Annual Report 2010 Annual Report 2010 - University of Kansas ...

LET TER FROM THE CHAIRDear Friend:Best care now.Not just a slogan but a statement. A statement ofour dedication in research, in education, in administration,and in clinical medicine to deliver the very best sothat our patients reap the benefit.How do we get there? We get there because wefollow five rules.Save the patient. The single, most important purpose.Do the right thing. While we focus on providing thebest care, we do it by treating others with the samegrace and humility we would ask to be treated withourselves.Ask questions, seek answers. The mark of an internist.It is what distinguishes us. It is what powers research.It is what drives the best care.Be the bridge. No matter where we work, we needpartners. Our scientists in medicine need scientists in thebasic sciences and in our community. Our clinicians needconsultants most of all, to do our best for our patients.As scientists and clinicians, we must work together tofind answers to deliver the best care. This in theacademic difference.Those who laugh, last. We all work hard. If we worktogether and enjoy each other, we are all the better for it.Taking our mission from the bench to the bedside,we seek to follow these five simple rules; they drive usforward. They drive us in the middle of the night whenwe come back to complete an experiment. They driveus in the middle of the night when we come in to theICU or to the emergency room to take care of a patient.They drive us in the middle of the night when we studyfor boards and prepare for our careers. They drive usin the middle of the night when we work to raise moneywith our community to further our mission. In the pagesof this report, you will see the story of how we seek toprovide the best care now.These pages are meant to tell the story of how wedo this together as the Department of Internal Medicine.They are meant to inspire as you see what makes usspecial. We want you to see why we come to work everyday excited and enthusiastic and with a sense of purposeto accomplish our mission like no other.Here you will find stories of people who take careof patients and do it with quality that is unrivaled in thehealthcare field. You can measure this achievement bymany means. With awards from US News and WorldReport and from the University Health System Consortium,we are consistently recognized as one of the bestmedical centers in the United States. Bold, but true.And our quality tells our story.In medical education, our residents routinely listtheir experience with faculty as one of the most importantdrivers they have. When our residents concludetheir training, our program is always ranked as superior.In research, our projected 20 percent improvementin our NIH rankings shows the resources and the depthto transform medicine.In each of these areas, we are here to provide thebest care now. So read on and learn our story. I believeyou will find our narrative compelling and insightful.Sincerely,Steven W. Stites, M.D.Peter T. Bohan Professor and Chair,Department of Internal MedicineUniversity of Kansas Medical CenterDepartment of Internal Medicine, University of Kansas Medical Center Annual Report 2010 1

COMMUNITY OUTREACHDoctor for a DayDepartment of Internal Medicine, University of Kansas Medical Center Annual Report 2010 2

COMMUNITY OUTREACHOn September 13, 2010, the Department of InternalMedicine hosted the first annual “Doctor for a Day” event.This was an educational outreach program for high schoolstudents from throughout the state of Kansas. The programwas designed to expose students to all aspects of academicmedicine, from bench to bedside. It also provided them theopportunity to talk one-on-one with faculty in their specificareas of interest while also pairing them with medicalstudents, residents and fellows, who were more than willingto answer questions and establish future mentoring andshadowing opportunities.The program started with a series of interactive lectureson cardiovascular diseases, infectious diseases, endocrinologymetabolism and genetics (diabetes), pulmonary and criticalcare medicine, gastroenterology and hematology/oncology.After a faculty luncheon, the students moved on to a varietyof lab tours including the REACH lab (Research in Exerciseand Cardiovascular Health), the Liver Center, the GreatPlains Diabetes basic science labs, the Gastroenterologycancer research labs and the School of Medicine’s skills labs.The closing session included the Associate Dean of Admissionsfrom the School of Medicine, who was able to addressspecific questions relating to pre-admission preparations,preferred academic matriculation tracks and financial cost.The true success in this program can be measured inthe follow-up from the students. One letter read as follows:“Dear Dr. Simpson: I want to thank you forspeaking to us at the Doctor for a Day event.I was truly fascinated by all of the informationyou gave us on severe sepsis. I never knew howcommon it was. About three years ago my oldersister developed severe sepsis and did notsurvive. She was born with a severe case ofcerebral palsy, so she could not talk or walk.We did not know anything was wrong until itwas too late, so your lecture hit close to home.It is encouraging to know there is someone outthere helping prevent what my family had togo through.”Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 3

EDUCATION

RESEARCHDr. Stubbs plans to use a mouse model of progressivekidney disease to elucidate the complex interaction betweenmineral metabolism pathways in relation to FGF23, and toidentify the specific contributions of these pathways tothe vascular and bone pathologies that are common inthis setting.Steven A. Weinman, MDProfessor, Division ofGastroenterology andHepatologyUnderstanding liver injuryproduced by HCV & alcoholThe JAK-STAT axis plays a critical role in signaling initiatedby various growth factors as related to cell survival andapoptosis. Over the past decade, Dr. Yu-Ting Xuan’s work hasidentified a role of this pathway in protection of heart muscleagainst ischemic injury, a phenomenon termed “ischemicpreconditioning.” With extensive experience in cellular andmolecular biology, Dr. Xuan is a leader in our quest to utilizethis information in protecting the heart during heart attacks.Currently, Dr. Yu-Ting Xuan’s NIH-funded research isfocused on understanding the complex signaling pathways involvedin the activation of transcription factors leading to theupregulation of cardioprotective proteins during myocardialischemia/reperfusion injury and ischemic preconditioning. Inrelated projects, Dr. Xuan’s team is also working on improvingthe survival of bone-marrow-derived adult stem cellsafter transplantation into the heart. If successful, resultsfrom these projects are likely to benefit thousands of patientswith coronary artery disease who experience heart attacks.Dr. Steven Weinman is leading NIH-funded projects todetermine how hepatitis C virus (HCV) infection interactswith alcohol and other environmental stresses to produceliver injury, cirrhosis, and hepatocellular carcinoma.Previous work from his group demonstrated that theviral core protein regulates mitochondrial calcium uptake,resulting in direct increases of mitochondrial superoxideproduction; alterations of cell death pathways; and oxidativemodification of DNA, proteins, and lipids. In collaborationwith Dr. Prashant Pandya, his laboratory has alsorecently shown that HCV-infected patients have a worseoutcome than non-infected patients when they developalcoholic hepatitis.Dr. Weinman’s current research is leading the wayin understanding how HCV alters normal liver protectiveresponses to alcohol and interferes with pathways that regulateantioxidant function, autophagy, and cell proliferation.This work is aimed at developing new clinical approaches toreduce liver injury produced by HCV and alcohol.Yu-Ting Xuan, PhDProfessor, Division ofCardiovascular Diseases,Cardiovascular ResearchInstituteGetting to the heart ofthe cardioprotectionWe want to thank all of our researchers for their contributionsto the advancement of medicine, and for continuingto keep the Department of Internal Medicine in the spotlightfor innovative and groundbreaking medical discoveries.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 11

ALLERGY, CLINICAL IMMUNOLOGY AND RHEUMATOLOGYDaniel J. Stechschulte, MD, Division DirectorThe Division faculty includesfive full-time, four part-time andfour volunteer clinical facultymembers. The Division plans toadd at least three faculty in rheumatologyand allergy in the nexttwo years.In the research arena, theDivision is expanding its basic andclinical research efforts, combiningthe two programs wheneverpossible. It expects to renew abasic science NIH-funded grantthat focuses on vascular biologyand inflammation, which has beena very productive program. Weexpect to secure additional extramuralfunding for basic research.In addition, more than 25 clinicalresearch initiatives explore treatmentsfor specific diseases suchas rheumatoid arthritis, systemiclupus erythematosus, scleroderma,asthma and hereditary angioedema(HAE). Other projects includeinflammatory osteoarthritis ofthe knee and the effect of intraarticularcorticosteroids on boneturnover in osteoarthritis.In regard to basic research,the Division has an NIH-R01grant and an NIH-Supplementalgrant, which support studies onthe role of mast cells on vascularinflammation and atherosclerosis.Basic research activities continueto facilitate interdisciplinarycollaborations with physicians andscientists from various departmentsand centers, including theCardiovascular Research Institute,Kidney Institute, Departmentof Pathology & LaboratorySciences, Department of Pharmacology,Toxicology & Therapeutics,Department of Molecular &Integrative Physiology, and theKansas City VA Medical Center.One of our faculty members continuesto serve as a study sectionmember for the American HeartAssociation and for the NIH onthe National Institute of Allergyand Infectious Diseases’ specialemphasis panel for Asthma andAllergic Diseases Cooperative ResearchCenter program projects.Educationally, the Divisionis expanding its RheumatologyFellowship Program from one totwo trainees per year. First-yearfellows have participated in anationally supervised musculoskeletalultrasound trainingprogram, which includes an offsitetwo-day training course anda one-day practical examination.A visiting professor grant broughtan internationally recognizedrheumatologist for a three-dayprogram, during which he gavea mixture of formal lectures andhands-on workshops highlightingmultiple applications of musculoskeletalultrasound. We now haveone full-time faculty member inrheumatology at the Kansas CityVA Hospital. Extramural fundingsupports full-body joint-examinationworkshops for 175 secondyearmedical students annuallyas part of their musculoskeletalmodule; these workshops aregiven by trained instructors whohave patients with rheumatoidarthritis.In its clinical practice theDivision is committed to providinghigh-quality, sensitive and efficientcare. The Division is amongleaders in rheumatology trainingin utilizing musculoskeletalultrasound to assess rheumaticdisorders and also has improvedthe accuracy and safety of jointinjections for treatment ofacute pain.With its two existing FellowshipPrograms, the Division dealswith all immunology-relateddiseases, ranging from hypersensitivityreactions to immunodeficiencyto autoimmune or immunesystem dysregulation. Sincethe immune system participatesin aging and cancer, and manyinflammatory diseases are treatedwith biologic medications affectingthe immune response, theImmunology and RheumatologyDivision interacts with almostevery specialty at the University.Recent Division highlights includeexpanded services at KUMC, KUMed West, and the Kansas CityVA Hospital, expanded residentand fellow lectures, more than 25ongoing clinical trials, multiplepresentations at national meetings,and continued NIH fundingfor basic research. Dr. Stechschultehas provided skilled leadership ofthe Division and its two FellowshipPrograms for more than30 years.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 12

FACULTY:Michelle L. Altrich, PhDJames Anderson, MDBasem Awadh, MDCelina C. Bernabe, DOKen D. Brandt, MDKottarappat N. Dileepan, PhDPaul L. Katzenstein, MDKevin M. Latinis, PhD, MDHerbert B. Lindsley, MDJohn D. Martinez, MDDaniel J. Stechschulte, MDConnie K. Teng, MDDamandeep Walia, MD**denotes VADr Herbert Lindsley examines a patient with apainful wrist, using a rheumatology office-basedultrasound instrument.

FACULTY:James Backes, PharmDKenneth Grasing, PhD*Patrick Moriarty, MDGreg Reed, PhDJanelle Ruisinger, PharmD*denotes VADr. Patrick Moriarty, Director for the AtherosclerosisCenter, is featured standing next totwo of the Center’s apheresis machines. Thesemachines, which filter plasma from the bodyand remove cholesterol, have the ability toimmediately improve a patient’s microvascularflow. KUMC is one of only a few Centers inNorth America that can provide this service.

FACULTY:Daniel Aires, MDKristi Canty, MD +Mark Cohen, MDBeatriz Coquilla-Canete, MD*Garth Fraga, MDKimberly Horii, MD +Thelda Kestenbaum, MDDeede Liu, MDBrandon Newell, MD +Amy Nopper, MD +James Scherbenske, MD*Vidya Sharma, MD +Allison Swanson, MD +Viseslav Tonkovic-Capin, MD*denotes VA+denotes CMHDr. Deede Liu talks with patient Janice Kingduring a recent office visit. Dr. Liu was able toget Ms. King’s chronic pyoderma gangrenosumulcers to heal by treating them with topicalcrushed dapsone. A report on this novel treatmenthas just been accepted for publication inthe Journal of Drugs in Dermatology.

ENDOCRINOLOGY, METABOLISM AND GENETICSLeland Graves, MD, Division DirectorThe Division supports a largeclinical practice as a regionalreferral center for patients withdiabetes, osteoporosis, thyroidcancer and other thyroid disease,as well as a wide range of adrenal,pituitary, ovarian, testicular andgenetic disorders. The Division hascoordinated a multidisciplinaryDiabetes Care Team to improveoutcomes for hospitalized patients.Physicians provide 3,000inpatient visits every year at theUniversity of Kansas Hospital.In the outpatient clinics, the EndocrineDivision provides 8,000visits to our physicians, diabeteseducators and bone-densityservices yearly.The Cray Diabetes and SelfManagement Center and theHiatt Osteoporosis Center areacknowledged for their excellenceand leadership. Such performanceis the work of eight committedfaculty members and a staff ofadvanced care providers, nurses,research personnel and administrativestaff.David Robbins, MD, founderand Director of the Cray DiabetesInstitute and the MidwestDiabetes Coalition, has built aninter-organizational, cross-statecollaboration of institutions andindividuals devoted to research,patient care, and education. TheDiabetes Institute applies $12million in external funding to researchin basic, translational, andpatient care. Statewide projectsadvance the education and careof patients with diabetes in ruralareas. A number of ongoing trialsare investigating new treatmentagents.Barbara Lukert, MD, directsthe newly organized MusculoskeletalInstitute, which bringstogether organizations and individualswithin different disciplinesworking on research in bone andskeletal health. Projects withinthe Hiatt Clinic are investigatingthe effect of vitamin D on bonehealth and vascular disease, andclinical trials are studying newagents to treat osteoporosis.Outside the classrooms,Internal Medicine residents rotatethrough inpatient and outpatientservices, learning diabetes managementfor acutely ill patientsand long-term management strategiesfor diabetes and other endocrinediseases. An EndocrinologyFellowship trains internists in thespecialty of Endocrinology, Diabetesand Metabolism.The Division’seducational mission reaches outdirectly to patients with diabetes,osteoporosis and other endocrinedisorders via classes, one-on-oneeducation, online learning, andcommunity-based programs.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 20

FACULTY:Rajib Bhattacharya, MDDebra CollinsMajed Dasouki, MDLeigh Eck, MDWayne Fowler, MD, PhD*Leland Graves, MDJoseph Kyner, MDBarbara Lukert, MDKurt Midyett, MDDavid Robbins, MDR. Neil Schimke, MD*denotes VADr. Leigh Eck performs a thyroid examinationon a patient during her recent follow-up visit.

GASTROENTEROLOGY, HEPATOLOGY AND MOTILITYMojtaba S. Olyaee, MD, Division DirectorThe Division of Gastroenterology(GI), Hepatology and Motilityat KUMC is highly committedto the principles of academic medicine.This is embodied by offeringthe highest quality of patient care,contributing to the advancementof the field by research and providinga fellowship program compatiblewith the highest standards.A sincere commitment to offer thebest possibilities to our patientsand to provide them with relevant,succinct, and clear informationto make an informed decision isone of the core values of our devotedteam of physicians, nurses,nutritionists, technologists, andadministrative staff. Our dedicatedfaculty members not onlyperform on the basis of such principlesin their daily practice, butalso train our fellows to performon the true values of academicmedicine in theory and action.One of the most importantavenues in this regard is introducingthe concept of patient care asa multifaceted yet highly dynamicmatter. Within our Division, wenot only approach the clinicalnecessities for each case fromour sub-specialized point of viewby using the state-of-the-artfacilities, but also maintain ourreview of long-term needs witha systematic approach. With awide spectrum of care, a series ofGI-related diseases, GI and livercancer and nonsurgical treatmentof esophageal cancer, therapeuticendoscopy and endoscopic ultrasound,diseases of liver includingliver transplantation, motilitydisorders are treated with highlysuccessful outcomes.Research, in this scenario,is of crucial importance, as it notonly advances the field (benefitingthe patients in the long term)but also expands the mindsbeyond daily matters of practicingmedicine. Our division, with opportunitiesfor clinical, molecular,and translational research,seeks to foster and promote ourlong-standing tradition of offeringfaculty and fellows a number ofopportunities to be involved incutting-edge research.Research maintains a traditionof excellence at the forefrontof discovery. Clinical studies focuson innovation: treatments for gastrointestinaldisorder and testingand developing technology suchas biomarkers for gastrointestinaldisease.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 22

FACULTY:Shrikant Anant, PhDAjay Bansal, MD*John Bonino, MDDan Buckles, MDAllan Cooke, MDWinston Dunn, MDTuba Esfandyari, MDFaris Farassati, PhD, Pharm DRichard Gilroy, MDScott Grisolano, MDMojtaba Olyaee, MDPrashant Pandya, DO*Amit Rastogi, MD*Savio Reddymasu, MD*Prateek Sharma, MD*Elena Sidorenko, MDRyan Taylor, MDSteven Weinman, MD, PhD* denotes VAThe chart above shows the continuum ofpatient care that is available to patients whochoose the Division of Gastroenterology fortheir healthcare services.

GENERAL AND GERIATRIC MEDICINEStewart Babbott, MD, Division DirectorAn energetic and committedfaculty of 39, including four chiefresidents, integrates the division’sfour major areas of focus– ambulatory medicine, geriatrics,hospital medicine and palliativecare. The Division’s mission is toprovide high-quality patient carethrough clinical service, education,and scholarship.Faculty members are involvedin the medical educationleadership of both undergraduateand graduate medical education.In addition to program leadershipof the third-year core InternalMedicine (IM) Clerkship andthe IM Residency Programs, ourfaculty is integrally involved inteaching students and residentsin both inpatient and outpatientsettings.The Division staffs the InternalMedicine residency clinic,which reported more than 15,035patient visits last year, and somefaculty members maintain privatepractices as well. The Divisionstaffs four housestaff HospitalMedicine services, three privateservices and a general medicineconsultation service.Faculty physicians are activelyinvolved in the medical directorships:collaborations betweenthe physicians and hospital to meetthe Five Star goals of the Universityof Kansas Hospital. These directorshipsinclude the design, implementation,and evaluation of theelectronic health record acrossthe health systems, hospital-basedcare, clinical nutrition, pneumonia(core measure focus), unit-basedcare and palliative medicine.Geriatrics – multidisciplinaryby nature – crosses over severaldepartments in the School ofMedicine. Within the GeneralMedicine and Geriatrics Division,four internal-medicine-trainedphysicians focus on geriatrics.Their work is primarily conductedat the Landon Center on Aging,a freestanding, modern facilitywith easy access for patients. Thisyear we have broadened our scopeof geriatric medicine practiceand clinical education to includepost-acute care of older adults ina community-based skillednursing unit.The Palliative Care Programalso uses a collaborative model tosupport patients and families whoare confronted with advancing,life-limiting illness. The programensures that patients’ preferencesare understood and honored, andthat patient comfort and familyneeds are met. In addition, thiscaring staff thoughtfully providesresponsible stewardship of healthcareresources. The program is alsoinvolved in a growing relationshipwith Kansas City Hospice, whichhas a 32-room facility for terminallyill patients who are unable toreturn home. Two Palliative Carefellows, one funded through KansasCity Hospice, rotate betweenthe two facilities during the year.The Division is involvedin two areas of funded research:(1) Medication use and risk inthe elderly, and 2) Communitybasedadult and childhood obesityprevention programs. Facultymembers are involved in scholarshipthrough the Office of Scholarly,Academic and ResearchMentoring, medical school andresidency initiatives and qualityprograms.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 24

Palliative CareDr. Lindy LandzaatHospital MedicineDr. Abebe AbebeFACULTY:Abebe Abebe, MDDavid Abernethy, MDZalina Ardasenov, MD, PhDWilliam Atkinson, MDStewart Babbott, MDJeffrey Beasley, DODavid Becker, MDKenneth Boc, MDJane Broxterman, MDRavindra Chuda, MDChristopher Crenner, MD, PhDEdward Ellerbeck, MDSarah Folscroft, MDWilliam Gabrielli, MD, PhDCheryl Gibson, PhDDeon Hayley, DORyan Hays, MDLaurie Hohberger, MDJessica Kalender-Rich, MDLynne Kallenbach, MDTheresa King, MDBrinda Koya, MDLindy Landzaat, DOBecky Lowry, MDAngela Mayorga-May, MDJimmy Mbogori, MDKurt Midyett, MDDavid Naylor, MDAmber Niewald, MDCarnie Nulton, M.D.Isaac Opole, MD, PhDRebecca Opole, MDAroop Pal, MDArchana Pareek, MDMelissa Parkhurst, MDPadma Poddutoori, MDKarin Porter-Williamson, MDCourtney Rhudy, MDSally Rigler, MDDominic Robine, DOMayra Sanchez, MDGillian Schmidt, MDLisa Shenkman, MDKy Stoltzfus, MDMohammad Taha, MDLisa Vansaghi, MDAmbulatory MedicineDr. Courtney RhudyGeriatricsDr. Deon Hayley*denotes VAThe essence of general medicine is its involvement in the continuum of patient care: inoffice, between the office and the hospital, across a person’s life span, and with a focuson older adults and people at the end of life. Similarly, we care for the learner across thecontinuum, from student to resident to faculty.

HEMATOLOGY AND ONCOLOGYPeter Van Veldhuizen, MD, Division DirectorWith 21 clinical faculty, 10research faculty, and 10 fellowsin-training,the Hematologyand Oncology Division strives toprovide the highest-quality compassionatecare to our patients.Our goal is to continue to providea comprehensive and multidisciplinaryapproach for patientsas we treat their disease, collaboratingwith other disciplines,including radiation oncology,surgery, pathology, radiology, andpsychosocial support to developthe best treatment approach.Highlights within theDivision include our Blood andMarrow- Transplant Program,Oncology Program, HematologyProgram, and Research Program.The combination of a strong clinicalpractice and a well-roundedresearch program is echoed inthe Division’s dynamic OncologyProgram, which is highlightedby site-specific expertise inthe areas of breast, head/neck,gastrointestinal, genitourinary,brain, and melanoma/sarcomaand lung cancer. Our emergingHematology Program in myeloma,lymphoma and myelodysplasia/elderly leukemia also echoes thatgrowth and development. Eachdiscipline works closely with itsmultidisciplinary clinical researchworking group to develop and promotenew, innovative treatmentapproaches, allowing us to offernovel drugs and clinical trials toour patients.Our active Blood-and-MarrowTransplant Program continues toexpand and serve as a regionalresource offering the highest inquality for our transplant patients.The Division’s nationallyrecognized Breast Cancer Preventionand Survivorship Program,led by Dr. Carol Fabian, continuesto offer the latest in technologyto help both predict breastcancer development and to ensurea return to normal life for thosewho have suffered from this disease.Success of this program ishighlighted by a recent $5 milliongrant from the Susan B. KomenFoundation to study the effect offlaxseed as a preventive strategy.Our Basic Science ResearchProgram continues to grow asthese researchers work closelywith our clinical staff to helpensure new clinical and laboratoryresearch findings reach patients asquickly as possible. Together withthe Cancer Center, the Universityand KUHospital we continue towork toward the universal goalof becoming an NCI-designatedCancer Center. This designationis considered the gold standard incancer research and is given onlyto institutions doing significantresearch to fight the war on cancer.Patients who require admissionto our hospital benefit fromthe division’s hospitalist servicewhich provides unique expertiseand care during patients’ hospitalstays. Additionally, throughour telemedicine/teleoncologyprogram and our interaction withthe Midwest Cancer Alliance weare able to reach out to patientsacross the state of Kansas. Theseefforts provide patients with additionalhematology/oncology expertiseand access to clinical trialsfor which they may otherwise havelimited access.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 26

FACULTY:Paul Brune, MDLisa Clough, MDArundhati Desai, MD*Albert Eid, MDWissam El Atrouni, MDNivedita Ganguly, MDKassem Hammoud, MDDana Hawkinson, MDDaniel Hinthorn, MDVinutha Kumar, MD*Michael Luchi, MDDavid McKinsey, MD*Joel McKinsey, MDFernando Merino, MDStephen Waller, MD*denotes VADr. Dana Hawkinson (foreground) withprincipal investigator Dr. Faris Farassati reviewa Western blot evaluating protein expressionof a novel herpesvirus used to target and killpancreatic cancer.

MEDICAL EDUCATIONLisa Vansaghi, MD, Division DirectorThe Department of InternalMedicine at the University ofKansas has been training residentssince 1956. Many of thesegraduates are now leaders in themedical community, publishedclinicians, and steadfast mentors.Our tradition of training excellentinternists continues.Residents are educated atthree training sites: the Universityof Kansas Hospital, the KansasCity Veterans Affair MedicalCenter, and the Leavenworth VAMedical Center. At the Universityof Kansas Hospital, residents haveopportunities to work with theDepartment of Internal Medicine’sout-standing clinician educators,learning not only traditional physicaldiagnosis and medical decisionmaking,but also the intricaciesof cutting-edge technology andresearch. At each Veterans Hospital,residents learn from dedicatedfaculty and gain valuable andrewarding experience in caringfor our nation’s veterans. Eachfacility provides opportunities forresidents to experience multiplefacets of medicine, includingboth general medicine and subspecialtycare.The Department of InternalMedicine at the University of Kansastrains sub-specialty fellowsin each of its 13 divisions. Aftercompletion of residency training,about 60 percent of graduatingresidents pursue fellowships, bothat KU and across the country.The Department is proud of therepresentation of its trainees at avariety of prestigious institutionsnationwide. Many return to KUto continue their careers uponcompletion of their training.About 20 percent of residentschoose to fulfill the primary-careneeds of the community and workin a private-practice setting. Theircontinuity care experience at theKU Internal Medicine, the KansasCity VA Hospital, KU WestwoodCampus Internal Medicineand a variety of private off-siteoutpatient clinics prepares themto address preventive, acute andchronic outpatient care. Additionally,a strong partnership withSwope Health Services fostersservice to patients with limitedresources.Another 20 percent of graduatingresidents become academicfaculty in general medicine, andcontinue to foster the tradition ofexcellent mentorship for medicalstudents and residents. Thus,residents have the opportunity tolearn from new emerging medicalleaders as well as more experiencedfaculty. The Department ofInternal Medicine’s faculty areinvolved in teaching at residentCore Conferences, Grand Rounds,Patient Safety Conference, ClinicopathologicConference, EthicsConference, and, most importantly,at the patient bedside. Itis no surprise that the ResidencyReview Committee for InternalMedicine commended our facultyfor its enthusiasm for teachingat our last accreditation visitin 2007.Although our program’s historyis filled with innovation in theclinical and diagnostic realm ofmedicine, our efforts in researchabound. Residents are at theforefront of cancer research, qualityimprovement, and advancesin medicine. Scholarly work is arequirement of the training program,but more than 50 percentof our residents surpass the requirementby devoting additionalelective time to research with afaculty mentor.Through the diversity of clinicalexperience and the mentorshipof faculty members, novicegraduates of medical school aretransformed into competent andcompassionate internists duringtheir three years of training. TheDepartment of Internal Medicinetakes great pride in its graduates.From 1956 to the present,the tradition continues to developstrong leaders within a dynamic,impacting, and valuable profession.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 30

Faculty:Stewart Babbott, MDJane Broxterman, MDLeigh Eck, MDAllan Fleming, MDAlex Hallock, MD*Becky Lowry, MDMichael Luchi, MDTrent Nauser, MD*Micah Pescetto, DOCourtney Rhudy, MDSally Rigler, MDStephanie Thompson, MDLisa Vansaghi, MDTim Williamson, MD*denotes VAResidents attend the daily noon conferenceat which core topics found on the AmericanBoard of Internal Medicine board examinationare presented. Noon conference is just oneof a multitude of conferences that help ourresidents become strong physicians.

FACULTY:Arnold M. Chonko, MDDennis Diederich, MDArchana Goel, MD*Jared Grantham, MDAditi Gupta, MDAmina Khan, MD*Ellen McCarthy, MDPeter Rowe, PhDVirginia Savin, MD*Mukut Sharma, PhD*Jason Stubbs, MDDarren Wallace, PhDConnie Wang, MDJames Wetmore, MDThomas Wiegmann, MDFranz Winklhofer, MDSri Yarlagadda, MD*denotes VADr. Franz Winklhofer speaks with a patientwho was diagnosed with polycystic kidneydisease in 2002. In 2005, this patient receiveda life-saving kidney transplant at KUMC.She recently celebrated her fifth year ofsuccessful recovery since transplantation.The patient now gives back by being activelyinvolved in fundraising efforts with thePolycystic Kidney Disease (PKD) Foundation.

OFFICE OF SCHOLARLY, ACADEMIC & RESEARCH MENTORINGSally Rigler, MD, Division DirectorThe Office of Scholarly,Academic & Research Mentoring(OSARM) was created in 2010to assist junior faculty in theDepartment of Internal Medicinewith scholarly development.Sally Rigler, MD, MPH, serves asInterim Director of the OSARM.She works primarily with juniorfaculty members who have beenawarded departmental pilotresearch funds and with those whoare currently applying for newawards. Susan Pingleton, MD,leads the Department of InternalMedicine’s efforts to implement aconsistent and structured mentoringprogram for all junior facultymembers. In the OSARM, Dr.Pingleton works primarily with 22junior faculty who comprise the“Incubator” faculty group. Thesefaculty members receive moreintensive mentoring support, datamanagement and biostatistical resources,and assistance with travelto present their work at nationalmeetings. Jonathan Mahnken,PhD, Associate Professor of Biostatistics,provides biostatisticalmentoring and analytic supportfor the research and scholarlyprojects of all OSARM facultymembers. Isaac Dong, MS, providesdata management services.The OSARM seminar seriesaddresses a wide variety of topicsappropriate for academic facultymembers, with scholarship beingbroadly envisioned and not limitedstrictly to typical hypothesistesting,funded research. Seminarofferings cover topics such aspromotion and tenure expectations,how to engage in scholarlyactivities such as manuscriptreview, how to prepare abstractsand poster presentations, howto become involved in nationalprofessional organizations, andhow to use the electronic healthrecord for scholarly projects. Thisseminar series also provides theIncubator faculty and researchawardeesa forum for presentingtheir own work.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 34

OSARM 2010 grant award recipientsDr. Nisreen Haideri,Division ofHematology/OncologyRecipient of anOSARM ResearchCareer Award“An Evaluation ofthe Molecular Effectsof Finasteride andSoy Isoflavones inthe Prevention ofProstate Cancer”Dr. Omar Aljitawi,Division ofHematology/OncologyRecipient ofan OSARMSeed Award“Ex vivo Expansionof Umbilical Cordblood Stem Cells”Dr. Leigh Eck,Division ofEndocrinology,Diabetes andMetabolismRecipient ofan OSARMSeed Award“Effect of DHASupplementationon Bone DensityChanges inLactating Women”Dr. PriyankaSharma,Division ofHematology/OncologyRecipient ofan OSARMSeed Award“Biomarker Analysisof Archived TripleNegative BreastCancer Specimens”Dr. Jason Stubbs,Division ofNephrology andHypertensionRecipient of anOSARM ResearchCareer Award“Impact of VitaminD Therapies onMonocyte Functionin End-Stage RenalDisease”INCUBATOR FACULTY:Abebe Abebe, MDDavid Becker, MDRajib Bhattacharya, MDJohn Bonino, MDLisa Clough, MDTuba Esfandyari, MDScott Grisolano, MDJessica Kalender-Rich, MDTheresa King, MDHeath Latham, MDBecky Lowry, MDFernando Merino, MDJoel Mermis, MDDavid Naylor, MDCourtney Rhudy, MDMatthew Sharpe, MDElena Sidorenko, MDAshley Simmons, MDLeslie Spikes, MDMohammad Taha, MDStephen Waller, MDConnie Wang, MDResearch planning and mentoring meeting for a project being developed byDr. Lisa Clough. From left to right: Dr. Susan Pingleton, Dr. Lisa Clough,Dr. Sally Rigler, Dr. Jonathan Mahnken, and Isaac Dong.

PULMONARY AND CRITICAL CARE MEDICINEAmy O’Brien-Ladner, MD, Division DirectorThis year more than ever, theDivision of Pulmonary and CriticalCare Medicine has escalatedits trajectory toward fulfilling itsgoals focused on the three missionsof the Department: qualitypatient care, research, and education.The Division entered the U.S.& World Report rankings in 2010,ranked 30th among pulmonaryand critical care programs from apool of 5,000 hospitals nationwide.However we are most proudof the ranking of sixth in the nationin overall survival of the patientscared for by these physicians.In addition, our focus onpatient care is manifested by ourTranslational Research Program.For example, the ongoing work ofthe Eli Lilly Distinguished Scholarin Critical Care Medicine strivesto improve the recognition andtreatment of septic shock throughoutthe state of Kansas. Anotherfocus of translational researchis grounded in the developmentof our large pulmonary-vascularcenter, focusing on the treatment,both conventional and in clinicaltrials, of pulmonary artery hypertension.This research, combinedwith an award from the Parker B.Francis Pulmonary Research Fellowshipand partnering with theDepartment of Integrated Physiology,resulted in work on the aberrationsin the pulmonary-vascularbed related to viral infectionthat result in pulmonary arterialhypertension and was published inthe prestigious American Journalof Respiratory Cell and MolecularBiology this year.Educationally, the Division isdedicated to the development andmaintenance of the ultimate PulmonaryCritical Care Fellowship:12 fellows undergo 24 months ofintense clinical training that includesall aspects of critical care,bronchoscopy-related proceduresand pulmonary medicine, as wellas spending a third year doing 12months on research projects thatrange from the most basic cancercell investigation to that associatedwith outcomes with our rapidresponseteam. All senior fellowspresented their work at the NationalAmerican Thoracic Societymeetings in New Orleans in 2010.All in all, the Division of Pulmonaryand Critical Care Medicine,while focusing on our three mainmissions, is also devoted to thecreation and maintenance ofsustainable and successful traineeand faculty careers in the field ofacademic medicine.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 36

FACULTY:Amy O’Brien-Ladner, MDH. William Barkman, MDMichael Crosser, MDTimothy Dwyer, MDGerald Kerby, MDNaresh Kodwani, MD*Heath Latham, MDJoel Mermis, MDTrenton Nauser, MD*Susan Pingleton, MDMark Plautz, MD*Frank Quijano, MDMatthew Sharpe, MDSteven Q. Simpson, MDLeslie Spikes, MDDamien Stevens, MDSteven W. Stites, MDTimothy Williamson, MD*denotes VAWhile attending meetings in Chicago, the faculty take time out for some team-building activities.

REPRESENTATIVE PUBL ICATIONSSheikh, A., & Vacek, J. L. Moving towardsthe future of dyslipidemia management.South Med J 2010;103(5):392-393.Simmons, A., Vacek, J., & Gupta, K.A case of left main systolic compressioncaused by a dilated pulmonary artery in apatient with congenital pulmonic stenosis.J Invasive Cardiol 2010;22(11):E176-179.Solomon, S., & Vacek, J. L. Reducingcardiac ischemic events in patients withACS: prasugrel versus clopidogrel. Commentary.Postgrad Med 2010;122(1):198-200.Sosland, R. P., Gollub, S. B., Wilson,D. B., & Moriarty, P. M. The first casereport of the treatment of transplant coronaryartery disease with dextran sulfateadsorption lipid apheresis. Ther ApherDial 2010;14(2):218-221.Tang, X., Rokosh, G., Sanganalmath, S.K., Yuan, F., Sato, H., Mu, J., Dai, S.,Li, C., Chen, N., Peng, Y., Dawn, B.,Hunt, G., Leri, A., Kajstura, J., Tiwari,S., Shirk, G., Anversa, P., & Bolli, R..Intracoronary administration of cardiacprogenitor cells alleviates left ventriculardysfunction in rats with a 30-day-old infarction.Circulation 2010;121(2):293-305.Vanga, S. R., Bommana, S., Kroll, M., &Lakkireddy, D. Impedance Changes onDefibrillation Coils after Atrial FibrillationAblation: Lead Damage or ElectromechanicalInterference? Pacing ClinElectrophysiol 2010.Vanhoose, L., Sawers, Y., Loganathan, R.,Vacek, J. L., Stehno-Bittel, L., Novikova,L., Al-Jarrah, M., & Smirnova, I. V..Electrocardiographic changes with the onsetof diabetes and the impact of aerobicexercise training in the Zucker DiabeticFatty (ZDF) rat. Cardiovasc Diabetol2010;9:56.Verma, A., Wulffhart, Z., Lakkireddy,D., Khaykin, Y., Kaplan, A., Sarak, B.,Biria, M., Pillarisetti, J., Bhat, P., Di Biase,L., Constantini, O., Quan, K., & Natale,A.. Incidence of left ventricular functionimprovement after primary prevention ICDimplantation for non-ischaemic dilated cardiomyopathy:a multicentre experience.Heart 2010;96(7):510-515.Whellan, D. J., Ousdigian, K. T., Al-Khatib, S. M., Pu, W., Sarkar, S., Porter,C. B., Pavri, B. B., & O’Connor, C. M.Combined heart failure device diagnosticsidentify patients at higher risk ofsubsequent heart failure hospitalizations:results from PARTNERS HF (Program toAccess and Review Trending Informationand Evaluate Correlation to Symptoms inPatients With Heart Failure) study. J AmColl Cardiol 2010;55(17):1803-1810.Zuba-Surma, E. K., Guo, Y., Taher, H.,Sanganalmath, S. K., Hunt, G., Vincent,R. J., Kucia, M., Abdel-Latif, A., Tang,X., Ratajczak, M. Z., Dawn, B., & Bolli,R. Transplantation of expanded bonemarrow-derived very small embryoniclikestem cells (VSEL-SCs) improves leftventricular function and remodeling aftermyocardial infarction. J Cell Mol Med 2010.Solomon S, Vacek JL. Invited article: PracticePearls. Prasugrel versus clopidogrel inpatients with acute coronary syndrome.Postgrad Med. 2010 Jan;122(1):198-200.Sosland, R. P., Gollub, S. B., Wilson,D. B., & Moriarty, P. M. The first casereport of the treatment of transplant coronaryartery disease with dextran sulfateadsorption lipid apheresis. Ther ApherDial 2010;14(2):218-221.Chehab BM, Gupta K, Vamanan K.Percutaneous treatment of severe diffusestenosis in heavily calcified infra-renalabdominal aorta using iliac extender endoprosthesis.Vasc Med 2010; 15:140.Vanga SR, Annapureddy C, Biria M,Lakkireddy D. Monomorphic OutflowTract Ventricular Tachycardia UniquePresenting Manifestation of Gitelman’sSyndrome. Journal of Atrial Fibrillation.2010; http://dx.doi.org/10.4022/jafib.v1i10.560.Pillarisetti J, Singh V, Gupta K. A55- year old man with chest pain andGiant T waves. J Electrocardiography.2010;43(1):40-42.Mbogori, J., Chawdhary, K., & Vacek,J. L. A man with a worried heart: transientleft ventricular apical ballooningand rhabdomyolysis. Am J Med2010;123(2):e11-12.Watson, L.J., Facundo, H.T., Ngoh, G.A.,Ameen, M., Brainard, R.E., Lemma,K.M., Long, B.W., Prabhu, S.D., Xuan,Y.T., Jones S.P. O-linked beta-N-acetylglucosaminetransferase is indispensablein the failing heart. Proc Natl Acad Sci US A 2010;107(41):17797-17802.Clinical PharmacologyDavis, P. F., Ozias, M. K., Carlson, S. E.,Reed, G. A., Winter, M. K., McCarson,K. E., & Levant, B. Dopamine receptor alterationsin female rats with diet-induceddecreased brain docosahexaenoic acid(DHA): interactions with reproductive status.Nutr Neurosci 2010;13(4):161-169.Faseru, B., Cox, L. S., Bronars, C. A.,Opole, I., Reed, G. A., Mayo, M. S.,Ahluwalia, J. S., & Okuyemi, K. S.Design, recruitment, and retention ofAfrican-American smokers in a pharmacokineticstudy. BMC Med Res Methodol2010;10:6.Grasing, K., Mathur, D., & Desouza,C. Written emotional expression duringrecovery from cocaine dependence: groupand individual differences in cravingintensity. Subst Use Misuse 2010;45(7-8):1201-1215.Grasing, K., Mathur, D., Newton, T. F., &DeSouza, C. Donepezil treatment and thesubjective effects of intravenous cocainein dependent individuals. Drug AlcoholDepend 2010;107(1):69-75.Moriarty, P., Sosland, R., Gibson, C., &Belmont, J. Comparison of different lowdensity lipoprotein apheresis machines onbrain natriuretic Peptide levels in patientswith familial hypercholesterolemia. TherApher Dial 2010;14(1):74-78.Moriarty, P. M., Luyendyk, J. P., Gibson,C. A., & Backes, J. M. Effect of lowdensitylipoprotein apheresis on plasmalevels of apolipoprotein e4. Am J Cardiol2010;105(11):1585-1587.Sosland, R. P., Gollub, S. B., Wilson,D. B., & Moriarty, P. M. The first casereport of the treatment of transplant coronaryartery disease with dextran sulfateadsorption lipid apheresis. Ther ApherDial 2010;14(2):218-221.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 39

REPRESENTATIVE PUBL ICATIONSNewton, T. F., De La Garza, R., 2nd, &Grasing, K. The angiotensin-convertingenzyme inhibitor perindopril treatment alterscardiovascular and subjective effectsof methamphetamine in humans. PsychiatryRes 2010;179(1):96-100.Shireman, T.I., Reichard, A., Nazir,N., Backes, J, Greiner, K.A. Quality ofdiabetes care for adults with developmentaldisabilities. Disability Health J2010;3(3):179.185.Ruisinger, J.F., Koerner, J.M., BackesJ.M., Moriarty, P.M. SupratherapeuticResponse to Ezetimibe in a StatinIntolerant Patient. Hospital Pharmacy2010;45:45-48.DermatologyDeng, B., Parthasarathy, S., Wang, W.,Gibney, B. R., Battaile, K. P., Lovell, S.,Zhu, H. Study of the individual cytochromeb5 and cytochrome b5 reductasedomains of Ncb5or reveals a unique hemepocket and a possible role of the CS domain.J Biol Chem 2010;285(39):30181-30191.Schweiger, E. S., Kwasniak, L., &Tonkovic-Capin, V. A patient with neviodbasal cell carcinoma syndrome treatedsuccessfully with photodynamic therapy:case report and review of the literature. JDrugs Dermatol 2010;9(2):167-168.Zhang, Y., Larade, K., Jiang, Z. G., Ito,S., Wang, W., Zhu, H., & Bunn, H. F.The flavoheme reductase Ncb5or protectscells against endoplasmic reticulumstress-induced lipotoxicity. J Lipid Res2010;51(1):53-62.Handler, M., Hamilton, H., Aires,D. Treatment of Peristomal PyodermaGangrenosum with Topical CrushedDapsone. Journal of Drugs in Dermatology2010; Status: accepted for publication.Miller, A., Dusing, R., Meggison, A.,Aires, D. (2010) Regression of internalmelanoma metastases following applicationof topical imiquimod to overlyingskin. Journal of Drugs in Dermatology2010; Status: accepted for publication.Endocrinology,Metabolism & GeneticsDasouki, M., Barohn, R., & Hegde, M.Novel human pathological mutations.Gene symbol: DMD. Disease: MuscularDystrophy, Duchenne. Hum Genet2010;127(1):109.Malik, V., Rodino-Klapac, L. R., Viollet,L., Wall, C., King, W., Al-Dahhak, R.,Lewis, S., Shilling, C. J., Kota, J., Serrano-Munuera,C., Hayes, J., Mahan, J. D.,Campbell, K. J., Banwell, B., Dasouki,M., Watts, V., Sivakumar, K., Bien-Willner, R., Flanigan, K. M., Sahenk, Z.,Barohn, R. J., Walker, C. M., & Mendell,J. R. Gentamicin-induced readthrough ofstop codons in Duchenne muscular dystrophy.Ann Neurol 2010;67(6):771-780.Renard, M., Holm, T., Veith, R., Callewaert,B.L., Ades, L.C., Baspinar, O.,Pickart, A., Dasouki, M., Hoyer, J.,Rauch, A., Trapane, P., Earing, M.G.,Coucke, P.J., Sakai, L.Y., Dietz, H.C.,De Paepe, A.M., & Loeys, B.L.,. AlteredTGFbeta signaling and cardiovascularmanifestations in patients with autosomalrecessive cutis laxa type I caused byfibulin-4 deficiency. Eur J Hum Genet2010;18(8):895-901.Midyett, L. K., Rogol, A. D., Van Meter,Q. L., Frane, J., & Bright, G. M. Recombinantinsulin-like growth factor (IGF)-Itreatment in short children with low IGF-Ilevels: first-year results from a randomizedclinical trial. J Clin Endocrinol Metab2010;95(2):611-619.Schimke, R. N., Collins, D. L., & Stolle,C. A. Paraganglioma, neuroblastoma,and a SDHB mutation: Resolution of a30-year-old mystery. Am J Med Genet A2010;152A(6):1531-1535.Gastroenterology,Hepatology and MotilityCamilleri, M., Thorne, N. K., Ringel, Y.,Hasler, W. L., Kuo, B., Esfandyari, T.,Gupta, A., Scott, S. M., McCallum, R.W., Parkman, H. P., Soffer, E., Wilding,G. E., Semler, J. R., & Rao, S. S. C.Wireless pH-motility capsule for colonictransit: prospective comparison withradiopaque markers in chronic constipation.Neurogastroenterol Motil2010;22(8):874-882, e233.Cohen, H., Tomasso, G., Luisa Cafferata,M., Zapata, C., Sharma, P., Armstrong,D., Moraes-Filho, J. P., Blasco, C., Corti,R., Estape, G., Leite Luna, L., Ortuño,R., Sakai, P., Salis, G., Taullard, D.,Trakal, E., Valdovinos, M., Vergara, M.,& Gónzalez, O. Latin American consensuson gastroesophageal reflux disease: anupdate on therapy. Gastroenterol Hepatol2010;33(2):135-147.Fiocca, R., Mastracci, L., Riddell,R., Takubo, K., Vieth, M., Yerian, L.,Sharma, P., Fernström, P., & Ruth, M.Development of consensus guidelines forthe histologic recognition of microscopicesophagitis in patients with gastroesophagealreflux disease: the Esohisto project.Hum Pathol 2010;41(2):223-231.Greenberger, N. J., & Sharma, P. Updatein gastroenterology and hepatology. AnnIntern Med 2010;153(1):34-39.Gupta, N., Nayak, R., Grisolano, S. W.,Buckles, D. C., & Tadros, P. N. Definingpatients at high risk for gastrointestinalhemorrhage after drug-eluting stentplacement: a cost utility analysis. J IntervCardiol 2010;23(2):179-187.Hejazi, R. A., Reddymasu, S. C., Namin,F., Lavenbarg, T., Foran, P., & McCallum,R. W. Efficacy of tricyclic antidepressanttherapy in adults with cyclic vomiting syndrome:a two-year follow-up study. J ClinGastroenterol 2010;44(1):18-21.Prasad, G. A., Bansal, A., Sharma, P., &Wang, K. K. Predictors of progression inBarrett’s esophagus: current knowledgeand future directions. Am J Gastroenterol2010;105(7):1490-1502.Reddymasu, S. C., Lin, Z., Sarosiek, I.,Forster, J., & McCallum, R. W. Efficacy ofgastric electrical stimulation in improvingfunctional vomiting in patients withnormal gastric emptying. Dig Dis Sci2010;55(4):983-987.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 40

REPRESENTATIVE PUBL ICATIONSReddymasu, S. C., & McCallum, R. W.Small intestinal bacterial overgrowth ingastroparesis: are there any predictors? JClin Gastroenterol 2010;44(1):e8-13.Reddymasu, S. C., Sarosiek, I., & Mc-Callum, R. W. Severe gastroparesis: medicaltherapy or gastric electrical stimulation. ClinGastroenterol Hepatol 2010;8(2):117-124.Rex, D. K., Fennerty, M. B., Sharma,P., Kaltenbach, T., & Soetikno, R. Bringingnew endoscopic imaging technologyinto everyday practice: what is therole of professional GI societies? Polypimaging as a template for moving endoscopicinnovation forward to answer keyclinical questions. Gastrointest Endosc2010;71(1):142-146.Sharma, P., & Kozarek, R. Role ofesophageal stents in benign and malignantdiseases. Am J Gastroenterol2010;105(2):258-273; quiz 274.Szabo, G., Wands, J. R., Eken, A., Osna,N. A., Weinman, S. A., Machida, K.,& Joe Wang, H. Alcohol and hepatitis Cvirus–interactions in immune dysfunctionsand liver damage. Alcohol Clin Exp Res2010;34(10):1675-1686.Wallace, M. B., Sharma, P., Lightdale,C., Wolfsen, H., Coron, E., Buchner, A.,Bajbouj, M., Bansal, A., Rastogi, A.,Abrams, J., Crook, J. E., & Meining, A.Preliminary accuracy and interobserveragreement for the detection of intraepithelialneoplasia in Barrett’s esophagus withprobe-based confocal laser endomicroscopy.Gastrointest Endosc 2010;72(1):19-24.Wang, T., Campbell, R. V., Yi, M. K.,Lemon, S. M., & Weinman, S. A. Role ofHepatitis C virus core protein in viralinducedmitochondrial dysfunction. J ViralHepat 2010;17(11):784-793.Wani, S., Mathur, S. C., Curvers, W. L.,Singh, V., Herrero, L. A., Hall, S. B.,Ulusarac, O., Cherian, R., McGregor,D. H., Bansal, A., Rastogi, A., Ahmed,B., Singh, M., Gaddam, S., Ten Kate, F.J., Bergman, J., & Sharma, P. Greaterinterobserver agreement by endoscopicmucosal resection than biopsy samplesin Barrett’s dysplasia. Clin GastroenterolHepatol 2010;8(9):783-788.Wani, S., Sayana, H., & Sharma, P. Endoscopiceradication of Barrett’s esophagus.Gastrointest Endosc 2010;71(1):147-166.Wozniak, A. L., Griffin, S., Rowlands,D., Harris, M., Yi, M., Lemon, S. M., &Weinman, S. A. Intracellular protonconductance of the hepatitis C virus p7protein and its contribution to infectiousvirus production. PLoS Pathog2010;6(9):e1001087.Zhang, D., O’Neil M, F., Cunningham, M.T., Fan, F., Olyaee, M., & Li, L. AbnormalWnt signaling and stem cell activation inreactive lymphoid tissue and low-grademarginal zone lymphoma. Leuk Lymphoma2010;51(5):906-910.General and Geriatric MedicineBefort, C. A., Donnelly, J. E., Sullivan,D. K., Ellerbeck, E. F., & Perri, M. G.Group versus individual phone-based obesitytreatment for rural women. Eat Behav2010;11(1):11-17.Cupertino, A. P., Richter, K., Cox, L. S.,Garrett, S., Ramirez, R., Mujica, F., &Ellerbeck, E. F. Feasibility of a Spanish/Englishcomputerized decision aidto facilitate smoking cessation efforts inunderserved communities. J Health CarePoor Underserved 2010;21(2):504-517.Faseru, B., Cox, L. S., Bronars, C. A.,Opole, I., Reed, G. A., Mayo, M. S.,Okuyemi, K. S. Design, recruitment, andretention of African-American smokers ina pharmacokinetic study. BMC Med ResMethodol 2010;10:6.Fils, J. M., Penick, E. C., Nickel, E. J.,Othmer, E., Desouza, C., Gabrielli, W.F., & Hunter, E. E. Minor versus majordepression: a comparative clinical study.Prim Care Companion J Clin Psychiatry2010;12(1):PCC 08m00752.Geraci, S. A., Babbott, S. F., Hollander,H., Buranosky, R., Devine, D. R., Kovach,R. A., & Berkowitz, L. AAIM Report onMaster Teachers and Clinician EducatorsPart 1: needs and skills. Am J Med2010;123(8):769-773.Geraci, S. A., Kovach, R. A., Babbott, S.F., Hollander, H., Buranosky, R., Devine,D. R., & Berkowitz, L. AAIM Report onMaster Teachers and Clinician EducatorsPart 2: faculty development and training.Am J Med 2010;123(9):869-872 e866.Landzaat, L. H., Sinclair, C. T., &Rosielle, D. A. Continuous-flow leftventricular assist device. N Engl J Med2010;362(12):1149; author reply 1149.McDyre, L. E., Hamilton, T., Murphy,D. M., Cavell, K. J., Gabrielli, W. F.,Hanton, M. J., & Smith, D. M. A cwEPR and ENDOR investigation on aseries of Cr(I) carbonyl complexes withrelevance to alkene oligomerizationcatalysis: [Cr(CO)4L]+ (L = Ph2PN(R)PPh2, Ph2P(R)PPh2). Dalton Trans2010;39(33):7792-7799.Moeller, K. E., Shireman, T. I., Generali,J., Rigler, S., & Mayorga, A. Pharmacystudents’ knowledge of black box warnings.Am J Pharm Educ 2010;74(1):5.Moriarty, P., Sosland, R., Gibson, C., &Belmont, J. Comparison of different lowdensity lipoprotein apheresis machines onbrain natriuretic Peptide levels in patientswith familial hypercholesterolemia. TherApher Dial 2010;14(1):74-78.Moriarty, P. M., Luyendyk, J. P., Gibson,C. A., & Backes, J. M. Effect of lowdensitylipoprotein apheresis on plasmalevels of apolipoprotein e4. Am J Cardiol2010;105(11):1585-1587.Nadkarni, M., Reddy, S., Bates, C. K.,Fosburgh, B., Babbott, S., & Holmboe,E. Ambulatory-Based Education in InternalMedicine: Current Organization andImplications for Transformation. Results ofA National Survey of Resident ContinuityClinic Directors. J Gen Intern Med 2010.Penick, E. C., Knop, J., Nickel, E. J.,Jensen, P., Manzardo, A. M., Lykke-Mortensen, E., & Gabrielli, W. F. Dopremorbid predictors of alcohol dependencealso predict the failure to recoverfrom alcoholism? J Stud Alcohol Drugs2010;71(5):685-694.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 41

From left to right: Darren Wallace, PhD – Research AssociateProfessor in Nephrology; James Calvet, PhD – Interim Director ofthe Kidney Institute; Stephen Parnell, PhD – Research AssistantProfessor in Biochemistry; and James Wetmore, MD – AssistantProfessor in Nephrology.

REPRESENTATIVE PUBL ICATIONSReddy, S. G., Babbott, S. F., Beasley,B. W., Nadkarni, M. M., Gertner, E. J.,& Holmboe, E. S. Prevalence and functionalityof electronic health records ininternal medicine continuity clinics. AcadMed 2010;85(8):1369-1377.Rigler, S. K., Ellerbeck, E., Whittle, J.,Mahnken, J., Cook-Wiens, G., & Shireman,T. I. Comparing methods to identifyhip fracture in a nursing home populationusing Medicare claims. Osteoporos Int 2010.Wetmore, J. B., Rigler, S. K., Mahnken,J. D., Mukhopadhyay, P., & Shireman,T. I. Considering health insurance: howdo dialysis initiates with Medicaid coveragediffer from persons without Medicaidcoverage? Nephrol Dial Transplant2010;25(1):198-205.Hematology/OncologyBefort, C. A., Austin, H., & Klemp, J. R.Weight control needs and experiencesamong rural breast cancer survivors.Psychooncology 2010.Blanke, C. D., Chansky, K., Christman,K. L., Hundahl, S. A., Issell, B. F., VanVeldhuizen, P. J., Budd, G. T., Abbruzzese,J. L., & MacDonald, J. S. S9511:a Southwest Oncology Group phase IIstudy of trimetrexate, 5-fluorouracil, andleucovorin in unresectable or metastaticadenocarcinoma of the stomach. Am JClin Oncol 2010;33(2):117-120.Cohen, M. S., Al-Kasspooles, M. F.,Williamson, S. K., Henry, D., Broward,M., & Roby, K. F. Combination intraperitonealchemotherapy is superior tomitomycin C or oxaliplatin for colorectalcarcinomatosis in vivo. Ann Surg Oncol2010;17(1):296-303.Dhar, K., Dhar, G., Majumder, M., Haque,I., Mehta, S., Van Veldhuizen, P. J.,Banerjee, S. Tumor cell-derived PDGF-B potentiates mouse mesenchymal stemcells-pericytes transition and recruitmentthrough an interaction with NRP-1. MolCancer 2010;9:209.Dorff, T. B., Goldman, B., Pinski, J. K.,Mack, P. C., Lara, P. N., Van Veldhuizen,P. J., Quinn, D. I., Vogelzang, N. J.,Thompson, I. M., & Hussain, M. H. A.Clinical and correlative results of SWOGS0354: a phase II trial of CNTO328(siltuximab), a monoclonal antibodyagainst interleukin-6, in chemotherapypretreatedpatients with castrationresistantprostate cancer. Clin Cancer Res2010;16(11):3028-3034.Fabian, C. J., Kimler, B. F., Zalles, C. M.,Klemp, J. R., Petroff, B. K., Khan, Q.J., Sharma, P., Setchell, K. D. R., Zhao,X., Phillips, T. A., Metheny, T., Hughes, J.R.,Yeh, H., & Johnson, K. A. Reduction inKi-67 in benign breast tissue of high-riskwomen with the lignan secoisolariciresinoldiglycoside. Cancer Prev Res (Phila)2010;3(10):1342-1350.Ganguly, N., Clough, L. A., Dubois, L. K.,McGuirk, J. P., Abhyankar, S., Aljitawi,O. S., O’Neal, N., Divine, C. L., & Ganguly,S. Low-dose cidofovir in the treatmentof symptomatic BK virus infection inpatients undergoing allogeneic hematopoieticstem cell transplantation: a retrospectiveanalysis of an algorithmic approach.Transpl Infect Dis 2010;12(5):406-411.Ganguly, S., Bradley, J. P., Patel, J. S., &Tilzer, L. Role of transfusion in stem celltransplantation: a freedom-from-transfusion(FFT), cost and survival analysis. JMed Econ 2010;13(1):55-62.Hashmi, M. H., & Van Veldhuizen, P. J.Interleukin-21: updated review of PhaseI and II clinical trials in metastatic renalcell carcinoma, metastatic melanoma andrelapsed/refractory indolent non-Hodgkin’slymphoma. Expert Opin Biol Ther2010;10(5):807-817.Hutt, K. J., Shi, Z., Petroff, B. K., & Albertini,D. F. The environmental toxicant2,3,7,8-tetrachlorodibenzo-p-dioxin disturbsthe establishment and maintenanceof cell polarity in preimplantation rat embryos.Biol Reprod 2010;82(5):914-920.Jablonska, O., Shi, Z., Valdez, K. E., Ting,A. Y., & Petroff, B. K. Temporal andanatomical sensitivities to the aryl hydrocarbonreceptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxinleading to prematureacyclicity with age in rats. Int J Androl2010;33(2):405-412.Kambhampati, S., Dhar, K., Mehta, S.,Haque, I., Dhar, G., Majumder, M., Ray,G., Vanveldhuizen, P. J., & Banerjee, S.K. K. 2-methoxyestradiol inhibits Barrett’sesophageal adenocarcinoma growthand differentiation through differentialregulation of the beta-catenin-E-cadherinaxis. Mol Cancer Ther 2010;9(3):523-534.Khan, Q. J., & Fabian, C. J. How Itreat vitamin d deficiency. J Oncol Pract2010;6(2):97-101.Khan, Q. J., Kimler, B. F., & Fabian, C. J.The relationship between vitamin D andbreast cancer incidence and natural history.Curr Oncol Rep 2010;12(2):136-142.Khan, Q. J., O’Dea, A. P., & Sharma, P.Musculoskeletal adverse events associatedwith adjuvant aromatase inhibitors. JOncol 2010;2010.Khan, Q. J., Reddy, P. S., Kimler, B. F.,Sharma, P., Baxa, S. E., O’Dea, A. P.,Klemp, J. R., & Fabian, C. J. Effectof vitamin D supplementation on serum25-hydroxy vitamin D levels, joint pain,and fatigue in women starting adjuvantletrozole treatment for breast cancer.Breast Cancer Res Treat 2010;119(1):111-118.Kubicek, G. J., Kimler, B. F., Wang, F.,Reddy, E. K., Girod, D. A., & Williamson,S. K. Chemotherapy in Head and NeckCancer: Clinical Predictors of Toleranceand Outcomes. Am J Clin Oncol 2010.Male, H. J., Davis, M. B., McGuirk, J. P.,Abhyankar, S., Aljitawi, O. S., Zhang,D., & Ganguly, S. Blastic plasmacytoiddendritic cell neoplasm should betreated with acute leukemia type inductionchemotherapy and allogeneic stem celltransplantation in first remission. Int JHematol 2010;92(2):398-400.McLeod, H.L., Sargent, D.J., Marsh, S.,Green, E.M., King, C.R., Fuchs, C. S.,Goldberg, R.M. Pharmacogenetic predictorsof adverse events and response tochemotherapy in metastatic colorectalcancer: results from North AmericanGastrointestinal Intergroup Trial N9741.J Clin Oncol 2010;28(20):3227-3233.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 43

REPRESENTATIVE PUBL ICATIONSMovsas, B., Langer, C.J., Ross, H.J.,Wang, L., Jotte, R.M., Feigenberg, S., Xu,F., Huang, C., Monberg M.J., & ObasajuC.K. Randomized phase II trial of cisplatin,etoposide, and radiation followed bygemcitabine alone or by combined gemcitabineand docetaxel in stage III A/Bunresectable non-small cell lung cancer. JThorac Oncol 2010;5(5):673-679.Petrylak, D. P., Tangen, C. M., VanVeldhuizen, P. J., Goodwin, J. W.,Twardowski, P. W., Atkins, J. N., Kakhil,S. R., Lange, M. K., Mansukhani, M., &Crawford, E. D. Results of the SouthwestOncology Group phase II evaluation (studyS0031) of ZD1839 for advanced transitionalcell carcinoma of the urothelium.BJU Int 2010;105(3):317-321.Reddy, V. P., Vanveldhuizen, P. J., Muehlebach,G. F., Dusing, R. W., Birkbeck,J. P., Williamson, S. K., Krishnan, L., &Meyers, D. G. Leiomyosarcoma of the inferiorvena cava: a case report and reviewof the literature. Cases J 2010;3:71.Tawfik, O., Davis, K., Kimler, B. F., Davis,M. K., Hull, S., Fan, F., Khan, Q. J.,O’Dea, A. P., & Thomas, P. Clinicopathologicalcharacteristics of triple-negativeinvasive mammary carcinomas in African-American versus Caucasian women. AnnClin Lab Sci 2010;40(4):315-323.Ting, A. Y., & Petroff, B. K. Tamoxifendecreases ovarian follicular loss fromexperimental toxicant DMBA and chemotherapyagents cyclophosphamide anddoxorubicin in the rat. J Assist ReprodGenet 2010;27(11):591-597.Williamson, S. K., Moon, J., Huang, C.H., Guaglianone, P. P., LeBlanc, M., Wolf,G. T., & Urba, S. G. Phase II evaluationof sorafenib in advanced and metastaticsquamous cell carcinoma of the head andneck: Southwest Oncology Group StudyS0420. J Clin Oncol 2010;28(20):3330-3335.Infectious DiseasesArthurs, S. K., Eid, A. J., Deziel, P. J.,Marshall, W. F., Cassivi, S. D., Walker,R. C., & Razonable, R. R. The impact ofinvasive fungal diseases on survival afterlung transplantation. Clin Transplant2010;24(3):341-348.Boyce, R. D., Deziel, P. J., Otley, C. C.,Wilhelm, M. P., Eid, A. J., Wengenack,N. L., & Razonable, R. R. Phaeohyphomycosisdue to Alternaria species intransplant recipients. Transpl Infect Dis2010;12(3):242-250.Brown, R. A., Gralewski, J. H., Eid,A. J., Knoll, B. M., Finberg, R. W., &Razonable, R. R. R753Q single-nucleotidepolymorphism impairs toll-like receptor2 recognition of hepatitis C virus core andnonstructural 3 proteins. Transplantation2010;89(7):811-815.Eid, A. J., Arthurs, S. K., Deziel, P. J.,Wilhelm, M. P., & Razonable, R. R. Clinicalpredictors of relapse after treatment ofprimary gastrointestinal cytomegalovirusdisease in solid organ transplant recipients.Am J Transplant 2010;10(1):157-161.Eid, A. J., Brown, R. A., Arthurs, S. K.,Lahr, B. D., Eckel-Passow, J. E., Larson,T. S., & Razonable, R. R. A prospectivelongitudinal analysis of cytomegalovirus(CMV)-specific CD4+ and CD8+T cells in kidney allograft recipientsat risk of CMV infection. Transpl Int2010;23(5):506-513.Eid, A. J., & Razonable, R. R. New developmentsin the management of cytomegalovirusinfection after solid organ transplantation.Drugs 2010;70(8):965-981.Ganguly, N., Clough, L. A., Dubois,L. K., McGuirk, J. P., Abhyankar, S.,Aljitawi, O. S., Ganguly, S. Low-dosecidofovir in the treatment of symptomaticBK virus infection in patients undergoingallogeneic hematopoietic stem cell transplantation:a retrospective analysis of analgorithmic approach. Transpl Infect Dis2010;12(5):406-411.Wu, J., Henderson, C., Feun, L., VanVeldhuizen, P., Gold, P., Zheng, H.,Ryan T., Blaszkowsky, L.S., Chen, H.,Costa, M., Rosenzweig, B., Nierodzik,M., Hochster, H., Muggia, F., Abbadessa,G., Lewis, J., Zhu, A.X. Phase II study ofdarinaparsin in patients with advanced hepatocellularcarcinoma. Invest New Drugs2010;28(5):670-676.Nephrology and HypertensionBae, K. T., & Grantham, J. J. Imagingfor the prognosis of autosomal dominantpolycystic kidney disease. Nat RevNephrol 2010;6(2):96-106.Boskey, A. L., Chiang, P., Fermanis, A.,Brown, J., Taleb, H., David, V., & Rowe,P. S. MEPE’s diverse effects on mineralization.Calcif Tissue Int 2010;86(1):42-46.Boukpessi, T., Gaucher, C., Léger, T.,Salmon, B., Le Faouder, J., Willig, C.,Rowe, P. S., Garabédian, M., Meilhac, O.,& Chaussain, C. Abnormal presence of thematrix extracellular phosphoglycoproteinderivedacidic serine- and aspartate-richmotif peptide in human hypophosphatemicdentin. Am J Pathol 2010;177(2):803-812.Bryan, C. F., Abdulkarim, B., Forster, J.,Nelson, P. W., Diederich, D., Murillo, D.,& Markham, L. A new role for the virtualcrossmatch in kidney allograft reuse.Transplantation 2010;89(6):764-765.Fishbane, S., Milligan, S. L., Lempert,K. D., Hertel, J. E. W., Wetmore, J. B.,Oliver, M. J., Blaney, M., Gillespie, B.S., Jacobs, J. R., & Begelman, S. M. TheHALT polycystic kidney disease trials:design and implementation. Clin J Am SocNephrol 2010;5(1):102-109.Fisher, M. A., McCarthy, E. T., & Manz,M. C. Prevalence of gingival overgrowthin renal transplant recipients on sirolimusimmunosuppressive therapy is not clearlyestablished. J Evid Based Dent Pract2010;10(2):93-95.Fisher, M. A., Taylor, G. W., West, B. T.,& McCarthy, E. T. Bidirectional relationshipbetween chronic kidney and periodontaldisease: a study using structuralequation modeling. Kidney Int 2010.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 44

REPRESENTATIVE PUBL ICATIONSGrantham, J. J., Cook, L. T., Wetzel,L. H., Cadnapaphornchai, M. A., & Bae, K.T. Evidence of extraordinary growth in theprogressive enlargement of renal cysts. ClinJ Am Soc Nephrol 2010;5(5): 889-896.Grantham, J. J., & Sullivan, L. P. TheBirth and Early Development of JASN. JAm Soc Nephrol 2010;21(1):1-2.Kugita, M., Nishii, K., Morita, M., Yoshihara,D., Kowa-Sugiyama, H., Yamada,K., Yamaguchi, T., Wallace, D. P., Calvet,J. P., Kurahashi, H., & Nagao, S. Globalgene expression profiling in early-stagepolycystic kidney disease in the Han:SPRDCy rat identifies a role for RXR signaling.Am J Physiol Renal Physiol 2010.McCarthy, E. T., Sharma, M., & Savin,V. J. Circulating permeability factors inidiopathic nephrotic syndrome and focalsegmental glomerulosclerosis. Clin J AmSoc Nephrol 2010;5(11):2115-2121.Nagao, S., Morita, M., Kugita, M., Yoshihara,D., Yamaguchi, T., Kurahashi, H.,Wallace, D. P. Polycystic kidney diseasein Han:SPRD Cy rats is associated withelevated expression and mislocalizationof SamCystin. Am J Physiol Renal Physiol2010;299(5):F1078-1086.Shireman, T. I., Almehmi, A., Wetmore,J. B., Lu, J., Pregenzer, M., & Quarles,L. D. Economic analysis of cinacalcetin combination with low-dose vitamin Dversus flexible-dose vitamin D in treatingsecondary hyperparathyroidism inhemodialysis patients. Am J Kidney Dis2010;56(6):1108-1116.Srivastava, T., McCarthy, E. T., Sharma,R., Cudmore, P. A., Sharma, M., Johnson,M. L., & Bonewald, L. F. ProstaglandinE(2) is crucial in the response of podocytesto fluid flow shear stress. J CellCommun Signal 2010;4(2):79-90.Stubbs, J. R., Idiculla, A., Slusser, J.,Menard, R., & Quarles, L. D. Cholecalciferolsupplementation alters calcitriol-responsivemonocyte proteins and decreasesinflammatory cytokines in ESRD. J AmSoc Nephrol 2010;21(2):353-361.Torres, V. E., Boletta, A., Chapman, A.,Gattone, V., Pei, Y., Qian, Q., Wallace, D.P., Weimbs, T., & Wüthrich, R. P. Prospectsfor mTOR inhibitor use in patientswith polycystic kidney disease and hamartomatousdiseases. Clin J Am Soc Nephrol2010;5(7):1312-1329.Wang, C. J., Creed, C., Winklhofer, F.T., & Grantham, J. J. Water Prescriptionin Autosomal Dominant Polycystic KidneyDisease: A Pilot Study. Clin J Am SocNephrol 2010.Wetmore, J. B. Review: insufficientevidence exists on the benefit of vitaminD in patients with chronic kidney diseasenot requiring dialysis. Ann Intern Med2010;152(8):JC4-12.Wetmore, J. B., Liu, S., Krebill, R., Menard,R., & Quarles, L. D. Effects of cinacalcetand concurrent low-dose vitamin Don FGF23 levels in ESRD. Clin J Am SocNephrol 2010;5(1):110-116.Wetmore, J. B., Palsson, R., Belmont, J.M., Sigurdsson, G., Franzson, L., & Indridason,O. S. Discrepancies between creatinine-and cystatin C-based equations:implications for identification of chronickidney disease in the general population.Scand J Urol Nephrol 2010;44(4):242-250.Wetmore, J. B., Santos, P. W., Mahnken,J. D., Krebill, R., Menard, R., Gutta, H.,& Quarles, L. D. Elevated FGF23 LevelsAre Associated with Impaired Calcium-Mediated Suppression of PTH in ESRD. JClin Endocrinol Metab 2010.Xia, S., Li, X., Johnson, T., Seidel, C.,Wallace, D. P., & Li, R. Polycystindependentfluid flow sensing targetshistone deacetylase 5 to prevent thedevelopment of renal cysts. Development2010;137(7):1075-1084.Yamaguchi, T., Reif, G. A., Calvet, J. P., &Wallace, D. P. Sorafenib inhibits cAMPdependentERK activation, cell proliferation,and in vitro cyst growth of humanADPKD cyst epithelial cells. Am J PhysiolRenal Physiol 2010;299(5):F944-951.Zhang, P., Wang, H., Rowe, P. S., Hu,B., & Wang, Y. MEPE/OF45 as a newtarget for sensitizing human tumour cellsto DNA damage inducers. Br J Cancer2010;102(5):862-866.Pulmonary andCritical Care MedicineDhillon, N. K., Li, F., Xue, B., Tawfik,O., Morgello, S., Buch, S., & O’BrienLadner, A. Effect of Cocaine on HIVmediatedPulmonary Endothelial andSmooth Muscle Dysfunction. Am J RespirCell Mol Biol 2010.Gracia, F., Armien, B., Simpson, S. Q.,Munoz, C., Broce, C., Pascale, J. M.,& Koster, F. Convalescent pulmonarydysfunction following hantavirus pulmonarysyndrome in Panama and the UnitedStates. Lung 2010;188(5):387-391.Latham, H. E., Dwyer, T. T., Gregg, B.L., & Simpson, S. Q. An in vitro studycomparing a peripherally inserted centralcatheter to a conventional central venouscatheter: no difference in static anddynamic pressure transmission. BMCAnesthesiol 2010;10:18.Simpson, S. Q., Spikes, L., Patel, S.,& Faruqi, I. Hantavirus pulmonarysyndrome. Infect Dis Clin North Am2010;24(1):159-173.Pingleton, S. K., Davis, D. A., & Dickler,R. M. Characteristics of qualityand patient safety curricula in majorteaching hospitals. Am J Med Qual2010;25(4):305-311.Pingleton, S.K., Davis DA. Learningabout the education of quality and safetyrequires clinical data. Am J Med, inpress.Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 45

CHAIRMAN’S OFFICESteven W. Stites, MDPeter T. Bohan Professor and Chair(913)588-6000Krista WimberlyAdministrative Coordinator(913) 588-6001Marcia PresslyAdministrative Coordinator(913) 588-6002Paula DaughertyAdministrative Assistant(913) 588-6000ADMINISTRATIONPatrick SteffenSenior Administrator(913) 588-5294Dustin CarrilloAssistant Administrator(913) 588-3982COMMUNICATIONSChristine AdamsSenior Director of Communications(913) 945-5077RESEARCHBuddhadeb Dawn, MDVice Chair for ResearchInternal Medicine ProfessorshipEndowed Professorships held by the faculty in the Department of Internal Medicine:Peter T. Bohan Chair in MedicineDr. Steven W. StitesCapital Federal Masonic Professorship ofthe University of Kansas Cancer CenterDr. Gary DoolittleMaureen and Marvin Dunn, MDProfessorship in Cardiovascular MedicineDr. Buddhadeb DawnRobert P. Hudson/Ralph H. MajorProfessorship in History and Philosophyof MedicineDr. Christopher CrennerKansas Masonic Cancer Research ChairDr. Carol FabianJoy McCann Professorship for Women inMedicine and ScienceDr. Susan PingletonDelbert D. Neis, MD Professorship inCardiovascular DiseasesDr. David WilsonDr. Sam E. Roberts ProfessorshipDr. Leland Graves IIISosland Family Professorship inPreventive MedicineDr. Edward F. EllerbeckHarry Statland EndowedProfessorship in NephrologyDr. Jared GranthamBrenda StewartResearch Administrator(913) 588-3851Darsey DavidsonAdministrative Assistant(913) 588-5293RESIDENCY OFFICELisa Vansaghi, MDDivision DirectorGerri McPhersonResidency Program Coordinator(913) 588-6050KU ENDOWMENTASSOCIATIONPeggy PersonDirector of Development(913) 588-5441Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 46

DIVISIONAL OFFICESAllergy, Immunology andRheumatologyDaniel Stechschulte, MDDivision DirectorKelly HinshawDivision Coordinator(913) 588-6008Cardiovascular DiseasesBuddhadeb Dawn, MDDivision DirectorRenee FalskenAdministrative Assistant(913) 588-6015Bobbi SidorenkovDirector Finance and AdministrationCardiovascular Research Institute(913) 945-7021Clinical PharmacologyPatrick Moriarty, MD, FACP, FACCDivision DirectorJudy HultquistDivision Coordinator(913) 588-6057DermatologyDaniel Aires, MDDivision DirectorSusan KovashAdministrative Assistant(913) 588-3840Endocrinology, Metabolismand GeneticsLeland Graves, III, MDDivision DirectorTiffany AubreyDivision Coordinator(913) 588-6841Gastroenterology/HepatologyMojtaba Olyaee, MDDivision DirectorLiz RamirezDivision Administrator(913) 588-3283General MedicineStewart Babbott, MDDivision DirectorChristy KieserSenior Coordinator(913) 588-5165Hematology/OncologyPeter Van Veldhuizen, MDDivision DirectorBea ColetonDivision Coordinator(913) 588-3802Infectious DiseasesDaniel Hinthorn, MDDivision DirectorJudy SpeerDivision Coordinator(913) 588-6035Nephrology and HypertensionFranz Winklhofer, MDDivision DirectorKelsi RemmertDivision Coordinator(913) 588-6075Office of Scholarly Academic andResearch Mentoring (OSARM)Sally Rigler, MDDivision DirectorJennifer SullivanAdministrative Assistant(913) 588-4031Pulmonary and CriticalCare MedicineAmy O’Brien-Ladner, MDDivision DirectorBarbara RobinsonDivision Coordinator(913) 588-6046Department of Internal Medicine, University of Kansas Medical Center Annual Report 2010 47

Department of Internal Medicine Faculty Giving 2010Dr. Wissam I. El AtrouniDr. Basem AwadhDr. Stewart F. Babbott & Dr. Cecelia BabbottDr. Lisa McNichols CloughDr. Michael Crosser & April S. CrosserDr. Buddhadeb Dawn *Dr. Kottarappat N. Dileepan & Dr. Kanakam DileepanDr. Timothy T. Dwyer III & Diane M. DwyerDr. Leigh M. EckDr. Albert J. EidDr. Leland Graves IIIDr. Dana J. Hawkinson & Courtney Goddard-HawkinsonDr. Daniel R. Hinthorn & Aletha S. HinthornDr. Gerald R. Kerby & Arlis Bergsten Kerby *Dr. Lindy LandzaatDr. Heath E. Latham & Shannon Newton LathamDr. Herbert B. Lindsley & Dr. Carol J. Lindsley *Dr. Chien LiuDr. Barbara P. LukertDr. Fernando Luis Merino & Caroline S. ChabooDr. Patrick M. Moriarty & Lucille M. MoriartyDr. Amy O’Brien-Ladner & Dale Ladner*Dr. Seyed M. Olyaee & Maryam S. Olyaee*Dr. Courtney S. RhudyDr. Sally K. RiglerDr. David C. Robbins & Dr. Linda Colle RobbinsDr. Elena Igorevna SidorenkoDr. Steven Q. Simpson and Dr. Pamela J. Nicklaus*Dr. Daniel J. Stechschulte & Helen C. StechschulteDr. Steven Stites & Dr. Sandra R. Stites *Dr. Ky B. Stoltzfus & Tanya OrtmanDr. Connie K. TengDr. Lisa M. Vansaghi & Dr. Tom VansaghiDr. Stephen K. Williamson & Marta R. Williamson *Dr. Tim Williamson & Dr. Karin Porter-Williamson **Denotes Deans Club member. A Deans Club member gives a $1,000 or more annual gift to the Department.

Art Direction and Design: Sarah Russell, Blackbird Studio, LLCPhotography: Elissa MonroeDepartment of Internal MedicineUniversity of Kansas Medical Center3901 Rainbow Blvd.Mailstop 1022Kansas City, KS 66160www2.kumc.edu/internalmedicine/