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Genetic susceptibility to adverse drug effects - Epidemiology ...

Genetic susceptibility to adverse drug effects - Epidemiology ...

Genetic susceptibility to adverse drug effects - Epidemiology

Genetic susceptibility to adverse drug effects Common variants in the ABCB1 and NOS1AP genes Albert-Jan Aarnoudse

  • Page 2 and 3: Genetic susceptibility to adverse d
  • Page 4 and 5: Genetic Susceptibility to Adverse D
  • Page 8: Contents 1. General introduction 11
  • Page 12 and 13: General Introduction 1 General Intr
  • Page 14 and 15: General Introduction cells where it
  • Page 16: General Introduction 27. 28. 29. 30
  • Page 20 and 21: 2 Age- and gender specific incidenc
  • Page 22 and 23: Age- and gender specific incidence
  • Page 24 and 25: Age- and gender specific incidence
  • Page 26 and 27: Age- and gender specific incidence
  • Page 28: Age- and gender specific incidence
  • Page 32 and 33: 3.1 Common ABCB1 variants are assoc
  • Page 34 and 35: Common ABCB1 variants are associate
  • Page 36 and 37: Common ABCB1 variants are associate
  • Page 38 and 39: Common ABCB1 variants are associate
  • Page 40 and 41: Common ABCB1 variants are associate
  • Page 42 and 43: Common ABCB1 variants are associate
  • Page 44: Common ABCB1 variants are associate
  • Page 47 and 48: Chapter 3.2 Introduction Digoxin is
  • Page 49 and 50: Chapter 3.2 excluded. Up to 4 QTc m
  • Page 51 and 52: Chapter 3.2 Table 1 baseline charac
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    Chapter 3.2 Table 3 QTc difference

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    Chapter 3.2 Discussion In the prese

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    Chapter 3.2 References 1. 2. 3. 4.

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    3.3 ABCB1 (MDR1) gene polymorphisms

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    ABCB1 (MDR1) gene polymorphisms are

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    ABCB1 (MDR1) gene polymorphisms are

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    ABCB1 (MDR1) gene polymorphisms are

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    ABCB1 (MDR1) gene polymorphisms are

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    ABCB1 (MDR1) gene polymorphisms are

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    ABCB1 (MDR1) gene polymorphisms are

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    4.1 Common NOS1AP variants are asso

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    Common NOS1AP variants are associat

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    Common NOS1AP variants are associat

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    Common NOS1AP variants are associat

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    Common NOS1AP variants are associat

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    Common NOS1AP variants are associat

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    Common NOS1AP variants are associat

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    Chapter 4.2 Introduction Digoxin (d

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    Chapter 4.2 Genotyping. All partici

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    Chapter 4.2 Table 1 Baseline charac

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    Chapter 4.2 Table 2 NOS1AP genotype

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    Chapter 4.2 of digoxin users we fou

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    Chapter 4.2 References 1. 2. 3. 4.

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    4.3 Cardiovascular drugs, NOS1AP an

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    Cardiovascular drugs, NOS1AP and QT

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    Cardiovascular drugs, NOS1AP and QT

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    Cardiovascular drugs, NOS1AP and QT

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    Cardiovascular drugs, NOS1AP and QT

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    Cardiovascular drugs, NOS1AP and QT

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    Cardiovascular drugs, NOS1AP and QT

  • Page 118:

    Cardiovascular drugs, NOS1AP and QT

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    Chapter 4.4 Introduction Sulfonylur

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    Chapter 4.4 potentially affecting t

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    Chapter 4.4 Table 2 Average change

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    Chapter 4.4 had lower mortality rat

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    Chapter 4.4 In population based stu

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    Chapter 4.4 26. 27. 28. 29. 30. 31.

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    5 Effect of ABCB1 and NOS1AP genoty

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    Chapter 5 Introduction Digoxin is o

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    Chapter 5 Echocardiography. Our pri

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    Chapter 5 Table 1 Population charac

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    Chapter 5 Table 3 Association betwe

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    Chapter 5 Table 5 Effect of digoxin

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    Chapter 5 Discussion Digoxin is kno

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    Chapter 5 References 1. 2. 3. 4. 5.

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    6 General discussion

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    Chapter 6 2 per 1000 person years o

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    Chapter 6 cardial repolarization. B

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    Chapter 6 ated with reduced mortali

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    Chapter 6 selection bias. However,

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    Chapter 6 of the main problems is t

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    Chapter 6 References 1. 2. 3. 4. 5.

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    Chapter 6 49. 50. 51. 52. 53. 54. 5

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    Chapter 6 2007;356(11):1094-7. 101.

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    7 Summary 171

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    Chapter 7.1 2677-3435 TTT-haplotype

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    Samenvatting 7.2 Samenvatting Ondan

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    Samenvatting gereerden de regressie

  • Page 183 and 184:

    Chapter 8 proefschrift. Verder spec

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    9 About the author Albert-Jan Aarno

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    Chapter 10 Aarnoudse ALHJ, Dieleman

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