Cover Introduction ProSure Clinical Studies ... - Abbott Nutrition

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Cover Introduction ProSure Clinical Studies ... - Abbott Nutrition

CoverInfluence of nutritional parameters including bioelectrical impedance and systemicinflammatory response on quality of life and prognosis in advanced non-small cell lungcancer patients naive to chemotherapy: a prospective studySánchez-Lara K, Turcott JG, Juárez E, Guevara P, Nuñez-Valencia C, Flores D, Oñate-Ocaña, LF, Arrieta OPresented in part as a poster at the 14th World Conference on Lung Cancer of the International Association for the Study of LungCancer, July 3-7, 2011, Amsterdam, The NetherlandsIntroductionProSureClinical StudiesSupportingPublicationsPatients with advanced non-small cell lung cancer (NSCLC) whowere naive to treatment with good performance status (ECOG 0-2)were included in this prospective, randomized, single-blind study.Objective:To evaluate the influence of nutritional parameters on quality life andsurvival in advanced NSCLC patients.Study Design:• Study Population: Patients with advanced NSCLC, n =119• length of Study: One week before treatment throughcompletion of two courses of chemotherapy ~ 2 months• Intervention: 2 servings ProSure (240 mL/serving) orisocaloric diet with nutritional assessmentOutcomes:• Malnutrition measured by Subjective Global Assessment (SGA),weight loss >10%, body mass index (BMI) >24 was associatedwith a decrease in the majority of quality of life (QoL) domains.• Patients with ECOG 2 and malnutrition parameters showedlower overall survival (OS); however after multivariate analysis,ECOG 2 (HR 2.7 [95% CI 1.5-4.7] P =0.001), phase angle ≤ 5.8(3.02 [1.2-7.11] P =0.011) and SGA (2.7 [95% CI 1.31-5.5] P=0.005) were associated with poor survival.• Patients were divided into low, medium, and high risk groupsaccording to regression coefficients with OS at 1 year of 78.4%,53% and 13.8%, respectively.EPA -eicosapentaenoic acid

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