LewisAn important limitation of randomised trials is that,unless they are very large, they may provide little informationabout rare, but important, complications of treatments.Safety issues are, therefore, sometimes better illuminated byobservational studies than by controlled trials.Many causes of <strong>maternal</strong> death are very rare, and treatmen<strong>to</strong>ptions for these may never be subjected <strong>to</strong> formalscientific study. Inevitably, recommendations for care <strong>to</strong>avoid such <strong>deaths</strong> in the future rely on lesser levels of evidence,and frequently on ‘expert opinion’. This does notmean that the Report is not evidence-based, merely that,necessarily, the evidence cannot be in the form of a randomisedcontrolled trial or case–control study because of therelative rarity of the condition.The use of vignettes andrecommendationsThe Centre for Maternal and Child Enquiries (CMACE)policy on the use of vignettes and the development of recommendationsis available on the website at www.cmace.org.uk.In the past, some Reports have been characterised by theuse of a significant number of detailed vignettes, s<strong>to</strong>ries thatbroadly describe the circumstances surrounding the <strong>deaths</strong>of individual women and the lessons that may be drawnfrom them. Recognising that ensuring that everyone, includingfamily members and professional staff, require completereassurance about the guiding principle of maintaining confidentialityout of respect for those who have died, thenumber of vignettes has been reduced, as have some of themore identifiable details given in them. CMACE only usesvignettes <strong>to</strong> help in the identification of lessons learnt forthe improvement of future professional practice or overallservice delivery. The vignettes used in this Report do notinclude the full circumstances of any individual case. Theyneither provide nor imply a complete overall assessment orjudgement of the <strong>to</strong>tality of care provided in a case,although they may point <strong>to</strong> where general lessons may belearnt from particular aspects of care. Individual details invignettes may be changed <strong>to</strong> protect the anonymity of thewoman. CMACE cannot confirm or deny the identity ofany individual woman, aspects of whose care may beincluded within a vignette, because all records used in theEnquiry are destroyed before publication of the Report.Further details on the method of enquiry are included inAppendix 1 of this Report.Severe <strong>maternal</strong> morbidity, ‘nearmisses’It is increasingly recognised that the study of near-missmorbidity can complement enquiries in<strong>to</strong> <strong>maternal</strong> deathand provide valuable additional information <strong>to</strong> guide preventionand treatment of potentially life-threatening conditions.Maternal <strong>deaths</strong> represent the tip of the iceberg ofdisease; a much larger number of women suffer from nearmissmorbidity, increasing the power of these studies <strong>to</strong>investigate risk fac<strong>to</strong>rs for both the occurrence of diseaseand progression <strong>to</strong> death and other severe complications.In this Report, the latest results of two systems for severemorbidity or ‘near-miss’ surveillance are reported inAppendix 2 and, where relevant, in the individual Chaptersdescribing the rates of clinical causes of death. These arethe UKOSS 5,6 and the Scottish Confidential Audit of SevereMaternal Morbidity (SCASMM). 8The UK Obstetric Surveillance System(UKOSS)Surveillance of specific near-miss <strong>maternal</strong> morbidities andother rare disorders of pregnancy has been conductedthrough the UKOSS since 2005. 1 UKOSS is an active, negativesurveillance system. Cases are actively sought througha routine monthly mailing <strong>to</strong> nominated reporting obstetricians,midwives, risk management midwives and anaesthetistsin all consultant-led maternity units in the UK. Allconsultant-led units participate in UKOSS reporting.Clinicians are asked <strong>to</strong> complete the monthly report cardindicating whether there has been a woman with one ofthe conditions under study delivered in the unit during theprevious month. They are also asked <strong>to</strong> complete a ‘nilreport’ indicating if there have not been any cases;this allows participation <strong>to</strong> be moni<strong>to</strong>red and confirmsthe denomina<strong>to</strong>r population for calculation of diseaseincidence.In response <strong>to</strong> a report of a case, collaborating cliniciansare sent a data collection form asking for further demographicand pregnancy information, as well as details of diagnosis,management and outcomes for mother and infant. Forsome conditions, clinicians are also asked <strong>to</strong> supply detailsabout a comparison woman delivered in the same unit.This system allows for a rolling programme of parallelstudies <strong>to</strong> be conducted, and, because case–control andcohort studies may be carried out as well as descriptivestudies, a range of research questions can be addressed. Inaddition <strong>to</strong> estimating disease incidence or prevalence,UKOSS studies can be used <strong>to</strong> quantify risk and prognosticfac<strong>to</strong>rs, audit national management and prevention guidelinesand describe disease management, as well as describeoutcomes for both mothers and their infants. Descriptive,case–control and cohort studies are conducted and peerreviewedpapers are published. Further details of surveillanceof near-miss morbidities using UKOSS are includedin the relevant chapters of this report, and key points aresummarised in Appendix 2A.24 ª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203
Introduction: Aims, objectives and definitions used in this ReportScottish Confidential Audit of SevereMaternal MorbidityAn audit of a range of defined severe <strong>maternal</strong> morbiditieshas been carried out continuously in all consultant-ledmaternity units in Scotland since 2003. The methodology issimilar <strong>to</strong> that of UKOSS, with a designated midwife coordina<strong>to</strong>rin each unit who identifies cases and sends completeddata <strong>to</strong> the Reproductive Health Programme of NHSQuality Improvement Scotland, which analyses the dataand produces an annual report. 8 Particularly detailed informationis collected and analysed for all cases of majorobstetric haemorrhage and of eclampsia. For these twoconditions, each unit also provides a self-assessment of thequality of care provided. The continuous nature of theaudit using identical criteria and case definitions over severalyears has allowed the identification of changes in therates of some morbidities, as well as assessment of compliancewith guidelines and changes in clinical management.Appendix 2B is a summary of the findings from SCASMMfor the triennium <strong>2006</strong>–<strong>2008</strong>, and some information fromthe audit is included in other relevant chapters.The aims and objectives of theEnquiryThe overall aim is <strong>to</strong> save the lives of as many mothers andnewborns as possible through the expert anonymous reviewof the circumstances surrounding and contributing <strong>to</strong> each<strong>maternal</strong> death in the UK. Apart from the specific issuesand learning points that may emerge from certain cases orcauses of death, the findings from individual cases are alsoaggregated <strong>to</strong>gether <strong>to</strong> learn wider lessons and <strong>to</strong> formulateand disseminate more general recommendations.Its objectives are:• <strong>to</strong> improve the care that pregnant and recently deliveredwomen receive and <strong>to</strong> reduce <strong>maternal</strong> mortalityand morbidity rates still further, as well as the proportionof <strong>deaths</strong> caused by substandard care.• <strong>to</strong> assess the main causes of and trends in <strong>maternal</strong><strong>deaths</strong> and, where possible, severe morbidity and <strong>to</strong>identify any avoidable, remediable or substandard fac<strong>to</strong>rsthat could be changed <strong>to</strong> improve care; <strong>to</strong> promulgatethese findings and subsequent recommendations <strong>to</strong>all relevant healthcare professionals and <strong>to</strong> ensure thattheir uptake is audited and moni<strong>to</strong>red.• <strong>to</strong> <strong>make</strong> recommendations concerning the improvemen<strong>to</strong>f clinical care and service provision, includinglocal audit, <strong>to</strong> commissioners of obstetric services and<strong>to</strong> providers and professionals involved in caring forpregnant women.• <strong>to</strong> suggest directions for future areas for research andaudit at a local and national level.• <strong>to</strong> contribute <strong>to</strong> regular shorter reports on overalltrends in <strong>maternal</strong> mortality as well as producing amore in-depth triennial Report.The Enquiry’s role in the provision ofhigh-quality clinical careAlthough the Enquiry has always had the support of professionalsinvolved in caring for pregnant or recently deliveredwomen, it is also a requirement that all <strong>maternal</strong><strong>deaths</strong> should be subject <strong>to</strong> this confidential enquiry, andall health professionals have a duty <strong>to</strong> provide the informationrequired.In participating in this Enquiry, all health professionalsare asked for two things:• if they have been caring for a woman who died, <strong>to</strong>provide the Enquiry with a full, accurate and unbiasedaccount of the circumstances leading up <strong>to</strong> her death,with supporting records, and• irrespective of whether they have been caring for awoman who died or not, <strong>to</strong> reflect on and take anyactions that may be required, either personally or aspart of their wider institution, as a result of the recommendationsand lessons contained within this Report.At a local commissioning level, maternity healthcarecommissioners, such as Primary Care Trusts and LocalHealth Boards, should commission services which meet therecommendations set out in this and previous Reports andensure that all staff participate in the Enquiry if required,as part of their contract.At service provider level, the findings of the Enquiryshould be used:• <strong>to</strong> ensure that all staff are regularly updated andtrained on the signs and symp<strong>to</strong>ms of critical illness,such as infection, and the early identification, managementand resuscitation of seriously ill women• <strong>to</strong> develop and regularly update multidisciplinaryguidelines for the management of complications duringor after pregnancy• <strong>to</strong> review and modify, where necessary, the existingarrangements for the provision of maternity or obstetriccare• <strong>to</strong> ensure that all Direct and unexpected Indirect <strong>maternal</strong><strong>deaths</strong> are subject <strong>to</strong> a local review and critical incidentreport, which is made available <strong>to</strong> the Enquiry aspart of its own process of review, as well as disseminatingits key findings and recommendations <strong>to</strong> all localmaternity staff• <strong>to</strong> introduce an obstetric early warning system chart asrecommended in this and previous Reports• <strong>to</strong> promote local audit and clinical governance.At a national level—in every country, the findings ofsuccessive Reports have been used <strong>to</strong> develop nationalª <strong>2011</strong> Centre for Maternal and Child Enquiries (CMACE), BJOG 118 (Suppl. 1), 1–203 25
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- Page 4 and 5: AcknowledgementsSaving Mothers’ L
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- Page 8 and 9: Forewordbeen written jointly by a m
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Normanwhich there was catastrophic
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Normanrecommendations made in succe
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DawsonBox 5.1. The UK amniotic flui
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O’HerlihyTable 6.1. Numbers of Di
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McClure, CooperChapter 8: Anaesthes
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Oates, Cantwell4 Kendel RE, Chalmer
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Lewismaternal mortality rates or ra
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Garrod et al.supportive but challen
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Lucas, Millward-Sadler95 mmHg. This
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MillerAppendix 1: The method of Enq
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