Multiwave PROMicrowave Reaction Systemfor Synthesis::: Excellence in Microwave Synthesis
Multiwave PROChallenging technologyAnton Paar has been working in the field of microwave technology for more than three decades.Using high-quality materials and innovative solutions, Anton Paar defines the standard for toplevelinstruments.The Multiwave PRO platform serves two groups: professionals in synthetic chemistry and traceanalysis. This brochure focuses on the use of Multiwave PRO as a microwave reaction systemfor parallel synthesis.One for allDo you need a small instrument for method development or a large instrument for the multigramscale? Now there is no need to choose: Multiwave PRO serves both. You can upgrade thesystem to cover different scales at any time by just adding rotors.Save ressources by reducing reaction timesWhenever time equals money, microwave synthesis is the method of choice. Parallel synthesiswith Multiwave PRO saves processing time in any scale. The combination of sealed vesseltechnology with reaction conditions beyond the boiling point of the applied solvent significantlyreduces the reaction time.Get in touch with your microwave synthesis systemMultiwave PRO has an on-board PC which provides an intuitive and multilingual state-of–theartsoftware solution. Its large color touchscreen enables convenient operation and is easy toread from a distance. The standardEthernet connection allows networkprinting of in-situ generatedexperiment reports. Data storage onan USB device is also supported.Close to youFor the entire working life of yourMultiwave PRO, specialists fromAnton Paar are at your service. Withsubsidiaries and sales partnersworldwide, you are close to anexperienced team which speaksyour language and providesapplication support and training.
Excellence in Microwave SynthesisVariety of configurationsWith its diverse rotor types Multiwave PRO serves allscales from milligram to multigram synthesis in chemicallaboratories. For your special needs in parallel synthesiswe offer a family of high-throughput rotors in plate formattogether with well-established scale-up rotors.➤ Reaction screening with a new dimensionThe microtiter plates are made from silicon carbide and sealable.With this equipment you can process up to 192 high-temperatureand high-pressure reactions at a time.➤ Parallel optimization in different solventsRotor configurations utilizing silicon carbide allow the use of differentsolvents in the same experiment. With Multiwave PRO you cangenerate libraries with up to 96 members under utmost temperaturehomogeneity.➤ Scale up at optimized conditionsMultiwave PRO masters the liter scale with 16 parallel multigramreactions using the identical protocols from previous reactionscreening and optimization steps.➤ Unrivaled special applicationsUp to 8 multigram reactions can be performed simultaneouslyutilizing gaseous reagents or even applying near-critical waterconditions.
Reaction Screening &Method Optimization➤ High-throughput rotors for methoddevelopmentApplications related to drug development,proteomics, forensics and similar research areaspredominantly deal with small quantities.A range of small-scale high-throughput rotors forMultiwave PRO perfectly match the requirements ofmicrowave-assisted parallel method development.➤ High reproducibility with siliconcarbideUsing silicon carbide plates ensures the utmosttemperature homogeneity in plate format. Thissignificantly increases the reproducibility of chemicalreactions. With these systems any solvent can beemployed as consistent microwave absorptivity isensured by the SiC plates.➤ Plate chemistry at hightemperatures and pressuresAn aluminum sealing mechanism for the microtiterplates allows you to perform plate chemistry atelevated temperatures and pressures. This meansthe same microwave conditions can be applied forsubsequent scaling up from the initial idea to gramscalesynthesis.➤ Easy and efficient librarygenerationYour optimized procedures for valuable scaffolds orintermediates can be directly performed in the entrymodel, Rotor 64MG5. This economical configurationenables seamless preparation of up to 64 derivativesin one go. Focused product libraries can be quicklyprepared in parallel in a single experiment employingidentical reaction conditions for all building blockcombinations.
A Quicker Route toYour ResultsMicrowave irradiation is a modern tool for synthesisapplications. The route it provides to your results is4 quick4 precise4 economicalWhen applying microwave technology, you do not needto change your usual procedures. Simply continue yourchemistry but heat more effectively with microwaves.Your routine tools remain:4 common microtiter plate processing,4 standard HPLC/GC vials,4 any typical organic solvents.There is no need for reoptimization with microwaveabsorbingsolvents or for product transfer to analyzer vials.The plate format fits any standard analytic autosampler.Rotor 4x48MC 4x20MGC 4x24MG5 64MG5Positions 192 80 96 64Reaction container 6x8 SiCmicrotiter plateHPLC/GC vials in5x4 SiC plateGlass vials in6x4 SiC plateGlass vials inPTFE holderReaction controlRemote IR controlRemote IR control of each SiC plateof 16 positionsOperation volume 0.02 mL to 0.3 mL 0.1 mL to 1.5 mL 0.3 mL to 3.0 mLOperationparameters200 °C @ 20 bar (290 psi)Max. designpressure55 bar (800 psi) 33 bar (480 psi)Typical applicationsReactionscreening,combinatorialchemistryMethoddevelopment,proteomics,forensicsParalleloptimization,library generationLibrary generation
Large-scale & HighperformanceSynthesis➤ Scale-up rotors for large-scaleparallel synthesisThe large-scale rotors for Multiwave PRO meet therequirements of multigram applications and highperformancesynthesis. The vessels used for largescalesynthesis are modular and interchangeable,using the same vessel caps and liners. Opening andsealing Multiwave PRO’s rotors, vessels and sensorsis quick and simple - just use your hands. This toolfreehandling is unique to Anton Paar and simplifiesthis frequently repeated work step.Precisely tooled fluoropolymer liners and sealsallow the processing of various chemical reactionsin solution and in solid phase. Thick-walled quartzvessels are available which withstand extremeconditions up to 300 °C and 80 bar. These aresuitable even for near-critical water chemistry.➤ Precise reaction controlAn immersing temperature probe in a referencevessel combined with infrared sensors monitoringthe external vessel temperature provide utmostaccuracy in the control of reaction conditions. Anadditional hydraulic pressure system simultaneouslymonitors the pressure in all vessels of Rotor 8N.The sensors are already installed and ready for use.For convenient handling, the sensors transfer data tothe Multiwave PRO controller wirelessly, so you donot need to connect cables before loading the rotor.➤ Safe and smooth operationMultiwave PRO’s high overpressure toleranceprovides trouble-free operation even under extremeconditions. To ensure a safe working environment,pressure is released and noxious vapors areexhausted automatically before you open the rotor.
Efficient Scale-up➤ Direct scalability up to themultigram rangeAll methods developed in the high-throughputrotors can be directly transferred to the scale-uprotors. With a capacity of about 15 g per vessel aproductivity of approximately 200 g product per runcan be achieved.➤ Scale-up with low-absorbingsolventsTo enable scale-up of methods utilizing low-absorbingsolvents Multiwave PRO uses passive-heatingelements made from silicon carbide. Adding theseto the vessels enables efficient heating of mixturescontaining non-polar solvents.➤ Create a gas atmosphere in eachvesselAn ingeniously simple gas loading system enablesyou to create a reactive or inert gas atmosphereindividually in each vessel. Pressures up to 20 barcan be applied prior to reactions for safe andeffective syntheses with sensitive substrates andgaseous reagents.Rotor 48MF50 16MF100 16HF100 8NXF100 8NXQ80No. of vessels 48 16 8ReactioncontrolOne reference vessel with immersing temperatureprobe and pressure sensorRemote IR control in 16 positionsOne reference vessel withimmersing temperature probeRemote IR control in all positionsLiner material PFA PTFE-TFM n/aPressure jacket PEEK Ceramic QuartzVolume 50 mL 100 mL 80 mLOperationparametersMax. designpressureTypicalapplications200 °C @ 20 bar (290 psi)60 bar(870 psi)240 °C @ 40 bar(580 psi)115 bar(1670 psi)Multigram library generation, parallel scale-up,synthesis of key intermediates, nanomaterials260 °C @ 60 bar(870 psi)Pre-pressurizedreactions,nanomaterials140 bar(2000 psi)300 °C @ 80 bar(1160 psi)Near-criticalwater chemistry,nanomaterials
Fotos: Croce & WirAnton Paar ® GmbHAnton-Paar-Str. 20A-8054 GrazAustria - EuropeTel: +43 (0)316 257-0Fax: +43 (0)316 257-257E-mail: email@example.comWeb: www.anton-paar.comInstruments for:Density & concentrationmeasurementRheometry & viscometrySample preparationMicrowave synthesisColloid scienceX-ray structure analysisRefractometryPolarimetryHigh-precision temperaturemeasurementSpecificationssubject to changewithout notice.04/12 D19IP004EN-A