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3 years ago

Molecular Genomics slides - Brainmapping.ORG

Molecular Genomics slides - Brainmapping.ORG

Molecular Genomics slides -

Take Home MessageMolecular Imaging GenomicsDavid C. Glahn, PhDOlin Neuropsychiatry Research Center &Department of Psychiatry, Yale University• “This may be themost important thingI say in this lecture.There is no one sizefits all in geneticanalysis of complextraits.”–Laura AlmasyJuly 22, 2010How to do GeneticsQuestions for the Study ofQuestionWhat do you want to know?SampleWho do you need to study?MethodHow will you use your data?1) Is this trait influenced by genetic factors? How strong arethese genetic influences?2) Which traits are influenced by the same genes?3) Where are the genes that influence a trait?4) What are the specific genes that influence the trait?5) What specific genetic variants influence the trait and howdo they interact with each other and with the environment?Question 3: LocalizationWhere are the genes thatinfluence a trait?Two Common Methods forGene LocalizationLinkage analyses: test for co-segregation ofphenotype and genotype within families - afunction of physical connections of genes onchromosomesAssociation analyses: test for deviations ofphenotype-genotype combinations from thatpredicted by their separate frequencies - afunction of linkage disequilibrium created bypopulation history

Quantitative Genomics slides - Brainmapping.ORG
Molecular Genetics & Genomics
The Unseen Genome - Institute for Molecular Bioscience
Genetics: From Genes to Genomes Evolution at the Molecular Level ...
Molecular Biometry in the Genomic Era DNA Microarrays.