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Medicinal Chemistry Course

Medicinal Chemistry Course

Concentration of the

Concentration of the protonated omeprazoleform in the acidic compartment of the parietal cellC H 3OCH 3CH 3O+N CH 2SHH +HNNOCH 3C H 3OCH 3CH 3ON CH 2SHNNOCH 3SHH + ,K + -ATPaseCytosolLindberg / von UngeC H 3OCH 3CH 3ON CH 2SHNNOCH 3Blood

Transformation of omeprazole to sulfenamide andthe inhibitory reaction with H + ,K + -ATP-aseH 3CCH 3O N : NH 3C CH 2S NOHH 3CCH 3OCH 33 stepsH +N+CH 2SNNSHOCH 3OCH 3H + ,K + -ATPaseLindberg / von Unge

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