Gruss_CV (PDF / 348.3 KB) - CellNetworks

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Gruss_CV (PDF / 348.3 KB) - CellNetworks

Prof. Dr. Oliver Gruss

Zentrum für Molekulare Biologie (ZMBH)

DKFZ ZMBH Alliance

D-69120 Heidelberg, Germany

Phone: +49-(0)6221-54 6815

Fax: +49-(0)6221-54 5893

Email

13/10/1967, Münster Professor

SCIENTIFIC VITA

o.gruss@zmbh.uni-heidelberg.de

1989 - 1994 Study of Biochemistry (Regensburg)

1994 - 1998 PhD thesis at the ZMBH, University Heidelberg (with Prof. B. Dobberstein)

1998 - 2003 Post-Doc at EMBL, Heidelberg (with Prof. Iain Mattaj)

2003 - 2010 Junior Group Leader at the ZMBH, University Heidelberg

2010 Professor (non-tenured) for Molecular Biology at the ZMBH

FIELDS OF INTEREST

Cell Biology, Mechanism and Regulation of cell Division and cell cycle control, Ran

regulation of M-Phase and spindle assembly, spindle proteomics; Nuclear organization,

SMN-complex

CURRENTLY FUNDED PROJECTS

DFG Normalverfahren (4 PhD students), Bioquant Promotionskolleg (1 PhD student),

Landesstiftung Baden-Württemberg (1 PhD student), Currently supervision of 6 PhD theses

PUBLICATIONS (since 2000):

Hofmann JC, Husedzinovic A, Gruss OJ. The function of spliceosomal components in open

mitosis. Nucleus, 1, 447-459 (2010)

Gruss, OJ. Nuclear transport receptor goes moonlighting, Nat Cell Biol, 12:703-10 (2010)

Berger SM, Pesold B, Reber S, Schönig K, Berger AJ, Weidenfeld I, Miao J, Berger MR,

Gruss OJ, Bartsch D. Quantitative analysis of conditional gene inactivation using rationally

designed, tetracycline-controlled miRNAs, Nucleic Acid Res, 38:e168 (2010)

Hearst SM, Gilder AS, Sandeep SN, Davis MD, George EM, Whittom AA, Toyota CG,

Husedzinovic A, Gruss OJ, Hebert M. Cajal body formation correlates with differential coilin

phosphorylation in primary and transformed cell lines, J Cell Sci, 122:1872-81 (2009)

Reber S, Over S, Kronja I and Gruss OJ. CaM kinase II Initiates meiotic spindle

depolymerisation independently of APC/C activation, J Cell Biol, 183:1007–17 (2008)


Brunet S, Dumont J, Lee KW, Kinoshita K, Hikal P, Gruss OJ, Maro B and Verlhac MH.

Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.

PLoSOne, 3, e3338 (2008)

Tegha-Dunghu J, Neumann B, Reber S, Krause R, Erfle H, Walter T, Held M, Rogers P,

Hupfeld K, Ruppert T, Ellenberg J and Gruss OJ. Eml3 is a nuclear microtubule binding

protein required for proper alignment of chromosomes in metaphase. J Cell Sci. 121:1718-

26. (2008)

Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW and Karsenti

E. Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle

assembly rate. J Cell Biol. 180(5):867-75 (2008)

Petri S, Grimmler M, Over S, Fischer U and Gruss OJ. Dephosphorylation of SMN by

PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex. J Cell Biol,

179(3):451-65. (2007)

Dumont J, Petri S, Pellegrin F, Terret ME, Bohnsack MT, Rassinier P, Georget V, Kalab P,

Gruss OJ, and Verlhac MH. A centriole- and RanGTP-independent spindle assembly

pathway in meiosis I of vertebrate oocytes. J. Cell Biol. 176(3):295-305. (2007)

Godl K*, Gruss OJ*, Eickhoff J, Wissing J, Blencke S, Weber M, Degen H, Brehmer D, Orfi

L, Horvath Z, Keri G, Muller S, Cotten M, Ullrich A, Daub H.

Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on

cellular kinase signaling. Cancer Res. 2005 Aug 1;65(15):6919-26. *shared first authorship

Gruss OJ, Vernos I.

The mechanism of spindle assembly: functions of Ran and its target TPX2. J Cell Biol. 2004

Sep 27;166(7):949-55. Review.

Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, Gruss OJ, Carazo-Salas RE.

Importin alpha-regulated nucleation of microtubules by TPX2. EMBO J. 2003 May

1;22(9):2060-70.

Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Sillje H, Karsenti, E, Mattaj IW,

Vernos I.

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle

formation in HeLa cells. Nat Cell Biol. 2002 Nov;4(11):871-9.

Kufer TA, Sillje HH, Korner R, Gruss OJ, Meraldi P, Nigg EA.

Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 2002 Aug

19;158(4):617-23.

Hetzer M, Gruss OJ, Mattaj IW.

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear

envelope assembly. Nat Cell Biol. 2002 Jul;4(7):E177-84. Review.

Carazo-Salas RE, Gruss OJ, Mattaj IW, Karsenti E.

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitoticspindle

assembly. Nat Cell Biol. 2001 Mar;3(3):228-34.

Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos

I, Karsenti E, Mattaj IW.


Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2

activity. Cell. 2001 Jan 12;104(1):83-93.

Hetzer M, Bilbao-Cortes D, Walther TC, Gruss OJ, Mattaj IW.

GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell. 2000,

Jun;5(6):1013-24.

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