Lecture Antimicrobial peptides .pdf

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CarcininSDS-PAGERelf et al, 199911.5 kDa14.5 kDa6.5 kDaCharacteristics• molecular mass: 11.5 kDa• cationic• constitutive• kills Gram +ve bacteria• salt requiring• heat stable to 98ºC
Penaeidins(shrimps)Destoumieux et al, 2000Family of antimicrobial <strong>peptides</strong>, 5.5-6.5 kDa,from Pennaeus vannameiPredominantly active against Gram-+ bacteria & fungiSynthesized and stored in granular haemocytesCationic, constitutive
Page 1: ANTIMICROBIAL PEPTIDES
Page 5: Tried to develop therapeutic usefor
Page 8 and 9: Why the interest?• Increasing int
Page 10 and 11: Emerging Vancomycin-resistant Enter
Page 12 and 13: PREDICTED VALUE OF NEW ANTIBIOTICS(
Page 14 and 15: • Small, 3-4 kDa peptidesMAMMALIA
Page 16: β-DEFENSINSprepropiece20 - 30 aaac
Page 19 and 20: Structural diversity of AMPs1-disul
Page 21 and 22: How do AMPs work?eg protegrin
Page 23 and 24: Hydrophobic interactionsANTIMICROBI
Page 25 and 26: SYNERGISM• Mor et al., 1994 demon
Page 27 and 28: Toll receptors• Originally discov
Page 29 and 30: AMPS: ACTIVATION & STIMULATIONDEFEN
Page 31 and 32: AMPs in MytilusAMPs produced in hae
Page 33: Antibacterial peptides in C. maenas
Page 37 and 38: Summary• Diverse group of low mol

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