Challenges in Establishing the Role of Immunotherapy in Prostate ...

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Challenges in Establishing the Role of Immunotherapy in Prostate ...

Antibody Responses to Prostate-AssociatedAntigens in Patients With Prostatitis andProstate Cancer• Using a phage immunoblot approach, we evaluated IgG responses inpatients with prostate cancer (n = 126), patients with chronic prostatitis(n = 45), and men without prostate disease (n = 53)• RESULTS: We found that patients with prostate cancer or prostatitis haveIgG specific for multiple common antigens. A subset of 23 proteins wasidentified to which IgG were detected in 38% of patients with prostatecancer and 33% patients with prostatitis versus 6% of controls (P < 0.001and P = 0.003, respectively). Responses to multiple members were nothigher in patients with advanced disease, suggesting antibody immuneresponses occur early in the natural history of cancer progression• CONCLUSIONS: These findings suggest an association betweeninflammatory conditions of the prostate and prostate cancer, and suggestthat IgG responses to a panel of commonly recognized prostate antigenscould be potentially used in the identification of patients at risk for prostatecancer or as a tool to identify immune responses elicited to prostate tissueMaricque BB, et al. The Prostate. 2011;71(2):134-146.14

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