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<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Imaging Sciences Pathway ProgramPart <strong>of</strong> a presentation at the 2009 ECEDHA meetingArye NehoraiChair, <strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>The Eugene <strong>and</strong> Martha Lohman Pr<strong>of</strong>essor <strong>of</strong> <strong>Electrical</strong> <strong>Engineering</strong>www.ese.wustl.edu
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Motivation• Imaging sciences are multi-disciplinary,requiring knowledge <strong>of</strong> biology,chemistry, physics, engineering, <strong>and</strong>applied mathematics• Washington University has manyimaging resources <strong>and</strong> experts. It isnationally ranked in the top three <strong>of</strong> NIHfunding for imaging sciences research• Imaging Sciences Pathway emphasizesbiomaging for undergraduate studentsin engineering, the physical <strong>and</strong> lifesciences
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Imaging Sciences Pathway Goals• Educate “renaissance scientists” whose knowledge <strong>of</strong> the physicalsciences, engineering, chemistry, <strong>and</strong> biology will allow them toexplore new frontiers within the various <strong>and</strong> ever-exp<strong>and</strong>ingresearch domains <strong>of</strong> imaging sciences• Provide undergraduate students with extraordinary opportunities tocarry out research with more than 60 leading investigators in theimaging sciences from more than 15 clinical <strong>and</strong> sciencedepartments• Provide undergraduate students in the physical <strong>and</strong> life sciences<strong>and</strong> engineering first-h<strong>and</strong> experience in this exciting area <strong>of</strong>biomedicine
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Imaging Sciences Pathway ProgramConsists <strong>of</strong> two parts:• An introductory freshman/sophomore seminar introduces prospectivePathway students to the diverse imaging sciences research under way inArts & Sciences, the School <strong>of</strong> <strong>Engineering</strong> & Applied Science, <strong>and</strong> theSchool <strong>of</strong> Medicine.• Courses for juniors <strong>and</strong> seniors focus on chemistry, physics, computerscience, engineering, <strong>and</strong> molecular cell biology as they relate to imagingsciences.
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Imaging Sciences Pathway CurriculumCore courses:1) Seminar in Imaging Sciences (BIO 1810)2) Introduction to Cell Biology (BIO 334)Principles <strong>of</strong> Biology I (BIO 2960)DNA Science: A H<strong>and</strong>s-On Workshop (BIO 280)Biochemistry (BIO 4501/CHEM 456)3) Principles & Applications <strong>of</strong> Biological Imaging (BIO 5146)4) Contrast Agents for Biological Imaging (BIO/CHEM 5147)Biological Imaging Technology (ESE 489/589/BME 494)Students completing the ISP requirements receive a Milestone on their transcripts
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>ISP Undergraduate Research• Students choose two faculty mentors fromdifferent disciplines (e.g., engineering <strong>and</strong>biology), with one being the primary mentor• Junior <strong>and</strong> senior Pathway students participate inan interdisciplinary imaging research project inthe lab <strong>of</strong> the primary <strong>and</strong>/or secondary mentor• Students can receive credit for independentresearch• Students also participate in summer researchinternships between their junior <strong>and</strong> senior years;stipends are available through NIH R90 funds
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>FacilitiesThe Pathway makes extensive use <strong>of</strong> the University’s vast imagingresources, which cover the full spectrum from molecularmicroscopy to full body human imaging.
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>BSEE CurriculumImaging Sciences Pathway PlanCourseCreditsBreadth Elective 9Free Electives 4 <strong>of</strong> 11EE Electives 3 <strong>of</strong> 15Total 16
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>BSEE Imaging Sciences Program (Cont.)Imaging Sciences Pathway PlanCoursesCHEM 112AGeneral Chemistry IICHEM 152 GeneralChemistry Lab.BIO 1810 Seminarin Imaging SciencesBIO 2960 Principles<strong>of</strong> Biology IBIO 5146 Principles<strong>and</strong> Applications <strong>of</strong>Biological ImagingESE 489 BiologicalImaging TechnologyCredits321433Total 16• Students participate in imagingresearch projects <strong>and</strong> can receive creditsunder ESE 497 Undergraduate Research.• 16 total units required for ISP withpre‐requisites.• 20 available units in traditionalcurriculum consisting <strong>of</strong> free <strong>and</strong>breadth electives.
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>BSEE Imaging Sciences ProgramCourse SubstitutionsEE Curriculum Flexible Courses Switch to ISP Required + Prerequisite Courses(CHEM 111A, 151 are in BSEE Curriculum)9 units <strong>of</strong> Breadth Electives • 3 units CHEM 112A Gen. Chemistry 2• 2 units CHEM 152 Gen. Chemistry 2 Lab• 4 units BIO 2960 Principles <strong>of</strong> Biology 14 <strong>of</strong> 11 units <strong>of</strong> Free Electives • 1 unit BIO 1810 Seminar In Imaging Sciences• 3 units BIO 5146 Principles <strong>and</strong> Applications <strong>of</strong>Biological Imaging3 <strong>of</strong> 15 units <strong>of</strong> EE Electives • 3 units ESE 489 Biological Imaging TechnologyTotal Units 16• 3 units <strong>of</strong> ESE 497 Undergraduate Research onimaging research projects
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Example: ESE 489/589 BiologicalImaging Technology
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>ESE 489/589 Biological Imaging Technology• Course coordinators <strong>and</strong> modality experts:– J. A. O’Sullivan, ESE– J. P. Culver, Radiology– Y.-C. Tai, Radiology– J. Shimony, RadiologyExperts in EE, physics, biomedical physics,radiology.• Textbook-based:J. L. Prince <strong>and</strong> J. M. Links,Medical Imaging Signals<strong>and</strong> <strong>Systems</strong>, Prentice-Hall, 2006• Four lectures per modality:– Physics, mathematics, imaging– Lab tours <strong>and</strong> original literature critique12ModalitiesFundamentalsRadiographicNuclearOpticalUltrasoundMagnetic ResonanceAvanto 1.5 T MRIScanner
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Biological Imaging TechnologyBiologicalOrgan(e.g. CT, MRI, US)Tissue(e.g. Intrinsic optical imaging<strong>of</strong> cat visual cortex)Cells(e.g. fluorescencemicroscopy)
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>Lab Tours• State-<strong>of</strong>-the art CT <strong>and</strong>PET-CT imaging facilities•• Siemens equipmentBiograph 64/40: PET-CTscannerCT (anatomical image)SOMATOM Definition CT ScannerFused PET-CTPET (functional image)Data (PETCT-165) from R. Laforest <strong>and</strong> M. Mintun, Radiology
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>• Contrasting state-<strong>of</strong>-the-artfacilities with foundationalpapers• Siemens equipmentLiterature CritiqueW. C. Roentgen,Nature, 1896SOMATOM Definition CT Scanner
<strong>Department</strong> <strong>of</strong> <strong>Electrical</strong> & <strong>Systems</strong> <strong>Engineering</strong>• Contrasting state-<strong>of</strong>-the-artfacilities with foundationalpapersLiterature Critique (Cont.)• Siemens equipmentFirst PET machine,designed <strong>and</strong> built atWashington University inSt. LouisBiograph 64/40: PET-CT scannerE. H<strong>of</strong>fman, M. Phelps, N.A. Mullani, C. S. Higgins,<strong>and</strong> M. M.Ter- Pogossian,Instrumentations <strong>and</strong>Physics, 1976