Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ...
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<strong>Development</strong> Strategies vsOutsourcing OptionsCommon strategies to overcome impacts <strong>of</strong>low solubility on product development:– Salt formation– Particle size reduction• Milling• Nanosizing– Conversion to amorphous form/high-energy solid– Solid dispersion– Solubilization– Lipid-based drug delivery4To save time and resources in productdevelopment, relatively simpler approachesshould be tried first.– Which <strong>of</strong> them should we outsource?
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