Rhinitis, Polyposis, Sinusitis - Hamilos.pdf - AInotes

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Rhinitis, Polyposis, Sinusitis - Hamilos.pdf - AInotes

Allergic Rhinitis: MediatorsMast Cell Degranulation:HistaminePGD 2LTC 4LTD 4LTE 4Preformed mediatorsHistamineProteasesItching, Sneezing, Cholinergicglandular secretionIncreased Vasodilation &Vascular PermeabilityIncreased Vasolidation &Vascular Permeability(causing rhinorrhea, nasalcongestion but not sneezing)Newly formed mediatorsCys LTs, PGs, PAFBradykininTNF-α, GM-CSF

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