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logy and laboratory medicineucla pathology andlaboratory medicine2013 Annual Reportucla pathology and laboratorynd laboratory medicinepa-thol-o-gy (p-thl-j)n. pl. pa-thol-o-giesThe scientific study of the natureof disease and its causes, processes,development, and consequences.

contentsintroduction1Jonathan Braun, MD, PhDclinical services3567Growth In Outreach Enhances Teaching and ResearchWhile Strengthening Department’s Bottom LineBringing UCLA Pathology/Laboratory Services to The CommunityDepartment Will Play Key Role In UCLA Health’s Partnership With ChinaUCLA’s Expanding Global Presenceresearch enterprise9111213Deciphering The Genetic Basis of Disease Across Populations: Path and Lab’s Pioneering RoleClinical Genomics Center Uses Powerful Sequencing Test to Improve Diagnosis andTreatment of Genetic DisordersNext-Generation Sequencing of Human Genome Paving the Way Toward Personalized MedicineFund Managers: Invaluable Members of the Research Teameducation15171819“Flipping” the Traditional Classroom: Students Do the Teaching in DGSOM Histopathology LabInteractive Labs Introduce Medical Students to DermatopathologyMed School puts Molecular Genetics FirstUnderstanding the Complexities of Inflammationresearch services21232425Translational Pathology Core Laboratory Seeks to Fulfill the Promise of BiobankingPathology Portal Improves Access to Department’s ServicesEngageUC will Inform Federal and State Debate on Biobanking PracticesFreeze-Dried Storage of Tissues May Offer “Best Of Both Worlds”department in depth26293032Who’s Who in Pathology & MetricsAwards & RecognitionAlumniOpportunities for Givingeditors: karyn greenstone & sharon webb • writer: dan gordon • design: susan landesmann designphotography: margaret sison • additional photography: todd cheney, reed hutchinson, jian yu rao & kosal taing© 2013 Regents of the University of California

jonathan braun, md, phdthe quiet heroA friend of mine, whose work is philosophy, is always reading. Do you know his favoriteperiodical? It is People Magazine. He explained that it explored each week how fame and wealthdo not guarantee a happy or meaningful life! In this annual report, we reflect on my quiet heroes –those who not only bring about real and important change, but also provide the inspiration to bringout what is best in others and make the world that much more of a better place.Thanks to Dr. Binder and the amazing people who fashion Pathology into a new mode of caredelivery, and educate our physician trainees not only in pathology expertise but also in the role ofservice. With the opening of BURL Laboratories, we are now poised to extend this special amalgamof quality and service to communities throughout the north, west, and south of Los Angeles County.Extending our boundaries even further, our Department, along with UCLA Health and the Jonsson ComprehensiveCancer Center, has entered into landmark arrangements with the Cancer Institute and Hospital, ChineseAcademy of Medical Sciences (CAMS). This builds on our successful partnerships over the past several years incare and teaching with academic health centers and municipal Hangzhou. The new relationship with CAMS willbroaden the scope of these partnerships for clinical trials and translational research with leading investigatorsthroughout China.While we extend our global presence in China and elsewhere, we are also mindful of the needs closer to home,as we begin consultative telepathology services to underserved pathology practices located throughout SouthernCalifornia. Partnerships with six communities will initiate this program, and will build from there to a network tosupport community-based practices throughout California.Even closer to home, our Clinical Genomics Center has implemented the remarkable breakthroughs in highthroughputsequencing and disease-diagnostic genetic bioinformatics as a practical health care service. Thisis finally bringing closure to families and individuals who have been waiting years for what they once thought werequestions without answers. The rapid diagnosis of complex genetic diseases allows patients, families, and theirhealth care team to move onto planning for medical care, and strategies to identify and eventually avert diseasein unaffected family members.Our department is intensely devoted to research, nearly $50M presently in force. What drives this creativeenterprise is David Islas and our Fund Managers. They pilot projects through the complex path from inceptionto funding, and steward these precious funds to assure the greatest value to our investigators and traineescientists in their challenging experimental work.It is in the classroom where researchers of tomorrow are inspired by some of the most creative and innovativefaculty in the nation. Through the innovation of the “flipped” classroom, Elena Stark inspires future medicalleaders to think independently, and Wayne Grody, Steve Bensinger and Chandra Smart encourage fundamentalunderstanding of human processes, and not simple rote learning.As the path from research to clinical innovation shortens, the distinctions between health care and researchdiminish as patient biospecimens serve care and research today, and data to guide care of the same patientswith improved care tomorrow. This creates conceptual, ethical, and operational challenges for dynamic healthsystems like UCLA centers. Sarah Dry, William Yong , Justin Perry and their teams in the TranslationalPathology Core Laboratory, EngageUC, and the Pathology Portal, have created a new framework to solvethese challenges for the UCLA clinical and research communities.In this annual report, read the stories of these quiet heroes: exceptional people, and the exceptional ways thatthey enable UCLA to serve the needs and dreams of our community.Dr. Jonathan Braun, Professor and Chair, Department of Pathology and Laboratory Medicinepathology & laboratory medicine at ucla 1

BURL opening receptionattendees, including DavidFeinberg, MD, MBA, CEO,UCLA Hospital System;Lee Flores, BURL manager;Arnold Scheer, CAO;Jonathan Braun, MD, PhD,Chair; Shannon O’Kelley,COO, UCLA Hospital System;Scott Binder, MD, Sr. ViceChair, Clinical Services.the slides for the specimens obtained in the Departmentof Medicine’s Division of Dermatology for thediagnosis of skin diseases. Those slides are analyzedby trained dermatopathologists under the leadershipof Dr. Chandra Smart, the program’s director. Theinterdisciplinary program, unique in Southern California,represents a direction that Dr. Binder expects tobecome a significant trend in the outreach program.Lung and Molecular Pathology. Lung pathologyand molecular pathology services now include alarge and comprehensive panel of sophisticatedmolecular tests to better evaluate lung cancers and offerimproved guidance for treatment and clinical trialoptions to patients. The new genetic tests for lungcancer have been developed by UCLA’s MolecularDiagnostics Laboratories to complement thetraditional anatomic pathology evaluation of lungcancer. Ultimately, this will enable the pathologyteam to expand its role from classifying and staging acancer to reporting the genetic changes that mayprovide clues to treatment strategies and informclinicians and patients on the prognosis of the disease.Gastrointestinal (GI) Pathology. The GI pathologyservice is a large-volume, sub-specialty-trained groupthat incorporates modern diagnostic techniques,maintains an intra-divisional diagnostic conference,participates in clinical research and attends internationalGI pathology meetings. Devoted to anatomicpathology diagnostics, the service prepared 18,845diagnostic reports in 2012. It provides additional subspecialtyconsultations intra-operatively and on weekends.Advances in the clinical application of the molecularunderstanding of disease have resulted in theservice augmenting reports using molecular geneticand immunohistochemical (IHC) techniques.explore Outreachpathnet.medsch.ucla.edu/outreachGenitourinary (GU) Pathology. The genitourinarypathology section has developed or adoptedadvanced and sophisticated technologies to furtherimprove the quality of patient care. All cases of prostatectomyare now processed as whole-mount sections,enabling accurate enumeration of tumors as well asthe reporting of the pathologic features of each tumorindividually. A team consisting of pathologists, radiologistsand urologists has developed a targeted biopsytechnology that allows improved detection of clinicallysignificant prostate cancers. Many patients withindolent tumors are now enrolled in the active surveillanceprogram instead of receiving radical treatmentsthat carry potentially significant side effects.Neuropathology. The neuropathology section isnow conducting isocitrated dehydrogenase 1 and 2(IDH1 and IDH2) mutation detection, sequencing teststhat can detect common and rare mutations of theIDH1 gene as well as IDH2 mutations – the presence ofwhich in gliomas is associated with a better prognosisand can affect patient management. Tests are offeredfor FUS and TDP-43, immunohistochemical markersthat can assist in the classification of frontotemporallobar degeneration. In addition to existing musculardystrophy markers, investigations of rare musculardystrophies are offered, as are evaluations for epilepsydisorders and rare genetic disorders, the latter usingwhole genome sequencing.Hematopathology. The outreach workflow continuesto increase for the hematopathology section, withan 8 percent increase in bone marrow cases and a 14percent increase in flow cases for 2012 vs. 2011. Since2009, bone marrow volume has increased 34 percentand flow panels to leukemia have increased 31 percent.The hematopathology service’s consultations includeevaluation of blood, bone marrow, lymph nodes andhematolymphoid lesions in other body sites that aresubmitted by pathologists and oncologists throughoutthe nation as well as from other countries.Hepatobiliary/Renal Pathology. The hepatobiliarypathology service provides rapid, high-qualitydiagnostic histopathology for liver disease on bothbiopsy and surgical material, with extensive experiencein hepatitis and biliary disease, neoplastic hepatobiliarydisease and transplant pathology. The renalpathology section handles a large volume of diagnosticrenal biopsies, and also evaluates and interprets transplantbiopsies, nephrectomy specimens and posttransplantationcomplications. n4 pathology & laboratory medicine at ucla

inging ucla pathology/laboratoryservices to the communityThe Department of Pathology and LaboratoryMedicine has joined UCLA Healthand the Department of Medicine in a partnershipto deliver additional health services to the SanFernando Valley, Conejo Valley, and SouthBay regions of Los Angeles County.In March, the Department of Pathology andLaboratory Medicine and UCLA Health openeda state-of-the-art outreach reference laboratory,Bruin University Reference Laboratory (BURL), inPanorama City. Laboratory support of new UCLAHealth facilities followed, including “STAT” labs(designed to provide quick-turnaround services)serving UCLA Health’s new primary and secondarycare facility in Westlake Village. The BURL WestlakeVillage Patient Service Center has patient blood drawstations and offers immediate results for many bloodand urine chemistries, along with other STAT testing.“BURL is designed as a price-competitive,quality-driven outpatient laboratorywith locations throughout the SanFernando Valley, Conejo Valley, Westsideand South Bay regions of Los Angeles.”- Scott Binder, MD, Medical Director, BURLThe Westlake Village office is the first of six newUCLA facilities scheduled to open over the next twoyears in service areas beyond UCLA’s Westwood andSanta Monica campuses; other sites include ThousandOaks, Porter Ranch, Calabasas, Santa Clarita andRedondo Beach. The state-of-the-art offices willoffer a full range of primary-care sub-specialties(internal medicine, family medicine, pediatrics,women’s health), as well as ancillary and secondarycareservices. The new practices will also engagein community education and outreach throughnewsletters, physician lectures and participationin outreach programs accessible to the community(e.g., in shopping centers, health fairs andfarmer’s markets).By establishing new locations, supporting themwith local laboratory facilities, and participatingin local programs, UCLA is expanding its ability toprovide convenient, high-quality care to people wholive or work outside traditional primary care serviceareas, while providing a gateway to higher levels ofcare within the UCLA system for patients who needsuch services. nCLINICAL SERVICESpathology & laboratory medicine at ucla 5

Digital imaging will facilitateimproved communication andeducation among pathologists.CLINICAL SERVICESFernando Palma-Diaz, MD, Assistant Director, Telepathologyucla’s expanding global presenceThe UCLA Department of Pathology and LaboratoryMedicine has been at the forefront ofinternational telepathology development through itspartnership with China, and has now committeda significant effort toward integrating telepathologyinto daily practice closer to home. Recently, thedepartment received a substantial grant from theState of California to provide consultative telepathologyservices to underserved pathology practicesthroughout Southern California. The funding willbe used to acquire digital slide scanners that will beinstalled in remote pathology groups, and will enablethe department to begin space remodeling to accommodatetelepathology functions.Once installed and operational, these scannerswill allow pathologists working in underserved communitiesto obtain second-opinion consultationsfrom UCLA specialists on challenging pathologycases. This technology enables rapid transmissionof scanned slide data to the consultant pathologist,avoiding delays that occur when glass slides mustbe transported from one site to another. In additionto improving patient care – particularly forcases with urgent diagnoses – digital imaging willfacilitate improved communication and educationamong pathologists.agreement between Ronald Reagan UCLA MedicalCenter and Second Affiliate Hospital of ZhejiangUniversity (SAHZJU) in China. As part of the agreement,UCLA pathologists provide second-opiniondiagnoses to pathologists and other physicians inSAHZJU. Both cytological and histological casesare included, and cases span a broad range of organsystems, including head and neck, lung, gynecological,soft tissue and bone, neurological, and hematological.In addition, periodic multidisciplinary videoconferencesare held to discuss interesting cases.The program has expanded to reach much of Chinathrough additional collaborative agreements withtwo major reference labs (Dian Inc. and Adicon Inc.)and prominent institutions such as Cancer Hospital,Chinese Academy of Medical Science. The program’ssuccess has also stimulated similar collaborationsin other areas, including radiology, oncology, andnuclear medicine. nexplore Telepathologypathology.ucla.edu/telepathologyThe department’s international telepathologyprogram began in 2010 with a collaborativepathology & laboratory medicine at ucla 7

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esearch enterprisedeciphering the genetic basis of disease acrosspopulations: path and lab’s pioneering rolerRecent breakthroughs in high-throughputgenotyping and sequencing technologies haveushered in an era of large-scale genome-widedisease studies that have identified hundreds of geneticvariants associated with risk for many diseases. Studiesaimed at unraveling the genetic basis of Mendeliantraits (those caused by the disruption of a single gene)have been particularly successful. Technological andcomputational advances have made it possible to scanDNA in patients that have the disease – revealing, inmost cases, the responsible genes. The efficiency ofsuch studies is reinforced by the successful translationof these findings in clinical settings, with UCLA actingas a pioneer in analyzing the entire protein-encodinggenome of a patient for diagnostic purposes.But the most common diseases – including mostcancers, type 2 diabetes, and heart disease – do nothave Mendelian traits; rather, they are a complexproduct of many genes that together influencedisease risk. Although large-scale genome-widestudies have been highly successful in identifyingthe loci harboring genetic risk variants for commondiseases, the complex correlation structure of thehuman genome means that the risk variants identifiedin these studies typically are not themselves causal,but are associated with unobserved causal geneticvariants. Thus, although identifying the causal variantsis crucial in understanding the functional basis of adisease, for most common diseases the true causalvariants have yet to be discovered.In an attempt to bridge this gap, Dr. Bogdan Pasaniucand colleagues in the UCLA Department of Pathologyand Laboratory Medicine are conducting studies usingsophisticated genotyping or sequencing approachesfor tens to hundreds of thousands of individuals ofdifferent ethnicities. Dr. Pasaniuc’s lab has found agreat benefit to studying multi-ethnic populations.“Not only is it important to study the genetic basisof disease across a wide range of ethnicities for thebenefit of a larger group of people, but computationaland statistical approaches can leverage geneticdiversity across populations to strengthen our abilityto find causal variants,” Dr. Pasaniuc explains.Of particular interest in studying disease acrossethnicities are admixed populations (populations withrecent ancestry from different continents) such asAfrican Americans and Hispanic Americans, who areoften medically underserved while carrying a disproportionatelyhigh burden of disease. Because of thediversity of their genomes, admixed populations offerthe promise of capturing additional genetic diversitycompared with studies of homogeneous populationssuch as Europeans. This poses particular technicalBogdan Pasaniuc, PhDfocuses on admixedpopulations forgreater understandingof genetic risk factorsfor common diseases.pathology & laboratory medicine at ucla 9

Of particular interest in studying diseaseacross ethnicities are admixed populations...such as African Americans and HispanicAmericans, who are often medically underservedwhile carrying a disproportionatelyhigh burden of disease.challenges, since in admixed populations, correlationamong genetic variants exists both at a fine scale inthe ancestral populations and at a coarse scale, dueto chromosomal segments of recently shared ancestry.By jointly modeling both types of genetic structurein African American genomes, Dr. Pasaniuc andcolleagues showed that a combined approach achievesgreater statistical power to identify risk loci than whatcan be achieved in studies of homogeneous populationssuch as Africans or Europeans.The vast amount of data currently being generatedby sequencing technologies increases the need foraccurate yet computationally efficient methods ofperforming disease scans in multi-ethnic cohorts todecipher the genetic basis of disease in various populations.Such efforts will go a long way toward translatinggenetic findings for common diseases to the clinic,improving diagnostics and treatment decisions. nexplore Dr. Pasaniuc’s labbogdanlab.pathology.ucla.edu10 pathology & laboratory medicine at ucla

clinical genomics center uses powerful sequencing testto improve diagnosis and treatment of genetic disordersIt is estimated that as much as 10% of the U.S. populationsuffers from a Mendelian genetic disease.More than 4,000 Mendelian genetic diseases havebeen described, with the precise genetic mutationidentified. These discoveries have contributed significantlyto our understanding of biology, as wellas the mutations that lead to human diseases.However, an even larger set of genes remains to bediscovered. Dr. Stan Nelson’s research has led to thesuccessful implementation of genomic sequencingapproaches that enable researchers to efficiently andeconomically search the entire human genome inindividuals for disease-causing mutations. Usingthis approach, Dr. Nelson’s group has identified thegenetic cause for more than 17 Mendelian geneticdiseases in the last three years.test called clinical exome sequencing. Under Dr. Nelson’sguidance as the center’s director, this genomesequencing test is not only proving to be much moresensitive at finding the root cause of many serioushuman diseases, but it is also resulting in novel genediscovery and leading to new approaches to the developmentof therapies. In the past year,Dr. Nelson’s group has been able to specificallydiagnose children with developmental delay, autism,seizure disorders, muscular dystrophy, and otherdisorders. Many of these children have mutations inpreviously unrecognized genes; providing the specificdiagnosis ends a patient’s medical odyssey and oftenpoints health care providers toward more tailoredmedical interventions. nRESEARCH ENTERPRISEBased on these successful efforts, Dr. Nelson andcolleagues have launched the UCLA Clinical GenomicsCenter, featuring a new and powerful diagnosticexplore Clinical Genomicspathology.ucla.edu/genomicsFar left and below:Hane Lee, PhDBottom left:Stan Nelson, MD.

next-generation sequencing of human genomepaving the way toward personalized medicineNext-generation sequencing(NGS) offers the promiseof significantly enhancing ourunderstanding of how geneticdifferences affect health anddisease. Compared withconventional Sanger sequencing(considered “first-generation”technology), these new methodscan inexpensively yield largevolumes of sequence data. Thecontrast is stark: For example,NGS technology can produce 600,000 megabytesof data at a cost of four cents per megabyte, whereasfirst-generation technology produces 0.06 megabytesat a cost of $1,500 per megabyte of data.The second-generation sequencers, such as the HiSeq2500 and Ion Proton, have already realized whatwas once only a dream: the ability to sequence onehuman genome in one day for $1,000. Now, thirdgenerationsequencers, such as those produced byOxford Nanopore Technologies, have the potential toachieve what was once unthinkable: sequencinga human genome in 15 minutes.Now, third-generation sequencers,have the potential to achieve whatwas once unthinkable: sequencinga human genome in 15 minutes.The ability to sequence an entire human genomequickly and cheaply will profoundly affect the waywe think about scientific approaches in basic, appliedand clinical research. With further improvement ofthe bioinformatics infrastructure and more detailedclinical annotation of the human genome, NGS-basedpersonalized medicine is on the way to revolutionizedisease diagnosis, prognosis and treatment. nexplore Next-Generation Sequencingpathology.ucla.edu/cmsXinmin Li, PhD, Director, Clinical Microarray Core

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education“flipping” the traditional classroom: studentsdo the teaching in dgsom histopathology labThe traditional lecture setting is going by thewayside in some academic arenas, replaced by a newmethod of teaching that better engages students,increasing their enthusiasm and sparking their curiosity.The interactive learning environment of the “flippedclassroom” is sometimes called “inverted instruction”because the majority of teaching is by students tostudents. It’s a platform that elevates students’ intake,processing, and recall of data.The flipped-classroom concept has been gainingmomentum in a variety of educational institutions,including the classrooms at UCLA’s David Geffen Schoolof Medicine, where the Department of Pathologyand Laboratory Medicine strives for this enriched levelof teaching by flipping the first-year histopathologylaboratory sessions. The approach is not to beconfused with problem-based learning (PBL), in which,for example, groups of students analyze a case studythat reflects lectures by one or more professors. WhilePBL is also a form of active learning, it requires a baseknowledge specific to the topic – i.e., the case studydemonstrates the information that was previouslytaught traditionally.In a flip-teaching/inverted-classroom scenario, theauthority to introduce and explain primary informationbecomes the responsibility of the students. Studentsresearch, gather and evaluate the subject from varioussources – instructor-created supplements (e.g.,PowerPoint modules), the internet, and textbooks –prior to class. After such preparation, they teach it toeach other in the classroom/lab setting. This materialintegration, also known as hybrid learning, promotesmany perspectives on a subject, raising questions ormaking connections that might not have been revealedfrom simply listening to a lecture.It’s a win-win structure for both the professor andthe students: The professor gains time to observe thestudents and communicate with them, while thestudents gain a wider field of cognition as the flippedclassroom adapts to different forms of comprehension.The students master the information because they areforced to explain the material to their peers.In the histopathology laboratory for first-yearstudents at UCLA’s David Geffen School of Medicine,Dr. Elena Stark conducts a flipped classroom.Dr. Stark’s lab classroom in the 1P corridor has eighttables hosting seven students each, the groups havingbeen assigned at the beginning of the year. At the headof each table is a computer monitor with access to ashared folder containing 3-6 Aperio virtual slides.First up: the Assessment Quiz. Starting off with a testmay sound unorthodox, but because the studentshave prepared the material on their own, it is theirresponsibility to arrive at the laboratory already in anactive state of mind. This way, from minute one of thelab session, their knowledge can be molded, sharpened,challenged and strengthened.Since the quiz isn’t for grading purposes, the evaluationgives the professor a good sense of the degreeof studying, explaining and understanding taking placeeach week. By eliminating any anxiety over a grade,students benefit by focusing on their own knowledge,M. Elena Stark, MD, PhD.pathology & laboratory medicine at ucla 15

the approach supports critical thinking,since students need to comprehend thesubject both for themselves and to beable to teach it to others.information, and each explains the material in his orher own way. “This is how you study,” asserts Dr. Stark.“This is how you learn.” The students listen to oneanother, interrupting with astute questions, seekingmore knowledge from each other. It is an activeand rich conversation – the opposite of the passivenote-taking (or checking one’s text messages) thatoccurs in the lecture hall.comparing it to the knowledge held by others, andlearning what is expected of them up to that point.What’s noteworthy is that although the students knowthat the quiz is not for a grade, the average score isabout 80%, with a mode of 90%-100%: proof that themajority of students come to the lab session preparedand ready to teach.The second phase begins once the quiz Scantron formsare collected. Now it is time for the students to discusstheir answers with their peers.A brief overview presented by Dr. Stark introducesthe Aperio slide to which the handout/teaching guiderefers, orienting the students for their investigation.With the ability to navigate and magnify the image onmonitors, each group consults with its members onthe issues prompted by the handout/teaching guide.A give-and-take discussion ensues.Again, Dr. Stark circulates and confirms. She remindseveryone that when learning from each other,“emphasize thinking your way through the material vs.memorizing tidbits of information.”“Why did you pick ‘A’ over ‘B’?”“Because ‘B’ identifies both characteristics…”Meanwhile, Dr. Stark circulates and confirms theperson(s) with the correct answer(s), asking them toexpand on their thought processes surrounding thequestion. After the entire quiz has been scrutinizedwithin each group, the class connects as a whole foranother review. Dr. Stark asks the questions to all:“The answer to #5 is?”“And why is this important to recognize?”(Assessment quizzes are later posted to Intranet/ANGEL as a supplement for reference. The studentscan email the professor with more queries.)The third stage employs a handout, which serves asa teaching guide. The students open the first Aperioslide. Today, the lesson is on the histopathology of themucosa of the stomach, and the first slide is “StomachFundus.” The teaching guide consists of multiple pagescontaining directions (“find,” “locate,” “identify”) alongwith probing questions (“What are the componentsof the lamina propria?” “Does the structure and locationof GALT make sense in terms of its function?”);a comparison chart; and fill-in-the-blank sentences(Describe, to your peers, the cell populations that arefound in the gastric glands). Together, these promptscover the vast data that the students had to exploreprior to class.A summarization session follows, conducted byDr. Stark, who again redirects any applied notions orinquiries from one student to them all.“Good question! Who has a possible answer?”As time and subject matter progress, so does theflip teaching process, with three more Aperio slides.The lab period concludes with the students applyingtheir knowledge on two case studies, presented by aguest lecturer.Many professors and instructors are praising theflipped classroom approach, but does this alternativelearning process make for more enriching education?According to some first-year medical students, itcertainly does. One student notes that working ingroups presents a less intimidating environmentfor inquiring about misunderstandings and delvinginto challenges. Another declares that the approachsupports critical thinking, since students need tocomprehend the subject both for themselves and tobe able to teach it to others. It was none other thanAlbert Einstein who agreed: “If you can’t explain itsimply, you don’t understand it well enough.” nDr. Stark notes that “the same information is packagedin different ways” in the flipped classroom. Differentstudents in a group emphasize different pieces of16 pathology & laboratory medicine at ucla

Principles of inheritanceand molecular geneticmechanisms underlie allfields of medicine — fromsurgery to psychiatry andeverything in between.Wayne Grody, MD, PhDmed school puts molecular genetics firstWith the advent of the “block” curriculum severalyears ago, instruction of UCLA medicalstudents in the field of genetics moved from the lastquarter of the second year, at the close of their preclinicalstudies, to Block 1 of the first year – indeed,starting in the very first week of that block. This reflectsthe understanding that we have entered the eraof genomic medicine. Principles of inheritance andmolecular genetic mechanisms underlie allfields of medicine – from surgery to psychiatry andeverything in between. Patient care in all fields willincreasingly rely on a thorough understanding ofthese concepts in order to provide optimal stateof-the-arttests and treatments, while avoidinginappropriate use of molecular diagnostic testswith the potential to harm the patient, both medicallyand psychosocially.The Department of Pathology and LaboratoryMedicine is responsible for the content in Block 1,making it the first discipline and first cohort ofmedical school faculty that the new studentsencounter. While the students can’t be expectedto have any clinical context for these concepts asthey start the curriculum, many are surprised andexcited to learn that there are clinical applicationsto the molecular biology content they studied asundergraduates, according to Dr. Wayne Grody,professor and director of UCLA’s Molecular DiagnosticsLaboratories, who presents most of the lecturesand laboratory exercises during that first week.An important component of Dr. Grody’s approach tothe course, and to the entire “Genetics Thread” thatstretches through all four years of medical school, isto convey to the students that molecular genetic testsdo not exist in a vacuum. These tests carry tremendousconsequences for the person being tested, aswell as for that individual’s blood relatives. Dr. Grody’slectures and lab exercises stress these ethical issuesjust as strongly as the technical aspects, delving intosuch philosophical dilemmas as genetic privacy,informed consent, insurance and employment discrimination,inequity of access to expensive genetictests, and the burdens of exclusive gene patents.Student evaluations over the years demonstratethat they greatly appreciate this side of the storyand find it interesting and challenging, providingmuch food for thought and discussion both in andoutside the classroom. nexplore Educationpathology.ucla.edu/education18 pathology & laboratory medicine at ucla

understanding the complexities of inflammationInflammation is a complex, multi-componentresponse that protects the host from a harmfulinvader or tissue destruction. It represents an earlydefense warning system of the body, designed tominimize danger, mitigate damage and start therepair process. To achieve this essential task, theinflammatory system relies on an intricate series ofmolecular sensors stationed on high alert throughoutthe body. Once these sensors sound the alarm, thebody activates an ever-growing array of molecularand cellular effectors tasked with protecting thehost from dangerous foreign invaders or minimizingtissue damage from traumatic injury. Without the fullarmamentarium of this system, people can experiencea myriad of problems, ranging from life-threateninginfections to an autoimmune disease such as lupus.If left unchecked, excessive inflammatory responsescan cause significant disease and death, likelycontributing to atherosclerosis, diabetes and obesity,to name a few.Dr. Steven Bensinger, who has been studying theinflammatory response and the immune system fornearly 15 years, teaches first-year medical studentsabout the principles of inflammation. “The goal is notto memorize details, many of which will ultimatelyfade from their memory,” he explains. “Rather, I wantthe students to fundamentally understand how theinflammatory system works.”Excessive inflammatoryresponses can causesignificant disease anddeath, likely contributingto atherosclerosis,diabetes and obesity,to name a few.Dr. Bensinger starts with anatomy so that studentscan see the tissues that are involved, then introducesthe cellular players of the inflammatory system:neutrophil and macrophage. Next, he covers themyriad molecular effectors dedicated to rapidlyresponding to danger signals. Finally, students learnabout the resolution of the inflammatory response –including the brakes of the system, keeping the hostfrom the ever-escalating response. “The principles ofinflammation, including how it functions in healthand contributes to disease, will serve as a foundationthroughout students’ medical education,” Dr.Bensinger notes. nEDUCATIONSteve Bensinger,VMD, PhD, andanatomy students.pathology & laboratory medicine at ucla 19

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esearch servicestranslational pathology core laboratoryseeks to fulfill the promise of biobankingThe growing emphasis on translational research(converting laboratory findings to clinical gains) andpersonalized medicine has increased the importanceof high-quality human tissue and fluid samples toidentify potential therapeutic targets, find prognosticbiological markers, and recognize markers that willfacilitate tailoring of individual therapies for cancerpatients. The biobanking practices associated withstoring such samples have changed significantly overthe past decade. A leader in this changing arena isDr. Sarah Dry, director of the UCLA Department ofPathology and Laboratory Medicine’s TranslationalPathology Core Laboratory (TPCL), which includesthe UCLA Institutional Biobank.In August 2012, TPCL became the fourth biorepositoryin the United States to be accredited by the Collegeof American Pathologists (CAP). Similar to laboratoryaccreditation, CAP biorepository accreditation is arigorous process designed to ensure that biorepositorieshave standard operating procedures in place thatconform to current best-practice standards; processesfor continual quality control monitoring and improvement;and appropriate initial and ongoing staff trainingprocesses. TPCL is now in the process of obtainingClinical Laboratory Improvement Amendments (CLIA)certification, as more patients want their samplesbanked for future personalized-medicine clinical use.Given the storage costs (space, freezers, electricity)involved with traditional biosample storage, biobankingresearchers are exploring alternative storage methods.One technique being studied by Dr. William H. Yong,UCLA neuropathologist, involves room temperaturestorage of lyophilized samples (see page 25).Two innovative additions to UCLA/TPCL biobankingare being introduced this year. One involves linkingwhole-slide digital images to samples in the biobankdatabase. The quality control slide for each biosampleis scanned on TPCL’s Aperio AT scanner and stored. Athumbnail image of the scanned slide appears in thedatabase, and a link to the full image enables staff orresearchers to immediately determine if the biosamplesatisfies research needs. The second innovationinvolves the installation of Daedalus Crimson softwareat UCLA. Crimson permits identification of soonto-be-discardedclinical samples for use in research.This technology will make it easier for researchers toobtain (with appropriate informed consent) both patientspecificand disease-specific samples.An important effort underway at UCLA involves institutingglobal informed consent for the use of remnantbiosamples in research. Recent federal and stateconcerns about patient privacy given current genomictesting capabilities suggest that continued use ofSarah Dry, MD, PhDpathology & laboratory medicine at ucla 21

Clara Magyar, PhD,Joseph Bautista,Voicu Ciobanu, PhDSarah Dry, MD,Delia Adefuinand Ping Fu ofthe TranslationalPathology CoreLaboratory.CAP biorepository accreditation is a rigorousprocess designed to ensure that biorepositorieshave standard operating procedures in place thatconform to current best-practice standards.“anonymous” or coded samples may not be consideredsufficient protection for human research subjects, andthat informed consent may be required. Dr. Dry hasbeen leading a UCLA group that is evaluating thisissue and determining how to implement appropriatechanges at UCLA. This effort parallels and complementsDr. Dry’s efforts on her recent National Institutesof Health grant for biobanking and informed consent.Pioneering biobanking practices ensures that UCLAwill continue to lead the way in translational researchand personalized medicine. nexplore Translational Pathology Core Laboratorypathology.ucla.edu/tpcl22 pathology & laboratory medicine at ucla

A centralized and comprehensiveresource for investigators lookingto access services offered by thedepartment’s core facilities.RESEARCH SERVICESpathology portal improves accessto department’s servicesThe new Center for Pathology ResearchServices (CPRS), under the leadership of JustinPerry (manager) and Dr. Sarah Dry (director), willserve as a centralized and comprehensive resource forinvestigators looking to access services offered by thedepartment’s core facilities. These facilities include:Clinical Microarray Core LaboratoryClinical and Translational Research Laboratoryto a single location. The CPRS is staffed by a groupof research coordinators and located on the A-levelof the Center for Health Sciences building, enablingresearchers to contact a single office or website forall of their study needs. This includes basic inquiresabout services offered, protocol reviews, pricing,budget development, Institutional Review Boardsupport, invoicing, result reporting and specimenhandling, among other operational and logisticalservices.Justin PerryHigh-Throughput ClinicalProteomics Core LaboratoryTranslational Pathology Core LaboratoryUCLA Immunogenetics CenterRather than investigators spending valuable timeand resources determining whom to contact about aparticular question, all inquiries can now be directedWith the CPRS, researchers can expect increasedaccess to the available services, improved coordinationand processing speed for service requests, andsignificant cost savings through greater use of sharedresources. The CPRS aims to facilitate and expandutilization of the department’s core facilities whilesupporting UCLA researchers in their efforts. nexplore Research Servicespathology.ucla.edu/rslpathology & laboratory medicine at ucla 23

EngageUC will inform federal and statedebate on biobanking practicesthree-year, $2 million National Institute ofA Health grant has been awarded to UCLADepartment of Pathology and Laboratory Medicine’sSarah Dry, MD, PhD, and two colleagues at UCSan Francisco. This effort to inform debate on theissue of informed consent practices in the use ofbiosamples for genomic research, is in responseto concerns expressed by both federal and stategovernment funding agencies.Researchers will solicit communityparticipation and adviceon biobanking and informedconsent issues.“EngageUC,” has three objectives:Develop harmonized biobanking operations andgovernance practices among the University ofCalifornia’s (UC’s) five biomedical campuses (Davis,Irvine, Los Angeles, San Diego and San Francisco);Create uniform administrative practices forinter-UC research activities by working withthe institutional officials at each campus; andConduct a randomized clinical trial of differenttypes of informed consent forms for use ofbiosamples in research.The researchers will solicit community participationand advice on biobanking and informed consent issuesusing a process known as Deliberate CommunityEngagement during weekend-long meetings in bothNorthern and Southern California. Ultimately, theirgoal is to have a standing community advisory boardto UC on issues of biobanking and the use of biosamplesin research. nexplore EngageUCpathology.ucla.edu/engageuc24 pathology & laboratory medicine at ucla

Now a group headed byWilliam H. Yong, MD, is seekingto achieve the best of bothworlds — developing betterways to store tissues at roomtemperature while preservingnucleic acids and proteins.RESEARCH SERVICESWilliam H. Yong, MDfreeze-dried storage of tissues mayoffer “best of both worlds”Using a freezer to store tissue and blood isarguably the most effective approach to modernpathological analysis. But there are drawbacks,including the cost of freezing the biospecimensand their vulnerability to thawing as a result offreezer failure or other events. Securing funding andspace for banks of freezers can be challenging forbiomedical institutions. On the other hand, formalinfixed paraffin embedded tissues – the most commonbiospecimens stored – can remain relatively stableat room temperature over the long term, but thesetissues contain fragmented and cross-linked nucleicacids, limiting their value. Now a group headed byWilliam H. Yong, MD, director of the Brain TissueTranslational Resource, is seeking to achieve thebest of both worlds – developing better ways to storetissues at room temperature while preserving nucleicacids and proteins.Dr. Yong’s group has conducted studies showing thatwhen brain tumor tissue is freeze-dried (lyophilized)and stored in vacuum-sealed vials for a year at roomtemperature, nucleic acids and proteins are suitablefor histology, mutation detection, and proteinanalyses, including enzymatic assays. Ribonucleicacids (RNA), though amenable for genetic analyses,show some evidence of degradation in such conditions,so Dr. Yong and colleagues are exploring ways tobetter stabilize RNA in the freeze-dried tissue as theymove closer to their ultimate goal. A variety of factors,including light, oxygen, humidity and peroxidation,can degrade nucleic acids, so Dr. Yong’s group isevaluating additives that might mitigate their effects.The researchers have also lyophilized samples thatare 2-4 years old to determine their characteristics.While the investigation into the freeze-dried storageapproach continues, Dr. Yong and colleagues arealso looking at ways to protect precious frozensamples from being lost as a result of extended lossof power from earthquakes or other events. Theybelieve diversified storage, in both location andmodality, may be the answer. Samples can be storedin freezers in different rooms or buildings so that ifthere is damage in one location, all will not be lost.In the future, the group hopes that stabilized tissuesstorable at room temperature will lower the monetary,labor, space and environmental costs necessary tosupport biobanks, which are critical for propellingpersonalized molecular therapy research. nexplore Brain TissueTranslational Resourcepathology.ucla.edu/bttrpathology & laboratory medicine at ucla 25

who’s who in pathologyEXECUTIVE LEADERSHIPJonathan Braun, MD, PhDProfessor and ChairScott W. Binder, MDSenior Vice Chair,Clinical ServicesLinda G. Baum, MD, PhDVice Chair, Academic AffairsKenneth A. Dorshkind, PhDVice Chair, ResearchThomas A. Drake, MDVice Chair, Information SystemsCharles R. Lassman, MD, PhDVice Chair, Clinical EducationElaine F. Reed, PhDVice Chair, Research ServicesElena Stark, MD, PhDVice Chair, Medical andDental EducationArnold Scheer, MPHChief Administrative OfficerCLINICAL LEADERSHIPTamar Baruch-Oren, MDMedical Director,Olympia Medical CenterLinda G. Baum, MD, PhDMedical Director, UCLAClinicial LaboratoriesScott W. Binder, MDMedical Director,Clinical Outreach ServicesSteven D. Hart, MDMedical Director, SMUCLAKimberly A. Mislick, MD, PhDMedical Director,Northridge HospitalRobert J. Morin, MDMedical Director, Harbor-UCLA Medical CenterScott D Nelson, MD.Chief, Pathology, SMUCLANora Ostrzega, MDChief and Medical Director,UCLA Olive View CountyMedical CenterDIVISION CHIEFSLinda G. Baum, MD, PhDLaboratory MedicineJonathan W. Said, MDAnatomic PathologySECTION CHIEFSSophia K. Apple, MDBreast PathologySunita M. Bhuta, MDHead and Neck PathologyScott W. Binder, MDDermatopathologyAnthony W. Butch, PhDClinical ChemistryAnthony W. Butch, PhDToxicologyGalen R. Cortina, MD, PhDGastrointestinal PathologyMichael C. Fishbein, MDAutopsy/Decedent AffairsMichael C. Fishbein, MDCardiac PathologyBen J. Glasgow, MDOphthalmic PathologyWayne W. Grody, MD, PhDMolecular Pathology andClinical Genomics,Orphan Disease TestingJiaoti Huang, MD, PhDGenitourinary PathologyRomney Humphries, PhDClinical MicrobiologyCharles R. Lassman, MD, PhDLiver Pathology;Renal PathologyStephen Lee, MDHematologyNeda A. Moatamed, MDGynecologic PathologyScott D. Nelson, MDOrthopedic Pathology,Skeletal & Soft Tissue PathologyJian Yu Rao, MDCytopathologyNagesh P. Rao, PhD, FACMGCytogeneticsElaine F. Reed, PhDImmunogeneticsEmma Taylor, MDDermatopathology, VA West LosAngeles Healthcare CenterMichael A. Teitell, MD, PhDPediatric and Neonatal PathologyHarry V. Vinters, MDNeuropathologyW. Dean Wallace, MDPulmonary PathologyAlyssa Ziman, MDTransfusion MedicineFELLOWSHIP PROGRAMSophia K. Apple, MDDirector, CytopathologyGalen R. Cortina, MD, PhDDirector, GI and LiverMichael C. Fishbein, MDDirector, CardiopulmonaryWayne W. Grody, MD, PhDDirector, Molecular GeneticsDirector, Molecular PathologyCharles R. Lassman, MD, PhDDirector, Surgical PathologyNora Ostrzega,MDDirector, Surgical Pathology(Olive View)Sheeja T. Pullarkat, MDDirector, HematopathologyNagesh P. Rao, PhD, FACMGDirector, CytogeneticsG. Peter Sarantopoulos,MDDirector, DermatopathologyWilliam H. Yong, MDDirector, NeuropathologyAlyssa Ziman, MDDirector,Transfusion Medicine ProgramRESIDENCY PROGRAMCharles R. Lassman, MD, PhDDirectorDinesh S. Rao, MD, PhDAssociate DirectorPeggy S. Sullivan, MDAssociate DirectorAlyssa Ziman, MDAssociate DirectorMEDICAL & DENTAL EDUCATIONElena Stark, MD, PhDDirector, Integrative Anatomy;Thread Chair, Anatomy andHistopathology, School ofMedicineThomas A. Drake, MDBlock 1 Chair, School of MedicineKathleen A. Kelly, PhDBlock 4 Chair, School of MedicineLee A. Goodglick, PhDCo-Director, IMED SeminarSeries, School of DentistryCENTERS & LABORATORIESScott W. Binder, MDMedical Director, BruinUniversity ReferenceLaboratory (BURL)Sunita M. Bhuta, MDDirector, Transmission ElectronMicroscopy LaboratoryAnthony W. Butch, PhDDirector, Olympic AnalyticalLaboratory Director, Clinical andTranslational ResearchLaboratoryKingshuk Das, MDDirector of Operations, GeneticMedicine; Associate Director,Diagnostic MolecularPathology LaboratorySarah M. Dry, MDDirector, TranslationalPathology Core Laboratory;Director, Center forPathology Research ServicesWayne W. Grody, MD, PhDDirector, Molecular DiagnosticsLaboratories; Director,Orphan Disease TestingLaboratory; Director,Genetic MedicineOliver Hankinson, PhDChair Molecular ToxicologyInterdepartmental ProgramJames LeBlanc, PhDDirector, High ThroughputClinical ProteomicsXinmin Li, PhDTechnical Director, ClinicalMicroarray Core LaboratoryStanley Nelson, MDDirector, Clinical GenomicsCenterElaine F. Reed, PhDDirector, ImmunogeneticsCenterDavid B. Seligson, MDCo-Director, BiomarkerInnovations Laboratory;Director, Tissue Array CoreFacilitySophie X. Song, MD, PhDDirector, Clinical FlowCytometryLaboratory; Director, BoneMarrow LaboratoryMichael A. Teitell, MD, PhDDirector, Cancer NanotechnologyProgram Area (JCCC)W. Dean Wallace, MDDirector, Laboratory SafetyADMINISTRATIONJosephine AlviarManager Academic Services& PayrollMarkus AveryDirector, Personnel and PayrollPam BumertsManager, Transfusion MedicineDebra CobbDirector of Operations,Clinical LaboratoriesPaul ColonnaManager, Microbiology,Cytogenetics and MolecularPathologyDiana CraryManager, Core Laboratoriesand Point of Care TestingElisa DeRoblesManager, Billing and OutreachServices; Assistant to SeniorVice Chair, Clinical ServicesGeri GoodeliunasManager, Clinical Laboratory,SMUCLAKaryn GreenstoneDirector of Communicationsand Strategic ProjectsSharon HigginsDirector of Operations:Space Facilities, Safetyand ComplianceChristopher HernandezDirector of FinanceDavid IslasManager,Research AdministrationChristina KimManager, Student Affairsand Training ActivitiesDebra LacavaManager,UCLA Immunogenetics CenterMary LevinProgram Director, School ofCytotechnology; Clinical LabManager, Cytology ServicesMary Alice MitaAdministrative Director,Clinical ServicesJustin PerryManager, Sales & Services andProcurement Activities;Manager, Clinical ResearchServicesJustine PomakianManager, Special ProjectsMerian RazManager, Clinical SupportServicesAnn ShadlerDirector of Operations,Anatomic PathologyDennis SunseriManager,Pathology Information SystemsMarivic VisicoManager, Regulatory Affairs,Compliance, Education andSafetyNora WarschawManager,Molecular DiagnosticsLaboratoriesSharon WebbDirector of BusinessDevelopmentFULL PROFESSORSSophia K. Apple, MDRaymond L. Barnhill, MDLinda G. Baum, MD, PhDJudith A. Berliner, PhDSunita M. Bhuta, MDScott W. Binder, MDJonathan Braun, MD, PhDAnthony W. Butch, PhDDavid A. Bruckner, A, ScDMichael J. Cecka, PhDDavid S. Chia, PhDAlistair J. Cochran, MDGalen R. Cortina, MD, PhDGay M. Crooks, MBBSKenneth A. Dorshkind, PhDThomas A. Drake, MDRita B. Effros, PhDMichael C. Fishbein, MDRichard A. Gatti, MDDavid W. Gjertson, PhDBen J. Glasgow, MDWayne W. Grody, MD, PhDOliver Hankinson, PhDSharon L. Hirschowitz, MDJiaoti Huang, MD, PhDKathleen A. Kelly, PhDCharles R. Lassman, MD, PhDStephen Lee, MD26 pathology & laboratory medicine at ucla

Xinmin Li, PhDScott D. Nelson, MDJian Yu Rao, MDNagesh P. Rao, PhD, FACMGElaine F. Reed, PhDNora Rozengurt, DVM, PhDJonathan W. Said, MDRobert H. Schiestl, PhDElena Stark, MD, PhDMichael A. Teitell, MD, PhDPeter J. Tontonoz, MD, PhDRobert B. Trelease, PhDHarry V. Vinters, MDHanlin L. Wang, MD, PhDWilliam H. Yong, MDASSOCIATE PROFESSORTamar Baruch-Oren, MDNicole A. Dawson, MDSarah M. Dry, MDLee A. Goodglick, MBA, PhDXin Liu, MD, PhDQun Lu, MDJoseph M.A. Miller, PhDNeda A. Moatamed, MDSheeja T. Pullarkat, MDFabiola Quintero-Rivera, MD, FACMGRajalingam Raja, PhDDavid B. Seligson, MDSophie X. Song, MD, PhDW. Dean Wallace, MDAlyssa Ziman, MDASSISTANT PROFESSORSteven J. Bensinger, VMD, PhDKingshuk Das, MDDavid W. Dawson, MD, PhDJosh L. Deignan, PhD, FACMGSamuel W. French, MD, PhDOmai B. Garner, PhDSteven D. Hart, MDHailiang Hu, PhDRomney Humphries, PhDSibel Kantarci, PhD, FACMGNegar Khanlou, MDJames P. Lister, PhDDavid Lu, MDKimberly A. Mislick, MD, PhDBita V. Naini, MDM. Fernando Palma-Diaz, MDBogdan Pasaniuc, PhDDinesh S. Rao, MD, PhDG. Peter Sarantopoulos, MDStephen P. Schettler, PhDChandra N. Smart, MDLu Song, PhDPeggy S. Sullivan, MDYin Sun, PhDCarlos Tirado, PhD, FACMGMadhuri Wadehra, PhDAparche B. Yang, MDQiuheng (Jennifer) Zhang, PhDwho’s research who in services pathologyJOINT APPOINTMENTSteven M. Dubinett, MDTomas Ganz, MD, PhDRichard P. Kaplan, MDMichael Kuo, MDJerzy W. Kupiec-Weglinski, MD, PhDSiavash K. Kurdistani, MDBenhur Lee, MDStanley Nelson, MDMichael Phelps, PhDCharalabos E. Pothoulakis, MDGary Schiller, MDS. Andrew Schwartz, MDRam R. Singh, MDEmma Taylor, MDJames G. Tidball, PhDHong Wu, MD, PhDAnna Wu Work, PhDMichael Zucker, MDENDOWED CHAIRSScott W. Binder, MDPritzker Family Endowed TermChair in PathologyMichael C. Fishbein, MDFrances and Albert PianskyChair in AnatomyRichard A. Gatti, MDRebecca Smith Chair in A-TResearchBenjamin J. Glasgow, MDWasserman Professor ofOpthalmologyJerzy W. Kupiec-Weglinski, MD, PhDJoan S. and Ralph N. GoldwynChair in Immunobiology andTransplantationMichael E. Phelps, PhDNorton Simon Chair in BiophysicsCharalabos Pothoulakis, MDEli and Edythe L. BroadFoundation Chair in InflammatoryBowel Disease ResearchMichael A. Teitell, MD, PhDLya and Harrison LattaEndowed Chair in PathologyEMERITUSAnthony M. Adinolfi, PhDMarcel A. Baluda, PhDJohn H. Campbell, PhDPasquale A. Cancilla, MDCarmine D. Clemente, PhDWalter F. Coulson, PhDHideo H. Itabashi, MDPaul I. Liu, MDJoseph M. Mirra, MDFaramarz Naeim, MDRoberta K. Nieberg, MDDonald E. Paglia, MDShi-Kaung Peng, MDLawrence D. Petz, MDDavid D. Porter, MDDenis O. Rodgerson, PhDGeorge S. Smith, MDNora C. Sun, MDMitsuo T. Takasugi, PhDJulien L. VanLancker, MDMaurice A. Verity, MDElizabeth Wagar, MDHOUSESTAFFJosephine Aguilar, PSFSerge Alexanian, MDLayla Alizadeh, MDFernando Antelo, MDKulvara Anuruckparadorn, MDRamir Arcega, MDMeenakshi Bhasin, MDKritsanapol (Pong) Boon-Unge, MDMarian Butcher, MDShelley Chang, MD, PhDSue Chang, MDSalma Dabiri, MDAna Laura De La Cruz, MDMatthew M. DeNicola, MDDonny Dumani, MDVanda Farahmand, MDGregory A. Fishbein, MDDorina Gui, MD, PhDJulie Jackson, MDAaron James, MDMichael E. Kallen, MDSusan Kerkoutian, MDJustin Kerstetter, MDMazdak A. Khalighi, MDAdnan R. Khan, MDChristopher J.Y. Kim, MDDong-Hoon Kim, MD. PhDJutatip Kintarak, MDNam K. Ku, MDCorina Kwan, DOThomas D. Lee, MDErick Lin, MD, PhDLawrence K. Low, MD, PhDShino D. Magaki, MD, PhDBrian Nagao, MDIrma V. Oliva, MDBeth Palla, MDJeffrey M. Petersen, MDMonica Phillips, MDKantang Satayasoontorn, MDAtsuko Seki, MDLisa Smith, DOMarie Sohsman, MDAlbert Su, MDKeng-Chih (Kenny) Su, MDEric Swanson, MDMaria E. Vergara-Lluri, MDAnnie Wu, MDWinnie Wu, MDSteven Yea, MD, PhDASSISTANT & ASSOCIATERESEARCHERSCheryl Irene Champion, PhDRong Rong Huang, MDJanina Jiang, PhDYiping Jin, MDYael D. Korin, PhDJames F. Leblanc, PhDHane Lee, PhDSangderk Lee, PhDNu Lu, MDClara E. Magyar, PhDVei Hsien Mah, MDEncarnacion Montecino-Rodriguez,PhDKotoka Nakamura, PhDPing Rao, PhDHong Yu, MD, PhDPOST-DOCTORAL SCHOLARSMandana Amiri, PhDBeata Berent Maoz, PhDJelena Brezo, PhDApril M. Bobenchik, PhDJinkuk Choi, PhDEszter Deak, PhDThilini Ranga Fernando, PhDJessica Aaron Fowler, PhDEkambaram Ganapathy, PhDNegar Montakhab Ghahramani, PhDCarmen Giltner, PhDAyaka Ito, PhDMarius Ciprian Jones, PhDRonik Khachatoorian, PhDYoko Kidani, PhDStephen David Lee, PhDZhen Li, PhDMahta Nili, PhDIan H. McHardy, PhDJeffrey Thomas McNamara, PhDShelley Anne Miller, PhDKiyoko Miyata, PhDAmelie Claire Montel-Hagen, PhDJayanth Kumar Palanichamy,PhDpublicationsare onlineChristina M. Priest, PhDSalemiz Sandoval, PhDShakir Sayani, PhDKatrin Schaefer, PhDSamuel Storm, PhDSandra Thiemann, PhDNicole Marie Valenzuela, PhDHaolei Wan, PhDBo Wang, PhDKevin Jason Williams, PhDTing-Hsiang Sherry Wu, PhDYuxin Yin, PhDThomas Andrew Zangle, PhDLi Zhang, PhDGRADUATE STUDENTRESEARCHERSJoseph P. ArgusMichael Dawson ArensmanRobert BrownDana CaseChee Jia ChinJennifer Ping ChouJeffrey Nels DockAmy Helene HenkinJason Seung Pyo HongWilliam Sang KimLisa KohnLin LinNathan Thomas MartinNorma Iri Rodriguez MalaveXin RongSahar SalehiEriko Christine ShimadaTara Ann TeslaaMaomeng TongChristine Marie Van HornNicole C. WalshJiexin WangWen-Yun YangAutumn Gabrielle Yorkpathology.ucla.edu/publicationsfor updated faculty publications.DEPARTMENT IN DEPTHpathology & laboratory medicine at ucla 27

metricsfacilitiesTotal number of square feet ofClinical, Research, and Teaching spacetotal space in square feet = 254,980department of pathologytotal = 1,226 peopleclinical:146,485research:41,543staff: 984core lab: 12,568professional researchseries: 18faculty: 117residents/fellows: 45postdoc researchers: 37grad student researchers: 25awaiting tenantimprovements:10,387educational, academic,& administration43,997clinical metrics 2013(projected)research fundingtotal = $46.7 millionother granting agencies: $16mnih funding: $30.7mnearly6 MILLIONclinical lab tests15department inventions in 201259,500outreach cases41,000cytology cases31,000surgical pathology cases7,100molecular pathology cases21,000cytogenetics cases28 pathology & laboratory medicine at ucla

Raymond Barnhill, MD: Founders’ Award of theAmerican Society of Dermatopathologyawards & recognitionsElena Stark, MD, PhD: UCLA DGSOM Class of2015 Golden Apple Award for Excellence in TeachingDEPARTMENT IN DEPTHKingshuk Das, MD: 2012 Daljit s. & ElaineSarkaria FellowshipGregory Fishbein, MD: 2013 Daljit S. & ElaineSarkaria FellowshipSamuel French, Sr., MD:2014 American Society for Investigative PathologyGold-Headed Cane AwardDennis Goldfinger, MD: The Suzanne LedinLectureship And Award, Suzanne LedinMemorial Foundation, Presented By The CaliforniaBlood Bank Society, April 3, 2012Wayne Grody, MD, PhD:President, American College of Medical GeneticsArno Roscher Endowed Lectureship, InternationalCollege of SurgeonsBowes Award Lectureship in Medical Genetics,Harvard Medical SchoolGolden Apple Award, UCLA Intercampus MedicalGenetics Training ProgramAMP Leadership Award, Association forMolecular PathologyMike Teitell, MD, PhD: 2013 Harrison LattaChair in PathologyRobert Trelease, PhD: appointed AssociateEditor, Anatomical Sciences Education (officialjournal of American Association of Anatomists).Jonathan Wisco, PhD: American Associationof Anatomists 2013 Basmajian AwardVoted BEST DOCTORS® 2013:Scott Binder, MDAlistair Cochran, MDGalen Cortina, MD, PhDCharles Lassman, MD, PhDSheeja Pullarkat, MDJonathan Said, MDHanlin Wang, MD, PhDElaine Reed, PhD: ASHI Rose PayneDistinguished Scientist Award & 2012 RachelMcKenna Memorial Lecturerexplore faculty awards & recognitionspathology.ucla.edu/newspathology & laboratory medicine at ucla 29

alumni updateWHERE ARE THEY NOW?CANADAWASHINGTONMONTANANORTH DAKOTAMINNESOTAOREGONWISCONSINNEW YORKMASSACHUSETTSRHODE ISLANDNEBRASKAIOWAPENNSYLVANIACONNECTICUTCALIFORNIANEVADAUTAHCOLORADOMISSOURIILLINOISOHIOINDIANAKENTUCKYVIRGINIANEW JERSEYMARYLANDDISTRICT OF COLUMBIAARIZONANEW MEXICOOKLAHOMAARKANSASTENNESSEENORTH CAROLINASOUTH CAROLINAALABAMAGEORGIATEXASLOUISIANAALASKAFLORIDAHAWAIIBRAZIL1-3 ALUMNI7-9 ALUMNI13-15 ALUMNI4-6 ALUMNI10-12 ALUMNI100+ ALUMNI30 pathology & laboratory medicine at ucla

The Clinical and Research Alumni Committees area vital part of the Department of Pathology and LaboratoryMedicine at UCLA. Coordinating the needs ofthe alumni with the resources of the department, thecommittees provide educational and mentoring opportunities,encourage activity and philanthropy,and provide an opportunity for alumni to keep andmake new and valued connections. Valerie McWhorter,MD, is Chair of the Clinical Research Committee;alumni updateJosh Deignan, PhD, FACMG chairs the ResearchAlumni Committee.The Pathology Clinical and Research Alumni Committeesare delighted to represent our former traineesand ensure the link between them and the UCLADepartment of Pathology and Laboratory Medicineremains strong. To learn more, or to subscribe to ournewsletter, please visit our website.DEPARTMENT IN DEPTHRecent Highlights:n The first Clinical Alumni Newsletter is introducedn Clinical and Research Alumni Web pageslaunched: pathology.ucla.edu/alumnin New Clinical Alumni Facebook Page(search “UCLA Pathology Alumni”)n Active Research Alumni LinkedIn Page(search “UCLA Pathology Research Alumni)n Alumni Mentoring and Teaching Programs:. Mohammad Kamal, MD and Valerie McWorther,MD address career issues. Kimberly Mislick, MD, PhD addresses medicaldirectorship of the community laboratoryexplore...Clinical & Research Alumnipathology.ucla.edu/alumniActive Research Alumni LinkedIn Page(search “UCLA PathologyResearch Alumni”)New Clinical Alumni Facebook Page(search “UCLA Pathology Alumni”)

opportunities for givingENDOWED CHAIRSExecutive Endowed Chair: $3,000,000Permanent Endowed Chair: $2,000,000Professional Development 5-Year(renewable) Term Chair: $1,000,000Recruitment/DistinguishedService/Teaching (1-5 year) Term Chair: $500,000EDUCATIONGraduate Student Researcher: $500,000Postdoctoral Researcher/Fellow: $1,000,000Clinical Resident Trainee: $500,000Summer Youth Trainee: $10,000Teaching Awards: $250,000Lectureships: $250,000CLINICAL INNOVATIONCore Laboratories: $2,000,000• Clinical Genomics Laboratory• Translational Pathology Core Lab• Clinical Microarray Core Lab• High-throughput ClinicalProteomics Core Lab• Clinical Immunology Research LabDEDICATED RESEARCHResearch Funding: $250,000• Stem Cells in Prostate Cancer• Finding New Treatments for Brain Cancer• Personalizing Treatment for Sarcomas• Molecular Therapy of Obesity And Diabetes• Women’s Health Studies• Restoring the Aging Immune System• Advancing Transfusion Medicine• Inflammatory Bowel Disease(Crohn’s and Ulcerative Colitis)• Controlling Inflammation-Mediated Atherosclerosis• Rapid Diagnosis of Congenital Mendelian DiseaseNAMING OPPORTUNITIESFor support of a dedicated research instituteor center, including capital improvementsand/or programmatic support: $10,000,000• University Immunogenetics Centerexplore opportunities for givingand make donations onlinepathology.ucla.edu/giving2012 Volkswagen City of Angels Fun Ride,benefitting the UCLA Blood & Platelet Center.L to R: Dr. Linda Baum, Dr. Scott Binder,Dr. Alyssa Ziman, Peter Heumann, City of AngelsFun Ride Founder; Maria Marsh, owner of PaceSportswear; Howie Neftin, owner of NeftinVolkswagen; and Pamela Bumerts.32 pathology & laboratory medicine at ucla

We Thank Our Generous Supporters, Including:American Cancer Society, Inc.American Societyof HematologyDr. Richard Braun& Mrs. Barbara BraunCrohn’s & ColitisFoundation of AmericaJoseph Drown FoundationThe Leona M. and Harry B.Helmsley Charitable TrustLya Cordova LattaMizutani Foundation for GlycoscienceDrs. Elaine and Daljit SarkariaDEPARTMENT IN DEPTHA Closer LookThe Crohn’s & Colitis Foundationof America, and The Leona M. andHarry B. Helmsley Charitable TrustThrough a competitive grant to JonathanBraun, MD, PhD, The Crohn’s & ColitisFoundation of America, and The LeonaM. and Harry B. Helmsley CharitableTrust, generously support the Departmentof Pathology and Laboratory Medicinein research on the role of intestinalmicrobes in Crohn’s disease. This multicenternational study aims to uncover thedisease-significant microbes and theirproducts, and to determine how to targetthem for treatment and prevention of thiscommon intestinal disease. CCFA has beena longstanding partner of the Department,advancing its research on Crohn’s diseaseand colorectal cancer, and the careerdevelopment of young scientists anddoctors devoted to these health concerns ofour community.Ms. Agi Hirshberg and theHirshberg Foundation forPancreatic Cancer ResearchThe Department of Pathology and LaboratoryMedicine is grateful for contributionsfrom Ms. Agi Hirshberg and the HirshbergFoundation for Pancreatic CancerResearch in support of innovative researchunder the direction of David Dawson, M.D.His work focuses on genetic modificationsthat have shown potential to slow or stopthe cancer’s progression.The Foundation also has long-sustainedkey partnerships with the UCLA Centerfor Pancreatic Diseases, UCLA Divisionof Digestive Diseases, Simms/Mann UCLACenter for Integrative Oncology, UCLADepartment of Chemistry and Biochemistry,and others and has been instrumentalin the University’s efforts to find a curefor pancreatic cancer, an aggressive anddeadly disease.Joseph Drown FoundationIn the past year, the Joseph DrownFoundation renewed its support of importantresearch in ataxia-telangiectsia (A-T)under the direction of Richard Gatti, M.D.Private contributions have helped UCLAbecome a leader in this area, and such vitalfunding helps to ensure continued progresstoward improved treatments for DNArepair-deficiency disorders. The Departmentis appreciative of the Foundation’scommitment to preserving excellence inA-T and related investigations.“It is a privilege to support a department thattrains people of such high caliber and integrity,who go out and do so much for the community.”– Lya Cordova Latta

UCLA Department of Pathologyand Laboratory Medicineucla pathoDavid Geffen School of Medicine at UCLA10833 Le Conte AvenueLos Angeles, CA 90095-1732Ronald Reagan UCLA Medical Center757 Westwood PlazaLos Angeles, CA 90095Santa Monical UCLA Medical Center& Orthopaedic Hospital1260 15th Street, Ste. 808Los Angeles, CA 90404ucla pathology a