[NEW] suggestions [NEW] suggestions - Acros Organics

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[NEW] suggestions [NEW] suggestions - Acros Organics

12[NEW] suggestionsfor the organic chemistfrom Acros OrganicsA Fisher Scientific Company


12 NEW suggestionsfor the organic chemistBoronic acids and derivatives......................................................................................................................3New Boronic esters......................................................................................................................................4New Rhodium, Ruthenium, and Tin complexes............................................................................................5Grubb’s Catalysts ........................................................................................................................................6New Organosilicon Reagents ......................................................................................................................7Organic Synthesis Tools ..............................................................................................................................8Chiral 2-alkyl succinates: ChiroTech ® Products ..........................................................................................9Valuable Cyclopentane Derivatives: ChiroTech ® Products ........................................................................10Asymmetric Hydrogenation tools ..............................................................................................................11Catecholborane..........................................................................................................................................12Phosphines, Ligands and Ligand-Precursors - Triarylphosphines ............................................................13Phosphines, Ligands and Ligand-Precursors - Chelating, non-chiral Phosphineligands ..........................14Register at www.acros.com and discoverthe new features of our website.Please check our new catalogue edition or our web sitewww.acros.com for a larger selection.2 • 12 NEW suggestions for the organic chemist


A Fisher Scientific CompanyA Fisher Scientific CompanyBoronic acidsand derivativesfrom Acros OrganicsArylboronic acids and their esters are highly popular synthetic intermediates inorganic synthesis, both for their ease of conversion to other functional groups (suchas phenols 1 and aryl halides 2etc.), and to their efficientPd-catalyzed coupling witharyl or vinyl halides ortriflates to form biaryl andalkyl aryl derivatives. 3,4,5,6,7Literature:1. Webb, K. S. and Levy D., Tetrahedron Lett., 1995, 36, 5117.2. Thiebes, C. T.; Surya Prakash, G. K.; Petasis, N. A.; Olah, G., Synlett, 1998, 141.3. Suzuki, A., Pure Appl. Chem. 1994, 66, 213.4. Suzuki, A. in Metal Catalyzed Cross-coupling Reactions, Diederich, F. and Stang, P. J., Ed.; Wiley-VCH: New York,1998, pp.49-97.5. Miyaura, N. and Suzuki, A. Chem. Rev., 1995, 95, 2457-2483.6. Suzuki, A., J. Organometallic Chem., 1999, 576, 147-168.7. Miyaura, N.; Ishiyama, T.; Sasaki, H.; Ishikawa, M.; Satoh, M.; Suzuki, A., J. Am. Chem. Soc., 1989, 111, 314-321.8. Occhiato, E. G.; Trabocchi, A.; Guarna, A., J. Org.Chem. 2001, 66(7), 2459-2465.9. Kamatani, A. and Overman, L. E., J. Org. Chem., 1999, 64, 8743-8744.10. Miyaura. N., Advances in Metal Organic Chemistry, 1998, 6, 187A selection of the corresponding Acros Organics offerings:2,4,6-Trimethylphenylboronic acid . . . . . . . . . . . . . .359794-(Trimethylammonium)methylphenylboronic acid . . .359784-Trifluoromethylphenylboronic acid . . . . . . . . . . . .359763-Trifluoromethylphenylboronic acid . . . . . . . . . . . .359752-Trifluoromethylphenylboronic acid . . . . . . . . . . . .359744-Trifluoromethoxyphenylboronic acid . . . . . . . . . . .359733-Trifluoromethoxyphenylboronic acid . . . . . . . . . . .359722,4,6-Trichlorophenylboronic acid . . . . . . . . . . . . . .359713-Thioanisoleboronic acid . . . . . . . . . . . . . . . . . . . .35970Thianthrene-1-boronic acid . . . . . . . . . . . . . . . . . . .359698-Quinoline boronic acid . . . . . . . . . . . . . . . . . . . . .359674-Phenoxyphenylboronic acid . . . . . . . . . . . . . . . . .35964Phenoxathiin-4-boronic acid . . . . . . . . . . . . . . . . . .35963Naphthalene-2-boronic acid . . . . . . . . . . . . . . . . . . .359623,4-Methylenedioxyphenylboronic acid . . . . . . . . . . .359583-Methoxyphenylboronic acid . . . . . . . . . . . . . . . . .359574-Methoxycarbonylphenylboronic acid . . . . . . . . . . .359562-Methoxy-5-formylphenylboronic acid . . . . . . . . . . .359545-Methoxy-2-formylphenylboronic acid . . . . . . . . . . .359534-Methoxy-2-formylphenylboronic acid . . . . . . . . . . .359524-(Methanesulfonyl)phenylboronic acid . . . . . . . . . .359513-Isopropoxycarbonylphenylboronic acid . . . . . . . . .359504-Iodophenylboronic acid . . . . . . . . . . . . . . . . . . . .359483-Iodophenylboronic acid . . . . . . . . . . . . . . . . . . . .359475-Indolylboronic acid . . . . . . . . . . . . . . . . . . . . . . .359464-Formylphenylboronic acid . . . . . . . . . . . . . . . . . .359383-Formylphenylboronic acid . . . . . . . . . . . . . . . . . .359372-Formylphenylboronic acid . . . . . . . . . . . . . . . . . .359362-Fluorophenylboronic acid . . . . . . . . . . . . . . . . . . .359344-Ethylphenylboronic acid . . . . . . . . . . . . . . . . . . . .359324-Ethoxyphenylboronic acid . . . . . . . . . . . . . . . . . .359313-Ethoxycarbonylphenylboronic acid . . . . . . . . . . . .359303,5-Dimethylphenylboronic acid . . . . . . . . . . . . . . . .359293,4-Dimethylphenylboronic acid . . . . . . . . . . . . . . . .359282,6-Dimethylphenylboronic acid . . . . . . . . . . . . . . . .359272-(N,N-Dimethylaminomethyl)phenylboronic acid . . . .359244-(N,N-Dimethylamino)phenylboronic acid . . . . . . . .359232,6-Dimethoxyphenylboronic acid . . . . . . . . . . . . . .359222,5-Dimethoxyphenylboronic acid . . . . . . . . . . . . . .359212,4-Dimethoxybenzeneboronic acid . . . . . . . . . . . . .359202-(4-Dihydroxyborane)phenyl-4-carboxyquinoline . . . .35919...Acros Organics has recently expanded its selection of boronic acids to include a wide variety of highly functionalised alkyland arylboronic acids. If the product of your choice is not listed or if you require larger quantities please inquire.12 NEW suggestions for the organic chemist • 3


A Fisher Scientific CompanyNewBoronic estersfrom Acros OrganicsNew Boronic esters for Suzuki coupling reactionsBoronic esters 1,2,3 are a valuable alternative to boronic acids in theSuzuki-reaction 4 , with better solubility in organic solvents and ahigh tolerance against functional groups 5 . The boronic esters aremade by a palladium-catalysed cross-coupling reaction ofalkoxydiboron compounds 6 with haloarenes.Acros Organics offers a new range of boronic esters andalkoxydiboron compounds.Recommended catalystfor cross-coupling1.1’-Bis(diphenylphosphino)ferrocene-palladium(II)dichloridedichloromethane complexAO 34868 PdCl 2 (dppf)Synthesisroute to arylboronic estersSelection of related alkoxydiboron compoundsSelection of available arylboronic esters(1) T.D.Marder, N.C. Norman Topics in Catalysis 5 (1998) 63-73(2) T. Ishiyama, N.Miyaura, J.Organometal.Chem. 611 (2000) 392-402(3) M.H.Todd, S. Balasubramanian and C. Abell, Tet.Lett. (1997), 38,6781-6784(4) N.Miyaura, Advances in Metal-Organic Chemistry (Vol 6, p 187-243)(5) T. Watanabe, N. Miyaura and A. Suzuki, Synlett. (1992) 207-210(6) T. Ishiyama, M. Murata, N. Miyaura, J. Org. Chem. (1995), 60, 7508-75104 • 12 NEW suggestions for the organic chemist


A Fisher Scientific CompanyNew Rhodium,Ruthenium, andTin complexesfrom Acros OrganicsRhodium and Ruthenium complexesWith a steadily growing interest in organometallic complexes, newly developedcompounds continue to broaden the scope of possible chemical applications fromresearch to industrial level. Organometallic complexes permit the design of newchemical transformations in which the synthesis of highly complex organic moleculesis achieved with a high level of regio- and stereocontrol as well as a high atomeconomy.A very large and growing number of organic ligands, inorganic compounds andorganometallic complexes can be found in our product portfolio to respond to theneed of the metallo-organic chemists. Listed below are our recent additions ofrhodium, ruthenium, and tin compounds, for additional products please check ourweb site.Acros Organics productsRhodium ComplexesAcetylacetonatobis(ethylene)rhodium (I) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36338Bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36339(+)-1,2-Bis((2S,5S)-diethylphospholano)benzene(cyclooctadiene)rhodium (I) trifluoromethanesulfonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36341(-)-1,2-Bis((2R,5R)-dimethylphospholano)benzene(cyclooctadiene)rhodium (I) tetrafluoroborate . . . . . . . . . .36342(+)-1,2-Bis((2S,5S)-dimethylphospholano)benzene(cyclooctadiene)rhodium (I) tetrafluoroborate . . . . . . . . . .36343(+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium (I)trifluoromethanesulfonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36345(-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium (I)trifluoromethanesulfonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36344Dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36347Hexarhodium hexadecacarbonyl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36324Rhodium(III) acetylacetonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .32545Tetrarhodium dodecacarbonyl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36325Ruthenium ComplexesCarbonyl(dihydrido)tris(triphenylphosphine)ruthenium (II) . . . . . . . . . . . . . . . . . . . . . . . . .36328cis-Dichlorobis(2,2'-bipyridine)ruthenium (II)dihydrate . . . . . . . . . . . . . . . . . . . . . . . . . . . .36330Di-m-chlorobis (p-cymene)chlororuthenium (II) . .36329Dichloro(pentamethylcyclopentadienyl)ruthenium (III) polymer . . . . . . . . . . . . . . . . . .36332Dichlorotricarbonylruthenium (II) dimer . . . . . . .36333Hexaammineruthenium (III) chloride . . . . . . . . .36334Grubb's catalyst . . . . . . . . . . . . . . . . . . . . . . .35197Grubb's second generation catalyst . . . . . . . . .35616Ruthenium (III) nitrosyl chloride monohydrate . .36336Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)ruthenium (III). [Ru(TMHD)3] . . . . . . . . . . . . . .36337Tin Complexesn-Butyltin hydroxide oxide hydrate . . . . . . . . . .35279Dimethyltin dichloride . . . . . . . . . . . . . . . . . . .34782Di-n-octyltin oxide . . . . . . . . . . . . . . . . . . . . . .35243Diphenyltin dichloride . . . . . . . . . . . . . . . . . . .34784Diphenyltin oxide . . . . . . . . . . . . . . . . . . . . . .35336Hexa-n-butylditin . . . . . . . . . . . . . . . . . . . . . . .35151Methyltin trichloride . . . . . . . . . . . . . . . . . . . .34783Tetrakis(dimethylamino)tin . . . . . . . . . . . . . . .32106Tetravinyltin . . . . . . . . . . . . . . . . . . . . . . . . . .32108Tin(II) acetate . . . . . . . . . . . . . . . . . . . . . . . .35353Tin(II) tetrafluoroborate, 50% solution . . . . . . .35877Tributyl(vinyl)tin . . . . . . . . . . . . . . . . . . . . . . .35000Trimethyl(phenylethynyl)tin . . . . . . . . . . . . . . .35335Enter these product codes in the quick search box at www.acros.com to find out more about available packsizes.12 NEW suggestions for the organic chemist • 5


A Fisher Scientific CompanyGrubb’sCatalystsfrom Acros OrganicsGrubb’s Catalysts for Olefinmetathesis-reactions (*)Ruthenium-based catalysts for the ring-closing-reaction of di-olefines ("RCM")(Scheme 1) and the ring-opening-cross-metathesis of olefins ("ROM" ) (Scheme 2)and the ring-opening-metathesis-polymerisation ("ROMP") (Scheme 3).The catalyst is highly active and tolerant against various functional groups.The 2nd generation catalysts shows even higher activity in metathesis reactions thanthe original Grubb’s catalyst.(*) Note: sold for research purposes only. Use of the catalyst for purposes other than research must belicensed by the Californian Institute of Technology.Grubb’s first generation CatalystGrubb’s second generation catalystCAS 172222-30-9 CAS 246047-72-3ApplicationsScheme 1: Ring Closing ("RCM")Scheme 2: Ring Opening ("ROM")Scheme 3: Ring Opening Polymerisation("ROMP")A selection of the corresponding Acros Organics offerings:351970010 - 1 gm . . . . . . . . . . . .Bis(tricyclohexylphosphine) -benzylidene ruthenium (IV) dichloride351970050 - 5 gm . . . . . . . . . . . .Bis(tricyclohexylphosphine) -benzylidene ruthenium (IV) dichloride356162500 - 250 mg . . . . .Tricyclohexylphophine-1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-ylidene-benzylidene-ruthenium(IV) dichloridePlease check our new catalogue edition or our web site www.acros.com for a larger selection.(1) M. Schuster, S. Blechert Angew. Chem. 109, 1997, 2124.(2) T. M. Trnka, R.H. Grubbs, Acc. Chem. Res. 34, 18, 2001.(3) A. Fürstner Top. Catal 4, 1997, 285.(4) P. Schwab, M.B.France, J.W. Ziller. R.H. Grubbs Angew. Chem. 107, 1995, 2179.(5) A. Fürstner Angew. Chem., 112, 2000, 3140.6 • 12 NEW suggestions for the organic chemist


A Fisher Scientific CompanyNew OrganosiliconReagentsfrom Acros OrganicsBis(trimethylsilyl)ketene Acetals :Versatile Organosilicon Reagents for Aldolisation Reactions.Since the work of Mukaiyama 1 in 1974 on the aldol reaction using silylenol ethers,silylketene acetals have seen an explosive growth in their use as building blocks inorganic synthesis. Among these new reagents, bis (trimethylsilyl) ketene acetals arenow the organosilicon compounds of choice for type aldol condensations because oftheir ease of preparation, clean products and high selectivity.The direct homologation of aldehydes into unsaturated conjugated carboxylic acidswith the introduction of two carbon atoms in the resulting chain is a very attractivereaction, since polyethylenic carboxylic acids are very useful intermediates in the totalsynthesis of natural products.OSiMe 3 OSiMe 3CH 2 -CO 2 SiMe 3 Me 3 SiMe 3 SiSiMe 3OSiMe 3OSiMe 333101 33105 33112 33111CO 2 SiMe 3Indeed, the condensation of reagent 33101 with a wide range of aldehydes in the presence of catalytic amount of catalyst takes place at room temperature togive the corresponding α,β-ethylenic carboxylic acids in excellent yield and with a total E stereoselectivity 2,3 . Reagent 33105 has proven to be suitable for onepot four-carbon homologation of aldehydes 4 and imines 5 . Silylated acetate 6 33112 and crotonate 7 33111 can be used for the construction of many importantbuilding blocks.OCO 2 HQueen Substance of HoneybeeQueen Substance of honeybee was selected as a target fortotal synthesis of a natural product with the aim todemonstrate the utility of our organosilicon reagents. Thefollowing retrosynthetic scheme represents the most efficienttotal synthesis described up today. Thus, the Queen Substancehas been prepared in seven steps in 34% over yield 8 .OOCHO+OSiMe 3+Me 3 SiOSiMe 3OSiMe 3OSiMe 3A selection of the corresponding Acros Organics offerings:33101 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1,1-Bis(trimethylsilyloxy)-2-trimethylsilylethene33105 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1,1-Bis(trimethylsilyloxy)-1,3-butadiene33112 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Trimethylsilyl trimethylsilylacetate33111 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Trimethylsilyl 4-trimethylsilylcrotonatePlease check our new catalogue edition or our web site www.acros.com for a larger selection.Request your copy of our reprint from Prof. Bellassoued review of Bis(Trimethylsilyl)Ketene Acetals :A document with a lot of applications, references and many tables of results, complete with thecomprehensive list of these organosilicon reagents available from stock at Acros Organics !(1) Mukaiyama, T.; Banno, K.; Narasaka, K. J. Am. Chem. Soc. 1974, 96, 7503.(2) Bellassoued,M.; Gaudemar, M. Tetrahedron Lett. 1990, 31, 209.(3) Bellassoued, M.; Lensen, N.; Bakasse, M.; Mouelhi, S. J. Org. Chem. 1998, 63, 8785.(4) Bellassoued, M.; Gaudemar, M. J. Organometal. Chem. 1984, 263, C21.(5) Bellassoued, M.; Ennigrou, R.; Gil, R.; Lensen, N. Synthetic Commun, 1998, 28, 3955.(6) Bellassoued, M.; Dubois, J. E.; Bertounesque, E. Synthetic Commun, 1987, 17, 1181.(7) Bellassoued, M.; Ennigrou, R.; Gaudemar, M. J. Organometal. Chem. 1988, 338, 149.(8) Bellassoued, M.; Majidi, A. Tetrahedron Lett. 1991, 32, 7253.12 NEW suggestions for the organic chemist • 7


A Fisher Scientific CompanyAsymmetricHydrogenation toolsfrom Acros OrganicsDuPHOS and BPE ligands and catalystsRhodium catalysts incorporating chiral 1,2-bis(phospholano)benzene (DuPHOS) and1,2-bis(phospholano)ethane (BPE) ligands are extremely effective for theenantioselective hydrogenation of a variety of prochiral unsaturated substrates. Inaddition, variation of the phospholane substituents allows for an optimization of thesteric compatibility between ligand and substrate, hence enhancing theenantioselectivity of the corresponding reaction. Some examples on the application ofsuch catalysts in the enantioselective hydrogenation of enamides are listed below.Most common catalysts precursors include cationic rhodium complexes such as[(COD)Rh] + X - where X is OTf or BF 4 (eq. 1):Enantioselective Hydrogenation of Enamides: 1,2,3A valuable reaction for the preparation of enantiomerically pure α-1-arylalkylamines, an important class of compounds that found applicationsas resolving agents, chiral auxiliaries and intermediates in the synthesis ofa wide range of biologically active molecules.A selection of the corresponding Acros Organics offerings:36369 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene36371 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene36372 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(-)-1,2-Bis((2R,5R)-2,5-diethylphospholano)benzene36340 . . . . . . . . .(-)-1,2-Bis-((2R,5R)diethylphospholano)benzene(cyclooctadiene)rhodium(I) triflate36341 . . . . . . . .(+)-1,2-Bis((2S,5S)-diethylphospholano)benzene(cyclooctadiene)rhodium(I) triflate36342 . . . . . . . . . .(-)-1,2-Bis((2R,5R)-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) BF 436343 . . . . . . . . .(+)-1,2-Bis((2S,5S)-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) BF 436344 . . . . . . . .(-)-1,2-Bis-((2R,5R)dimethylphospholano)benzene(cyclooctadiene)rhodium(I) triflate36345 . . . . . . .(+)-1,2-Bis((2S,5S)-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) triflate36346 . . . . . . . .(+)-1,2-Bis((2R,5R)-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) triflatePlease check our new catalogue edition or our web site www.acros.com for a larger selection ofcyclopentane derivatives and additional scaffolds and advanced intermediates1 Burk, M. J.; Wang, Y. M.; Lee, J. R; J. Am. Chem. Soc. 1996, 118, 5142-5143.2 Burk, M. J.; Casy, G.; Johnson, N. B; J. Org. Chem. 1998, 63, 6084-6085.3 Robinson, A. J.; Stanislawski, P.; Mulholland, D.; J. Org. Chem.; 2001, 66, 4148-4152.12 NEW suggestions for the organic chemist • 11


A Fisher Scientific CompanyPhosphines, Ligandsand Ligand-Precursorsfrom Acros Organics1) TriarylphosphinesPhoshine ligands are extremely versatile in transition-metalchemistry and especially in homogenous catalysis and thereforealmost ubiquitous. Different sterical and electronical properties ofthe ligand can strongly effect the activity of the catalyst.20649BIS(PENTAFLUOROPHENYL)PHENYLPHOSPHINE 98%+FF32113TRIMESITYL-PHOSPHINE, 97%FFFFPFFCH 3CH 3H 3 CCH 3 CH 3PFFC H 3CH 3H CCH 3314042TRIPHENYLPHOSPHINEP36496TRIS(2,6-DIMETHOXYPHENYL)-PHOSPHINEH 3 CCH 3OOOOH 3 CCH 3POH 3 CCH 3OO29480TRI-(2-FURYL)-PHOSPHINEOPO35534TRIS(4-TRIFLUOROMETHYLPHENYL)PHOSPHINE, 99%FFFF F FPFFF364202-CHLORO-6-(DIPHENYL-PHOSPHINO)PYRIDINEPNCl42233TRI-P-TOLYL-PHOSPHINE, 95%PCH 3H 3CCH 330575DIPHENYL(PENTAFLUORO-PHENYL)PHOSPHINEF FFFFP42221TRIS(4-CHLOROPHENYL)PHOSPHINE, 97%ClPClCl30634FTRIS(4-FLUOROPHENYL)PHOSPHINEP364212,6-BIS(DIPHENYLPHOSPHINO)PYRIDINEPNP31316TRIS(PENTA-FLUORO-PHENYL)PHOSPHINEFFFFFFPFFFF FFF35180TRIS(2-THIENYL)PHOSPHINE, 98%SSPSFFFF31533DIPHENYL(P-TOLYL)-PHOSPHINE, 96%C H 3P42224TRIS(4-METHOXY-PHENYL)PHOSPHINE,95%H 3 COOPCH 3CH 3O42232TRI-O-TOLYLPHOSPHINE,99%CH 3P CH 3H 3C31728TRI-M-TOLYLPHOSPHINE, 98%H 3 CPCH 3H 3 C12 NEW suggestions for the organic chemist • 13


A Fisher Scientific CompanyPhosphines, Ligandsand Ligand-Precursorsfrom Acros Organics2) Chelating, non-chiral PhosphineligandsPhoshine ligands are extremely versatile in transition-metalchemistry and especially in homogenous catalysis and thereforealmost ubiquitous. Different sterical and electronical properties ofthe ligand can strongly effect the activity of the catalyst.363751,2-BIS(DIPHENYL-PHOSPHINO)BENZENE29361BIS(DIPHENYLPHOSPHINO)METHANE, 98%PPPP31682BIS(2-DIPHENYL-PHOSPHINO,ETHYL)PHENYLPHOSPHINE,97%PPP147911,2-BIS(DIPHENYL-PHOSPHINO)ETHANE, 98%PP348011,1’-BIS(DIPHENYL-PHOSPHINO)FERROCENE-P -FeP310051,3-BIS(DIPHENYL-PHOSPHINO)PROPANE, 97%PP34779BIS(DIPHENYL-PHOSPHINO)ACETYLENE,98%32089CIS-1,2-BIS (DIPHENYLPHOSPHINO)ETHYLENE, 98%PPP363851,2-BIS(DICYCLOHEXYLPHOSPHINO)ETHANEPPP296461,4-BIS(DIPHENYLPHOS-PHINO)BUTANE, 98%P31004TRANS-1,2-BIS(DIPHENYL-PHOSPHINO)ETHYLENE,97%P363871,1’-BIS(DIISOPROPYLPHOSPHINO)FERROCENE, 98%PPH 3CCH 3-PCH Fe CH 33H CH 3C3P -H 3CCH 3321471,2-BIS(DICHLORO-PHOSPHINO)ETHANE, 97%36371,2-BIS(DIPENTA-FLUOROPHENYL- FPHOSPHINO)ETHANEFFF F310031,2-BIS(DIMETHYL-PHOSPHINO)ETHANE, 97%FH 3CPPCH 3CH 3PP320851,5-BIS(DIPHENYL-PHOSPHINO)PENTANE, 97%31683TRIS[2-(DIPHENYL- PHOSPHINO)ETHYL]P PFF FF PHOSPHINE,F FPP97%FP FPFFPFFF FCH 3P14 • 12 NEW suggestions for the organic chemist


Technical service on the webFirst, look for the product(s)you’re interested in by using thesearch functionsCall up MSDS data, available in English /Dutch / French / German / Italian / Spanish(for registered users)More than 250 info sheets are linked to ourproduct database. These sheets are alsoavailable under the menu option “library”.The “molfile” allows you to copy andpaste molecule data directly intochemical drawing programs.View the infrared spectrum of a molecule.Click on the spectrum for more details.Click on “3D model” to see a 3-dimensionalview of the molecules. Rotate, zoom, move orchange the style or add symbols as you like.Registered users can request productspecifications or certificates of analysisthrough our website.Select “certificates” or “specifications”on the home page.Fill in the Acros Organics lot code forthe product of which you want to viewthe certificate of analysis. This lotcode can be found on the labels of ourproducts.TIPThe lot code consists of 7 digits. Youmay have to omit the last 3 digits ifyou see a 10 digits code.(e.g.: A0116441)Use the “specifications” button toview product specifications. Just typein the product code (5 digits).Register atwww.acros.comand discover thenew featuresof our website.You can print these forms, or save themas a PDF file (Acrobat Reader required).Registered users can forward theirtechnical questions directly to ourTechnical Service by clicking the "techquestions" button.


A Fisher Scientific CompanyACROS ORGANICSGeel West Zone 2Janssen Pharmaceuticalaan 3aB-2440 Geel, BelgiumTel.: +32(0)14/57.52.11Fax: +32(0)14/59.34.34ACROS ORGANICS USA500 American Road,Morris Plains, NJ 07950Tel.: 1-800-766-7000Fax: 1-800-926-1166Internet: http://www.fishersci.com(US orders only)ACROS ORGANICS on-lineInternet: http://www.acros.comE-Mail: info@acros.com

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