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microRNA• Mature microRNAs areBiogenesis:single stranded RNAs~22nt in length• Function in the posttranscriptionalregulationof gene expressionpredominantly throughbase-pairing with the3’UTR of target mRNAcausing• mRNA cleavage anddegradation• Inhibition of proteintranslationSeed region:Bases 2- 8 at the 5’ region of the maturemicroRNA.Level of complementarity in this region willdetermine efficiency of binding to thetarget.
Impact of microRNA regulation• Sanger miRBase Sequence Database - Release16.0 (Sept. 2010) contains 1212 mature humanmiRNA• Algorithm for the prediction of microRNA targets• MicroCosm• TargetScan• PicTar• Each miRNA is predicted d to have between 10’sto 100’s of mRNA targets
Page 1: Widespread Dysregulation ofMiRNAs i
Page 5 and 6: Advantages of looking at miRNA prof
Page 7 and 8: microRNA signatures• Already esta
Page 9 and 10: MiRNAs Differentially Expressed inN
Page 13 and 14: A miRNA expressionprofile associate
Page 15 and 16: Result: miRNA expression signature
Page 17 and 18: Stratification of 11q− tumors bas
Page 19 and 20: Conclusion• Our work identifies a

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