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Gastroenterology and Hepatology - The Royal Wolverhampton NHS ...

THE ROYAL

WOLVERHAMPTON

HOSPITALS NHS TRUST

Welcome to the latest

Gastroenterology and

Hepatology Evidence

Newsletter. This will be

produced every 2-3 months

and lists the most recent

literature in the field.

Gastroenterology and

Hepatology– the latest

evidence

Issue 1 January 2013

In This Issue

Journal Articles by

Subject

2

Bariatric Surgery

Clostridium Difficile

Colon, Small Bowel &

Rectum

Endoscopy

Functional GI Disorders

Gut Microbiota

Helicobacter Pylori

Inflammatory Bowel

Diseases

Liver

Neurogastroenterology

Nutrition

Oesophagus

Pancreas

Pharmacy

Stomach

NICE Guidelines

2

3

4

6

7

7

Crohn’s Disease

Crohn’s disease and ulcerative colitis are the two main components of inflammatory bowel

disease.1 Crohn’s disease is a relapsing inflammatory disease, mainly affecting the

gastrointestinal tract, and frequently presents with abdominal pain, fever, and clinical signs

of bowel obstruction or diarrhoea with passage of blood or mucus, or both. Because its

incidence and prevalence are rising (appendix p 1) in all ethnic groups and because of the

systemic nature of the illness, Crohn’s disease concerns an increasingly diverse group of

clinicians. Source: Lancet

Reference

Baumgart DC and Sandborn WJ (2012) Crohn’s disease. Lancet, 380 (9853), pp.1590-

1605. Doi: 10.1016/S0140-6736(12)60026-9.

Link to full text article, a current Athens password is required to access this article.

Cochrane Systematic

Reviews

Behind the Headlines

Current Contents In

Library Developments

8

9

9

10

Ulcerative Colitis

Ulcerative colitis and Crohn’s disease are the two main forms of inflammatory bowel

disease. Despite some shared characteristics, these forms can be distinguished by

differences in genetic predisposition, risk factors, and clinical, endoscopic, and histological

features. The precise cause of inflammatory bowel disease is unknown; however,

genetically susceptible individuals seem to have

a dysregulated mucosal immune response to commensal gut flora, which results in bowel

inflammation.

Inflammation in ulcerative colitis is characteristically restricted to the mucosal surface. The

disorder starts in the rectum and generally extends proximally in a continuous manner

through the entire colon; however, some patients with proctitis or left-sided colitis might

have a caecal patch of inflammation. Disease distribution is stratified by the extent of

colonic involvement, from proctitis to left-sided colitis or extensive colitis (pancolitis).

Reference

Ordas I et al (2012) Ulcerative colitis. Lancet, 380 (9853), pp.1606-1619. Doi: 10.1016/

S0140-6736(12)60150-0

Link to full text article, a current Athens password is required to access this article.

1


Journal Articles

Many of the full text documents links in this

newsletter require an Athens password for

access. For best results you are advised to

log-in to your Athens account first. Those

freely available will be indicated. In some

cases print copies will be available for

consultation within the Bell Library.

Bariatric Surgery

Willis K & Sheiner E (2012) Bariatric surgery

and pregnancy: the magical solution.

Journal of Perinatal Medicine, Online first

December 2012, pp. 1-8. Doi:10.1038

/ajg.2012.414.

Link to Abstract

Clostridium Difficile

Motzkus-Feagan, CA et al (2012) Statin use

and the risk of Clostridium difficile in

academic medical centres. Gut, 61 (11), pp.

1538-1543. Doi: 10.1136/gutjnl-2011-3011378.

Link to full text article, Athens password

required.

Van Nood E et al (2013) Duodenal infusion

of donor faeces for recurrent clostridium

difficile. New England Journal of Medicine,

368 (5), pp. 407-415. Doi: 10.1056/

NEJMoal1205037.

Print copy available in Bell Library for

consultation.

Full text available on line after 3 month

embargo by publisher.

Villanueva C et al (2013) Transfusion

strategies for acute upper gastrointestinal

bleeding. New England Journal of Medicine,

367 (16), pp. 11-21. Doi: 10.1056/

NEJMoal1211801.

Print copy available in Bell Library for

consultation

Full text available on line after 3 month

embargo by publisher.

Colon, Small Bowel & Rectum

Demetri GD et al (2013) Efficacy and safety

of regorafenib for advanced

gastrointestinal stromal tumours after

failure of imatinib and sunitinib (GRID): an

international, multicentre, randomised,

placebo-controlled, phase 3 trial. The

Lancet, 381 (9863), pp. 295-302.

Print copy available in Bell Library for

consultation.

Full text available via NHS Evidence

2

Grothey A et al (2013) Regorafenib

monotherapy for previously treated

metastatic colorectal cancer (CORRECT) an

international, multicentre randomised,

placebo-controlled phase 3 trial. The

Lancet, 381 (9863), pp. 303-312.

Print copy available in Bell Library for

consultation.

Full text available via NHS Evidence

Hacki, C et al (2013) Metronomic oral

topotecan prolongs survival and reduces

liver metastasis in improved preclinical

orthotropic and adjuvant therapy colon

cancer models. Gut, 62 (2), pp. 259-271.

Link to full text article, no password required.

Katz PO et al (2013) A Dual-Action, Low-

Volume Bowel Cleanser Administered the

Day Before Colonoscopy: Results From the

SEE CLEAR II Study. American Journal

Gastroenterology, Doi: 10.1038/ajg.2012.441.

[Published ahead of print].

Link to full text, no password required.

Khan SA et al (2012) Guidelines for the

diagnosis and treatment of

cholangiocarcinoma: an update. Gut, 61

(12), pp. 1657-1669.

Link to full text, an Athens password is

required.

Ihama Y et al (2012) Diagnosis of intestinal

tuberculosis using a monoclonal antibody

to mycobacterium tuberculosis. World

Journal of Gastroenterology, 18 (47), pp.

6974-6980.

Link to full text, an Athens password is

required.

Lamb CA (2013) Sexually transmitted

infections manifesting as proctitis. Frontline

Gastroenterology, 4 (1), pp. 32-40. Doi:

10.1136/flgastro-2012-100274.

Print copy available in Bell Library for

consultation. .

Link to full text, an Athens password is

required.

Marimuthu K et al (2012) A meta-analysis of

the effect of combinations of immune

modulating nutrients on outcome in

patients undergoing major open

gastrointestinal surgery. Annals of Surgery,

255 (6), pp. 1060-8.

Full text available via interlibrary loan, there is

a charge for this service.

Mekenkamp LJM et al (2013) Chromosome

20pll gains are associated with liverspecific

metastasis in patients with

colorectal disease. Gut, 62 (1), pp. 94-101.

Doi: 10.1136/gutjnl-20111-301587.

Print copy available in Bell Library for

consultation.


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required.

Moreira L (2012) Identification of Lynch

syndrome among patients with colorectal

cancer. JAMA, 308 (15), pp. 1555-65.

Print copy available in Bell Library for

consultation

Link to full text article, an Athens password

is required.

Muls AC et al (2013) Managing

gastrointestinal symptoms after cancer

treatment: a practical approach for

gastroenterologists. Frontline

Gastroenterology, 4 (1), pp. 57-68. Doi:

10.1136/flgastro-2012-100218.

Print copy available in Bell Library for

consultation.

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required.

Sharaf RN et al (2013) Comparative

effectiveness and cost-effectiveness of

screening colonoscopy vs. sigmoid and

alternative strategies. American Journal

Gastroenterology, 108 (1), pp. 120-132. Doi:

10.1038/ajg.2012.380

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Vermeire S & Gils A (2013) Value of drug

level testing and antibody assays in

optimising biological therapy. Frontline

Gastroenterology, 4 (1), pp. 41-43. Doi:

10.1136/flgastro-2012-100241.

Print copy available in Bell Library for

consultation.

Link to full text, an Athens password is

required.

Villanueva C et al (2013) Transfusion

strategies for acute upper gastrointestinal

bleeding. New England Journal of Medicine,

368 (1), pp. 11-21. Doi: 10.1056/

NEJMoa1211801.

Print copy available in Bell Library for

consultation.

Full text available on line after 3 month

embargo by publisher.

Zhao J et al (2012) Patterns and prognosis

of locally recurrent rectal cancer following

multidisciplinary team. World Journal of

Gastroenterology, 18 (47), pp. 7.

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required.

Endoscopy

Gavin DR et al (2013) The national

colonoscopy audit: a nationwide

assessment of the quality and safety of

colonoscopy in the UK. Gut, 62 (2), pp. 242-

249.

Link to full text, Athens password required.

3

Author’s Conclusions: This is the first

national audit of colonoscopy that has

successfully captured the majority of adult

colonoscopies performed across an entire

nation during a defined time period. The data

confirm that there has been a significant

improvement in the performance of

colonoscopy in the UK since the last study

reported seven years ago (CIR 76.9%) and

that performance is above the required

national standards.

Hammond JS et al (2013) Surgical

endoscopy training: the joint advisory

group on gastrointestinal endoscopy

national review. Frontline Gastroenterology,

4 (1), pp. 20-24. Doi: 10.1136/flgastro-2012-

100242.

Print copy available in Bell Library for

consultation.

Link to full text article, Athens password

required.

Jensen M et al (2013) Double balloon

enteroscopy in children: a case series

highlighting risks, and a review of the

literature. Frontline Gastroenterology, 4 (1),

pp. 82-86. Doi: 10.1136/flgastro-2012-100229.

Print copy available in Bell Library for

consultation.

Link to full text article, Athens password

required.

Murugesan SV et al (2013) Evaluation of new

anaesthetist-led propofol sedation service

for endoscopy within a UK day case

setting. Frontline Gastroenterology, 4 (1), pp.

73-81. Doi: 10.1136/flgastro-2012-100255.

Print copy available in Bell Library for

consultation.

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required.

Steed H et al (2013) The hidden endoscopic

burden of Roux-enY gastric bypass

surgery. Frontline Gastroenterology, 4 (1), pp.

69-72. Doi: 10.1136/flgastro-2012-100268.

Print copy available in Bell Library for

consultation.

Link to full text article, Athens password

required.

Functional GI Disorders

Townsend MK et al (2013) Risk factors for

fecal incontinence in older women.

American Journal of Gastroenterology, 108 (1)

pp. 113-119. Doi: 10.1038/ajg.2012.364

Link to full text, no password required.


Gut Microbiota

Iebba V (2012) Gut microbiota and the

immune system: an intimate partnership in

health and disease. International Journal of

Immunopathology Pharmacology, 25 (4), pp.

823-33.

Link to abstract.

Murphy EF et al (2013) Divergent metabolic

outcomes arising from targeted

manipulation of the gut microbiota in dietinduced

obesity. Gut, 62 (2), pp. 220-226.

Link to full text, an Athens password is

required.

Simren M (2013) Intestinal microbiota in

functional bowel disorders: a Rome

foundation report. Gut, 62 (1), pp. 159-176.

Doi: 10.1136/gutjnl-20111-302167.

Print copy available in Bell Library for

consultation.

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Helicobacter Pylori

Baudron RC et al (2012) Does helicobacter

pylori infection increase incidence of

dementia? The persoones agees QUID

study. Journal of the American Geriatric

Society,61 (1), pp. 74-78.

Link to Abstract. Link to full text.

Genta RM & Lash MD (2013) No bugs

bugging you? Emerging insights into

helicobacter–negative gastritis. American

Journal of Gastroenterology, 108 (1) pp. 72-

74. Doi: 10.1038/ajg.2012.377

Link to full text, no password required.

Liou JM et al (2012) Sequential versus triple

therapy for the first-line treatment of

Helicobacter pylori: a multicentre, openlabel,

randomised trial. Lancet. 2012 Nov 15.

pii: S0140-6736(12)61579-7. Doi:

10.1016/S0140-6736(12)61579-7

Print copy available in Bell Library for

consultation.

Full text available via NHS Evidence

Malfertheiner P et al (2012) Helicobacter

pyloris: clinical management. Current

Opinion in Gastroenterology, 28 (6), pp. 608-

614.

Link to abstract.

Megraud F et al (2013) Helicobacter pylori

resistance to antibiotics in Europe and its

relationship to antibiotic consumption. Gut,

62 (1), pp. 34-42. Doi: 10.1136/gutjnl-20111-

301113.

Print copy available in Bell Library for

consultation.

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required.

Nordenstedt H et al (2013) Helicobacter

pylori-negative gastritis: prevalence and

risk factors. American Journal of

Gastroenterology, 108 (1) pp. 65-71. Doi:

10.1038/ajg.2012.372

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Inflammatory Bowel Diseases

Bakhautdin B et al (2013) Protective role of

macrophage-derived ceruloplasmin in

inflammatory bowel disease. Gut, 62 (2), pp.

201-208.

Link to full text, no password is required.

Fitzgerald MP (2013) The organisation and

structure of inflammatory bowel disease

services for children and young people in

the UK in 2010: significant progress but

still room for improvement. Frontline

Gastroenterology, 4 (1), pp. 20-31. Doi:

10.1136/flgastro-2012-100159.

Print copy available in Bell Library for

consultation.

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required.

Ford AC et al (2013) Ulcerative colitis. BMJ,

346 (7894), pp. 29-34.

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consultation.

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required.

Hebuterne X et al (2013) Endoscopic

improvement of mucosal lesions inpatients

with moderate to severe ileocolonic

Crohn’s diseases following treatment with

certolizmab pegol. Gut, 62 (2), pp. 201-208.

Link to full text, no password is required.

Hueber W et al (2012) Secukinumab, a

human anti—IL-17A monoclonal antibody,

for moderate to severe Crohn’s disease:

unexpected results of a randomised,

double-blind placebo-controlled trial. Gut,

61 (1), pp. 1693-1700.

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required.

4


Laharie D (2012) Ciclosporin versus

infliximab in patients with severe ulcerative

colitis refractory to intravenous steroids: a

parallel, open-label randomised controlled

trial. Lancet, 380 (9857), pp. 1909-15.

Print copy available in Bell Library for

consultation.

Full text available via NHS Evidence

Lazarev M (2013) Relationship between

proximal crohn’s disease location and

disease behaviour and surgery: a crosssectional

study of the IBD genetics

consortium. American Journal of

Gastroenterology, 108 (1) pp. 90-98. Doi:

10.1038/ajg.2012.389

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Ludvigsson JF et al (2013) The Oslo

definitions for coeliac disease and related

terms. Gut, 62 (1), pp. 43-52. Doi:

10.1136/gutjnl-20111-301346.

Print copy available in Bell Library for

consultation.

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McNamee EN (2013) Ectopic lymphoid

tissue alters the chemokine gradient,

increases lymphocyte retention and the

exacerbates murine ileitis. Gut, 62 (1), pp.

53-62. Doi: 10.1136/gutjnl-20111-301272.

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consultation.

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required.

Nakarai A et al (2013) Evaluation of healing

of ulcerative colitis by quantitative fecal

immunochemical tests. American Journal of

Gastroenterology, 108 (1) pp. 83-89. Doi:

10.1038/ajg.2012.315

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Nanda KS et al (2013) Impact antibodies to

infliximab on clinical outcomes and serum

infliximab levels in patients with

inflammatory bowel disease (IBD): a meta

analysis. American Journal of

Gastroenterology, 108 (1) pp. 40-47. Doi:

10.1038/ajg.2012.363

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Reding KW et al (2013) Relationships

between patterns of alcohol consumption

and gastrointestinal symptoms among

patients with irritable bowel syndrome.

American Journal of Gastroenterology,

doi:10.1038/ajg.2012.414.

Sandborn WJ et al (2013) Andrographic

paniculata extract (HMPL-004 for active

ulcerative colitis. American Journal of

Gastroenterology, 108 (1) pp. 90-98. Doi:

10.1038/ajg.2012.340

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Scharl M et al (2013) Interleukin-13 and

transforming growth factor β synergise in

the pathogenesis of human intestinal

fistulae. Gut, 62 (1), pp. 63-72. Doi:

10.1136/gutjnl-20111-301498.

Print copy available in Bell Library for

consultation.

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required.

Shivashanker R et al (2012) Incidence of

spondyloarthropathy in patients with

Crohn’s disease: a population-based study.

Journal of Rheumatology, 39 (11), pp. 2148-

2152. Doi: 10.3899/jrheum.120321.

Link to abstract.

Link to full text, no password required.

Steck N et al (2011) Bacterial proteases in

IBD and IBS. Gut, 61 (11), pp. 1610-1618.

Doi: 10.1136/gutjnl-20111-300775.

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required.

Weitkamp JH et al (2013) Necrotising

enterocolitis is characterised by disrupted

immune regulation and diminished

mucosal regulatory (FOXP3)/effector (CD4,

CD8) T cell ratios. Gut, 62 (1), pp. 73-82. Doi:

10.1136/gutjnl-20111-301551.

Print copy available in Bell Library for

consultation.

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required.

Neurath MF & Travis SPL (2012) Mucosal

healing in inflammatory bowel diseases: a

systematic review. Gut, 61 (11), pp. 1619-

1635. Doi: 10.1136/gutjnl-20111-302830.

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required.

5


Liver

Berzigotti A et al (2013) Cardiovascular risk

factors and systemic endothelial function

in patients with cirrhosis. American Journal

of Gastroenterology, 108 (1) pp. 65-71. Doi:

10.1038/ajg.2012.362

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Chan HLY (2013) Peginterferon therapy for

chronic hepatitis B: one size fits all? Gut,

62 (2), pp. 185-187.

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require

Chen YW et al (2012) Is an estimated

glomerular filtration rate better than

creatinine to be incorporated into the endstage

liver disease score? World Journal of

Hepatology, 4 (11), pp. 291-298.

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required.

Dusheiko G & Wedemeyer (2012) New

protease inhibitors and direct-acting

antivirals for hepatitis C: interferon’s long

goodbye. Gut, 61 (12), pp. 1647-1652.

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required.

Kriese S & Heneghan MA (2013) Current

concepts in the diagnosis and management

of autoimmune hepatitis. Frontline

Gastroenterology, 4 (1), pp. 2-11. Doi:

10.1136/flgastro-2012-100208.

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consultation.

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required.

Mufti AR & Reau N (2013) A patient with a

positive hepatitis B surface antigen.

Frontline Gastroenterology, 4 (1), pp.12-12.

Doi: 10.1136/flgastro-2012-100147.

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consultation.

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required.

Neurogastroenterology

Cirillo C et al (2013) Nerve activity

recordings in routine human intestinal

biopsies. Gut, 62 (2), pp. 227-235.

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required.

Jones RB et al (2012) Functional

neuroimaging demonstrates that ghrelin

inhibits the central nervous system

response to ingested lipid. Gut, 61 (11), pp.

1543-1551.

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required.

6

Nutrition

Inns SJ & Emmanuel AV (2013) Survey of UK

and New Zealand gastroenterologist’

practice regarding dietary advice and food

exclusion in irritable bowel syndrome and

inflammatory bowel disease. Frontline

Gastroenterology, 4 (1), pp. 44-50. Doi:

10.1136/flgastro-2012-100231.

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consultation.

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required.

Chatu S et al (2013) Factors associated with

vitamin D deficiency in a multicultural

inflammatory bowel disease cohort.

Frontline Gastroenterology, 4 (1), pp. 51-56.

Doi: 10.1136/flgastro-2012-100241.

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consultation.

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required.

Oesophagus

Londono R (2012) Esophagus and

regenerative medicine. World Journal of

Gastroenterology, 18 (47), pp.6894-6899.

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required.

Rohof WO et al (2012) Effect of azithromycin

on acid reflux, hiatus hernia and proximal

acid pocket in the postpandial period. Gut,

61 (12), pp. 1670-1677.

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required.

Rohof WO et al (2013) Esophageal stasis on

a timed barium esophagogram predicts

recurrent symptoms in patients with longstanding

achalasia. American Journal of

Gastroenterology, 108 (1) pp. 49-55. Doi:

10.1038/ajg.2012.318.

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Sharma P et al (2013) Standard endoscopy

with random biopsies versus narrow band

imaging targeted biopsies in Barrett’s

oesophagus: a prospective, international,

randomised controlled trial. Gut, 62 (1), pp.

15-21. Doi: 10.1136/gutjnl-20111-300962.

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consultation.

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required.


Totonelli G (2012) Esophageal tissue

engineering: a new approach for

esophageal replacement. World Journal of

Gastroenterology, 18 (47), pp.6900-6907.

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required.

Pancreas

Amaral AFS et al (2012) Pancreatic cancer

risk and levels of trace elements. Gut, 61

(11), pp.1583-1588. Doi: 10.1136/gutjnl-2011-

301086.

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required.

Banks PA et al (2013) Classification of acute

pancreatitis – 2012: revision of the Atlanta

classification and definitions by

international consensus. Gut, 62 (1), pp.

102-111. Doi: 10.1136/gutjnl-20111-302779.

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consultation.

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required.

Baumgart S et al (2013) Oncogenic

transcription factors: cornerstones of

inflammation-linked pancreatic

carcinogenesis. Gut, 62 (2), pp. 310-316.

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required.

Facy O (2012) Diagnosis of postoperative

pancreatic fistula. British Journal of Surgery,

99 (8), pp. 1072-1075. Doi: 10.1002/bjs.8774.

Michl P & Gress TM (2013) Current concepts

and novel targets in advanced pancreatic

cancer. Gut, 62 (2), pp. 317-326.

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required.

Sadr-Azodi O et al (2013) Abdominal total

adiposity and the risk of acute pancreatitis:

a population-based prospective cohort

study. American Journal of Gastroenterology,

108 (1) pp. 140-142. Doi:

10.1038/ajg.2012.384.

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Stomach

Camilleri M et al (2013) Clinical guideline:

management of gastroparesis. American

Journal of Gastroenterology, 108 (1) pp. 18-

37. Doi: 10.1038/ajg.2012.373

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Ivanova T et al (2013) Integrated

epigenomics identifies BMP4 as a

modulator of cisplatin sensitivity in gastric

cancer. Gut, 62 (1), pp. 22-33. Doi:

10.1136/gutjnl-20111-301113.

Print copy available in Bell Library for

consultation.

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required.

NICE Guidelines

Colorectal cancer (QS20) August 2012

This quality standard defines clinical best

practice within this topic area. It provides

specific, concise quality statements, measures

and audience descriptors to provide the public,

health and social care professionals,

commissioners and service providers with

definitions of high-quality care.

The quality standard covers the diagnosis and

management of adults (18 years and older)

with newly diagnosed and recurring

adenocarcinoma of the colon and rectum. It

includes diagnosis of suspected colorectal

cancer, staging of the disease, management of

both local and metastatic disease, and followup

and regular surveillance for those free from

disease after treatment.

Crohn’s disease: management in

adults children and young people

(CG152) October 2012.

Pharmacology

Connor A et al (2012) Consensus guidelines

for the safe prescription and administration

of oral bowel cleaning agents. Gut, 61 (11),

pp.1525-1532. Doi: 10.1136/gutjnl-2011-

300861.

This clinical guideline (published October

2012) offers evidence-based advice on the

management of Crohn’s disease in adults,

children and young people.

Laparoscopic gastric plication for

the treatment of severe obesity

(IPG432) November 2012

7


The National Institute for Health and Clinical

Excellence (NICE) has issued full guidance to

the NHS in England, Wales, Scotland and

Northern Ireland on Laparoscopic gastric

plication for the treatment of morbid obesity.

Laparoscopic gastric plication reduces the size

of the stomach to limit food intake. It is carried

out using keyhole surgery through several

(usually 5 or 6) small cuts in the abdomen

(belly). It involves folding the stomach in on

itself and stitching it together to reduce its

volume by about 70%. None of the stomach is

removed and the procedure is potentially

reversible.

Laparoscopic insertion of a

magnetic bead band for gastrooesophageal

reflux disease

(IPG431) September 2012

The National Institute for Health and Clinical

Excellence (NICE) has issued full guidance to

the NHS in England, Wales, Scotland and

Northern Ireland on Laparoscopic insertion of

a magnetic-bead band for gastro-oesophageal

reflux disease.

In patients with gastro-oesophageal reflux

disease, the acidic contents of the stomach

are able escape backwards into the

oesophagus (gullet). This is known as acid

reflux and causes heartburn (a burning

sensation or pain) or an acid sensation or taste

in the mouth. This happens because the

sphincter (ring of muscle) that keeps the

stomach contents down isn’t working properly.

This procedure involves placing a small

flexible band of interlinked titanium beads with

magnetic cores around the lower oesophagus,

just above the stomach. The aim is that the

magnetic attraction between the beads will

help to keep the sphincter closed when not

eating to prevent acid reflux, but the person

can still belch or vomit.

Cochrane Reviews

Antibiotics for Uncomplicated

Diverticulitis. November 2012

Author’s Conclusion: The newest evidence

from one RCT says there is no significant

difference between antibiotics versus no

antibiotics in the treatment of uncomplicated

8

diverticulitis. Previous RCTs have only

suggested a non-inferiority between different

antibiotic regimes and treatment lengths. This

new evidence needs confirmation from more

RCTs before it can be implicated safely in

clinical guidelines. On-going RCTs will be

published in the years to come and more are

needed. The role of antibiotics in the treatment

of complicated diverticulitis has not been

investigated yet.

Shabanzadeh DM, Wille-Jorgensen P.

Antibiotics for uncomplicated diverticulitis.

Cochrane Database Syst Rev. 2012 Nov

14;11:CD009092. Doi: 10.1002/14651858.

CD009092.pub2.

Erythropoietin or darbepoetin for

patients with cancer. December 2012

Author’s Conclusions: ESAs reduce the

need for red blood cell transfusions but

increase the risk for thromboembolic events

and deaths. There is suggestive evidence that

ESAs may improve QoL. Whether and how

ESAs affects tumour control remains

uncertain. The increased risk of death and

thromboembolic events should be balanced

against the potential benefits of ESA treatment

taking into account each patient`s clinical

circumstances and preferences. More data are

needed for the effect of these drugs on quality

of life and tumour progression. Further

research is needed to clarify cellular and

molecular mechanisms and pathways of the

effects of ESAs on thrombogenesis and their

potential effects on tumour growth.

Tonia T, Mettler A, Robert N, et al.

Erythropoietin or darbepoetin for patients with

cancer. Cochrane Database Syst Rev. 2012

Dec 12;12:CD003407. Doi:

10.1002/14651858.CD003407.pub5

Methotrexate for induction of

remission in refractory Crohn`s

disease. December 2012

Author’s Conclusions: There is evidence

from a single large randomized trial which

suggests that intramuscular methotrexate (25

mg/week) provides a benefit for induction of

remission and complete withdrawal from

steroids in patients with refractory Crohn's

disease. Lower dose oral methotrexate does


not appear to provide any significant benefit

relative to placebo or active comparator.

However, these trials were small and further

studies of oral methotrexate may be justified.

Comparative studies of methotrexate to drugs

such as azathioprine or 6-mercaptopurine

would require the randomization of large

numbers of patients. The addition of

methotrexate to infliximab therapy does not

appear to provide any additional benefit over

infiximab monotherapy. However these studies

were relatively small and further research is

needed to determine the role of methotrexate

when used in conjunction with infliximab or

other biological therapies.

McDonald JW, Tsoulis DJ, Macdonald JK, et

al. Methotrexate for induction of remission in

refractory Crohn`s disease. Cochrane

Database Syst Rev. 2012 Dec

12;12:CD003459. Doi:

10.1002/14651858.CD003459.pub3

Omentoplasty for

esophagogastrostomy after

esophagectomy. November 2012

Author’s Conclusion: Omentoplasty may

provide an additional benefit to decrease the

incidence of anastomotic leakage after

esophagectomy and esophagogastrostomy for

esophageal cancer patients without increasing

or decreasing other complications, especially

for those patients treated with THE. Further

randomized controlled trials are still needed to

investigate the influences of omentoplasty in

different operation procedures of

esophagectomy and esophagogastrostomy on

the incidence of anastomotic leakage,

anastomotic stricture, long-term survival rate

and quality of life after esophagectomy and

esophagogastrostomy.

Yuan Y, Zeng X, Hu Y, et al. Omentoplasty for

esophagogastrostomy after esophagectomy.

Cochrane Database Syst Rev. 2012 Nov

14;11:CD008446. Doi: 10.1002/14651858.

CD008446.pub2.

Perioperative buffered versus nonbuffered

fluid administration for

surgery in adults. December 2012

administration of non-buffered saline-based

fluids. The use of buffered fluids is associated

with less metabolic derangement, in particular

hyperchloraemia and metabolic acidosis.

Larger studies are needed to assess robust

outcomes such as mortality.

Burdett E, Dushianthan A, Bennett-Guerrero

E, et al. Perioperative buffered versus nonbuffered

fluid administration for surgery in

adults. Cochrane Database Syst Rev. 2012

Dec 12;12:CD004089. Doi:

10.1002/14651858. CD004089.pub2

Transparent Cap Colonoscopy

versus Standard Colonoscopy to

Improve Caecal Intubation. December

2012

Author’s Conclusions: This review suggests

that a transparent cap on the end of the

colonoscope may give a marginally faster

caecal intubation time compared with standard

colonoscopy. It also suggests that there is a

better polyp detection rate and less pain with

the cap. However, the authors feel that further

randomised controlled trials in this area would

provide more clinically significant information

on this adjunct to colonoscopy.

Morgan J, Thomas K, Lee-Robichaud H, et al.

Transparent Cap Colonoscopy versus

Standard Colonoscopy to Improve Caecal

Intubation. Cochrane Database Syst Rev.

2012 Dec 12;12:CD008211. Doi:

10.1002/14651858.CD008211.pub3

Behind the Headlines

Weight Loss with Gastric-Band

Surgery Durable beyond 10 Years.

Medscape

New Books Added to Stock

Brown SR et al (2012)

Contemporary

coloproctology. London:

Springer-Verlag

Author’s Conclusion: The administration of

buffered fluids to adult patients during surgery

is equally safe and effective as the

9


Current Contents In ….

Click on the title to link to the contents page of

the latest edition. Those marked with an

asterik require an Athens password to access

the full text. You may browse the content by

going to NHS Evidence, then selecting the

Journals option. Impact Factors are included

in brackets were available.

American Journal of Gastroenterology

(IF7.282)

BMC Gastroenterology (IF2.42)

*Canadian Journal of Gastroenterology

Case Reports in Gastroenterology

Clinics of Colon and Rectal Surgery

*Diseases of the Colon and Rectum (IF3.132)

*European Journal of Gastroenterology and

Hepatology (IF1.757)

*Frontline Gastroenterology

Gastroenterology (IF11.68)

Gastroenterology and Hepatology (IF5.63)

*Gut: an International Journal of

Gastroenterology and Hepatology (IF10.111)

*Hepatology (IF11.665)

*Hepatology International (IF2.65)

*Journal of Gastroenterology (IF4.160)

*Journal of Gastroenterology and Hepatology

(IF2.865)

*Scandinavian Journal of Gastroenterology

*Therapeutic Advances in Gastroenterology

*World Journal of Gastroenterology (IF2.092)

World Journal of Hepatology (IF2.471)

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