SIOP 2012 – ADVANCE PROGRAMME Saturday 6th October 2012 ...

10:40-10:55A Response-Based ABVD Regimen with or without Radiotherapy for Pediatric Lowand Intermediate Risk Hodgkin Lymphoma in Central america and dominicanrepublic A report from AHOPCAErick Castellanos 1 , Monika Metzger 2 , Soad Fuentes 3 , Armando Peña 4 , FulgencioBaez 5 , Jessika Gamboa 6 , Rosa Nieves 7 , Pedro De Alarcon 810:55-11:10Impact of IFRT Among Pediatric Patients with Chemosensitive Hodgkin Lymphoma: aSubgroup Analysis of the COG AHOD 0031 studyAnne-Marie Charpentier 1 , Debra L. Friedman 2 , Suzanne Wolden 3 , Cindy Schwartz 4 ,Alisha Albert-Green 5 , Kara M. Kelly 6 , Louis Constine 7 , David C. Hodgson 111:10-11:25The Epstein-Barr virus oncogene, LMP1 up-regulates discoidin domain receptor 1and mediates collagen-induced phenotypic changes in the malignant cells ofHodgkin´s lymphoma.Fathima Zumla Cader 1,2 , Martina Vockerodt 1 , Eszter Nagy 1 , Pamela Kearns 1,2 , PaulMurray 111:25-11:40Albumin: A Predictor of EFS in MC Hodgkin LymphomaCindy L Schwartz 1 , Joel A Kaplan 2 , Lu Chen 3 , Robert E. Hutchison 4 , Kara M Kelly 5 ,Suzanne L Wolden 6 , Debra L Friedman 7 , Childrens Oncology Group11:40-11:55IN CHILDHOOD B-CELL NON HODGKIN’S LYMPHOMA (B-NHL) AND MATURE B-CELLACUTE LEUKEMIA (B-AL) WITH CNS DISEASE AT DIAGNOSIS, PATIENTS WITH BLASTS INCSF ARE AT HIGHER RISK OF EVENTVéronique Minard-Colin 1 , Anne Auperin 2 , Guy Leverger 3 , Claudine Schmitt 4 , NadiaAladjidi 5 , Jean Michon 6 , Catherine Patte 111:55-12:10COMPLETE TUMOR RESPONSES IN LYMPHOMA PATIENTS WHO RECEIVE AUTOLOGOUSCYTOTOXIC T LYMPHOCYTES TARGETING EBV LATENT MEMBRANE PROTEINSCatherine Bollard 1 , Stephen Gottschalk 2 , Adrian Gee 2 , Malcolm Brenner 3 , Helen EHeslop 2 , Cliona M Rooney 410:40 – 12:10 Frobisher Room 1Free Paper Session 6 – BRAINChairs: Darren Hargrave and Maura Massimino10:40-10:55Chemotherapy for children with Neurofibromatosis type 1 and progressive LowGrade Glioma: Preliminary outcome analysis from the SIOP-LGG 2004 NF1 StudyEnrico Opocher 1 , Gianluca De Salvo 2 , Astrid Gnekow 3 , David A. Walker 4 , JacquesGrill 5 , Susan V Picton 6 , Amedeo A. Azizi 7 , Pablo Hernàiz Driever 8 , Astrid Sehested 9 ,Elisabetta Viscardi 10 , Giorgio Perilongo 11 , SIOP-E LGG working group

Rinaldi 5 , Rudolf Maibach 6 , Mark Krailo 7 , Dan Aronson 8 , Tomoro Hishiki 9 , IvoLeuschner 10 , Dolores Lopez-Terrada 11 , Dietrich von Schweinitz 4 , Irene Schmidt 4 ,Kenichiro Watanabe 12 , Kenichi Yoshimura 13 , Anna Covezzoli 5 , Marisa deRosa 5 ,Marcio Malogolowkin 14 , Giorgio Perilongo 1514:35-14:50TARGETED THERAPIES FOR PATIENTS WITH ADVANCED FIBROLAMELLARHEPATOCELLULAR CARCINOMA: FROM BENCH TO BEDSIDEIshwaria Mohan Subbiah 1 , Vivek Subbiah 1,2 , Aung Naing 1 , Siqing Fu 1 , Sarina A Piha-Paul 1 , Ahmed O Kaseb 3 , Gerald S Falchook 1 , Dongfeng Tan 4 , Cynthia E Herzog 2 , PeteM Anderson 2 , Razelle Kurzrock 114:50-15:05PROMOTER METHYLATION OF IGFBP3 AND RASSF1 MAY BE USED AS BIOMARKERS FORHIGH-RISK HEPATOBLASTOMAMelanie Eichenmüller 1 , Ivonne Regel 1 , Beate Haeberle 1 , Josef Mueller-Hoecker 2 ,Dietrich von Schweinitz 1 , Roland Kappler 115:05-15:20A GENOME-WIDE ASSOCIATION STUDY IDENTIFIES NEW CANDIDATE LOCI ASSOCIATEDWITH PROGRESSION OF HEPATOBLASTOMA IN JPLT2 STUDY EXPERIENCEEiso Hiyama 1 , Arata Kamimatsuse 1 , Yuka Ueda 1 , Tomoro Hishiki 2 , Michihiro Yano 3 ,Komei Ida 4 , Satoshi Kondo 5 , Kenichiro Watanabe 6 , Takaharu Oue 7 , Tatsuro Tajiri 8 ,Akira Nakagawara 9 , Keiko Hiyama 10 , Japanese Study Group for Pediatric Liver Tumor(JPLT)

SIOP 2012 – ADVANCE PROGRAMMEPlease note that this PDF will be regularly updated.Sunday 7 th October 201208:30 – 09:30 Frobisher Auditorium 1Free Paper Session 10 – BONEChairs: Ross Pinkerton and Michael Paulussen08:30-08:45Ewing’s Sarcoma Family of tumors(ESFT): Does modality of local therapy impactoutcome? - Surgery versus Radiotherapy versus combined multimodal approachTushar Vora 1 , Sameer Rastogi 2 , Girish Chinnaswamy 1 , Brijesh Arora 1 , Siddharth Laskar 3 ,Ajay Puri 4 , Ashish Gulia 4 , Sajid Qureshi 5 , Seema Kembhavi 6 , Subhash Desai 6 , SaralDesai 7 , Nirmala Jambekar 7 , Manjri Dhige 8 , Mary Ann Muckaden 8 , Purna Kurkure 1 ,Shripad Banavali 208:45-09:00Salvage rates and prognostic factors after relapse in children and adolescents withsynovial sarcomaAndrea Ferrari 1 , Gian Luca De Salvo 2 , Patrizia Dall'Igna 3 , Cristina Meazza 1 , FrancescoDe Leonardis 4 , Carla Mazzitti 5 , Maria de Ioris 6 , Michela Casanova 1 , Modesto Carli 7 ,Gianni Bisogno 709:00-09:15RESULTS OF THE IRSG D9602 LOW-RISK PROTOCOL FOR 35 PATIENTS WITH ALVEOLARRHABDOMYOSARCOMA (ARMS), 1997-1999.Richard Raney 1 , Jane Meza 2 , Frederick Barr 3 , John Breneman 4 , Douglas Hawkins 5 ,Andrea Hayes-Jordan 6 , Winston Huh 7 , William Meyer 8 , David Parham 9 , DavidWalterhouse 10 , James Anderson 11 , Childrens Oncology Group, Arcadia, California,USA09:15-09:30Analysis of the value of high dose chemotherapy in relapsed Ewing sarcomapatients and comparison of high dose chemotherapy regimens busulfan-melphalanversus treosulfan-melphalan followed by autologous stem cell transplantationMeybrit Rasper 1,2 , Susanne Jabar 1 , Susanne Amler 3 , Andreas Ranft 1 , HeribertJuergens 1 , Uta Dirksen 1,208:30 – 09:30 Frobisher Room 1Free Paper Session 11 – BRAINChairs: Antony Michalski and Eric Bouffet08:30-08:45Prognostic and therapeutic role of TP53 mutations in medulloblastomasubgroups; therapeutic role of Lithium in abrogation of TP53 mutation associatedradiation resistance.

Nataliya Zhukova 1,2,3 , Dianna Martin 4 , Tatiana Lipman 5 , Pedro Castelo-Branco 6 , CindyZhang 7 , Michael Fraser 8 , Berivan Baskin 9 , Peter Ray 9 , Eric Bouffet 1 , BenjaminAlman 10,11 , Vijay Ramaswamy 12 , Peter Dirks 2,13 , Steven Clifford 14 , Stefan Rutkowski 15 ,Stefan Pfister 16 , Michael Taylor 2,13 , David Malkin 3,17 , Cynthia Hawkins 2,18 , Uri Tabori 2,3,1708:45-09:00Final Report of Outcome of Infants and Young children with Non-Glial CNS TumorsTreated on the “Head Start” III Prospective Clinical Trial, 2003—2009Girish Dhall, Ji Lingyun, Tom Belle Davidson, Raj Venkatramani, Wafik Zaky, KelleyHaley, Richard Sposto, Jonathan Lester Finlay09:00-09:15Outcome of children treated for Intracranial ependymoma: the First SIOP trial.Richard Grundy 1 , Tim Jaspan 1 , Donald Macarthur 1 , Sophie Wilne 1 , John-Paul Kilday 1 ,Conor Mallucci 2 , Nicky Thorp 3 , Martin English 4 , Kathryn Robinson 5 , Sarah Nicholson 6 ,Maura Massimino 7 , Eric Bouffet 8 , David Ellison 9 , David Machin 5 , International Societyof Paediatric Oncology09:15-09:30Molecular Subgroups of Paediatric EpendymomaHendrik Witt 1,2 , Steve Mack 3 , David T W Jones 1 , Natalie Jäger 4 , Sebastian Bender 1 ,Marina Ryzhova 5 , Paul A Northcott 1 , Marc Remke 3 , Elke Pfaff 1 , Theophilos Tzaridis 1 ,Martin Sill 6 , Axel Benner 6 , Ruth Isserlin 7 , Till Milde 2,8 , Nalin Gupta 9 , Matthias Karajannis 10 ,Daniel W Fults 11 , Adrian Stütz 12 , Tobias Rausch 12 , Jan Korbel 12 , Andreas E Kulozik 2 , GaryBader 7 , Andreas von Deimling 13,14 , Olaf Witt 2,8 , James T Rutka 3 , Peter Lichter 15 , AndreyKorshunov 13,14 , Michael D Taylor 3 , Stefan M Pfister 1,208:30 – 09:30 Frobisher Room 4Free Paper Session 12 – EPIDEMIOLOGYChairs: Jaqueline Clavel and Michael Murphy08:30-08:45Age-incidence patterns of lymphomas in children and young adults in England1995-2008Robert David Alston 1 , Jillian Maud Birch 1 , Martin McCabe 2 , Sarah Wallingford 3 ,Robert Carr 408:45-09:00The risk of childhood cancer with symptoms/signs presenting in primary care in theUK: a population-based case-control studyRachel Dommett 1 , Theresa Redaniel 2 , Richard Martin 2 , Willie Hamilton 3 , MichaelStevens 409:00-09:15Colombian health system inequities and its impact in childhood cancer survival:Initial Results of the First Pediatric Cancer Surveillance System in the CountryOscar Ramirez 1 , Maria Paula Aristizabal 2 , Luis Eduardo Bravo 3 , on behalf ofVIGICANCER working group

09:15-09:30Delayed diagnosis of children with cancer in Recife, Brazil manifests as advanceddisease and significantly decreases event-free survivalScott Howard 1 , Raul Ribeiro 1 , Marcia Pedrosa 2 , Mecneide Lins 2 , Kaline Maciel 2 ,Mariana Oliveira 2 , Arli Pedrosa 2 , Solange Campos 2 , Francisco Pedrosa 210:40 – 12:10 Frobisher Auditorium 1Free Paper Session 13 – NEUROBLASTOMAChairs: Ruth Ladenstein and TBC10:40-10:55Factors that contribute to inferior survival of low-risk stage 2B neuroblastomapatients: A Children’s Oncology Group studyDouglas R Strother 1 , Wendy B London 2,3 , Edward Tagge 4 , Hiroyuki Shimada 5 , Susan LCohn 6 , Childrens Oncology Group10:55-11:10Tandem high-dose chemotherapy (HDC) with thiotepa and Bu-Mel and autologousstem cell transplantation (ASCT): the way to improve very high risk neuroblastomapatients prognosis?Claudia Pasqualini 1 , Christelle Dufour 1 , Gisèle Goma 2 , Marie-Anne Raquin 1 ,Dominique Valteau-Couanet 111:10-11:25Detection of mRNA by RT-qPCR in bone marrow taken at diagnosis and postinductiontherapy predicts event-free survival in children with high-riskneuroblastoma; a SIOPEN Molecular Monitoring Group study.Susan Ann Burchill 1 , Virginie F. Viprey 1 , Walter M. Gregory 2 , Maria-Valeria Corrias 3 ,Andrei Tchirkov 4 , Katrien Swerts 5 , Ales Vicha 6 , Sandro Dallorso 3 , Penelope Brock 7 ,Roberto Luksch 8 , Dominique Valteau-Couanet 9 , Vassilios Papadakis 10 , GenevieveLaureys 5 , Ruth Ladenstein 11 , SIOPEN11:25-11:40Quantification of bone marrow disease in high risk neuroblastoma patients with anti-GD2 immunocytochemistry at diagnosis and at end of induction therapy – impact onevent-free and overall survival. A SIOPEN High Risk Study.Klaus Beiske 1 , Angela Sementa 2 , Marta Jeison 3 , Ales Vicha 4 , Jerzy Klijanienko 5 ,Vassilios Papadakis 6 , Yania Yañez 7 , Aleksandra Wieczorek 8 , Ariane Boubaker 9 , MiladaCvancarova 10 , Ulrike Pötschger 11 , Ruth Ladenstein 11 , Katrien Swerts 1211:40-11:55A Systematic Review of 131 I- meta Iodobenzylguanidine Therapy in NeuroblastomaJennifer E Gains 1 , Jayne S Wilson 2 , Keith Wheatley 2 , Mark N Gaze 111:55-12:10Molecular imaging pattern at diagnosis distinguishes the genomic type andtreatment outcome of neuroblastoma

Yen-Lin Liu 1,2 , Kai-Yuan Tzen 3 , Meng-Yao Lu 4 , Hsiu-Hao Chang 4 , Shiann-Tarng Jou 4 ,Yung-Li Yang 4 , Dong-Tsamn Lin 4 , Kai-Hsin Lin 4 , Yi-Ning Su 5 , Wen-Ming Hsu 6 , NationalTaiwan University Neuroblastoma Study Group10:40 – 12:10 Frobisher Room 1Free Paper Session 14 – GERM CELLChairs: Lindsay Frazier and James Nicholson10:40-10:55Progression free survival of Patients (pts) > 10 years with advanced testicular GCT isinferior to those < 10 years. Results of the MAKEI 96 Protocol for Extracranial GermCell Tumors (GCT)Gabriele Calaminus 1 , Dominik T Schneider 2 , Stephan Schönberger 3 , Ivo Leuschner 4 ,Katja Heinemann 1 , Ulrich Göbel 510:55-11:10Salvage therapy for refractory or recurrent pediatric germ cell tumors: the FrenchSFCE experienceCecile Faure-Conter 1 , Daniel Orbach 2 , Claire Cropet 3 , Marie Cecile Baranzelli 4 ,Helene Martelli 5 , Estelle Thebaud 6 , Cecile Verite 7 , Angelique Rome 8 , Sylvie Fasola 9 ,Nadege Corradini 10 , Nathalie Rocourt 11 , Didier Frappaz 1 , Nicolas Kalfa 12 , CatherinePatte 1311:10-11:25NON SEMINOMATOUS GCT (NSGCT) IN CHILDREN: FINAL LONG TERM RESULTS OF THEFRENCH SFOP/ SFCE TGM 95 PROTOCOL .Catherine Patte 1 , Daniel Orbach 2 , Hélène Sudour 3 , Cécile Vérité 4 , VirginieGandemer 5 , Hervé Rubie 6 , Sylvie Fasola 7 , Cécile Conter 8 , Angelique Rome 9 , HélèneMartelli 8 , Marie-Cécile Baranzelli 311:25-11:40Do Germinoma elements in Intracranial Non-Germinomatous Germ Cell Tumors(NGGCT) increase the risk of ventricular relapses?Gabriele Calaminus 1 , James Nicholson 2 , Claire Alapetite 3 , Rolf-Dieter Kortmann 4 ,Maria Luisa Garre 5 , Umberto Ricardi 6 , Frank H Saran 7 , Didier Frappaz 811:40-11:55EpCAM - a novel molecular target for the treatment of pediatric germ cell tumorsDaniela Topolar 1 , Gabriele Calaminus 2 , Vera Okpanyi 3 , Martin Fabritius 1 , SebastianHeikaus 4 , Nikolas H. Stoecklein 5 , Dominik T. Schneider 6 , Arndt Borkhardt 3 , DagmarDilloo 1 , Stefan Schönberger 111:55-12:10LIN28 is over-expressed in malignant germ-cell-tumours, resulting in let-7 downregulationand increased levels of pro-oncogenic gene targetsMatthew Murray 1,2 , Harpreet Saini 3 , Charlotte Siegler 1 , Jennifer Burrows 1 , Emily Barker 1 ,Stijn van Dongen 3 , Dawn Ward 1 , Ian Groves 1 , Cinzia Scarpini 1 , Mark Pett 1 , ClaireThornton 4 , Anton Enright 3 , James Nicholson 2 , Nicholas Coleman 1,5

10:40 – 12:10 Frobisher Room 4Free Paper Session 15 – LATE EFFECTSChairs: Adam Glaser and Tomasz Szcepanski10:40-10:55Secondary cancers among children diagnosed with acute lymphoblastic leukemiafrom L84-11 to L99-15 Tokyo Children’s Cancer Study Group protocolsYasushi Ishida 1,2 , Miho Maeda 2 , Chikako Kiyotani 2 , Yuki Aoki 2 , Yoko Kato 2 ,Shoko Goto 2 , Sachi Sakaguchi 2 , Kenichi Sugita 2 , Mika Tokuyama 2 , NaoyaNakadate 2 , Eizaburo Ishii 2 , Masahiro Tuchida 2 , Ryota Hosoya 1,2 , Tokyo ChildrensCancer Study Group10:55-11:10Thyroid carcinomas in long term childhood cancer survivorsFlorent de Vathaire 1,2,3 , Nadia Haddy 1,2,3 , Mike Hawkins 4 , Chiraz El-Fayech 1,2,3 , CécileTeinturier 1 , Odile Oberlin 5 , Cristina Veres 1,2,3 , Hélène Pacquement 6 , Martine Munzer 7 ,Tan Dat N'Guyen 7 , Pierre-Yves Bondiau 8 , Delphine Bercherie 9 , Anne Laprie 9 , IbrahimaDiallo 2,3,10 , Carole Rubino 2,3,1011:10-11:25Prediction of Excess Risks of Radiation-Induced Cardiac Mortality and SecondaryCancers after Radiotherapy for Hodgkin’s LymphomaAllison Toltz 1 , Naomi Shin 1 , Cecile Laude 2 , David Roberge 3 , Carolyn Freeman 2 , JanSeuntjens 1 , William Parker 111:25-11:40Ischemic and hemoragic cerebrovascular diseases following childhood cancertreatment. Dose response with brain radiation doseChiraz El Fayech 1,2,3 , Nadia Haddy 2,3,4 , Cristina Veres 2,3,4 , Catherine Guibout 2,3,4 ,Hélène Pacquement 5 , Odile Oberlin 6 , Cécile Teinturier 4 , Ibrahima Dialllo 2,3,4 , Florentde Vathaire 1,2,311:40-11:55Cardiac diseases following childhood cancer treatment: Cohort studyNadia Haddy 1 , Stéphanie Diallo 2 , Chiraz El-Fayech 2 , Boris Schwartz 2 , François Pein 3 ,Cristina Veres 2 , Odile Oberlin 4 , Catherine Guibout 2 , Helene Pacquement 5 , Pierre-YvesScarabin 6 , Xavier Jouven 7 , Mike Hawkins 8 , Jean Chavaudra 9 , Ibrahima Diallo 2 , Florentde Vathaire 211:55-12:10Iron overload in children undergoing cancer treatment: a clinical study.Maëlle de Ville de Goyet 1,2 , Stephane Moniotte 2,3 , Francis Veyckemans 4 , AnnieRobert 2,5 , Bénédicte Brichard 1,213:50 – 15:20 Frobisher Auditorium 1Free Paper Session 16 – PSYCHOSOCIAL

13:50-14:05Anxiety and depression in fathers and mothers of children with a life-threatening or achronic diseaseHedy van Oers 1 , Lotte Haverman 1 , Perrine Limperg 1 , Alice van Dijk-Lokkart 2 , HeleenMaurice-Stam 1 , Martha Grootenhuis 114:05-14:20Utility of parental intake forms to identify childhood cancer survivors with behavioraladjustment problemsClaire Mason, Christopher Recklitis14:20-14:35Relationship between Parent-Reported Cognition and Quality of Life Reported byPediatric Oncology PatientsJin-Shei Lai 1 , David Cella 1 , Jennifer Beaumont 1 , Stewart Goldman 214:35-14:50Pediatric Research Participation Questionnaire for AYA with CancerLamia Barakat 1,2 , Lisa Schwartz 1,2 , Anne Reilly 1,2 , Janet Deatrick 1,3 , Veronica Chavez 1 ,Valerie Mondestin 1 , Frank Balis 1,214:50-15:05Information needs in childhood cancer survivors: What they got and what they wantGisela Michel 1 , Stefan Essig 1 , Micòl E Gianinazzi 1 , Nicolas X von der Weid 2 , Claudia EKuehni 115:05-15:20Follow-Up Care of Adolescent Cancer Survivors: The Role of Health-BeliefsJudith Lupatsch 1 , Corina S Rueegg 1 , Laura Wengenroth 1 , Marc Oliver Teuffel 2 ,Claudia E. Kuehni 1 , Gisela Michel 113:50 – 15:20 Frobisher Room 1Free Paper Session 17 – BRAIN13:50-14:05Nestin protein expression discriminates WHO II ependymoma with poor outcomeTill Milde 1,2 , Thomas Hielscher 3 , Hendrik Witt 2,4 , Marcel Kool 4 , Stephen C. Mack 5 ,Hedwig E. Deubzer 1,2 , Ina Oehme 1 , Marco Lodrini 1 , Axel Benner 3 , Michael D. Taylor 5 ,Andreas von Deimling 6,7 , Andreas E. Kulozik 2 , Stefan M. Pfister 2,4 , Olaf Witt 1,2 , AndreyKorshunov 6,714:05-14:20The novel human high-risk ependymoma stem cell model DKFZ-EP1NS reveals thedifferentiation-inducing potential of treatment with the histone deacetylase inhibitorvorinostatTill Milde 1,2 , Susanne Kleber 3 , Andrey Korshunov 4,5 , Hendrik Witt 2,6 , Thomas Hielscher 7 ,Philipp Koch 8 , Hans-Georg Kopp 9 , Manfred Jugold 10 , Hedwig E. Deubzer 1,2 , InaOehme 1 , Marco Lodrini 1,2 , Hermann-Josef Gröne 11 , Axel Benner 7 , Oliver Brüstle 8 ,Andreas vonDeimling 4,5 , Andreas E. Kulozik 2 , Stefan M. Pfister 2,6 , Ana Martin-Villalba 3 , Olaf Witt 1,2

14:20-14:35Radiation Dose Effect in Pediatric High Grade Glioma: Results of the HIT-GBM-DatabaseJohannes E Wolff 1 , Rolf Kortmann 2 , Andreas Faldum 3 , Torsten Pietsch 4 , RobertKwiecin 5 , Monika Warmuth-Metz 6 , Stefan Rutkowski 7 , Christof Kramm 814:35-14:50Hotspot mutations define distinct epigenetic and biological subgroups of pediatricand young adult glioblastomaDominik Sturm 1 , Hendrik Witt 1,2 , Volker Hovestadt 3 , Dong-Anh Khuong-Quang 4 , DavidTW Jones 1 , Carolin Konermann 5 , Anders M Lindroth 5 , Elke Pfaff 1 , Andrey Korshunov 6 ,Marina Rizhova 7 , Till Milde 2,8 , Olaf Witt 2,8 , Marc Zapatka 3 , Xiao-Yang Liu 4 , V PeterCollins 9 , Marcel Kool 1 , Guido Reifenberger 10 , Peter Lichter 3 , Christoph Plass 5 , NadaJabado 4 , Stefan M Pfister 114:50-15:05Hypofractionated radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): Aprospective controlled randomized trial.Soha Ahmed 1 , Mohamed S. Zaghloul 2 , Eman Eldebawy 315:05-15:20Nimotuzumab and vinorelbine concomitantly to radiation and as maintenance fordiffuse pontine glioma in childhood: promising results on a series of 20 patientsMaura Massimino 1 , Veronica Biassoni 2 , Lorenza Gandola 3 , Elisabetta Schiavello 2 ,Emilia Pecori 3 , Paolo Potepan 4 , Filippo Spreafico 2 , Michela Casanova 2 , PiergiorgioModena 5 , Felice Giangaspero 6,7 , Ferdinand Bach 813:50 – 15:20 Frobisher Room 4Free Paper Session 18 – LEUKAEMIAChairs: Tomasz Szczepanski and Chi-Kong Li13:50-14:05Risk of Secondary Malignant Neoplasms in Survivors of Childhood AcuteLymphoblastic LeukemiaStephanie M. Perkins 1 , Eric T. Shinohara 1 , Haydar A. Frangoul 214:05-14:20Second Neoplasms after Treatment of Childhood Acute Lymphoblastic LeukemiaKjeld Schmiegelow 1 , Mette Levinsen 2 , Andrea Biondi 3 , Andishe Attarbaschi 4 , AndreBaruchel 5 , Mini Devidas 6 , Gabriele Escherich 7 , Brenda Gibson 8 , Christiane Heydrich 9 ,Keizo Horibe 10 , Yasushi Ishida 11 , Der-Cherng Liang 12 , Rob Pieters 13 , Caroline Piette 14 ,Ching-Hon Pui 15 , Susana Raimondi 15 , Lewis Silverman 16 , Martin Stanulla 17 , Batia Stark 18 ,Naomi Winick 19 , Maria Grazia Valsecchi 20 , AEIOP, BFM-Austria, BFM, COALL, DCOG,COG, DFCI, EORTC, FRALLE, INS, JAPAN, NOPHO, St Jude Childrens ResearchHospital, TPOG, UK

14:20-14:35NO DIFFERENCE IN EFS AND OS AFTER HIGH VERSUS LOW DOSE METHOTREXATEDURING CONSOLIDATION TREATMENT OF CHILDHOOD ACUTE LYMPHOBLASTICLEUKEMIA IN INTERMEDIATE RISK PATIENTS: RESULTS OF RANDOMISED MB 2002 STUDYAlexandr Karachunskiy 1 , Julia Roumiantseva 1 , Svetlana Lagoiko 1 , Olga Alejnikova 2 ,Dimitry Litvinov 1 , Natalia Ponomareva 3 , Konstantin Kondratchik 4 , AnastasiaShamardina 5 , Julia Abugova 1 , Ekaterina Mansurova 1 , Natalia Judina 6 , OlgaStreneva 7 , Arend von Stackelberg 8 , Alexandr Rumyantsev 1 , Günter Henze 8 , Moscow -Berlin Study Group14:35-14:50Outcome of Children Treated for Relapsed Acute Lymphoblastic Leukemia inCentral AmericaStacey Marjerrison 1 , Federico Antillion 2 , Ligia Fu 3 , Roberto Vasquez 4 , Lillian Sung 114:50-15:05Frequencies and prognostic impact of RAS mutations in MLL-rearranged AcuteLymphoblastic Leukemia in infantsEmma M.C. Driessen 1 , Eddy HJ van Roon 1 , Jill A.P. Spijkers-Hagelstein 1 , PaulineSchneider 1 , Paola de Lorenzo 2 , Maria Grazia Valsecchi 2 , Rob Pieters 1 , Ronald WStam 115:05-15:20Outcome of acute lymphoblastic leukemia (ALL) patients with MLL generearrangements (MLLr) treated on contemporary Children’s Oncology Group (COG)protocolsMignon L. Loh 1 , Elizabeth A. Raetz 2 , Kelly W Maloney 3 , Eric C Larsen 4 , Michael JBorowitz 5 , Andrew J Carroll 6 , Meenakshi Devidas 7 , Nyla A. Heerema 8 , Stephen B.Linda 7 , Brent L. Wood 9 , Julie Gastier-Foster 10 , Cheryl L. Willman 11 , Naomi J. Winick 12 ,Stephen P. Hunger 13 , William L. Carroll 2 , Childrens Oncology Group