part 1 - EuroAfrica-ICT

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COORDINATORProf David William TaylorUniversity of EdinburghRoyal Dick School for Veterinary StudiesCentre for infectious DiseasesOld College, North BridgeEH12 9YL EdinburghUnited KingdomE-mail: david.w.taylor@ed.ac.ukTel. (44-131) 650 70 14Fax (44-131) 651 39 03CONTRACTORSDr Samuel WanjiResearch Foundation in Tropical Diseases andEnvironmentDisease Control UnitMolyko 474BueaCameroonE-mail: swanji@yahoo.frTel. (237-332) 31 09Fax (237-332) 27 65Dr Vincent Ngwang TanyaInstitut de recherche agricole pourle développementRegional Centre of Irad WakwaVeterinary Research LaboratoryNgaoundereCameroonE-mail: vntanya@yahoo.comTel. (237-776) 90 83Fax (237-223) 35 38Prof Ohene AdjeiKwame Nkrumah University ofScience and TechnologyDepartment of Clinical Microbiology, School ofMedical SciencesUniversity Post OfficeKumasiGhanaE-mail: 25oadjei@africaonline.ghTel. (233-51) 605 31Fax (233-51) 620 17Dr Meba BanlaUniversité de LoméFaculte mixte de pharmacie et medicineDepartment of ophthalmology(onchocerciasis reference laboratory)LoméTogoE-mail: mebabania@hotmail.comTel. (228-550) 954Fax (228-902) 22 81Judith Elizabeth AllenUniversity of EdinburghCentre for Immunology and InfectionOld College, North BridgeEdinburghUnited KingdomE-mail: j.allen@ed.ac.ukTel. (44-131) 650 70 14Prof Alexander John TreesIncorporated Liverpool School of TropicalMedicineVeterinary ParasitologyPembroke PlaceL3 5QA LiverpoolUnited KingdomE-mail: tree@liv.ac.ukTel. (44-151) 705 31 18Fax (44-151) 705 33 73Prof Achim HöraufUniversitätsklinikum BonnInstitute for Medical Parasitology, BonnUniversitySigmund-Freud-Str. 2553105 BonnGermanyE-mail: hoerauf@parasit.meb.uniu-bonn.deTel. (49-228) 287 56 73Fax (49-228) 287 95 73Prof Hartwig Schulz-KeyEberhard Karls Universität TübingenInstitute of Tropical MedicineWilhelmstr. 772074 TübingenGermanyE-mail: hartwig.schulz-key@uni-tuebingen.deTel. (49-7071) 298 67 59Fax (49-7071) 29 59 96Dr Odile BainMuseum National d’Histoire NaturelleEcologie et Gestion de la Biodiversité,parasitologie comparée etmodèles experimentauxCuvier 577500505 ParisFranceE-mail: bain@mnhn.frTel. (33) 140 79 03 40 97Fax (33) 140 79 03 40 97Developing Countries
Biology and clinical staging of trypanosome neuroinvasion in sleeping sicknessPeriod: 01/10/2006 to 30/09/2009Budget from EC: EUR 1 700 000Coordinator: Prof Krister KristenssonKarolinska InstitutetThe NEUROTRYP project foresees a highly integratedinvestigation of sleeping sickness or human Africantrypanosomiasis (HAT). This is a neglected but re-emergingdisease in sub-Saharan Africa. HAT develops into an earlyhaemolymphatic and a subsequent encephalitic stage,during which the causative parasite Trypanosoma bruceiand/or increased numbers of lymphocytes are found in thecerebrospinal fluid. Arsenic compounds are still the drugsof choice for treatment at the encephalitic stage, but theyare associated with severe and often fatal side-effects.Drug resistance also poses a serious problem. There areimportant gaps in knowledge concerning the following:the mechanisms by which trypanosomes invade the brain;when, post-infection, such invasion occurs; and the effectsof drugs on trypanosomes that have invaded the brainparenchyma. Therefore, the objective of the NEUROTRYPconsortium is to discover molecules that may be consideredas markers for an effective staging of HAT, and design newtherapies by using drugs which have already passed clinicaltrials in humans for other indications.In order to discover mechanisms of parasite neuroinvasionand thereby devise candidate diagnostic markers for aneffective staging and new therapeutic management ofHAT, the NEUROTRYP project plans to pursue the followingactivities: diagnostic tools to be used in therapeutic decisions andcure assessment; toxicity drugs already in use for other diseases, whichcan interfere with trypanosomes that are invading orhave invaded the brain; logical parameters that correlate to trypanosomeneuroinvasion, as well as therapeutic windows for drugsto clear trypanosomes from the brain; by providing transfer of technology to and training forjunior investigators, especially African scientists; also todevelop expertise on HAT and other neuro-inflammatorydiseases, which plague the African continent.The research will provide new knowledge on the biology,epidemiology, and the technologies relevant to sustainablesurveillance systems of HAT on a regional scale. In addition, itwill provide information with the intention of improving theexisting treatment of sleeping sickness. Once established asrobust, such technologies can be incorporated into nationallaboratories and regional reference centres. By includingfive African and three European partners, the project willprovide a basis for the development of a strong and durablepartnership, with extensive interaction and exchangesbetween African and European countries. In particular,NEUROTRYP expects to do the following: tools for disease staging and cure assessment; and institutions, and establish durable collaborationbetween European and African laboratories; whereby drugs may be designed to inhibit and curetrypanosome neuroinvasion, which is the most seriouscomplication of African trypanosomiasis.Health and public health
Page 1 and 2: PROJECT SYNOPSESwith Africa in FP6E
Page 3 and 4: EUROPEAN COMMISSIONInternational Co
Page 5: In 2005, the African Union adopted
Page 8 and 9: 032289 / SHIELD....................
Page 10 and 11: 510790 / FOREAIM...................
Page 12 and 13: 015460 / OPTIWHEAT.................
Page 14 and 15: 517612 / MELIA.....................
Page 16 and 17: E. Multilateral coordination of nat
Page 19 and 20: In keeping with the increasingly in
Page 21 and 22: Land area [km2]Land area [km2]Popul
Page 23 and 24: A.DEVELOPING COUNTRIES1. Reproducti
Page 25 and 26: Promoting infant health and nutriti
Page 27 and 28: Simplified and rapid molecular assa
Page 29 and 30: Buruli ulcer: multidisciplinary res
Page 31 and 32: Support for clinical trial capacity
Page 33 and 34: Solar disinfection as an appropriat
Page 35 and 36: COORDINATORDr Kevin G McGuiganThe R
Page 37 and 38: Tsetse flies and the control of Afr
Page 39 and 40: Effects of Antiretrovirals for HIV
Page 41 and 42: The support collaboration: supporti
Page 43 and 44: Development of rapid field diagnost
Page 45 and 46: A multidisciplinary alliance to opt
Page 47 and 48: Strategies for health insurance mec
Page 49: Sustainable Control of Onchocercias
Page 53 and 54: Effectiveness of facility-based aud
Page 55 and 56: Experience of African countries wit
Page 57 and 58: Innate Immune Responses and Immunor
Page 59 and 60: T cell Regulation and the Control o
Page 61 and 62: Emergency contraception: a means to
Page 63 and 64: Addressing the health of children i
Page 65 and 66: Strengthening fairness and accounta
Page 67 and 68: Multi-disciplinary studies of human
Page 69 and 70: A.DEVELOPING COUNTRIES1. Managing h
Page 71 and 72: Tools for management and sustainabl
Page 73 and 74: Ecosystems, Societies, Consilience,
Page 75 and 76: COORDINATORDr Pierre FaillerUnivers
Page 77 and 78: Towards effective involvement of lo
Page 79 and 80: Integrating multiple demands on coa
Page 81 and 82: Prof Manfred HinzUniversity of Nami
Page 83 and 84: Exploring tradeoffs around farming
Page 85 and 86: Discovery Modelling Mediation Delib
Page 87 and 88: Earth Observation Initiative in for
Page 89 and 90: Main uses of the Grey mullet as ind
Page 91 and 92: Management of indigenous tree speci
Page 93 and 94: Dissemination of research results i
Page 95 and 96: Innovative tools and techniques for
Page 97 and 98: Innovative management of Acacia sen
Page 99 and 100: VGT Work How space helps to manage
Page 101 and 102:
Integrated trans-boundary river man
Page 103 and 104:
Cross sectoral commons governance i
Page 105 and 106:
The Environmental and Socio-economi
Page 107 and 108:
Sustainable options for People, Cat
Page 109 and 110:
COORDINATORDr João Gomes FerreiraD
Page 111 and 112:
Bridging restoration and multifunct
Page 113 and 114:
Transboundery networks of marine pr
Page 115 and 116:
Peri-urban mangrove forests as filt
Page 117 and 118:
A.DEVELOPING COUNTRIES1. Health of
Page 119 and 120:
Develoment of marker vaccines, comp
Page 121 and 122:
Epidemiology and new generation vac
Page 123 and 124:
Development of an “anti-disease
Page 125 and 126:
Networking to promote the sustainab
Page 127 and 128:
Upgrading quality and competitivene
Page 129 and 130:
Sahelian Fruit TreesPeriod: 01/01/2
Page 131 and 132:
Molecular, Environmental and Nutrit
Page 133 and 134:
Domestication and development of ba
Page 135 and 136:
Development of innovative and healt
Page 137 and 138:
Integrating BOMOSA cage fish farmin
Page 139 and 140:
Competence Platform on Energy Crop
Page 141:
Prof N.H. RavindranathIndian Instit
Page 144 and 145:
COORDINATORDr Daniel ClavelCentre d
Page 146 and 147:
COORDINATORProf Dr Frans JongejanUt
Page 148:
Dr José de la FuenteUniversidad de
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part 1 - EuroAfrica-ICT

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