities, 33, 2, 490-498 doi:
10.1016/j.ridd.2011.10.013
QCMRI Scientific Report 2012 95

18. Wallen, M. A., & Ziviani, J. M. (2012). Canadian Occupational Performance Measure:
Impact of blinded parent-proxy ratings on outcome. Canadian Journal of Occupational
Therapy, 79, 5-12. doi: 10.2182/cjot.2012.79.1.1
19. Feeney, R., Desha, L., Ziviani, J. & Nicholson, J. (2012). Health related quality of life of
children with speech and language difficulties: A review of the literature. International
Journal of Speech and Language Pathology, 14, 1, 59-72
doi:10.3109/17549507.2011.604791
Published Book Chapters and Reports
1. Ziviani, J., Poulsen, A. & Cuskelly, M. (2013). The art and science of motivation: A
therapist’s guide to working with children. Jessica Kingsley Publishers: London. p. 293
2. Poulsen, A., Ziviani, J. & Cuskelly, M. (2013) Understanding motivation in the context
of engaging children in therapy. In J. Ziviani, A. Poulsen & M. Cuskelly (Eds.), The art
and science of motivation: A therapist’s guide to working with children. Jessica Kingsley
Publishers: London. pp. 23-58.
3. Ziviani, J. & Poulsen, A. (2013) Connecting: nutriments from the social environment. In
J. Ziviani, A. Poulsen & M. Cuskelly (Eds.), The art and science of motivation: A
therapist’s guide to working with children. Jessica Kingsley Publishers: London. pp. 91-
122.
4. Greber, C., Hinojosa, J. & Ziviani, J. (2013) Achieving Success: Facilitating Skill
Acquisition and Enabling Participation. In J. Ziviani, A. Poulsen & M. Cuskelly (Eds.),
The art and science of motivation: A therapist’s guide to working with children. Jessica
Kingsley Publishers: London. pp. 123-158
5. Dunn, W. & Ziviani, J. (2013) Structuring and working with the environment. In J.
Ziviani, A. Poulsen & M. Cuskelly (Eds.), The art and science of motivation: A
therapist’s guide to working with children. Jessica Kingsley Publishers: London. pp.
225-248.
6. Crockett, J., Boyle, M. & Ziviani, J. (2013) What makes it work? A collaboration. In J.
Ziviani, A. Poulsen & M. Cuskelly (Eds.), The art and science of motivation: A
therapist’s guide to working with children. Jessica Kingsley Publishers: London. pp.
249-266.
7. Ziviani, J., Feeney, R., Cuskelly, M., Darlington, Y., Head, B., Meredith, P. & Khan, A.
(2012). Evaluation of Evolve Behaviour Support Services: Final Report to Department of
Communities (Disability and Community Care Services). The University of Queensland.
p.134
QCMRI Scientific Report 2012 96

Staff Profile
Name
Prof Jenny Ziviani
Dr Anne Poulsen
Ms Rachel Feeney
Dr Cathy McBryde
Position
Professor Children’s Allied Health Research
Post Doctoral Research Fellow
Research Officer
Research Officer
Our Students
Research Degrees Completed
Name Supervisors Topic Degree
Anna Jovina
Sarah James
Laura Edwards
P Meredith
J Ziviani
J Ziviani
L Desha
J Ziviani
J Duggan
E Shepherd
Factors that Support Work Performance
using an Attachment Theory Perspective
Motor skill and physical activity participation
of children who are overweight
Barriers to providing a community based
model of care for children with complex
medical and health care needs
PhD
awarded
2012
Honours
First Class
2012
Honours
First Class
2012
Kerry Marnane
J Ziviani
L Miller
R Boyd
Mastery Motivation Questionnaire: Test
retest reliability
Honours
First Class
2012
Ziyan Chen
Chelsea Darlow
P Dodrill
J Ziviani
P Dodrill
J Ziviani
Sensory sensitivity and children with feeding
difficulties
Developmental status and children with
feeding difficulties
Honours
First Class
2012
Honours
First Class
2012
QCMRI Scientific Report 2012 97

Research Degrees Ongoing
Name Supervisor Topic Degree Commencement
Date
Tracee
Cunningham
A Hill
J Ziviani
Clinical reasoning and speech
pathology interventions for
children with ASD
MPhil 2012
Yolanda
Fernandez
J Ziviani
F Jones
M Cuskelly
Children with developmental
difficulties: Positive
engagement in leisure activities
and implication for physical and
psychosocial wellbeing
PhD 2011
Jeanne Marshall
P Dodrill
R Hill
J Ziviani
RCT of feeding intervention for
children with ASD
PhD 2010
Amanda Francis
J Ziviani
J Fleming
Transition from child to adult
services for children with
acquired brain injury
PhD 2011
Louise Mitchell
R Boyd
J Ziviani
Mitii: Web-based intervention
for rehabilitation
PhD 2011
Laura Miller
R Boyd
J Ziviani
Motivational predisposition and
therapy outcomes following an
innovative rehabilitation
program for children with
hemiplegia
PhD 2011
Kate Hunt
J Ziviani
M Cuskelly
P Meredith
Professional development
within a collaborative
interagency team based
intensive behavioural support
service
PhD 2011
Micah Perez
R Boyd
J Ziviani
Early upper limb intervention
for infants with hemiplegia
PhD 2011
Medha Kadhi
J Ziviani
M Cuskelly
Parent satisfaction and family
centred care in early
intervention
MPhil 2010
Rachel Feeney
L Desha
J Ziviani
A Khan
Quality of life and early
language disorder in children
PhD 2010
QCMRI Scientific Report 2012 98

Rachel Brough
L Desha
J Ziviani
M Turpin
Embedded playfulness in the
lives of young children
PhD 2010
Rachel
Colquhoun
Xianghong Tan
(Priscilla)
Katja Kotaniemi
Lillian Anderson
J Ziviani
F Jones
Y Fernandez
K Miller
J Ziviani
J Ziviani
A Poulsen
M Law
N Scarinci
H Morris
J Ziviani
Circus: a leisure experience for
children with developmental
disabilities
Reducing distress and pain in
children (3-10 years)
undergoing IV insertion in the
emergency department
Belief in Goal Self Competence
Scale (BiGSS): Exploring ways to
document occupational therapy
interventions
Cleft palette and children’s
developmental outcome
Honours 2012
Honours 2012
Honours 2012
Honours 2012
National and International Collaborators
Community and Professional Activities
‣ Prof Ziviani continues on the Board of Directors of Occupational Therapy Australia
Limited. This appointment supports the establishment of the Occupational Therapy
Research Foundation.
‣ Prof Ziviani continues on the Expert Reference Group for the Better Start for Children
with Disability, Department of Families, Housing, Community Services and Indigenous
Affairs (FaHCSIA) which advises government of interventions for children with
disabilities
‣ Prof Ziviani was on the Grant Review Panel for NHMRC in 2012.
‣ Prof Ziviani is a member of the Research Reference Group for MontroseAccess.
Research Group Contact Details
Child Health and Paediatrics
Level 3, Foundation Building
Royal Children’s Hospital
Herston Rd, Herston Queensland 4029
p: 07 3636 6109
e: j.ziviani@uq.edu.au
QCMRI Scientific Report 2012 99

Biostatistics and Epidemiology Unit
In 2012, QCMRI increased its capacity in Biostatistics and Epidemiology, with the addition of
another co-funded Biostatistician in collaboration with UQ’s School of Population Health.
The Biostatistics and Epidemiology team delivers QCMRI’s Education and Training Series,
comprising a suite of modules for Research Higher Degree students and Early Career
Researchers aimed at equipping them with core skills in study design, biostatistical software
packages, statistical analysis and other essential research techniques.
In 2012 members of the QCMRI Biostatistics and Epidemiology Unit were responsible for
delivering over 40 hours of continuing education to QCMRI members, collaborated on over
30 published papers, supervised 6 QCMRI RHD students, and were Chief Investigators on a
number of large QCMRI-administered grants. Unit members contributed to papers
published in prestigious journals such as the Journal of the American Medical
Association, Archives of Disease in Childhood, and the European Journal of Clinical Nutrition.
Summary of Research Activities and Achievements
Pertussis research
Substantial work on understanding the current epidemic done by both Dr Sarah Sheridan and
Ms Marlena Kaczmarek. Dr Sheridan had a research letter published in the prestigious Journal of
the American Medical Association on her work around the relative effectiveness of whole cell
and acellular pertussis vaccines. This work attracted considerable local and international media
attention.
Ms Kaczmarek presented her early findings on the role laboratory testing has played in the
current outbreak to the National Immunisation Conference held in Darwin in July 2012.
Awards
‣ Dr Sarah Sheridan was awarded a NHMRC PhD Scholarship in 2012.
QCMRI Scientific Report 2012 100

Research Grants and Achievements
Years Grant Agency Chief
Investigators
2010- QCMRI
2015
Sloots T, Nissen MD,
Lambert S, Grimwood
K.
Title
Molecular Microbiology and
Epidemiology of Respiratory
Infections in Children
Amount
$2,250,000
2011-
2015
NHMRC
Grimwood K, Lambert
SB, Ware R, Sloots T,
Nissen MD
2011 Stuart Kinner, David
Preen, Nick Lennox,
Tony Butler, Robert
Power, Coralie Ober
Burden of respiratory infection in
the first 2 years of life
Improving the health of Indigenous
and non-Indigenous ex-prisoners: a
multi-jurisdictional, mixedmethods
study (NHMRC Project
Grant administered by the
Macfarlane Burnet Institute)
$1,135,000
$461,695
Publications
Journal Articles
1. Coulthard, MG; Long, DA; Ullman, AJ; Ware, RS A randomised controlled trial of
Hartmann's solution versus half normal saline in postoperative paediatric spinal
instrumentation and craniotomy patients Archives of Disease in Childhood (2012) 97 6
491-496
2. Ireland, PJ; Donaghey, S; McGill, J; Zankl, A; Ware, RS; Pacey, V; Ault, J; Savarirayan, R;
Sillence, D; Thompson, E; Townshend, S; Johnston, LM Development in children with
achondroplasia: A prospective clinical cohort study Developmental Medicine and Child
Neurology (2012) 54 6 532-537
3. Brown, N; Rodger, S; Ware, R; Kimble, R; Cuttle, L Efficacy of a children's procedural
preparation and distraction device on healing in acute burn wound care procedures:
study protocol for a randomized controlled trial Trials (2012) 13 1 238
4. Auld, ML; Boyd, RN; Moseley, GL; Ware, RS; Johnston, LM Impact of Tactile
Dysfunction on Upper-Limb Motor Performance in Children With Unilateral Cerebral
Palsy Archives of Physical Medicine and Rehabilitation (2012) 93 4 696-702
5. Sakzewski, L; Carlon, S; Shields, N; Ziviani, J; Ware, RS; Boyd, RN Impact of intensive
upper limb rehabilitation on quality of life: A randomized trial in children with
unilateral cerebral palsy Developmental Medicine and Child Neurology (2012) 54 5
415-423
QCMRI Scientific Report 2012 101

6. Benfer, KA; Weir, KA; Bell, KL; Ware, RS; Davies, PSW; Boyd, RN Longitudinal cohort
protocol study of oropharyngeal dysphagia: Relationships to gross motor attainment,
growth and nutritional status in preschool children with cerebral palsy BMJ Open
(2012) 0 e001460
7. Ireland, PJ; Johnson, S; Donaghey, S; Johnston, L; Ware, RS; Zankl, A; Pacey, V; Ault, J;
Savarirayan, R; Sillence, D; Thompson, E; Townshend, S; McGill, J Medical
management of children with achondroplasia: Evaluation of an Australasian cohort
aged 0-5years Journal of Paediatrics and Child Health (2012) 48 5 443-449
8. Smith, AC; White, MM; McBride, CA; Kimble, RM; Armfield, NR; Ware, RS; Coulthard,
MG Multi-site videoconference tutorials for medical students in Australia ANZ Journal
of Surgery (2012) 82 10 714-719
9. Auld, ML; Ware, RS; Boyd, RN; Moseley, GL; Johnston, LM Reproducibility of tactile
assessments for children with unilateral cerebral palsy Physical and Occupational
Therapy in Pediatrics (2012) 32 2 151-166
10. Taylor, OD; Ware, RS; Weir, KA Speech Pathology Services to Children With Cancer and
Nonmalignant Hematological Disorders Journal of Pediatric Oncology Nursing (2012)
29 2 98-108
11. Paynter, S; Weinstein, P; Ware, RS; Lucero, MG; Tallo, V; Nohynek, H; Barnett, AG;
Skelly, C; Simoes, EA; Sly, PD; Williams, G Sunshine, rainfall, humidity and child
pneumonia in the tropics: time-series analyses Epidemiol Infect (2012) DOI:
10.1017/S09502
12. White, M; Murphy, AJ; Hallahan, A; Ware, RS; Fraser, C; Davies, PSW Survival in
overweight and underweight children undergoing hematopoietic stem cell
transplantation European Journal of Clinical Nutrition (2012) 66 10 1120-1123
13. Auld, ML; Boyd, R; Moseley, GL; Ware, R; Johnston, LM Tactile function in children with
unilateral cerebral palsy compared to typically developing children Disability and
Rehabilitation (2012) 34 17 1488-1494
14. Oftedal, S; Bell, KL; Mitchell, LE; Davies, PS; Ware, RS; Boyd, RN A systematic review of
the clinimetric properties of habitual physical activity measures in young children with
a motor disability Int J Pediatr (2012) 2012 976425
15. Rodwell, K; Edwards, P; Ware, RS; Boyd, R Salivary gland botulinum toxin injections for
drooling in children with cerebral palsy and neurodevelopmental disability: A
systematic review Developmental Medicine and Child Neurology (2012) 54 11 977-987
16. McVernon J, Nolan TM, Richmond P, Reynolds G, Nissen MD, Lambert SB, Marshall H,
Papa T, Rehm C. A randomised trial to assess safety and immunogenicity of alternative
formulations of a quadrivalent meningococcal (A, C, Y and W-135) tetanus protein
conjugate vaccine in toddlers. Pediatric Infectious Disease Journal 2012; 31:e15-e23.
17. Lambert SB, Selvey CE. Is this really an ethical evaluation of HPV vaccination policy in
Australia? [Letter]. Australia and New Zealand Journal of Public Health 2012; 36:96.
18. Goire N, Ohnishi M, Limnios A, Lahra M, Lambert SB, Nimmo GR, Nissen MD, Sloots TP,
Whiley DM. Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone
QCMRI Scientific Report 2012 102

esistance: a real-time PCR assay for direct detection of the Neisseria gonorrhoeae
H041 strain. Journal of Antimicrobial Chemotherapy 2012; 67:902-905.
19. Sheridan S, Lambert S, Grimwood K. Impact of rotavirus vaccination on childhood
gastroenteritis. Microbiology Australia 2012; 33:56-60.
20. Sheridan SL, Lambert SB. Australian immunisation registers: established foundations
and opportunities for improvement. [Letter]. Eurosurveillance 2012; 17:pii=20177.
21. Bryant KA, McVernon J, Marchant CD, Nolan TM, Marshall GS, Richmond P, Marshall H,
Nissen MD, Lambert SB, Aris E, Mesaros N, Miller JM. Immunogenicity and safety of
measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of
Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus
toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials. Human
Vaccines and Immunotherapeutics 2012; 8: 1036-1041.
22. Howard P, McCaw JM, Richmond P, Nissen M, Sloots T, Lambert SB, Lai M, Greenberg
M, Nolan T, McVernon J. Virus detection and symptom severity during influenza-like
illness in a population sample of healthy adults. Influenza and other respiratory viruses
2012; doi:10.1111/j.1750-2659.2012.00395.x.
23. Mackay IM, Lambert SB, Faux CE, Allen KM, Nissen MD, Sloots TP, Nolan TM.
Community-wide, contemporaneous circulation of a broad spectrum of human
rhinoviruses in healthy Australian preschool-aged children during a 12-month period.
Journal of Infectious Diseases 2012; doi:10.1093/infdis/jis476.
24. Sheridan SL, Ware RS, Grimwood K, Lambert SB. Number and order of whole cell
pertussis vaccines in infancy and disease protection. Journal of the American Medical
Association 2012; 308:454-456.
25. Richmond P, Nissen M, Marshall H, Lambert S, Roberton D, Gruber W, Jones T, Arora
A. A bivalent Neisseria meningitidis recombinant lipidated Factor H Binding Protein
vaccine in young adults: results of a randomised, controlled, dose-escalation Phase 1
trial. Vaccine 2012; 30:6163-6174.
26. Lambert SB. Postherpetic neuralgia after Herpes Zoster vaccination. [Letter]. Journal
of the American Medical Association 2012; 308:1427.
27. Goire N, Freeman K, Lambert SB, Nimmo GR, Limnios AE, Lahra MM, Nissen MD, Sloots
TP, Whiley DM. The influence of target population on non-culture based detection of
markers of Neisseria gonorrhoeae antimicrobial resistance. Sexual Health 2012; 9:422-
429.
28. Sheridan SL, Ware RS, Grimwood K, Lambert SB. Unexpectedly limited durability of
immunity following acellular pertussis vaccination in preadolescents in a north
American outbreak. [Letter]. Clinical Infectious Diseases 2012; 55:1434-1435.
29. Lambert SB, Sheridan SL, Grimwood K. Canadian rotavirus vaccine effectiveness data.
[Letter]. Canadian Family Physician 2012; 58:1081.
30. Lambert SB, Ware RS, Cook AL, Maguire FA, Whiley DM, Bialasiewicz S, Mackay IM,
Wang D, Sloots TP, Nissen MD, Grimwood K. Observational Research in Childhood
QCMRI Scientific Report 2012 103

Infectious Diseases (ORChID): a dynamic birth cohort study. BMJ Open 2012;
2:e002134.
31. McCaw JM, Howard PF, Richmond PC, Nissen M, Sloots T, Lambert SB, Lai M,
Greenberg M, Nolan T, McVernon J. Household transmission of respiratory viruses –
assessment viral, individual and household characteristics in a population study of
healthy Australian adults. BMC Infectious Diseases 2012; 12:345.
32. Kaczmarek M, Fielding JE, Carville KS, Franklin LJ, Wills M, Russo K, Batchelor M, Kelly
HA. A randomised cluster survey to estimate adolescent pertussis vaccination
coverage in Victoria. Victorian Infectious Diseases Bulletin, 2012. 15(1): p. 2-6.
Letters to the Editor
1. Sheridan, SL; Ware, RS; Grimwood, K; Lambert, SB Unexpectedly Limited Durability of
Immunity Following Acellular Pertussis Vaccination in Preadolescents in a North
American Outbreak Clinical Infectious Diseases (2012) 55 10 1434-1435
Staff Profile
Name
Dr Robert Ware
Dr Michael David
Dr Kerry-Ann O’Grady
Assoc Professor Stephen Lambert
Position
Senior Biostatistician
Biostatistician
Epidemiologist
Medical Epidemiologist
Our Students
Research Degrees Completed
Name Supervisors Degree
Lorelle Malyon
Rob Ware
MPhil
Allison Williams
QCMRI Scientific Report 2012 104

Research Degrees Ongoing
Name Supervisors Degree
Stuart Paynter
Gail Williams
Rob Ware
Peter Sly
Phil Weinstein
PhD
Siti Ma’on
Alison Williams
Sarah Sheridan
Marlena Kaczmarek
Sisira Edirippulige
Rob Ware
Jenny Batch
Peter Davies
Rob Ware
Lambert
Grimwood
Ware
Lambert
Kelly
Ware
PhD
PhD
PhD
PhD
Major Collaborators
‣ Communicable Diseases Unit, Chief Health Officer Division, Queensland Health
‣ National Centre for Immunisation Research and Surveillance, Children’s Hospital at
Westmead, NSW
Research Group Contact Details
QCMRI Biostatistics and Epidemiology Unity
C/- Level 4, Foundation Building
Royal Children’s Hospital
Herston, QLD 4029
p: 07 3636 1295
e: biostatistics@qcmri.org.au
QCMRI Scientific Report 2012 105

QCMRI Scientific Report 2011 114