Lecture Antimicrobial peptides .pdf

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α−helicalpeptideThe Shai-Matsuzaki-Huang ModelPhysicaldisruption ofmembrane &fragmentationCarpeting ofouter leaf.Peptidemoves intoinner leaf.Integration.Outerleaf stretchesrelative to inner.Stress results.Diffusion frommembrane tointracellulartargets.Phase transition & ‘wormhole’formation. Transient pores form.
SYNERGISM• Mor et al., 1994 demonstrated potent synergy between the 5dermaseptins (DSs1 to s5) from Phyllomedusa sauvagii (frog)• Occurs despite similar structure and proposed mode of action?• Proposed that significance of 5 closely related peptides is toprovide potent, broad-spectrum protection from invading microorganisms• Also known that antimicrobial synergy occurs betweendifferent peptides from Xenopus laevis eg., magainins• Multi-site mode of action means lower concentrations ofindividual active peptides are required
Page 1: ANTIMICROBIAL PEPTIDES
Page 5: Tried to develop therapeutic usefor
Page 8 and 9: Why the interest?• Increasing int
Page 10 and 11: Emerging Vancomycin-resistant Enter
Page 12 and 13: PREDICTED VALUE OF NEW ANTIBIOTICS(
Page 14 and 15: • Small, 3-4 kDa peptidesMAMMALIA
Page 16: β-DEFENSINSprepropiece20 - 30 aaac
Page 19 and 20: Structural diversity of AMPs1-disul
Page 21 and 22: How do AMPs work?eg protegrin
Page 23: Hydrophobic interactionsANTIMICROBI
Page 27 and 28: Toll receptors• Originally discov
Page 29 and 30: AMPS: ACTIVATION & STIMULATIONDEFEN
Page 31 and 32: AMPs in MytilusAMPs produced in hae
Page 33 and 34: Antibacterial peptides in C. maenas
Page 35 and 36: Penaeidins(shrimps)Destoumieux et a
Page 37 and 38: Summary• Diverse group of low mol

Lecture Antimicrobial peptides .pdf

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